| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisha Wang, Bharti, Rajnish Kumar, Pavel F Pavlov, Bengt Winbla. Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance. European journal of medicinal chemistry. vol 209. 2021-05-03. PMID:33139110. |
alzheimer's disease (ad) is the most common form of dementia characterized by presence of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau protein. |
2021-05-03 |
2023-08-13 |
Not clear |
| Yinyin Tan, Yanqun Zheng, Daiwen Xu, Zhanfang Sun, Huan Yang, Qingqing Yi. Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease. Cell & bioscience. vol 11. issue 1. 2021-05-02. PMID:33906678. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by the deposition of extracellular aggregates of amyloid-β (aβ), the formation of intraneuronal tau neurofibrillary tangles and microglial activation-mediated neuroinflammation. |
2021-05-02 |
2023-08-13 |
human |
| Monika Arbaciauskaite, Yu Lei, Yong Ku Ch. High-specificity antibodies and detection methods for quantifying phosphorylated tau from clinical samples. Antibody therapeutics. vol 4. issue 1. 2021-05-02. PMID:33928234. |
the ability to measure total and phosphorylated tau levels in clinical samples is transforming the detection of alzheimer's disease (ad) and other neurodegenerative diseases. |
2021-05-02 |
2023-08-13 |
Not clear |
| Islauddin Khan, Kumari Preeti, Valencia Fernandes, Dharmendra Kumar Khatri, Shashi Bala Sing. Role of MicroRNAs, Aptamers in Neuroinflammation and Neurodegenerative Disorders. Cellular and molecular neurobiology. 2021-05-02. PMID:33934227. |
ndds like alzheimer's disease, parkinson's disease, huntington's disease, multiple sclerosis, prion disease, and others are characterized by deposition of misfolded protein such as amyloid-ß, tau, α-synuclein, huntingtin and prion proteins. |
2021-05-02 |
2023-08-13 |
human |
| Edward S Wickstead, Murray A Irving, Stephen J Getting, Simon McArthu. Exploiting formyl peptide receptor 2 to promote microglial resolution: a new approach to Alzheimer's disease treatment. The FEBS journal. 2021-05-01. PMID:33811735. |
alzheimer's disease pathology has long been considered in terms of accumulation of amyloid beta and hyperphosphorylated tau, but the importance of neuroinflammation in driving disease has taken greater precedence over the last 15-20 years. |
2021-05-01 |
2023-08-13 |
human |
| Münteha Nur Sonuç Karaboga, Mustafa Kemal Sezgintür. Analysis of Tau-441 protein in clinical samples using rGO/AuNP nanocomposite-supported disposable impedimetric neuro-biosensing platform: Towards Alzheimer's disease detection. Talanta. vol 219. 2021-04-30. PMID:32887148. |
changes in isoforms of tau protein, which are critical for microtubule functioning, are accepted as being responsible for diseases characterized by dementia, in particular alzheimer's disease (ad). |
2021-04-30 |
2023-08-13 |
Not clear |
| Jochen Hammes, Gérard N Bischof, Karl P Bohn, Özgür Onur, Anja Schneider, Klaus Fliessbach, Merle C Hönig, Frank Jessen, Bernd Neumaier, Alexander Drzezga, Thilo van Eimere. One-Stop Shop: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 62. issue 2. 2021-04-29. PMID:32620704. |
one-stop shop: tau protein aggregations are a hallmark of amyloid-associated alzheimer disease and some forms of non-amyloid-associated frontotemporal lobar degeneration. |
2021-04-29 |
2023-08-13 |
Not clear |
| Yun Wei, Meixia Liu, Dongxin Wan. The propagation mechanisms of extracellular tau in Alzheimer's disease. Journal of neurology. 2021-04-29. PMID:33913022. |
the propagation mechanisms of extracellular tau in alzheimer's disease. |
2021-04-29 |
2023-08-13 |
Not clear |
| Yun Wei, Meixia Liu, Dongxin Wan. The propagation mechanisms of extracellular tau in Alzheimer's disease. Journal of neurology. 2021-04-29. PMID:33913022. |
the abnormal intracellular aggregation of tau has been strongly associated with alzheimer's disease (ad). |
2021-04-29 |
2023-08-13 |
Not clear |
| Samuel Iddi, Dan Li, Paul S Aisen, Michael S Rafii, Wesley K Thompson, Michael C Donohu. Predicting the course of Alzheimer's progression. Brain informatics. vol 6. issue 1. 2021-04-28. PMID:31254120. |
alzheimer's disease is the most common neurodegenerative disease and is characterized by the accumulation of amyloid-beta peptides leading to the formation of plaques and tau protein tangles in brain. |
2021-04-28 |
2023-08-13 |
Not clear |
| Philip S Insel, Elizabeth C Mormino, Paul S Aisen, Wesley K Thompson, Michael C Donohu. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. Brain communications. vol 2. issue 1. 2021-04-28. PMID:32140682. |
