| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Crystal M Vander Zanden, Eva Y Ch. Passive Immunotherapies Targeting Amyloid Beta and Tau Oligomers in Alzheimer's Disease. Journal of pharmaceutical sciences. vol 109. issue 1. 2021-03-25. PMID:31647950. |
passive immunotherapies targeting amyloid beta and tau oligomers in alzheimer's disease. |
2021-03-25 |
2023-08-13 |
Not clear |
| Matthew R Barron, Jane Gartlon, Lee A Dawson, Peter J Atkinson, Marie-Christine Pardo. Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation. Frontiers in immunology. vol 11. 2021-03-25. PMID:32194553. |
inflammation is considered a mechanistic driver of alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (nfts). |
2021-03-25 |
2023-08-13 |
mouse |
| Shu Lu, Xiaomin Yin, Jia Wang, Qun Gu, Qin Huang, Nana Jin, Dandan Chu, Ziqi Xu, Fei Liu, Wei Qia. SIRT1 regulates O-GlcNAcylation of tau through OGT. Aging. vol 12. issue 8. 2021-03-25. PMID:32310828. |
the o-glcnacylation levels of tau are decreased in alzheimer's disease (ad) brain. |
2021-03-25 |
2023-08-13 |
human |
| Mehrdad Ameri, Zahra Shabaninejad, Ahmad Movahedpour, Amirhossein Sahebkar, Soheila Mohammadi, Saereh Hosseindoost, Mohammad Saeid Ebrahimi, Amir Savardashtaki, Mohammad Karimipour, Hamed Mirzae. Biosensors for detection of Tau protein as an Alzheimer's disease marker. International journal of biological macromolecules. vol 162. 2021-03-25. PMID:32603732. |
biosensors for detection of tau protein as an alzheimer's disease marker. |
2021-03-25 |
2023-08-13 |
Not clear |
| Mehrdad Ameri, Zahra Shabaninejad, Ahmad Movahedpour, Amirhossein Sahebkar, Soheila Mohammadi, Saereh Hosseindoost, Mohammad Saeid Ebrahimi, Amir Savardashtaki, Mohammad Karimipour, Hamed Mirzae. Biosensors for detection of Tau protein as an Alzheimer's disease marker. International journal of biological macromolecules. vol 162. 2021-03-25. PMID:32603732. |
tau dysfunction is mainly associated with neurodegenerative diseases, particularly alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Xi Chen, Kaitlin E Cassady, Jenna N Adams, Theresa M Harrison, Suzanne L Baker, William J Jagus. Regional Tau Effects on Prospective Cognitive Change in Cognitively Normal Older Adults. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 2. 2021-03-25. PMID:33219003. |
studies suggest that tau deposition starts in the anterolateral entorhinal cortex (ec) with normal aging, and that the presence of β-amyloid (aβ) facilitates its spread to neocortex, which may reflect the beginning of alzheimer's disease (ad). |
2021-03-25 |
2023-08-13 |
Not clear |
| Sushil K Mishra, Yoshiki Yamaguchi, Makoto Higuchi, Naruhiko Sahar. Pick's Tau Fibril Shows Multiple Distinct PET Probe Binding Sites: Insights from Computational Modelling. International journal of molecular sciences. vol 22. issue 1. 2021-03-25. PMID:33396273. |
positron emission tomography (pet) radiotracers that bind to tau filaments in alzheimer's disease (ad) are in common use, but pet tracers binding to tau filaments of rarer, age-related dementias, such as pick's disease, have not been widely explored. |
2021-03-25 |
2023-08-13 |
Not clear |
| Elaine Wan Ling Chan, Emilia Tze Ying Yeo, Kelly Wang Ling Wong, Mun Ling See, Ka Yan Wong, Jeremy Kean Yi Yap, Sook Yee Ga. Piper sarmentosum Roxb. Attenuates Beta Amyloid (Aβ)-Induced Neurotoxicity Via the Inhibition of Amyloidogenesis and Tau Hyperphosphorylation in SH-SY5Y Cells. Current Alzheimer research. 2021-03-25. PMID:33761853. |
in alzheimer's disease, accumulation of beta amyloid (aβ) triggers amyloidogenesis and hyperphosphorylation of tau protein leading to neuronal cell death. |
2021-03-25 |
2023-08-13 |
Not clear |
| Iván Fernández-Cruz, Enrique Reynau. Proteasome Subunits Involved in Neurodegenerative Diseases. Archives of medical research. vol 52. issue 1. 2021-03-24. PMID:32962866. |
proteasome subunits interact with proteins that are known to accumulate in neurodegenerative diseases such as α-synuclein in parkinson's, tau in alzheimer's, and huntingtin in huntington's diseases. |
2021-03-24 |
2023-08-13 |
Not clear |
| Noemi Esteras, Andrey Y Abramo. Mitochondrial Calcium Deregulation in the Mechanism of Beta-Amyloid and Tau Pathology. Cells. vol 9. issue 9. 2021-03-24. PMID:32967303. |
aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological features in neurodegenerative disorders such as alzheimer's disease (ad) and other tauopathies including frontotemporal dementia (ftd). |
2021-03-24 |
2023-08-13 |
Not clear |
| Saleha Anwar, Anas Shamsi, Rajiv K Kar, Aarfa Queen, Asimul Islam, Faizan Ahmad, Md Imtaiyaz Hassa. Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases. International journal of biological macromolecules. vol 161. 2021-03-23. PMID:32535203. |
since the role of mark4 in the phosphorylation of tau protein and subsequently alzheimer's disease has been established, therefore, we have investigated the binding affinity and mark4 inhibitory potential of cholic acid (cha) using both computational and spectroscopic methods. |
