| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nipun Chopra, Ruizhi Wang, Bryan Maloney, Kwangsik Nho, John S Beck, Naemeh Pourshafie, Alexander Niculescu, Andrew J Saykin, Carlo Rinaldi, Scott E Counts, Debomoy K Lahir. MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties. Molecular psychiatry. 2021-01-14. PMID:31942037. |
alzheimer's disease (ad) is the most common age-related form of dementia, associated with deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated microtubule-associated protein tau (p-tau) and extracellular plaques primarily comprising amyloid- β (aβ) peptide. |
2021-01-14 |
2023-08-13 |
mouse |
| Jianlan Gu, Wen Hu, Xuefeng Tan, Shuting Qu, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Elevation of casein kinase 1ε associated with TDP-43 and tau pathologies in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31376192. |
elevation of casein kinase 1ε associated with tdp-43 and tau pathologies in alzheimer's disease. |
2021-01-13 |
2023-08-13 |
human |
| Jianlan Gu, Wen Hu, Xuefeng Tan, Shuting Qu, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Elevation of casein kinase 1ε associated with TDP-43 and tau pathologies in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31376192. |
alzheimer's disease (ad) is characterized by the presence of extracellular amyloid β plaques and intraneuronal neurofibrillary tangles of hyperphosphorylated microtubule-associated protein tau in the brain. |
2021-01-13 |
2023-08-13 |
human |
| Julie C Lauterborn, Conor D Cox, See Wing Chan, Peter W Vanderklish, Gary Lynch, Christine M Gal. Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease. Brain pathology (Zurich, Switzerland). vol 30. issue 2. 2021-01-13. PMID:31410926. |
reduced spine densities and age-dependent accumulation of amyloid β and tau pathology are shared features of down syndrome (ds) and alzheimer's disease (ad). |
2021-01-13 |
2023-08-13 |
Not clear |
| A Joly-Amado, H Davtyan, K Serraneau, P Jules, A Zitnyar, E Pressman, K Zagorski, T Antonyan, A Hovakimyan, H J Paek, M N Gordon, D H Cribbs, N Petrovsky, M G Agadjanyan, A Ghochikyan, D Morga. Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology. Neurobiology of disease. vol 134. 2021-01-13. PMID:31629891. |
abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a hallmark of tauopathies, neurodegenerative disorders that include alzheimer's disease (ad). |
2021-01-13 |
2023-08-13 |
mouse |
| Jinwang Ye, Yaling Yin, Huanhuan Liu, Lin Fang, Xiaoqing Tao, Linyu Wei, Yue Zuo, Ying Yin, Dan Ke, Jian-Zhi Wan. Tau inhibits PKA by nuclear proteasome-dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31668016. |
intraneuronal accumulation of wild-type tau plays a key role in alzheimer's disease, while the mechanisms underlying tauopathy and memory impairment remain unclear. |
2021-01-13 |
2023-08-13 |
mouse |
| Anne Messer, David C Butle. Optimizing intracellular antibodies (intrabodies/nanobodies) to treat neurodegenerative disorders. Neurobiology of disease. vol 134. 2021-01-13. PMID:31669671. |
advances in bioinformatics, screening protocols, and especially gene therapy are showing great promise for intrabody/ nanobody treatments of a full range of neurological disorders, including alzheimer's disease and related tau dementias, parkinson's disease and lewy body diseases, huntington's disease, amyotrophic lateral sclerosis, and prion diseases, among others. |
2021-01-13 |
2023-08-13 |
Not clear |
| Travis Rush, Jonathan R Roth, Samantha J Thompson, Adam R Aldaher, J Nicholas Cochran, Erik D Roberso. A peptide inhibitor of Tau-SH3 interactions ameliorates amyloid-β toxicity. Neurobiology of disease. vol 134. 2021-01-13. PMID:31698056. |
the microtubule-associated protein tau is strongly implicated in alzheimer's disease (ad) and aggregates into neurofibrillary tangles in ad. |
2021-01-13 |
2023-08-13 |
rat |
| Heesun Choi, Haeng Jun Kim, Jinhee Yang, Sehyun Chae, Wonik Lee, Sunwoo Chung, Jisoo Kim, Hyunjung Choi, Hyeseung Song, Chang Kon Lee, Jae Hyun Jun, Yong Jae Lee, Kyunghyeon Lee, Semi Kim, Hye-Ri Sim, Young Il Choi, Keun Ho Ryu, Jong-Chan Park, Dongjoon Lee, Sun-Ho Han, Daehee Hwang, Jangbeen Kyung, Inhee Mook-Jun. Acetylation changes tau interactome to degrade tau in Alzheimer's disease animal and organoid models. Aging cell. vol 19. issue 1. 2021-01-13. PMID:31763743. |
acetylation changes tau interactome to degrade tau in alzheimer's disease animal and organoid models. |
2021-01-13 |
2023-08-13 |
Not clear |
| Eliana Nachman, Anne S Wentink, Karine Madiona, Luc Bousset, Taxiarchis Katsinelos, Kieren Allinson, Harm Kampinga, William A McEwan, Thomas R Jahn, Ronald Melki, Axel Mogk, Bernd Bukau, Carmen Nussbaum-Kramme. Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species. The Journal of biological chemistry. vol 295. issue 28. 2021-01-13. PMID:32467226. |