neuroanatomical spread of amyloid β and tau in alzheimer's disease: implications for primary prevention. |
2021-04-28 |
2023-08-13 |
human |
| Philip S Insel, Elizabeth C Mormino, Paul S Aisen, Wesley K Thompson, Michael C Donohu. Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. Brain communications. vol 2. issue 1. 2021-04-28. PMID:32140682. |
disease time was estimated in 279 participants (183 cognitively unimpaired individuals, 61 mild cognitive impairment and 35 alzheimer's disease dementia patients) with available amyloid β and tau pet data. |
2021-04-28 |
2023-08-13 |
human |
| Jacques Hugon, Claire Paque. The PKR/P38/RIPK1 Signaling Pathway as a Therapeutic Target in Alzheimer's Disease. International journal of molecular sciences. vol 22. issue 6. 2021-04-28. PMID:33808629. |
neuropathological lesions in alzheimer's disease (ad) include amyloid plaques formed by the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated tau protein, synaptic and neuronal degenerations, and neuroinflammation. |
2021-04-28 |
2023-08-13 |
Not clear |
| Lydia Giménez-Llort, Mikel Santana-Santana, Míriam Ratia, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, Maria Victòria Clo. Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3. Brain sciences. vol 11. issue 4. 2021-04-28. PMID:33810622. |
a new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of β-amyloid and tau alzheimer's disease (ad) pathologies. |
2021-04-28 |
2023-08-13 |
mouse |
| Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wan. Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission. Cell stem cell. vol 26. issue 3. 2021-04-27. PMID:31978364. |
phospho-tau accumulation and adult hippocampal neurogenesis (ahn) impairment both contribute importantly to the cognitive decline in alzheimer's disease (ad), but whether and how tau dysregulates ahn in ad remain poorly understood. |
2021-04-27 |
2023-08-13 |
mouse |
| Tina Bilousova, Bryan J Simmons, Rachel R Knapp, Chris J Elias, Jesus Campagna, Mikhail Melnik, Sujyoti Chandra, Samantha Focht, Chunni Zhu, Kanagasabai Vadivel, Barbara Jagodzinska, Whitaker Cohn, Patricia Spilman, Karen H Gylys, Neil K Garg, Varghese Joh. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ACS chemical biology. vol 15. issue 6. 2021-04-26. PMID:32352753. |
inhibition of these enzymes provides a unique strategy to suppress the propagation of tau pathology in the treatment of alzheimer's disease (ad). |
2021-04-26 |
2023-08-13 |
Not clear |
| Alexa Pichet Binette, Étienne Vachon-Presseau, John Morris, Randall Bateman, Tammie Benzinger, D Louis Collins, Judes Poirier, John C S Breitner, Sylvia Villeneuv. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer's Disease. Biological psychiatry. vol 89. issue 8. 2021-04-23. PMID:32228870. |
amyloid and tau pathology associations with personality traits, neuropsychiatric symptoms, and cognitive lifestyle in the preclinical phases of sporadic and autosomal dominant alzheimer's disease. |
2021-04-23 |
2023-08-13 |
Not clear |
| Tengfei Guo, Deniz Korman, Suzanne L Baker, Susan M Landau, William J Jagus. Longitudinal Cognitive and Biomarker Measurements Support a Unidirectional Pathway in Alzheimer's Disease Pathophysiology. Biological psychiatry. vol 89. issue 8. 2021-04-23. PMID:32919611. |
amyloid-β (aβ) likely plays a primary role in alzheimer's disease pathogenesis, but longitudinal aβ, tau, and neurodegeneration (a/t/n) measurements in the same individuals have rarely been examined to verify the temporal dynamics of these biomarkers. |
2021-04-23 |
2023-08-13 |
Not clear |
| Kaj Blenno. A Review of Fluid Biomarkers for Alzheimer's Disease: Moving from CSF to Blood. Neurology and therapy. vol 6. issue Suppl 1. 2021-04-21. PMID:28733960. |
a set of core cerebrospinal fluid (csf) biomarkers for alzheimer's disease (ad) includes total tau (t-tau), phosphorylated tau (p-tau) and β-amyloid 42 (aβ42). |
2021-04-21 |
2023-08-13 |
Not clear |
| Ashok Iyaswamy, Senthil Kumar Krishnamoorthi, Ju-Xian Song, Chuan-Bin Yang, Venkatapathy Kaliyamoorthy, Huan Zhang, Sravan G Sreenivasmurthy, Sandeep Malampati, Zi-Ying Wang, Zhou Zhu, Benjamin Chun-Kit Tong, King-Ho Cheung, Jia-Hong Lu, Siva Sundara Kumar Durairajan, Min L. NeuroDefend, a novel Chinese medicine, attenuates amyloid-β and tau pathology in experimental Alzheimer's disease models. Journal of food and drug analysis. vol 28. issue 1. 2021-04-21. PMID:31883601. |
neurodefend, a novel chinese medicine, attenuates amyloid-β and tau pathology in experimental alzheimer's disease models. |
2021-04-21 |
2023-08-13 |
mouse |