| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Julius Pop. Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33766131. |
plasma neurofilament light and phosphorylated tau 181 as biomarkers of alzheimer's disease pathology and clinical disease progression. |
2021-06-24 |
2023-08-13 |
Not clear |
| Christopher Clark, Piotr Lewczuk, Johannes Kornhuber, Jonas Richiardi, Bénédicte Maréchal, Thomas K Karikari, Kaj Blennow, Henrik Zetterberg, Julius Pop. Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33766131. |
to assess the performance of plasma neurofilament light (nfl) and phosphorylated tau 181 (p-tau181) to inform about cerebral alzheimer's disease (ad) pathology and predict clinical progression in a memory clinic setting. |
2021-06-24 |
2023-08-13 |
Not clear |
| Yu Guo, Yu-Yuan Huang, Xue-Ning Shen, Shi-Dong Chen, Hao Hu, Zuo-Teng Wang, Lan Tan, Jin-Tai Y. Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33947453. |
characterization of alzheimer's tau biomarker discordance using plasma, csf, and pet. |
2021-06-24 |
2023-08-13 |
Not clear |
| Yu Guo, Yu-Yuan Huang, Xue-Ning Shen, Shi-Dong Chen, Hao Hu, Zuo-Teng Wang, Lan Tan, Jin-Tai Y. Characterization of Alzheimer's tau biomarker discordance using plasma, CSF, and PET. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33947453. |
we aimed to investigate the tau biomarker discrepancies of alzheimer's disease (ad) using plasma tau phosphorylated at threonine 181 (p-tau181), cerebrospinal fluid (csf) p-tau181, and av1451 positron emission tomography (pet). |
2021-06-24 |
2023-08-13 |
Not clear |
| Pei-Pei Guan, Long-Long Cao, Pu Wan. Elevating the Levels of Calcium Ions Exacerbate Alzheimer's Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau. International journal of molecular sciences. vol 22. issue 11. 2021-06-24. PMID:34072743. |
elevating the levels of calcium ions exacerbate alzheimer's disease via inducing the production and aggregation of β-amyloid protein and phosphorylated tau. |
2021-06-24 |
2023-08-13 |
Not clear |
| Viktor Maurer, Claudia Frank, Julian Cedric Porsiel, Sabrina Zellmer, Georg Garnweitner, Rainer Stosc. Step-by-step monitoring of a magnetic and SERS-active immunosensor assembly for purification and detection of tau protein. Journal of biophotonics. vol 13. issue 3. 2021-06-23. PMID:31721451. |
we report a bottom-up synthesis of iron oxide and gold nanoparticles, which are functionalized and combined to form a nanohybrid serving as an immune sensor, which selectively binds to tau protein, a biomarker for diagnosis of alzheimer's disease. |
2021-06-23 |
2023-08-13 |
Not clear |
| Kamalini G Ranasinghe, Jungho Cha, Leonardo Iaccarino, Leighton B Hinkley, Alexander J Beagle, Julie Pham, William J Jagust, Bruce L Miller, Katherine P Rankin, Gil D Rabinovici, Keith A Vossel, Srikantan S Nagaraja. Neurophysiological signatures in Alzheimer's disease are distinctly associated with TAU, amyloid-β accumulation, and cognitive decline. Science translational medicine. vol 12. issue 534. 2021-06-23. PMID:32161102. |
neurophysiological signatures in alzheimer's disease are distinctly associated with tau, amyloid-β accumulation, and cognitive decline. |
2021-06-23 |
2023-08-13 |
Not clear |
| Sruti Rayaprolu, Lenora Higginbotham, Pritha Bagchi, Caroline M Watson, Tian Zhang, Allan I Levey, Srikant Rangaraju, Nicholas T Seyfrie. Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 1. 2021-06-23. PMID:32898852. |
systems-based proteomics to resolve the biology of alzheimer's disease beyond amyloid and tau. |
2021-06-23 |
2023-08-13 |
Not clear |
| Sabrina Simoes, Jessica L Neufeld, Gallen Triana-Baltzer, Setareh Moughadam, Emily I Chen, Milankumar Kothiya, Yasir H Qureshi, Vivek Patel, Lawrence S Honig, Hartmuth Kolb, Scott A Smal. Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Science translational medicine. vol 12. issue 571. 2021-06-23. PMID:33239387. |
tau and other proteins found in alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. |
2021-06-23 |
2023-08-13 |
mouse |
| Pragati, Surajit Sarka. Shaggy functions downstream of dMyc and their concurrent downregulation confers additive rescue against tau toxicity in Drosophila. BioFactors (Oxford, England). vol 47. issue 3. 2021-06-23. PMID:33651466. |
neurodegenerative tauopathies such as alzheimer's and parkinson's diseases are characterized by hyperphosphorylation of tau protein and their subsequent aggregation in the forms of paired helical filaments and/or neurofibrillary tangles in specific areas of the brain. |
2021-06-23 |
2023-08-13 |
human |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
