| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amanda K Engstrom, Alicia C Walker, Rohitha A Moudgal, Dexter A Myrick, Stephanie M Kyle, Yu Bai, M Jordan Rowley, David J Kat. The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 46. 2021-01-25. PMID:33139560. |
previously, our laboratory implicated the histone demethylase lsd1 in tau-induced neurodegeneration by showing that lsd1 localizes to pathological tau aggregates in alzheimer's disease cases, and that it is continuously required for the survival of hippocampal and cortical neurons in mice. |
2021-01-25 |
2023-08-13 |
mouse |
| Belkis Atasever-Arslan, Yagmur Ozer, Fatih Ozen, Yunus Diler, Ayse D Yalci. Tumor necrosis factor alpha gene rs1799724 polymorphism in Alzheimer's disease. General physiology and biophysics. vol 39. issue 6. 2021-01-25. PMID:33226368. |
neurofibrillar tangles formed by the accumulation of hyperphosphorylated tau proteins in the intracellular space and the senile plaques formed by amyloid β (aβ) accumulating in extracellular environment are shown as two main elements of alzheimer's disease (ad). |
2021-01-25 |
2023-08-13 |
Not clear |
| Min Seok Baek, Hanna Cho, Hye Sun Lee, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyo. Effect of A/T/N imaging biomarkers on impaired odor identification in Alzheimer's disease. Scientific reports. vol 10. issue 1. 2021-01-22. PMID:32665636. |
in the alzheimer's disease spectrum, impaired odor identification ability may be attributable to neurodegeneration rather than the direct effect of aβ or tau burden. |
2021-01-22 |
2023-08-13 |
human |
| Ida Sonni, Orit H Lesman Segev, Suzanne L Baker, Leonardo Iaccarino, Deniz Korman, Gil D Rabinovici, William J Jagust, Susan M Landau, Renaud La Joi. Evaluation of a visual interpretation method for tau-PET with Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2021-01-22. PMID:33313377. |
evaluation of a visual interpretation method for tau-pet with positron emission tomography targeting tau (tau-pet) is a promising diagnostic tool for the identification of alzheimer's disease (ad). |
2021-01-22 |
2023-08-13 |
Not clear |
| Nabil F Darwich, Jessica M Phan, Boram Kim, EunRan Suh, John D Papatriantafyllou, Lakshmi Changolkar, Aivi T Nguyen, Caroline M O'Rourke, Zhuohao He, Sílvia Porta, Garrett S Gibbons, Kelvin C Luk, Sokratis G Papageorgiou, Murray Grossman, Lauren Massimo, David J Irwin, Corey T McMillan, Ilya M Nasrallah, Camilo Toro, Geoffrey K Aguirre, Vivianna M Van Deerlin, Edward B Le. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.). vol 370. issue 6519. 2021-01-21. PMID:33004675. |
neurodegeneration in alzheimer's disease (ad) is closely associated with the accumulation of pathologic tau aggregates in the form of neurofibrillary tangles. |
2021-01-21 |
2023-08-13 |
Not clear |
| Carlos M Martínez-Viturro, Andrés A Trabanco, Jordi Royes, Elena Fernández, Gary Tresadern, Juan A Vega, Alcira Del Cerro, Francisca Delgado, Aránzazu García Molina, Fulgencio Tovar, Paul Shaffer, Andreas Ebneth, Alexis Bretteville, Liesbeth Mertens, Marijke Somers, Jose M Alonso, José M Bartolomé-Nebred. Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders. Journal of medicinal chemistry. vol 63. issue 22. 2021-01-21. PMID:33197187. |
o-glcnacylation is a post-translational modification of tau understood to lower the speed and yield of its aggregation, a pathological hallmark of alzheimer's disease (ad). |
2021-01-21 |
2023-08-13 |
Not clear |
| Zeran Li, Fabiana H G Farias, Umber Dube, Jorge L Del-Aguila, Kathie A Mihindukulasuriya, Maria Victoria Fernandez, Laura Ibanez, John P Budde, Fengxian Wang, Allison M Lake, Yuetiva Deming, James Perez, Chengran Yang, Jorge A Bahena, Wei Qin, Joseph L Bradley, Richard Davenport, Kristy Bergmann, John C Morris, Richard J Perrin, Bruno A Benitez, Joseph D Dougherty, Oscar Harari, Carlos Cruchag. The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31456032. |
apart from amyloid β deposition and tau neurofibrillary tangles, alzheimer's disease (ad) is a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the cerebral cortex. |
2021-01-19 |
2023-08-13 |
Not clear |
| Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Bué. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31686182. |
among propagons, misfolded tau is thought to be involved in the pathogenic mechanisms of various "tauopathies" that include alzheimer's disease, progressive supranuclear palsy, and argyrophilic grain disease. |
2021-01-19 |
2023-08-13 |
human |
| Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Bué. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31686182. |
here, we review the available data in the literature and point out how the prion-like tau propagation has been extended from alzheimer's disease to tauopathies. |
2021-01-19 |
2023-08-13 |
human |
| Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Bué. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31686182. |
