| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sanjula P Wickramasinghe, Elizabeth Rhoade. Measuring Interactions Between Tau and Aggregation Inducers with Single-Molecule Förster Resonance Energy Transfer. Methods in molecular biology (Clifton, N.J.). vol 2141. 2021-03-15. PMID:32696388. |
tau is an intrinsically disordered protein implicated in the pathogenesis of alzheimer's disease and other neurodegenerative disorders. |
2021-03-15 |
2023-08-13 |
Not clear |
| Tamara Šmidlehner, Hugues Bonnet, Sabine Chierici, Ivo Piantanid. Fluorescently-labelled amyloid paired helical filaments (PHF) in monitoring its fibrillation kinetics. Bioorganic chemistry. vol 104. 2021-03-15. PMID:32911188. |
the core of the tau fibrils in alzheimer disease is a hexapeptide sequence organized in paired helical filaments (phf). |
2021-03-15 |
2023-08-13 |
Not clear |
| Jagan A Pillai, Mykol Larvie, Jacqueline Chen, Anna Crawford, Jeffery L Cummings, Stephen E Jone. Spatial patterns of correlation between cortical amyloid and cortical thickness in a tertiary clinical population with memory deficit. Scientific reports. vol 10. issue 1. 2021-03-15. PMID:33244036. |
to estimate regional alzheimer disease (ad) pathology burden clinically, analysis methods that enable tracking brain amyloid or tau positron emission tomography (pet) with magnetic resonance imaging (mri) measures are needed. |
2021-03-15 |
2023-08-13 |
Not clear |
| Mahmood Haj-Yahya, Pushparathinam Gopinath, Kolla Rajasekhar, Hilda Mirbaha, Marc I Diamond, Hilal A Lashue. Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding. Angewandte Chemie (International ed. in English). vol 59. issue 10. 2021-03-12. PMID:31863676. |
the consistent observation of phosphorylated tau in the pathology of alzheimer's disease has contributed to the emergence of a model where hyperphosphorylation triggers both tau disassociation from microtubules and its subsequent aggregation. |
2021-03-12 |
2023-08-13 |
Not clear |
| Laura Strohm, Christian Behrend. Glia-specific autophagy dysfunction in ALS. Seminars in cell & developmental biology. vol 99. 2021-03-11. PMID:31132469. |
prominent examples are amyloid beta and tau in alzheimer's disease, α-synuclein in parkinson's disease and transactive response dna binding protein 43 kda (tdp-43) in als and ftd. |
2021-03-11 |
2023-08-13 |
Not clear |
| Tina Ukmar-Godec, Susanne Wegmann, Markus Zweckstette. Biomolecular condensation of the microtubule-associated protein tau. Seminars in cell & developmental biology. vol 99. 2021-03-11. PMID:31260737. |
recent evidence suggests that the protein tau, which plays an important role in alzheimer's disease and other neurodegenerative disorders, phase separates in solution, forms tau phases with microtubules, and associates with phase-separated rna-binding protein granules in cells. |
2021-03-11 |
2023-08-13 |
Not clear |
| Joseph Therriault, Andrea L Benedet, Tharick A Pascoal, Sulantha Mathotaarachchi, Melissa Savard, Mira Chamoun, Emilie Thomas, Min Su Kang, Firoza Lussier, Cecile Tissot, Jean-Paul Soucy, Gassan Massarweh, Soham Rej, Paramita Saha-Chaudhuri, Judes Poirier, Serge Gauthier, Pedro Rosa-Net. APOEε4 potentiates the relationship between amyloid-β and tau pathologies. Molecular psychiatry. 2021-03-11. PMID:32161362. |
however, the association between apoeε4 and tau pathology, the other major proteinopathy of alzheimer's disease, has been controversial. |
2021-03-11 |
2023-08-13 |
human |
| Maud Gratuze, David M Holtzma. Targeting pre-synaptic tau accumulation: a new strategy to counteract tau-mediated synaptic loss and memory deficits. Neuron. vol 109. issue 5. 2021-03-11. PMID:33662267. |
synaptic tau accumulation is believed to promote synaptic loss, which contributes to cognitive deficits in alzheimer's disease and tauopathies. |
2021-03-11 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
transition metal nickel prevents tau aggregation in alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Rashmi Das, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Transition metal nickel prevents Tau aggregation in Alzheimer's disease. International journal of biological macromolecules. vol 156. 2021-03-10. PMID:31770557. |
the multifaceted effectors of alzheimer's disease primarily include tau, amyloid-β along with hyper activation of kinases, oxidative stress and mutations etc., makes it challenging to design therapeutics. |
2021-03-10 |
2023-08-13 |
Not clear |
