| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Giavanna Paterno, Brach M Bell, Alexis Riley-DiPaolo, Matthew J LaVoie, Benoit I Giasso. Polymerization of recombinant tau core fragments Frontiers in neuroscience. vol 17. 2024-01-01. PMID:38161790. |
the unique impact of tau phosphorylation on seeding propensity was also investigated by altering stretches of phospho-mimetic and phospho-null residues in the presence of alzheimer's disease tau core fibrils. |
2024-01-01 |
2024-01-05 |
Not clear |
| Marc S Weinberg, Yingnan He, Pia Kivisäkk, Steven E Arnold, Sudeshna Da. Effect of Metformin on Plasma and Cerebrospinal Fluid Biomarkers in Non-Diabetic Older Adults with Mild Cognitive Impairment Related to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-12-31. PMID:38160357. |
alzheimer's disease (ad) is a complicated condition involving multiple metabolic and immunologic pathophysiological processes that can occur with the hallmark pathologies of amyloid-β, tau, and neurodegeneration. |
2023-12-31 |
2024-01-05 |
human |
| Ali Mahzarnia, Michael W Lutz, Alexandra Bade. A Continuous Extension of Gene Set Enrichment Analysis Using the Likelihood Ratio Test Statistics Identifies Vascular Endothelial Growth Factor as a Candidate Pathway for Alzheimer's Disease via ITGA5. Journal of Alzheimer's disease : JAD. 2023-12-31. PMID:38160360. |
alzheimer's disease (ad) involves brain neuropathologies such as amyloid plaque and hyperphosphorylated tau tangles and is accompanied by cognitive decline. |
2023-12-31 |
2024-01-05 |
Not clear |
| Zimeng Cheng, Tianyue Han, Jingtong Yao, Kaixuan Wang, Xue Dong, Fan Yu, He Huang, Menglin Han, Qinghong Liao, Siyu He, Weiping Lyu, Qi L. Targeting glycogen synthase kinase-3β for Alzheimer's disease: Recent advances and future Prospects. European journal of medicinal chemistry. vol 265. 2023-12-31. PMID:38160617. |
senile plaques induced by β-amyloid (aβ) abnormal aggregation and neurofibrillary tangles (nft) caused by tau hyperphosphorylation are important pathological manifestations of alzheimer's disease (ad). |
2023-12-31 |
2024-01-05 |
Not clear |
| Laia Montoliu-Gaya, Michael L Alosco, Eukyung Yhang, Yorghos Tripodis, Daniel Sconzo, Madeline Ally, Lana Grötschel, Nicholas J Ashton, Juan Lantero-Rodriguez, Mathias Sauer, Bárbara Gomes, Johanna Nilsson, Gunnar Brinkmalm, Michael A Sugarman, Hugo J Aparicio, Brett Martin, Joseph N Palmisano, Eric G Steinberg, Irene Simkin, Katherine W Turk, Andrew E Budson, Rhoda Au, Lindsay Farrer, Gyungah R Jun, Neil W Kowall, Robert A Stern, Lee E Goldstein, Wei Qiao Qiu, Jesse Mez, Bertrand Russell Huber, Victor E Alvarez, Ann C McKee, Henrik Zetterberg, Johan Gobom, Thor D Stein, Kaj Blenno. Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study. Acta neuropathologica. vol 147. issue 1. 2023-12-30. PMID:38159140. |
optimal blood tau species for the detection of alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study. |
2023-12-30 |
2024-01-05 |
human |
| Ziyi Chen, Shu Liu, Hui Zhou, Meiyuan Wang, Shuhua Pei, Rongjin Wang, Zhongying Li. UPLC-Q-TOF/MS based serum and urine metabolomics strategy to analyze the mechanism of nervonic acid in treating Alzheimer's disease. Journal of pharmaceutical and biomedical analysis. vol 240. 2023-12-29. PMID:38157740. |
in this study, the results of serum biochemical indexes showed that nervonic acid improved inflammation and reduced amyloid β peptide (aβ) deposition and tau protein phosphorylation in alzheimer's disease (ad) rats. |
2023-12-29 |
2024-01-05 |
human |
| Calina Glynn, Joshua E Chun, Cameron C Donahue, Monica J S Nadler, Zhanyun Fan, Bradley T Hyma. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Biochemistry. 2023-12-28. PMID:38154792. |
