| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jonathan L Chen, Peiyuan Zhang, Masahito Abe, Haruo Aikawa, Liying Zhang, Alexander J Frank, Timothy Zembryski, Christopher Hubbs, HaJeung Park, Jane Withka, Claire Steppan, Lucy Rogers, Shawn Cabral, Martin Pettersson, Travis T Wager, Matthew A Fountain, Gavin Rumbaugh, Jessica L Childs-Disney, Matthew D Disne. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing. Journal of the American Chemical Society. vol 142. issue 19. 2021-04-13. PMID:32364710. |
one pre-mrna that is alternatively spliced and linked to neurodegenerative diseases is tau (microtubule-associated protein tau), which can cause frontotemporal dementia and parkinsonism linked to chromosome 17 (ftdp-17) and can contribute to alzheimer's disease. |
2021-04-13 |
2023-08-13 |
human |
| Qingqin S Li, Diana Ca. Integrated miRNA-Seq and mRNA-Seq Study to Identify miRNAs Associated With Alzheimer's Disease Using Post-mortem Brain Tissue Samples. Frontiers in neuroscience. vol 15. 2021-04-11. PMID:33833661. |
alzheimer's disease (ad), the leading form of dementia, is associated with abnormal tau and β-amyloid accumulation in the brain. |
2021-04-11 |
2023-08-13 |
Not clear |
| Omonigho M Bubu, Ogie Q Umasabor-Bubu, Arlener D Turner, Ankit Parekh, Anna E Mullins, Korey Kam, Madeline K Birckbichler, Fahad Mukhtar, Alfred K Mbah, Natasha J Williams, David M Rapoport, Mony de Leon, Girardin Jean-Louis, Indu Ayappa, Andrew W Varga, Ricardo S Osori. Self-reported obstructive sleep apnea, amyloid and tau burden, and Alzheimer's disease time-dependent progression. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-04-10. PMID:33090679. |
self-reported obstructive sleep apnea, amyloid and tau burden, and alzheimer's disease time-dependent progression. |
2021-04-10 |
2023-08-13 |
human |
| Aurelien Lathuiliere, Bradley T Hyma. Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids. Frontiers in neuroscience. vol 15. 2021-04-10. PMID:33828458. |
the ability of tau aggregates to recruit and misfold monomeric tau and propagate across brain regions has been studied extensively and is now recognized as a critical pathological step in alzheimer's disease (ad) and other tauopathies. |
2021-04-10 |
2023-08-13 |
human |
| David Townsend, Nigel J Fullwood, Edwin A Yates, David A Middleto. Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin. Biochemistry. vol 59. issue 41. 2021-04-09. PMID:32954725. |
a pathological signature of alzheimer's disease (ad) is the formation of neurofibrillary tangles comprising filamentous aggregates of the microtubule associated protein tau. |
2021-04-09 |
2023-08-13 |
Not clear |
| Zhourui Wu, Xia Liu, Liming Cheng, Keqiang Y. Delta-secretase triggers Alzheimer's disease pathologies in wild-type hAPP/hMAPT double transgenic mice. Cell death & disease. vol 11. issue 12. 2021-04-09. PMID:33311478. |
alzheimer's disease (ad) is the most common neurodegenerative disease with multifactorial pathologies including aβ containing senile plaques and neurofibrillary tangles (nft) consisted of aggregated tau. |
2021-04-09 |
2023-08-13 |
mouse |
| Alexis Moscoso, Michel J Grothe, Nicholas J Ashton, Thomas K Karikari, Juan Lantero Rodríguez, Anniina Snellman, Marc Suárez-Calvet, Kaj Blennow, Henrik Zetterberg, Michael Schöl. Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease. JAMA neurology. vol 78. issue 4. 2021-04-09. PMID:33427873. |
plasma phosphorylated tau at threonine 181 (p-tau181) has been proposed as an easily accessible biomarker for the detection of alzheimer disease (ad) pathology, but its ability to monitor disease progression in ad remains unclear. |
2021-04-09 |
2023-08-13 |
Not clear |
| Ming Lu, Michael J Pontecorvo, Michael D Devous, Anupa K Arora, Nicholas Galante, Anne McGeehan, Catherine Devadanam, Stephen P Salloway, P Murali Doraiswamy, Craig Curtis, Stephen P Truocchio, Matthew Flitter, Tricia Locascio, Marybeth Devine, Jennifer A Zimmer, Adam S Fleisher, Mark A Mintu. Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials. JAMA neurology. vol 78. issue 4. 2021-04-09. PMID:33587110. |
aggregated tau measured by visual interpretation of flortaucipir positron emission tomography and the associated risk of clinical progression of mild cognitive impairment and alzheimer disease: results from 2 phase iii clinical trials. |
2021-04-09 |
2023-08-13 |
Not clear |
| Smita Eknath Desale, Tushar Dubey, Subashchandrabose Chinnathamb. α-Linolenic acid inhibits Tau aggregation and modulates Tau conformation. International journal of biological macromolecules. vol 166. 2021-04-08. PMID:33130263. |
alzheimer's disease is characterized by important patho-proteins, which being composed of amyloid-β plaques and intracellular neurofibrillary tangles of tau. |
2021-04-08 |