| b' Elisabetta Lauretti, Domenico Pratic\\xc3\\xb. Alzheimer\'s disease: phenotypic approaches using disease models and the targeting of tau protein. Expert opinion on therapeutic targets. vol 24. issue 4. 2021-03-10. PMID:32116063.' |
alzheimer's disease: phenotypic approaches using disease models and the targeting of tau protein. |
2021-03-10 |
2023-08-13 |
Not clear |
| Pranglada Jearjaroen, Kanet Pakdeepak, Chainarong Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Jiraporn Tocharu. Inhibitory Effect of Hexahydrocurcumin on Memory Impairment and Amyloidogenesis in Dexamethasone-Treated Mice. Neurotoxicity research. vol 39. issue 2. 2021-03-10. PMID:32852718. |
a dexamethasone administration model induces overproduction of amyloid-β (aβ) and tau protein hyperphosphorylation and shows abnormalities of cholinergic function similar to alzheimer's disease (ad). |
2021-03-10 |
2023-08-13 |
mouse |
| Mohammed Amir Husain, Benoit Laurent, Mélanie Plourd. APOE and Alzheimer's Disease: From Lipid Transport to Physiopathology and Therapeutics. Frontiers in neuroscience. vol 15. 2021-03-10. PMID:33679311. |
alzheimer's disease (ad) is a devastating neurodegenerative disorder characterized by extracellular amyloid β (aβ) and intraneuronal tau protein aggregations. |
2021-03-10 |
2023-08-13 |
Not clear |
| Lanier Heyburn, Rania Abutarboush, Samantha Goodrich, Rodrigo Urioste, Andrew Batuure, Jaimena Wheel, Donna M Wilder, Peethambaran Arun, Stephen T Ahlers, Joseph B Long, Venkatasivasai Sujith Sajj. Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model. Frontiers in cellular neuroscience. vol 15. 2021-03-10. PMID:33679327. |
while repeated exposure to 8.5 psi bop led to a reduction in the alzheimer's disease (ad)-related proteins amyloid-β (aβ)40 and aβ42, these changes were not observed in the 10 psi group, which had a significant reduction in phosphorylated tau. |
2021-03-10 |
2023-08-13 |
rat |
| Ryszard Pluta, Sławomir Januszewski, Stanisław J Czuczwa. Brain Ischemia as a Prelude to Alzheimer's Disease. Frontiers in aging neuroscience. vol 13. 2021-03-10. PMID:33679381. |
recent studies on post-ischemic brain neurodegeneration have revealed the dysregulation of alzheimer's disease-associated genes such as amyloid protein precursor, α-secretase, β-secretase, presenilin 1, presenilin 2, and tau protein. |
2021-03-10 |
2023-08-13 |
rat |
| Jisu Shin, Seung-Hoon Yang, Young Eun Du, Keunwan Park, DaWon Kim, Daniel Shin, Jungwoo Kim, Seong-Hwan Kim, Yun Kyung Kim, Jongheon Shin, Dong-Chan Oh, YoungSoo Ki. Borrelidin from Saltern-Derived Halophilic Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-03-10. PMID:33681712. |
borrelidin from saltern-derived halophilic alzheimer's disease (ad) is characterized by the aggregation of two pathological proteins, amyloid-β (aβ) and tau, leading to neuronal and cognitive dysfunction. |
2021-03-10 |
2023-08-13 |
Not clear |
| Murray Andrews, Ryan Ross, Atul Malhotra, Sonia Ancoli-Israel, James B Brewer, Sarah J Bank. Sleep and Tau Pathology in Vietnam War Veterans with Preclinical and Prodromal Alzheimer's Disease. Journal of Alzheimer's disease reports. vol 5. issue 1. 2021-03-10. PMID:33681715. |
sleep and tau pathology in vietnam war veterans with preclinical and prodromal alzheimer's disease. |
2021-03-10 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
correlation of alzheimer disease neuropathologic staging with amyloid and tau scintigraphic imaging biomarkers. |
2021-03-09 |
2023-08-13 |
Not clear |
| Ivan Koychev, Monika Hofer, Nicholas Friedma. Correlation of Alzheimer Disease Neuropathologic Staging with Amyloid and Tau Scintigraphic Imaging Biomarkers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:32764121. |
these elements are the extent of involvement (spread) by cerebral aβ based on the progression model defined by the thal aβ phases, the extent of involvement (spread) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progression model defined by braak, and the consortium to establish a registry for alzheimer's disease score, which describes the density of neuritic plaques based on certain key locations in the neocortex. |
2021-03-09 |
2023-08-13 |
Not clear |
| Henryk Barthe. First Tau PET Tracer Approved: Toward Accurate In Vivo Diagnosis of Alzheimer Disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 61. issue 10. 2021-03-09. PMID:33004646. |
first tau pet tracer approved: toward accurate in vivo diagnosis of alzheimer disease. |
2021-03-09 |
2023-08-13 |
Not clear |