| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Francesca Munari, Carlo Giorgio Barracchia, Francesca Parolini, Roberto Tira, Luigi Bubacco, Michael Assfalg, Mariapina D'Onofri. Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies. International journal of molecular sciences. vol 21. issue 12. 2021-02-16. PMID:32575755. |
in alzheimer's disease, the microtubule associated tau protein accumulates within damaged neurons in the form of cross-beta structured filaments. |
2021-02-16 |
2023-08-13 |
Not clear |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
braak stages of tau neurofibrillary tangle accumulation have been incorporated in the criteria for the neuropathological diagnosis of alzheimer's disease. |
2021-02-16 |
2023-08-13 |
human |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
to this end, we studied 301 individuals (30 cognitively unimpaired young, 138 cognitively unimpaired elderly, 67 with mild cognitive impairment, 54 with alzheimer's disease dementia, and 12 with frontotemporal dementia) with amyloid-β 18f-nav4694, tau 18f-mk-6240, mri, and clinical assessments. |
2021-02-16 |
2023-08-13 |
human |
| Tharick A Pascoal, Joseph Therriault, Andrea L Benedet, Melissa Savard, Firoza Z Lussier, Mira Chamoun, Cécile Tissot, Muhammad Naveed Iqbal Qureshi, Min Su Kang, Sulantha Mathotaarachchi, Jenna Stevenson, Robert Hopewell, Gassan Massarweh, Jean-Paul Soucy, Serge Gauthier, Pedro Rosa-Net. 18F-MK-6240 PET for early and late detection of neurofibrillary tangles. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32671408. |
tau pet braak staging using high affinity tracers has the potential to be incorporated in the diagnosis of living patients with alzheimer's disease in the near future. |
2021-02-16 |
2023-08-13 |
human |
| Shotaro Shimonaka, Shin-Ei Matsumoto, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Moto. Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation. The Journal of biological chemistry. vol 295. issue 41. 2021-02-16. PMID:32759167. |
asparagine residue 368 is involved in alzheimer's disease tau strain-specific aggregation. |
2021-02-16 |
2023-08-13 |
Not clear |
| Shotaro Shimonaka, Shin-Ei Matsumoto, Montasir Elahi, Koichi Ishiguro, Masato Hasegawa, Nobutaka Hattori, Yumiko Moto. Asparagine residue 368 is involved in Alzheimer's disease tau strain-specific aggregation. The Journal of biological chemistry. vol 295. issue 41. 2021-02-16. PMID:32759167. |
to identify sequences for which deletion reduces tau aggregation, sh-sy5y cells expressing a series of 10 partial deletion (del 1-10, covering 244-400 aa) mutants of tau-ctf24 (243-441 aa) were treated with tau seeds prepared from a different tauopathy patient's brain (alzheimer's disease, progressive supranuclear palsy, and corticobasal degeneration) or recombinant tau, and then seed-dependent tau aggregation was assessed biochemically. |
2021-02-16 |
2023-08-13 |
Not clear |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
phosphorylated tau interactome in the human alzheimer's disease brain. |
2021-02-16 |
2023-08-13 |
human |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
accumulation of phosphorylated tau is a key pathological feature of alzheimer's disease. |
2021-02-16 |
2023-08-13 |
human |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
the pathological actions of phosphorylated tau are mediated by surrounding neuronal proteins; however, a comprehensive understanding of the proteins that phosphorylated tau interacts with in alzheimer's disease is surprisingly limited. |
2021-02-16 |
2023-08-13 |
human |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
to this end, we used two complementary proteomics approaches: (i) quantitative proteomics was performed on neurofibrillary tangles microdissected from patients with advanced alzheimer's disease; and (ii) affinity purification-mass spectrometry was used to identify which of these proteins specifically bound to phosphorylated tau. |
2021-02-16 |
2023-08-13 |
human |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
synaptic protein vamp2, vacuolar-atpase subunit atp6v0d1); therefore, we provide new evidence that they directly interact with phosphorylated tau in alzheimer's disease. |
2021-02-16 |
2023-08-13 |
human |
| Eleanor Drummond, Geoffrey Pires, Claire MacMurray, Manor Askenazi, Shruti Nayak, Marie Bourdon, Jiri Safar, Beatrix Ueberheide, Thomas Wisniewsk. Phosphorylated tau interactome in the human Alzheimer's disease brain. Brain : a journal of neurology. vol 143. issue 9. 2021-02-16. PMID:32812023. |
