| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Kawarabayashi, Takumi Nakamura, Kazuya Miyashita, Isamu Fukamachi, Yusuke Seino, Mikio Shoj. Novel ELISAs to measure total and phosphorylated tau in cerebrospinal fluid. Neuroscience letters. vol 722. 2021-04-19. PMID:32045623. |
cerebrospinal fluid (csf) total tau (t-tau) and tau protein phosphorylated at threonine 181 (p181tau) are established biomarkers for alzheimer's disease (ad). |
2021-04-19 |
2023-08-13 |
Not clear |
| Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Guro Berge, Linda R White, Øyvind Salvesen, Geir Bråthen, Sigrid Botne Sand. The Amyloid, Tau, and Neurodegeneration (A/T/N) Classification Applied to a Clinical Research Cohort with Long-Term Follow-Up. Journal of Alzheimer's disease : JAD. vol 74. issue 3. 2021-04-19. PMID:32116257. |
the unbiased amyloid, tau, and neurodegeneration (a/t/n) classification is designed to characterize individuals in the alzheimer continuum and is currently little explored in clinical cohorts. |
2021-04-19 |
2023-08-13 |
Not clear |
| Georgia Watt, Kani Shang, Jerzy Zieba, Juan Olaya, Henry Li, Brett Garner, Tim Kar. Chronic Treatment with 50 mg/kg Cannabidiol Improves Cognition and Moderately Reduces Aβ40 Levels in 12-Month-Old Male AβPPswe/PS1ΔE9 Transgenic Mice. Journal of Alzheimer's disease : JAD. vol 74. issue 3. 2021-04-19. PMID:32116258. |
alzheimer's disease (ad) is characterized by progressive cognitive decline and pathologically by the accumulation of amyloid-β (aβ) and tau hyperphosphorylation causing neurodegeneration and neuroinflammation. |
2021-04-19 |
2023-08-13 |
mouse |
| Kenjirou Ogawa, Ayumi Ishii, Aimi Shindo, Kunihiro Hongo, Tomohiro Mizobata, Tetsuya Sogon, Yasushi Kawat. Spearmint Extract Containing Rosmarinic Acid Suppresses Amyloid Fibril Formation of Proteins Associated with Dementia. Nutrients. vol 12. issue 11. 2021-04-19. PMID:33202830. |
neurological dementias such as alzheimer's disease and lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (aβ), tau, and/or α-synuclein (αsyn). |
2021-04-19 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33283854. |
csf tau microtubule binding region identifies tau tangle and clinical stages of alzheimer's disease. |
2021-04-19 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33283854. |
tau is a microtubule associated protein in the brain that aggregates in alzheimer's disease to form pathological tangles and neurites. |
2021-04-19 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33283854. |
insoluble tau aggregates composed of the microtubule binding region (mtbr) of tau are highly associated with the cognitive and clinical symptoms of alzheimer's disease. |
2021-04-19 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33283854. |
in contrast, levels of soluble forms of tau, such as csf total tau and phosphorylated tau-181 and tau-217, increase prior to tau aggregation in alzheimer's disease, but these biomarkers do not measure the mtbr of tau. |
2021-04-19 |
2023-08-13 |
Not clear |
| Kanta Horie, Nicolas R Barthélemy, Chihiro Sato, Randall J Batema. CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33283854. |
this finding suggests that csf level of tau species containing the upstream region of mtbr may reflect changes in tau pathology that occur in alzheimer's disease and could serve as biomarkers to stage alzheimer's disease and track the development of tau-directed therapeutics. |
2021-04-19 |
2023-08-13 |
Not clear |
| Marta Montero-Crespo, Marta Domínguez-Álvaro, Lidia Alonso-Nanclares, Javier DeFelipe, Lidia Blazquez-Llorc. Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease. Brain : a journal of neurology. vol 144. issue 2. 2021-04-19. PMID:33324984. |
alzheimer's disease is typically associated with extracellular deposits of amyloid-β peptide and accumulation of abnormally phosphorylated tau protein inside neurons (amyloid-β and neurofibrillary pathologies). |
2021-04-19 |
2023-08-13 |
human |
| Michael Bell, Hans Zempe. SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability. Reviews in the neurosciences. 2021-04-18. PMID:33866701. |
somatodendritic missorting of tau is a pathological hallmark of many neurodegenerative diseases, including alzheimer's disease (ad). |