the accumulation of amyloid tau aggregates is implicated in alzheimer's disease (ad) and other tauopathies. |
2021-01-13 |
2023-08-13 |
human |
| Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenber. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of biological chemistry. vol 295. issue 31. 2021-01-13. PMID:32493775. |
crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with alzheimer's disease. |
2021-01-13 |
2023-08-13 |
Not clear |
| Romany Abskharon, Paul M Seidler, Michael R Sawaya, Duilio Cascio, Tianxiao P Yang, Stephan Philipp, Christopher Kazu Williams, Kathy L Newell, Bernardino Ghetti, Michael A DeTure, Dennis W Dickson, Harry V Vinters, Philip L Felgner, Rie Nakajima, Charles G Glabe, David S Eisenber. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of biological chemistry. vol 295. issue 31. 2021-01-13. PMID:32493775. |
soluble oligomers of aggregated tau accompany the accumulation of insoluble amyloid fibrils, a histological hallmark of alzheimer disease (ad) and two dozen related neurodegenerative diseases. |
2021-01-13 |
2023-08-13 |
Not clear |
| Nirmal Chandra Barman, Niuz Morshed Khan, Maidul Islam, Zulkar Nain, Rajib Kanti Roy, Anwarul Haque, Shital Kumar Barma. CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review. Neurology and therapy. vol 9. issue 2. 2021-01-12. PMID:33089409. |
alzheimer's disease (ad) is a chronic and irreversible neurodegenerative disorder characterized by cognitive deficiency and development of amyloid-β (aβ) plaques and neurofibrillary tangles, comprising hyperphosphorylated tau. |
2021-01-12 |
2023-08-13 |
Not clear |
| Amelie Schäfer, Elizabeth C Mormino, Ellen Kuh. Network Diffusion Modeling Explains Longitudinal Tau PET Data. Frontiers in neuroscience. vol 14. 2021-01-12. PMID:33424532. |
alzheimer's disease is associated with the cerebral accumulation of neurofibrillary tangles of hyperphosphorylated tau protein. |
2021-01-12 |
2023-08-13 |
human |
| Manisha Prajapat, Phulen Sarma, Nishant Shekhar, Hardeep Kaur, Sanjay Singh, Subodh Kumar, Harpinder Kaur, Saniya Mahendiratta, Amit Raj Sharma, Sukhmandeep Kaur, Vidya M Mahalmani, Bikash Medh. Journal of advanced pharmaceutical technology & research. vol 11. issue 4. 2021-01-12. PMID:33425704. |
glycogen synthase kinase 3 beta (gsk3 β) plays a key role in pathologic hyper phosphorylation of tau and plays an important role in the pathogenesis of alzheimer's disease. |
2021-01-12 |
2023-08-13 |
Not clear |
| Stefan M Ivanov, Mariyana Atanasova, Ivan Dimitrov, Irini A Doytchinov. Cellular polyamines condense hyperphosphorylated Tau, triggering Alzheimer's disease. Scientific reports. vol 10. issue 1. 2021-01-11. PMID:32572101. |
cellular polyamines condense hyperphosphorylated tau, triggering alzheimer's disease. |
2021-01-11 |
2023-08-13 |
Not clear |
| Abdullahi Alausa, Sunday Ogundepo, Barakat Olaleke, Rofiat Adeyemi, Mercy Olatinwo, Aminat Ismai. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chinese medicine. vol 16. issue 1. 2021-01-11. PMID:33407732. |
this condition has been further attributed to mis-stability, deletion or mutation of tau protein, causing the onset of corticobasal degeneration, pick's diseases, progressive supranuclear palsy, argyrophilic grains disease, alzheimer's diseases etc. |
2021-01-11 |
2023-08-13 |
human |
| Xiaowen Jiang, Hongyuan Lu, Jingda Li, Wenwu Liu, Qiong Wu, Zihua Xu, Qinglong Qiao, Haotian Zhang, Huiyuan Gao, Qingchun Zha. A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology. Clinical and translational medicine. vol 10. issue 3. 2021-01-10. PMID:32652879. |
a natural bace1 and gsk3β dual inhibitor notopterol effectively ameliorates the cognitive deficits in app/ps1 alzheimer's mice by attenuating amyloid-β and tau pathology. |
2021-01-10 |
2023-08-13 |
mouse |
| Masami Masuda-Suzukake, Genjiro Suzuki, Masato Hosokawa, Takashi Nonaka, Michel Goedert, Masato Hasegaw. Dextran sulphate-induced tau assemblies cause endogenous tau aggregation and propagation in wild-type mice. Brain communications. vol 2. issue 2. 2021-01-10. PMID:33005889. |
accumulation of assembled tau protein in the central nervous system is characteristic of alzheimer's disease and several other neurodegenerative diseases, called tauopathies. |
2021-01-10 |
2023-08-13 |
mouse |
| Robert Y K Lai, Charles R Harrington, Claude M Wischi. Erratum: Lai, R.Y.K.; Harrington, C.R.; Wischik, C.M. Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease. Biomolecules 2016, 6, 19. Biomolecules. vol 6. issue 3. 2021-01-09. PMID:27529285. |
absence of a role for phosphorylation in the tau pathology of alzheimer's disease. |
2021-01-09 |
2023-08-13 |
Not clear |