four distinct trajectories of tau deposition identified in alzheimer's disease. |
2021-06-23 |
2023-08-13 |
Not clear |
| Jacob W Vogel, Alexandra L Young, Neil P Oxtoby, Ruben Smith, Rik Ossenkoppele, Olof T Strandberg, Renaud La Joie, Leon M Aksman, Michel J Grothe, Yasser Iturria-Medina, Michael J Pontecorvo, Michael D Devous, Gil D Rabinovici, Daniel C Alexander, Chul Hyoung Lyoo, Alan C Evans, Oskar Hansso. Four distinct trajectories of tau deposition identified in Alzheimer's disease. Nature medicine. vol 27. issue 5. 2021-06-23. PMID:33927414. |
alzheimer's disease (ad) is characterized by the spread of tau pathology throughout the cerebral cortex. |
2021-06-23 |
2023-08-13 |
Not clear |
| Camille Taccola, Pascal Barneoud, Sylvaine Cartot-Cotton, Delphine Valente, Nathalie Schussler, Bruno Saubaméa, Stéphanie Chasseigneaux, Véronique Cochois, Virginie Mignon, Emmanuel Curis, Murielle Lochus, Sophie Nicolic, Agnès Dodacki, Salvatore Cisternino, Xavier Declèves, Fanchon Bourasse. Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration. Neuropharmacology. vol 191. 2021-06-23. PMID:33940010. |
the inducible p25 overexpression mouse model recapitulate many hallmark features of alzheimer's disase including progressive neuronal loss, elevated aβ, tau pathology, cognitive dysfunction, and impaired synaptic plasticity. |
2021-06-23 |
2023-08-13 |
mouse |
| Huang Kuang, Cheng-Yong Tan, Hui-Zhen Tian, Li-Hua Liu, Mei-Wen Yang, Fen-Fang Hong, Shu-Long Yan. Exploring the bi-directional relationship between autophagy and Alzheimer's disease. CNS neuroscience & therapeutics. vol 26. issue 2. 2021-06-22. PMID:31503421. |
alzheimer's disease (ad) is characterized by β-amyloid (aβ) deposition and tau phosphorylation, in which its pathogenesis has not been cleared so far. |
2021-06-22 |
2023-08-13 |
Not clear |
| Yuan Zhao, Yidan Zhang, Jian Zhang, Xiangjian Zhang, Guofeng Yan. Molecular Mechanism of Autophagy: Its Role in the Therapy of Alzheimer's Disease. Current neuropharmacology. vol 18. issue 8. 2021-06-22. PMID:31934838. |
alzheimer's disease (ad) is a neurodegenerative disorder of progressive dementia that is characterized by the accumulation of beta-amyloid (aβ)-containing neuritic plaques and intracellular tau protein tangles. |
2021-06-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Randall J Bateman, Christophe Hirtz, Philippe Marin, François Becher, Chihiro Sato, Audrey Gabelle, Sylvain Lehman. Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-22. PMID:32183883. |
cerebrospinal fluid biomarker profiles characterized by decreased amyloid-beta peptide levels and increased total and phosphorylated tau levels at threonine 181 (pt181) are currently used to discriminate between alzheimer's disease and other neurodegenerative diseases. |
2021-06-22 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Randall J Bateman, Christophe Hirtz, Philippe Marin, François Becher, Chihiro Sato, Audrey Gabelle, Sylvain Lehman. Cerebrospinal fluid phospho-tau T217 outperforms T181 as a biomarker for the differential diagnosis of Alzheimer's disease and PET amyloid-positive patient identification. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-22. PMID:32183883. |
however, these changes are not entirely specific to alzheimer's disease, and it is noteworthy that other phosphorylated isoforms of tau, possibly more specific for the disease process, have been described in the brain parenchyma of patients. |
2021-06-22 |
2023-08-13 |
Not clear |
| Mamali Das, Kasi Pandima Dev. Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. Neurotoxicology. vol 84. 2021-06-22. PMID:33617922. |
alzheimer's disease (ad) etiology has been studied for a long time and it is found to be multifaceted involving the accumulation of amyloid β and tau protein. |
2021-06-22 |
2023-08-13 |
human |
| Roberta Cascella, Cristina Cecch. Calcium Dyshomeostasis in Alzheimer's Disease Pathogenesis. International journal of molecular sciences. vol 22. issue 9. 2021-06-22. PMID:34066371. |
alzheimer's disease (ad) is the most common age-related neurodegenerative disorder that is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles consisting of abnormally phosphorylated tau protein, and neuronal loss leading to cognitive decline and dementia. |
2021-06-22 |
2023-08-13 |
Not clear |
| Ping Kwan, Haruki Konno, Ka Yan Chan, Larry Bau. Rationale for the development of an Alzheimer's disease vaccine. Human vaccines & immunotherapeutics. vol 16. issue 3. 2021-06-21. PMID:31526227. |
however, amyloid β (aβ) or tau, which can act like infectious proteins, or prions, might induce alzheimer's disease (ad). |
2021-06-21 |
2023-08-13 |
Not clear |