reconstitution of the alzheimer's disease tau core structure from recombinant tau the protein tau misfolds into disease-specific fibrillar structures in more than 20 neurodegenerative diseases collectively referred to as tauopathies. |
2023-12-28 |
2023-12-31 |
Not clear |
| Jing Zhang, Hai-Tian Jiang, Dao-Bin Han, Hui Yu, Lu-Wen Wang, Bo S. [Research advances in the role of Rab GTPases in Alzheimer's disease]. Sheng li xue bao : [Acta physiologica Sinica]. vol 75. issue 6. 2023-12-27. PMID:38151346. |
extracellular deposition of β-amyloid (aβ) and intracellular hyperphosphorylated tau are the predominant pathological changes in alzheimer's disease (ad). |
2023-12-27 |
2023-12-30 |
Not clear |
| Morgane Darricau, Changsong Dou, Remi Kinet, Tao Zhu, Li Zhou, Xianglei Li, Aurélie Bedel, Stéphane Claverol, Caroline Tokarski, Taxiarchis Katsinelos, William A McEwan, Ling Zhang, Ran Gao, Mathieu Bourdenx, Benjamin Dehay, Chuan Qin, Erwan Bezard, Vincent Planch. Tau seeds from Alzheimer's disease brains trigger tau spread in macaques while oligomeric-Aβ mediates pathology maturation. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-12-27. PMID:38148705. |
tau seeds from alzheimer's disease brains trigger tau spread in macaques while oligomeric-aβ mediates pathology maturation. |
2023-12-27 |
2023-12-29 |
Not clear |
| Habbiburr Rehman, Ting Fang Alvin Ang, Qiushan Tao, Arielle Lauren Espenilla, Rhoda Au, Lindsay A Farrer, Xiaoling Zhang, Wei Qiao Qi. Comparison of Commonly Measured Plasma and Cerebrospinal Fluid Proteins and Their Significance for the Characterization of Cognitive Impairment Status. Journal of Alzheimer's disease : JAD. 2023-12-25. PMID:38143358. |
although cerebrospinal fluid (csf) amyloid-β 42 peptide (aβ 42) and phosphorylated tau (p-tau) and blood p-tau are valuable for differential diagnosis of alzheimer's disease (ad) from cognitively normal (cn) there is a lack of validated biomarkers for mild cognitive impairment (mci). |
2023-12-25 |
2023-12-27 |
Not clear |
| Lauren Walker, Johannes Attem. Prevalence of Concomitant Pathologies in Parkinson's Disease: Implications for Prognosis, Diagnosis, and Insights into Common Pathogenic Mechanisms. Journal of Parkinson's disease. 2023-12-25. PMID:38143370. |
pathologies characteristic of alzheimer's disease (i.e., hyperphosphorylated tau and amyloid-β (aβ) plaques), cardiovascular disease, and limbic predominant tdp-43 encephalopathy (late) often co-exist in patients with parkinson's disease (pd), in addition to lewy body pathology (α-synuclein). |
2023-12-25 |
2023-12-27 |
Not clear |
| Indalo Domene-Serrano, Raquel Cuadros, Felix Hernandez, Jesus Avila, Ismael Santa-Mari. Tridimensional Structural Analysis of Tau Isoforms Generated by Intronic Retention. Journal of Alzheimer's disease reports. vol 7. issue 1. 2023-12-25. PMID:38143771. |
our preliminary data suggests this newly discovered w-tau isoform might prevent aberrant aggregation of other tau isoforms but is significantly downregulated in tauopathies such as alzheimer's disease. |
2023-12-25 |
2023-12-27 |
human |
| Giorgio Guido, Katia Mangano, Lyubka Tancheva, Reni Kalfin, Gian Marco Leone, Andrea Saraceno, Paolo Fagone, Ferdinando Nicoletti, Maria Cristina Petrali. Evaluation of Cell-Specific Alterations in Alzheimer's Disease and Relevance of In Vitro Models. Genes. vol 14. issue 12. 2023-12-23. PMID:38137009. |
alzheimer's disease (ad) is a neurodegenerative disorder classically characterized by two neuropathological hallmarks: β-amyloid plaques and tau tangles in the brain. |
2023-12-23 |
