| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
at present, it is unclear whether and how tdp-43 and tau are associated with early or late hippocampal atrophy in alzheimer's disease and primary age-related tauopathy, whether either protein is also associated with faster rates of atrophy of other brain regions and whether there is evidence for protein-associated acceleration/deceleration of atrophy rates. |
2021-03-01 |
2023-08-13 |
Not clear |
| Keith A Josephs, Peter R Martin, Stephen D Weigand, Nirubol Tosakulwong, Marina Buciuc, Melissa E Murray, Leonard Petrucelli, Matthew L Senjem, Anthony J Spychalla, David S Knopman, Bradley F Boeve, Ronald C Petersen, Joseph E Parisi, Dennis W Dickson, Clifford R Jack, Jennifer L Whitwel. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a journal of neurology. vol 143. issue 11. 2021-03-01. PMID:33150361. |
the results suggest that tdp-43 and tau have different contributions to acceleration and deceleration of brain atrophy rates over time in both alzheimer's disease and primary age-related tauopathy. |
2021-03-01 |
2023-08-13 |
Not clear |
| Qiuting Wen, Shannon L Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R Farlow, Frederick W Unverzagt, Sujuan Gao, Liana G Apostolova, Andrew J Saykin, Yu-Chien W. Tau-related white-matter alterations along spatially selective pathways. NeuroImage. vol 226. 2021-03-01. PMID:33189932. |
progressive accumulation of tau neurofibrillary tangles in the brain is a defining pathologic feature of alzheimer's disease (ad). |
2021-03-01 |
2023-08-13 |
human |
| Andréa L Benedet, Antoine Leuzy, Tharick A Pascoal, Nicholas J Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blenno. Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33210117. |
it remains uncertain, however, how it relates to amyloid and tau pathology or neurodegeneration across the alzheimer's disease continuum. |
2021-03-01 |
2023-08-13 |
human |
| Andréa L Benedet, Antoine Leuzy, Tharick A Pascoal, Nicholas J Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blenno. Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33210117. |
cross-sectional associations between plasma nfl and pet amyloid and tau measures were independently assessed in two cohorts: adni [n = 198; 110 cognitively unimpaired, 88 cognitively impaired (mci n = 67, alzheimer's disease dementia n = 21), data accessed october 2018]; and translational biomarkers in aging and dementia [triad, n = 116; 74 cognitively unimpaired, 42 cognitively impaired (mci n = 16, alzheimer's disease dementia n = 26), data obtained november 2017 to january 2019]. |
2021-03-01 |
2023-08-13 |
human |
| Andréa L Benedet, Antoine Leuzy, Tharick A Pascoal, Nicholas J Ashton, Sulantha Mathotaarachchi, Melissa Savard, Joseph Therriault, Min Su Kang, Mira Chamoun, Michael Schöll, Eduardo R Zimmer, Serge Gauthier, Aurélie Labbe, Henrik Zetterberg, Pedro Rosa-Neto, Kaj Blenno. Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33210117. |
cross-sectional analyses in both cohorts showed that plasma nfl was associated with pet findings in brain regions typically affected by alzheimer's disease; associations were specific to amyloid pet in cognitively unimpaired and tau pet in cognitively impaired (p < 0.05). |
2021-03-01 |
2023-08-13 |
human |
| Betty M Tijms, Johan Gobom, Lianne Reus, Iris Jansen, Shengjun Hong, Valerija Dobricic, Fabian Kilpert, Mara Ten Kate, Frederik Barkhof, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Lars Bertram, Simon Lovestone, Johannes Streffer, Stephanie Vos, Isabelle Bos, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Henrik Zetterberg, Pieter Jelle Visse. Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33439986. |
in two independent cohorts (emif-ad mbd and adni) we found that 705 (77% of 911 tested) proteins differed between alzheimer's disease (defined as having abnormal amyloid, n = 425) and controls (defined as having normal csf amyloid and tau and normal cognition, n = 127). |
2021-03-01 |
2023-08-13 |
Not clear |
| Ruben Smith, Olof Strandberg, Niklas Mattsson-Carlgren, Antoine Leuzy, Sebastian Palmqvist, Michael J Pontecorvo, Michael D Devous, Rik Ossenkoppele, Oskar Hansso. The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33439987. |
increased knowledge about conditions affecting the rate of tau accumulation could guide the development of therapies halting the progression of alzheimer's disease. |
2021-03-01 |
2023-08-13 |
human |
| Ruben Smith, Olof Strandberg, Niklas Mattsson-Carlgren, Antoine Leuzy, Sebastian Palmqvist, Michael J Pontecorvo, Michael D Devous, Rik Ossenkoppele, Oskar Hansso. The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects. Brain : a journal of neurology. vol 143. issue 12. 2021-03-01. PMID:33439987. |
however, the factors modifying the rate of tau accumulation over time in alzheimer's disease are still largely unknown. |
2021-03-01 |
2023-08-13 |
human |
| Chongyang Chen, Pan Liu, Jing Wang, Haitao Yu, Zaijun Zhang, Jianjun Liu, Xiao Chen, Feiqi Zhu, Xifei Yan. Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. Frontiers in cell and developmental biology. vol 8. 2021-02-27. PMID:33634105. |