2021-03-23 |
2023-08-13 |
Not clear |
| Friedel Drepper, Jacek Biernat, Senthilvelrajan Kaniyappan, Helmut E Meyer, Eva Maria Mandelkow, Bettina Warscheid, Eckhard Mandelko. A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33106314. |
abnormal changes of neuronal tau protein, such as phosphorylation and aggregation, are considered hallmarks of cognitive deficits in alzheimer's disease. |
2021-03-23 |
2023-08-13 |
human |
| Nora Lemke, Valeria Melis, Dilyara Lauer, Mandy Magbagbeolu, Boris Neumann, Charles R Harrington, Gernot Riedel, Claude M Wischik, Franz Theuring, Karima Schwa. Differential compartmental processing and phosphorylation of pathogenic human tau and native mouse tau in the line 66 model of frontotemporal dementia. The Journal of biological chemistry. vol 295. issue 52. 2021-03-23. PMID:33127647. |
synapse loss is associated with motor and cognitive decline in multiple neurodegenerative disorders, and the cellular redistribution of tau is related to synaptic impairment in tauopathies, such as alzheimer's disease and frontotemporal dementia. |
2021-03-23 |
2023-08-13 |
mouse |
| Michele Longoni Calió, Amanda Cristina Mosini, Darci Souza Marinho, Geisa Nogueira Salles, Fernando Henrique Massinhani, Gui Mi Ko, Marimélia Aparecida Porcionatt. Leptin enhances adult neurogenesis and reduces pathological features in a transgenic mouse model of Alzheimer's disease. Neurobiology of disease. vol 148. 2021-03-23. PMID:33301880. |
alzheimer's disease (ad) is the most common dementia worldwide and is characterized by the presence of senile plaques by amyloid-beta (aβ) and neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-03-23 |
2023-08-13 |
mouse |
| Nicha Puangmalai, Nemil Bhatt, Mauro Montalbano, Urmi Sengupta, Sagar Gaikwad, Frank Ventura, Salome McAllen, Anna Ellsworth, Stephanie Garcia, Rakez Kaye. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell death & disease. vol 11. issue 5. 2021-03-22. PMID:32366836. |
internalization mechanisms of brain-derived tau oligomers from patients with alzheimer's disease, progressive supranuclear palsy and dementia with lewy bodies. |
2021-03-22 |
2023-08-13 |
Not clear |
| Nicha Puangmalai, Nemil Bhatt, Mauro Montalbano, Urmi Sengupta, Sagar Gaikwad, Frank Ventura, Salome McAllen, Anna Ellsworth, Stephanie Garcia, Rakez Kaye. Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies. Cell death & disease. vol 11. issue 5. 2021-03-22. PMID:32366836. |
soluble tau aggregates (tau oligomers) are the most toxic species that initiate neurodegeneration in tauopathies, such as alzheimer's disease (ad), progressive supranuclear palsy (psp), and dementia with lewy bodies (dlb). |
2021-03-22 |
2023-08-13 |
Not clear |
| Yun Kwon, Jisu Shin, Kwangho Nam, Joon Soo An, Seung-Hoon Yang, Seong-Heon Hong, Munhyung Bae, Kyuho Moon, Yakdol Cho, Jiwan Woo, Keunwan Park, Kyeonghwan Kim, Jongheon Shin, Byung-Yong Kim, YoungSoo Kim, Dong-Chan O. Rhizolutin, a Novel 7/10/6-Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease. Angewandte Chemie (International ed. in English). vol 59. issue 51. 2021-03-22. PMID:32844539. |
during an unbiased screening of natural product libraries, this novel compound was found to dissociate amyloid-β (aβ) plaques and tau tangles, which are key pathological hallmarks of alzheimer's disease (ad). |
2021-03-22 |
2023-08-13 |
mouse |
| Miao Zhang, Di Zhao, Guanghong Zhou, Chunbao L. Dietary Pattern, Gut Microbiota, and Alzheimer's Disease. Journal of agricultural and food chemistry. vol 68. issue 46. 2021-03-19. PMID:32090565. |
evidence suggests that diet may affect β-amyloid production and tau processing or may regulate inflammation, metabolism, and oxidative stress associated with alzheimer's disease, which can be exerted by gut microbiota. |
2021-03-19 |
2023-08-13 |
Not clear |
| Zeba Mueed, Devanshu Mehta, Pankaj K Rai, Mohammad A Kamal, Nitesh K Podda. Cross-Interplay between Osmolytes and mTOR in Alzheimer's Disease Pathogenesis. Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32418522. |
alzheimer's disease, categorized by the piling of amyloid-β (aβ), hyperphosphorylated tau, phfs, nfts and mtor hyperactivity, is a neurodegenerative disorder, affecting people across the globe. |
2021-03-19 |
2023-08-13 |
Not clear |
| Hiroyuki Shimada, Shinobu Minatani, Jun Takeuchi, Akitoshi Takeda, Joji Kawabe, Yasuhiro Wada, Aya Mawatari, Yasuyoshi Watanabe, Hitoshi Shimada, Makoto Higuchi, Tetsuya Suhara, Takami Tomiyama, Yoshiaki Ito. Heavy Tau Burden with Subtle Amyloid β Accumulation in the Cerebral Cortex and Cerebellum in a Case of Familial Alzheimer's Disease with APP Osaka Mutation. International journal of molecular sciences. vol 21. issue 12. 2021-03-19. PMID:32580499. |
heavy tau burden with subtle amyloid β accumulation in the cerebral cortex and cerebellum in a case of familial alzheimer's disease with app osaka mutation. |
2021-03-19 |
2023-08-13 |
Not clear |