2021-04-18 |
2023-08-13 |
human |
| Chotipanich Chanisa, Nivorn Monchaya, Kunawudhi Anchisa, Promteangtrong Chetsadaporn, Jantarato Attapo. Analysis of amyloid and tau deposition in Alzheimer's disease using World journal of nuclear medicine. vol 20. issue 1. 2021-04-16. PMID:33850491. |
analysis of amyloid and tau deposition in alzheimer's disease using this study aims to determine the deposition of |
2021-04-16 |
2023-08-13 |
Not clear |
| Satoshi Muraoka, Mark P Jedrychowski, Kiran Yanamandra, Seiko Ikezu, Steven P Gygi, Tsuneya Ikez. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. vol 9. issue 9. 2021-04-15. PMID:32854315. |
pathological hallmarks of alzheimer's disease (ad) are deposits of amyloid beta (aβ) and hyper-phosphorylated tau aggregates in brain plaques. |
2021-04-15 |
2023-08-13 |
Not clear |
| Isabelle Guisle, Maud Gratuze, Séréna Petry, Françoise Morin, Rémi Keraudren, Robert A Whittington, Sébastien S Hébert, Valérie Mongrain, Emmanuel Plane. Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature. Sleep. vol 43. issue 4. 2021-04-14. PMID:31702011. |
aggregates of hyperphosphorylated tau protein are a hallmark of alzheimer's disease (ad) and other tauopathies. |
2021-04-14 |
2023-08-13 |
mouse |
| Henrik Zetterberg, Barbara B Bendli. Biomarkers for Alzheimer's disease-preparing for a new era of disease-modifying therapies. Molecular psychiatry. vol 26. issue 1. 2021-04-14. PMID:32251378. |
clinical trial results presented in 2019 suggest that antibody-based removal of cerebral amyloid β (aβ) plaques may possibly clear tau tangles and modestly slow cognitive decline in symptomatic alzheimer's disease (ad). |
2021-04-14 |
2023-08-13 |
Not clear |
| Adriana Savastano, Garima Jaipuria, Loren Andreas, Eckhard Mandelkow, Markus Zweckstette. Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific reports. vol 10. issue 1. 2021-04-14. PMID:33273615. |
the aggregation of hyperphosphorylated tau into amyloid fibrils is closely linked to the progression of alzheimer's disease. |
2021-04-14 |
2023-08-13 |
Not clear |
| Adriana Savastano, Garima Jaipuria, Loren Andreas, Eckhard Mandelkow, Markus Zweckstette. Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils. Scientific reports. vol 10. issue 1. 2021-04-14. PMID:33273615. |
the proline-rich region of tau remains poorly defined in the context of tau amyloid structures, despite the clustering of several phosphorylation sites, which have been associated with alzheimer's disease. |
2021-04-14 |
2023-08-13 |
Not clear |
| Zhongbo Chen, David Zhang, Regina H Reynolds, Emil K Gustavsson, Sonia García-Ruiz, Karishma D'Sa, Aine Fairbrother-Browne, Jana Vandrovcova, John Hardy, Henry Houlden, Sarah A Gagliano Taliun, Juan Botía, Mina Ryte. Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage. Nature communications. vol 12. issue 1. 2021-04-14. PMID:33824317. |
using human brain rna-sequencing data, we show the intron-3-retaining transcript to be more abundant in alzheimer's disease with more severe tau and amyloid pathological burden. |
2021-04-14 |
2023-08-13 |
human |
| Jonathan L Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J Frank, Timothy Zembryski, Christopher Hubbs, HaJeung Park, Jane Withka, Claire Steppan, Lucy Rogers, Shawn Cabral, Martin Pettersson, Travis T Wager, Matthew A Fountain, Gavin Rumbaugh, Jessica L Childs-Disney, Matthew D Disne. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. Journal of the American Chemical Society. vol 142. issue 19. 2021-04-13. PMID:32364710. |
one pre-mrna that is alternatively spliced and linked to neurodegenerative diseases is tau (microtubule-associated protein tau), which can cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and can contribute to alzheimer's disease. |
2021-04-13 |
2023-08-13 |
human |
| Qingqin S Li, Diana Ca. Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs Associated With Alzheimer's Disease Using Post-mortem Brain Tissue Samples. Frontiers in neuroscience. vol 15. 2021-04-11. PMID:33833661. |
alzheimer's disease (ad), the leading form of dementia, is associated with abnormal tau and β-amyloid accumulation in the brain. |
2021-04-11 |
2023-08-13 |
Not clear |