first, in alzheimer's disease, the progression of tau aggregation follows stereotypical anatomical stages which may be considered as spreading. |
2021-01-19 |
2023-08-13 |
human |
| Morvane Colin, Simon Dujardin, Susanna Schraen-Maschke, Guy Meno-Tetang, Charles Duyckaerts, Jean-Philippe Courade, Luc Bué. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy. Acta neuropathologica. vol 139. issue 1. 2021-01-19. PMID:31686182. |
it has been shown that tau may be secreted in the interstitial fluid in an active manner as reflected by high and constant concentration of extracellular tau during alzheimer's pathology. |
2021-01-19 |
2023-08-13 |
human |
| Botond Penke, Mária Szűcs, Ferenc Bogá. Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer's Pathogenesis. Molecules (Basel, Switzerland). vol 25. issue 7. 2021-01-19. PMID:32260279. |
oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: their role in alzheimer's pathogenesis. |
2021-01-19 |
2023-08-13 |
Not clear |
| Botond Penke, Mária Szűcs, Ferenc Bogá. Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer's Pathogenesis. Molecules (Basel, Switzerland). vol 25. issue 7. 2021-01-19. PMID:32260279. |
the structural polymorphism and the physiological and pathophysiological roles of two important proteins, β-amyloid (aβ) and tau, that play a key role in alzheimer's disease (ad) are reviewed. |
2021-01-19 |
2023-08-13 |
Not clear |
| Magdalena Przybyla, Janet van Eersel, Annika van Hummel, Julia van der Hoven, Miheer Sabale, Anne Harasta, Julius Müller, Mehul Gajwani, Emmanuel Prikas, Thomas Mueller, Claire H Stevens, John Power, Gary D Housley, Tim Karl, Michael Kassiou, Yazi D Ke, Arne Ittner, Lars M Ittne. Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature. Brain : a journal of neurology. vol 143. issue 6. 2021-01-19. PMID:32375177. |
hyperphosphorylation and deposition of tau in the brain characterizes frontotemporal dementia and alzheimer's disease. |
2021-01-19 |
2023-08-13 |
mouse |
| Travis B Thompson, Pavanjit Chaggar, Ellen Kuhl, Alain Goriel. Protein-protein interactions in neurodegenerative diseases: A conspiracy theory. PLoS computational biology. vol 16. issue 10. 2021-01-18. PMID:33048932. |
a long standing hypothesis that amyloid-beta drives alzheimer's disease has proven the subject of contemporary controversy; leading to new research in both the role of tau protein and its interaction with amyloid-beta. |
2021-01-18 |
2023-08-13 |
human |
| Jisu Park, Hyunwoo Choi, Young Doo Kim, Seo-Hyun Kim, Youbin Kim, Youngdae Gwon, Dong Young Lee, Sung-Hye Park, Won Do Heo, Yong-Keun Jun. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular psychiatry. 2021-01-16. PMID:33452442. |
in tauopathies, including alzheimer's disease (ad), tau protein abnormally accumulates and induces dysfunction of the affected neurons. |
2021-01-16 |
2023-08-13 |
mouse |
| Tomohiro Imamura, Yuki T Yanagihara, Yasumasa Ohyagi, Norimichi Nakamura, Kyoko M Iinuma, Ryo Yamasaki, Hirohide Asai, Masahiro Maeda, Kazuma Murakami, Kazuhiro Irie, Jun-Ichi Kir. Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model. Neurobiology of disease. vol 137. 2021-01-15. PMID:31927145. |
insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an alzheimer's disease model. |
2021-01-15 |
2023-08-13 |
mouse |
| Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L Croteau, Marie-Christine Galas, Vilhelm A Boh. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta neuropathologica communications. vol 8. issue 1. 2021-01-15. PMID:32131898. |
insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of alzheimer disease (ad) and other tauopathies. |
2021-01-15 |
2023-08-13 |
mouse |
| Lennart Müller-Thomsen, Diba Borgmann, Kerstin Morcinek, Sophia Schröder, Brigitte Dengler, Natasha Moser, Felix Neumaier, Toni Schneider, Hannsjörg Schröder, Stefan Huggenberge. Consequences of hyperphosphorylated tau on the morphology and excitability of hippocampal neurons in aged tau transgenic mice. Neurobiology of aging. vol 93. 2021-01-15. PMID:32278495. |
the intracellular accumulation of hyperphosphorylated tau characterizes many neurodegenerative diseases such as alzheimer's disease and frontotemporal dementia. |
2021-01-15 |
2023-08-13 |
mouse |
| Joseph Therriault, Tharick A Pascoal, Melissa Savard, Andrea L Benedet, Mira Chamoun, Cecile Tissot, Firoza Lussier, Min Su Kang, Emilie Thomas, Tatsuhiro Terada, Soham Rej, Gassan Massarweh, Ziad Nasreddine, Paolo Vitali, Jean-Paul Soucy, Paramita Saha-Chaudhuri, Serge Gauthier, Pedro Rosa-Net. Topographic Distribution of Amyloid-β, Tau, and Atrophy in Patients With Behavioral/Dysexecutive Alzheimer Disease. Neurology. vol 96. issue 1. 2021-01-15. PMID:33093220. |
topographic distribution of amyloid-β, tau, and atrophy in patients with behavioral/dysexecutive alzheimer disease. |
2021-01-15 |
2023-08-13 |
Not clear |