2023-12-25 |
human |
| Roshni C Lalwani, Claude-Henry Volmar, Claes Wahlestedt, Keith A Webster, Lina A Shehade. Contextualizing the Role of Osteopontin in the Inflammatory Responses of Alzheimer's Disease. Biomedicines. vol 11. issue 12. 2023-12-23. PMID:38137453. |
alzheimer's disease (ad) is characterized by progressive accumulations of extracellular amyloid-beta (aβ) aggregates from soluble oligomers to insoluble plaques and hyperphosphorylated intraneuronal tau, also from soluble oligomers to insoluble neurofibrillary tangles (nfts). |
2023-12-23 |
2023-12-25 |
Not clear |
| Yue Zuo, Hui-Ting Liu, Lai-Biao Lin, Rui-Zhu Yue, Huan-Huan Liu, Hong-Wei Wang, Lu Wang, Ruan-Ling Hou, Wei-Zhen Liu, Chang-Zheng Li, Jian-Zhi Wang, Peng Li, Ya-Ling Yi. A new metal ion chelator attenuates human tau accumulation-induced neurodegeneration and memory deficits in mice. Experimental neurology. 2023-12-23. PMID:38141802. |
neuronal neurofibrillary tangles containing tau hyperphosphorylation proteins are a typical pathological marker of alzheimer's disease (ad). |
2023-12-23 |
2023-12-25 |
mouse |
| Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wan. A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function. Frontiers in aging neuroscience. vol 15. 2023-12-22. PMID:38131009. |
a tau fragment links depressive-like behaviors and cognitive declines in alzheimer's disease mouse models through attenuating mitochondrial function. |
2023-12-22 |
2023-12-24 |
mouse |
| Yamei Wang, Jianhao Wang, Hongyu Chen, Xiang Li, Ruifeng Xu, Feng Gao, Hang Yu, Fang Li, Dongdong Qin, Jiabei Wang, Yuke Shi, Yiyi Li, Songyan Liu, Xi Zhang, Shuai Ding, Yiqian Hu, Liqin Huang, Xin-Ya Gao, Zuneng Lu, Jin Luo, Zhi-Hao Wan. A tau fragment links depressive-like behaviors and cognitive declines in Alzheimer's disease mouse models through attenuating mitochondrial function. Frontiers in aging neuroscience. vol 15. 2023-12-22. PMID:38131009. |
alzheimer's disease (ad) is the most prevalent neurodegenerative disease characterized by extracellular senile plaques including amyloid-β peptides and intracellular neurofibrillary tangles consisting of abnormal tau. |
2023-12-22 |
2023-12-24 |
mouse |
| Patrick W Cullinane, Sarah Wrigley, Jacy Bezerra Parmera, Fernanda Valerio, Thomas O Millner, Karen Shaw, Eduardo De Pablo-Fernandez, Thomas T Warner, Zane Jaunmuktan. Pathology of neurodegenerative disease for the general neurologist. Practical neurology. 2023-12-21. PMID:38124186. |
this review aims to elucidate the hallmark pathological features of neurodegenerative diseases commonly seen in general neurology clinics, such as alzheimer's disease and parkinson's disease; rare but well-known diseases, including progressive supranuclear palsy, corticobasal degeneration and multiple system atrophy and more recently described entities such as chronic traumatic encephalopathy and age-related tau astrogliopathy. |
2023-12-21 |
2023-12-23 |
Not clear |
| Vivian Hook, Sonia Podvin, Charles Mosier, Ben Boyarko, Laura Seyffert, Haley Stringer, Robert A Rissma. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracellular vesicles and circulating nucleic acids. vol 4. issue 4. 2023-12-21. PMID:38125374. |
tau accumulates in alzheimer's disease (ad), frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17), chronic traumatic encephalopathy (cte), progressive supranuclear palsy, and related tauopathies. |
2023-12-21 |
2023-12-23 |
human |
| Khalid Iqba. Tau and Alzheimer's disease: Past, present and future. Cytoskeleton (Hoboken, N.J.). 2023-12-21. PMID:38126608. |
tau and alzheimer's disease: past, present and future. |
2023-12-21 |
2023-12-23 |
human |