2023-08-13 |
Not clear |
| Sarah Lemprièr. Distinct microglial profiles associated with amyloid and tau pathology in Alzheimer disease. Nature reviews. Neurology. vol 17. issue 4. 2021-04-07. PMID:33750932. |
distinct microglial profiles associated with amyloid and tau pathology in alzheimer disease. |
2021-04-07 |
2023-08-13 |
Not clear |
| Deirdre M O'Shea, Kelsey R Thomas, Breton Asken, Athene K W Lee, Jennifer D Davis, Paul F Malloy, Stephen P Salloway, Stephen Correi. Adding cognition to AT(N) models improves prediction of cognitive and functional decline. Alzheimer's & dementia (Amsterdam, Netherlands). vol 13. issue 1. 2021-04-07. PMID:33816757. |
this study sought to determine whether adding cognition to a model with alzheimer's disease biomarkers based on the amyloid, tau, and neurodegeneration/neuronal injury-at(n)-biomarker framework predicts rates of cognitive and functional decline in older adults without dementia. |
2021-04-07 |
2023-08-13 |
Not clear |
| Héctor Solís-Chagoyán, Aline Domínguez-Alonso, Marcela Valdés-Tovar, Jesús Argueta, Zuly A Sánchez-Florentino, Eduardo Calixto, Gloria Benítez-Kin. Melatonin Rescues the Dendrite Collapse Induced by the Pro-Oxidant Toxin Okadaic Acid in Organotypic Cultures of Rat Hilar Hippocampus. Molecules (Basel, Switzerland). vol 25. issue 23. 2021-04-06. PMID:33255515. |
the pro-oxidant compound okadaic acid (oka) mimics alterations found in alzheimer's disease (ad) as oxidative stress and tau hyperphosphorylation, leading to neurodegeneration and cognitive decline. |
2021-04-06 |
2023-08-13 |
rat |
| Rebecca M Fleeman, Elizabeth A Procto. Astrocytic Propagation of Tau in the Context of Alzheimer's Disease. Frontiers in cellular neuroscience. vol 15. 2021-04-06. PMID:33815065. |
astrocytic propagation of tau in the context of alzheimer's disease. |
2021-04-06 |
2023-08-13 |
Not clear |
| Cass Leonard, Christian Phillips, James McCart. Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer's Disease Protofibril Core. Frontiers in molecular biosciences. vol 8. 2021-04-06. PMID:33816551. |
insight into seeded tau fibril growth from molecular dynamics simulation of the alzheimer's disease protofibril core. |
2021-04-06 |
2023-08-13 |
Not clear |
| Cass Leonard, Christian Phillips, James McCart. Insight Into Seeded Tau Fibril Growth From Molecular Dynamics Simulation of the Alzheimer's Disease Protofibril Core. Frontiers in molecular biosciences. vol 8. 2021-04-06. PMID:33816551. |
aggregates of the microtubule associated tau protein are a major constituent of neurofibrillary lesions that define alzheimer's disease (ad) pathology. |
2021-04-06 |
2023-08-13 |
Not clear |
| Cécile Tissot, Joseph Therriault, Tharick A Pascoal, Mira Chamoun, Firoza Z Lussier, Melissa Savard, Sulantha S Mathotaarachchi, Andréa L Benedet, Emilie M Thomas, Marlee Parsons, Ziad Nasreddine, Pedro Rosa-Neto, Serge Gauthie. Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-04-06. PMID:33816761. |
association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to alzheimer's disease. |
2021-04-06 |
2023-08-13 |
Not clear |
| Yongchao Song, Tailin Xu, Qinglin Zhu, Xueji Zhan. Integrated individually electrochemical array for simultaneously detecting multiple Alzheimer's biomarkers. Biosensors & bioelectronics. vol 162. 2021-04-05. PMID:32392158. |
sensitive and selective detection of multiple alzheimer's biomarkers including tau, apoe4, amyloid-β and mirna-101 on such mini-pillar-based biosensor is also achieved. |
2021-04-05 |
2023-08-13 |
Not clear |
| Anas Shamsi, Saleha Anwar, Taj Mohammad, Mohamed F Alajmi, Afzal Hussain, Md Tabish Rehman, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443670. |
microtubule affinity-regulating kinase (mark4) plays a key role in alzheimer's disease (ad) development as its overexpression is directly linked to increased tau phosphorylation. |
2021-04-02 |
2023-08-13 |
Not clear |
| Moustafa T Gabr, Florent Barbaul. First dual binder of microRNA-146a and monomeric tau: a novel approach for multitargeted therapeutics for neurodegenerative diseases. Chemical communications (Cambridge, England). vol 56. issue 67. 2021-04-02. PMID:32699863. |
we report a new approach for the development of multitargeted therapeutics for alzheimer's disease (ad) based on dual targeting of monomeric tau and biogenesis of microrna-146a. |
2021-04-02 |
2023-08-13 |
Not clear |
| Shibi Muralidar, Senthil Visaga Ambi, Saravanan Sekaran, Diraviyam Thirumalai, Balamurugan Palaniappa. Role of tau protein in Alzheimer's disease: The prime pathological player. International journal of biological macromolecules. vol 163. 2021-04-02. PMID:32784025. |
role of tau protein in alzheimer's disease: the prime pathological player. |
2021-04-02 |
2023-08-13 |
Not clear |