alzheimer's disease (ad) is characterized by extracellular amyloid plaques composed of β-amyloid (aβ) and intracellular neurofibrillary tangles containing hyperphosphorylated tau protein. |
2021-02-27 |
2023-08-13 |
mouse |
| Umar H Iqbal, Emma Zeng, Giulio M Pasinett. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 14. 2021-02-26. PMID:32664669. |
the aggregation and accumulation of amyloid-β plaques and tau proteins in the brain have been central characteristics in the pathophysiology of alzheimer's disease (ad), making them the focus of most of the research exploring potential therapeutics for this neurodegenerative disease. |
2021-02-26 |
2023-08-13 |
Not clear |
| Carmen Martínez-Cué, Noemí Rued. Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome. International journal of molecular sciences. vol 21. issue 18. 2021-02-26. PMID:32962300. |
however, by the fourth decade of life, all individuals with ds develop neuropathology identical to that found in sporadic alzheimer's disease (ad), including the development of amyloid plaques and neurofibrillary tangles due to hyperphosphorylation of tau protein, loss of neurons and synapses, reduced neurogenesis, enhanced oxidative stress, and mitochondrial dysfunction and neuroinflammation. |
2021-02-26 |
2023-08-13 |
Not clear |
| Vidyasagar Naik Bukke, Moola Archana, Rosanna Villani, Antonino Davide Romano, Agata Wawrzyniak, Krzysztof Balawender, Stanislaw Orkisz, Sarah Beggiato, Gaetano Serviddio, Tommaso Cassan. The Dual Role of Glutamatergic Neurotransmission in Alzheimer's Disease: From Pathophysiology to Pharmacotherapy. International journal of molecular sciences. vol 21. issue 20. 2021-02-26. PMID:33050345. |
alzheimer's disease (ad) is an age-related dementia and neurodegenerative disorder, characterized by aβ and tau protein deposition impairing learning, memory and suppressing synaptic plasticity of neurons. |
2021-02-26 |
2023-08-13 |
Not clear |
| Jodie B Nichols, Michael Malek-Ahmadi, Pierre N Tariot, Geidy E Serrano, Lucia I Sue, Thomas G Beac. Vascular Lesions, APOE ε4, and Tau Pathology in Alzheimer Disease. Journal of neuropathology and experimental neurology. vol 80. issue 3. 2021-02-26. PMID:33617650. |
vascular lesions, apoe ε4, and tau pathology in alzheimer disease. |
2021-02-26 |
2023-08-13 |
Not clear |
| Michael J Pontecorvo, C Dirk Keene, Thomas G Beach, Thomas J Montine, Anupa K Arora, Michael D Devous, Michael Navitsky, Ian Kennedy, Abhinay D Joshi, Ming Lu, Geidy E Serrano, Lucia I Sue, Anthony J Intorcia, Shannon E Rose, Angela Wilson, Leanne Hellstern, Natalie Coleman, Matthew Flitter, Patricia Aldea, Adam S Fleisher, Mark A Mintun, Andrew Siderow. Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer's disease pathology: a clinicopathological study. EJNMMI research. vol 10. issue 1. 2021-02-25. PMID:32542468. |
comparison of regional flortaucipir pet with quantitative tau immunohistochemistry in three subjects with alzheimer's disease pathology: a clinicopathological study. |
2021-02-25 |
2023-08-13 |
human |
| Chris Ho Ching Yeung, Kathleen Wen Din Lau, Shiu Lun Au Yeung, C Mary Schoolin. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. European journal of epidemiology. vol 36. issue 1. 2021-02-24. PMID:32929646. |
amyloid, tau and risk of alzheimer's disease: a mendelian randomization study. |
2021-02-24 |
2023-08-13 |
Not clear |
| Chris Ho Ching Yeung, Kathleen Wen Din Lau, Shiu Lun Au Yeung, C Mary Schoolin. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. European journal of epidemiology. vol 36. issue 1. 2021-02-24. PMID:32929646. |
this study was carried out to assess the effect of amyloid and tau on alzheimer's disease using two-sample mendelian randomization design. |
2021-02-24 |
2023-08-13 |
Not clear |
| Aurelio J Dregni, Pu Duan, Mei Hon. Hydration and Dynamics of Full-Length Tau Amyloid Fibrils Investigated by Solid-State Nuclear Magnetic Resonance. Biochemistry. vol 59. issue 24. 2021-02-23. PMID:32453948. |
the microtubule-associated protein tau aggregates into distinct neurofibrillary tangles in brains afflicted with multiple neurodegenerative diseases such as alzheimer's disease and corticobasal degeneration (cbd). |
2021-02-23 |
2023-08-13 |
Not clear |
| Panchanan Maiti, Jayeeta Manna, Zoe N Burch, Denise B Flaherty, Joseph D Larkin, Gary L Dunba. Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 18. 2021-02-23. PMID:32933008. |
alzheimer's disease (ad) is characterized by amyloid (aβ) aggregation, hyperphosphorylated tau, neuroinflammation, and severe memory deficits. |
2021-02-23 |
2023-08-13 |
Not clear |
| Dawn C Matthews, Aaron Ritter, Ronald G Thomas, Randolph D Andrews, Ana S Lukic, Carolyn Revta, Jefferson W Kinney, Babak Tousi, James B Leverenz, Howard Fillit, Kate Zhong, Howard H Feldman, Jeffrey Cumming. Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia. Alzheimer's & dementia (New York, N. Y.). vol 7. issue 1. 2021-02-23. PMID:33614888. |
rasagiline effects on glucose metabolism, cognition, and tau in alzheimer's dementia. |
2021-02-23 |
2023-08-13 |
Not clear |