combined, our results reveal new potential drug targets for the treatment of tauopathies and provide insight into how phosphorylated tau mediates its toxicity in alzheimer's disease. |
2021-02-16 |
2023-08-13 |
human |
| Clifford R Jack, Heather J Wiste, Stephen D Weigand, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Tanis J Ferman, Bradley F Boeve, Kejal Kantarci, Prashanthi Vemuri, Michelle M Mielke, Jennifer Whitwell, Keith Josephs, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. Predicting future rates of tau accumulation on PET. Brain : a journal of neurology. vol 143. issue 10. 2021-02-16. PMID:33094327. |
all 337 participants had: a baseline study visit with mri, amyloid pet, and tau pet exams, at least one follow-up tau pet exam; and met clinical criteria for membership in one of two clinical diagnostic groups: cognitively unimpaired (n = 203); or cognitively impaired (n = 134, a combined group of participants with either mild cognitive impairment or dementia with alzheimer's clinical syndrome). |
2021-02-16 |
2023-08-13 |
human |
| Clifford R Jack, Heather J Wiste, Stephen D Weigand, Terry M Therneau, Val J Lowe, David S Knopman, Hugo Botha, Jonathan Graff-Radford, David T Jones, Tanis J Ferman, Bradley F Boeve, Kejal Kantarci, Prashanthi Vemuri, Michelle M Mielke, Jennifer Whitwell, Keith Josephs, Christopher G Schwarz, Matthew L Senjem, Jeffrey L Gunter, Ronald C Peterse. Predicting future rates of tau accumulation on PET. Brain : a journal of neurology. vol 143. issue 10. 2021-02-16. PMID:33094327. |
in cognitively impaired individuals, imaging and clinical variables consistent with early onset alzheimer's disease phenotype were associated with higher rates of tau pet accumulation suggesting this may be a highly advantageous group in which to conduct proof-of-concept clinical trials that target tau-related mechanisms. |
2021-02-16 |
2023-08-13 |
human |
| Silvia Fossati, Jaime Ramos Cejudo, Ludovic Debure, Elizabeth Pirraglia, Je Yeong Sone, Yi Li, Jingyun Chen, Tracy Butler, Henrik Zetterberg, Kaj Blennow, Mony J de Leo. Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2021-02-15. PMID:31334328. |
plasma tau complements csf tau and p-tau in the diagnosis of alzheimer's disease. |
2021-02-15 |
2023-08-13 |
Not clear |
| Silvia Fossati, Jaime Ramos Cejudo, Ludovic Debure, Elizabeth Pirraglia, Je Yeong Sone, Yi Li, Jingyun Chen, Tracy Butler, Henrik Zetterberg, Kaj Blennow, Mony J de Leo. Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2021-02-15. PMID:31334328. |
plasma tau may be an accessible biomarker for alzheimer's disease (ad), but the correlation between plasma and cerebrospinal fluid (csf) tau and the value of combining plasma tau with csf tau and phospho-tau (p-tau) are still unclear. |
2021-02-15 |
2023-08-13 |
Not clear |
| Sebastian Palmqvist, Arman Eshagh. Spatial Distribution of Tau and β-Amyloid Pathologies and Their Role in Different Alzheimer Disease Phenotypes. Neurology. vol 96. issue 5. 2021-02-15. PMID:33262229. |
spatial distribution of tau and β-amyloid pathologies and their role in different alzheimer disease phenotypes. |
2021-02-15 |
2023-08-13 |
Not clear |
| Emma L van der Ende, John C van Swiete. Fluid Biomarkers of Frontotemporal Lobar Degeneration. Advances in experimental medicine and biology. vol 1281. 2021-02-15. PMID:33433873. |
in recent years, significant progress has been made in developing biomarkers of neurodegenerative diseases: amyloid-β and tau in cerebrospinal fluid (csf) can be used to exclude alzheimer's disease, while neurofilament light chain (nfl) is emerging as a promising, albeit nonspecific, marker of neurodegeneration in both csf and blood. |
2021-02-15 |
2023-08-13 |
Not clear |
| Elisa Canepa, Silvia Fossat. Impact of Tau on Neurovascular Pathology in Alzheimer's Disease. Frontiers in neurology. vol 11. 2021-02-15. PMID:33488493. |
impact of tau on neurovascular pathology in alzheimer's disease. |
2021-02-15 |
2023-08-13 |
human |
| Hiroyuki Watanabe, Haruka Tatsumi, Sho Kaide, Yoichi Shimizu, Shimpei Iikuni, Masahiro On. Structure-Activity Relationships of Radioiodinated 6,5,6-Tricyclic Compounds for the Development of Tau Imaging Probes. ACS medicinal chemistry letters. vol 11. issue 2. 2021-02-13. PMID:32071677. |
tau aggregate, which is the main component of the neurofibrillary tangle, is an attractive imaging target for diagnosing and monitoring the progression of alzheimer's disease (ad). |
2021-02-13 |
2023-08-13 |
Not clear |