| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Azhaar A Ashraf, Melanie Dani, Po-Wah S. Low Cerebrospinal Fluid Levels of Hemopexin Are Associated With Increased Alzheimer's Pathology, Hippocampal Hypometabolism, and Cognitive Decline. Frontiers in molecular biosciences. vol 7. 2021-01-06. PMID:33392254. |
we analyzed baseline csf heme/iron proteins (multiplexed mass spectrometry-based assay), amyloid and tau (luminex platform), baseline/longitudinal neuroimaging (mri, fdg-pet) and cognitive outcomes in 86 cognitively normal, 135 mild-cognitive impairment and 66 alzheimer's participants from the alzheimer's disease neuroimaging initiative-1 (adni-1) cohort. |
2021-01-06 |
2023-08-13 |
human |
| Nicolas Rouleau, William L Cantley, Volha Liaudanskaya, Alexander Berk, Chuang Du, William Rusk, Emily Peirent, Cole Koester, Thomas J F Nieland, David L Kapla. A Long-Living Bioengineered Neural Tissue Platform to Study Neurodegeneration. Macromolecular bioscience. vol 20. issue 3. 2021-01-05. PMID:32065736. |
diseased samples display decreased spontaneous electrical activity and a subset displays sporadic-like indicators of increased pathological β-amyloid and tau markers characteristic of alzheimer's disease with concomitant increases in oxidative stress. |
2021-01-05 |
2023-08-13 |
human |
| Bin Peng, Qiang Yang, Rachna B Joshi, Yuancai Liu, Mohammed Akbar, Byoung-Joon Song, Shuanhu Zhou, Xin Wan. Role of Alcohol Drinking in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis. International journal of molecular sciences. vol 21. issue 7. 2021-01-05. PMID:32230811. |
epidemiological studies have reported a reduction in the prevalence of alzheimer's disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of aβ and tau phosphorylation. |
2021-01-05 |
2023-08-13 |
Not clear |
| Masako Nakano, Kenta Kubota, Eiji Kobayashi, Takako S Chikenji, Yuki Saito, Naoto Konari, Mineko Fujimiy. Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer's disease model by increasing the expression of microRNA-146a in hippocampus. Scientific reports. vol 10. issue 1. 2021-01-05. PMID:32612165. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β and tau. |
2021-01-05 |
2023-08-13 |
mouse |
| Jing Zhao, Yanan Zhu, Xuehong Song, Yuanyuan Xiao, Guowei Su, Xinyue Liu, Zhangjie Wang, Yongmei Xu, Jian Liu, David Eliezer, Trudy F Ramlall, Guy Lippens, James Gibson, Fuming Zhang, Robert J Linhardt, Lianchun Wang, Chunyu Wan. 3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Angewandte Chemie (International ed. in English). vol 59. issue 5. 2021-01-04. PMID:31692167. |
prion-like transcellular spreading of tau in alzheimer's disease (ad) is mediated by tau binding to cell surface heparan sulfate (hs). |
2021-01-04 |
2023-08-13 |
Not clear |
| Pragati, Soram Idiyasan Chanu, Surajit Sarka. Reduced expression of dMyc mitigates Tau Neuroscience letters. vol 715. 2021-01-04. PMID:31715291. |
reduced expression of dmyc mitigates tau tauopathies such as alzheimer's disease (ad), pick's disease (pid), frontotemporal dementia with parkinsonism linked to chromosome 17 (ftdp-17) etc. |
2021-01-04 |
2023-08-13 |
human |
| Ana I Duarte, Emanuel Candeias, Inês N Alves, Débora Mena, Daniela F Silva, Nuno J Machado, Elisa J Campos, Maria S Santos, Catarina R Oliveira, Paula I Moreir. Liraglutide Protects Against Brain Amyloid-β International journal of molecular sciences. vol 21. issue 5. 2021-01-04. PMID:32143329. |
liraglutide protects against brain amyloid-β alzheimer's disease (ad) is the most common form of dementia worldwide, being characterized by the deposition of senile plaques, neurofibrillary tangles (enriched in the amyloid beta (aβ) peptide and hyperphosphorylated tau (p-tau), respectively) and memory loss. |
2021-01-04 |
2023-08-13 |
mouse |
| Chi-Chang Weng, Ing-Tsung Hsiao, Qing-Fang Yang, Cheng-Hsiang Yao, Chin-Yin Tai, Meng-Fang Wu, Tzu-Chen Yen, Ming-Kuei Jang, Kun-Ju Li. Characterization of Molecules (Basel, Switzerland). vol 25. issue 7. 2021-01-04. PMID:32290239. |
characterization of misfolding, aggregation, and cerebral accumulation of tau deposits are hallmark features of alzheimer's disease. |
2021-01-04 |
2023-08-13 |
Not clear |
| Zall Hirschstein, Gautam Reddy Vanga, Guirong Wang, Zachary M Novakovic, Patricia Grass. MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus. Biochimica et biophysica acta. General subjects. vol 1864. issue 11. 2021-01-04. PMID:32738275. |
extracellular beta-amyloid (aβ), intra-neuronal hyper-phosphorylated tau protein, and chronic inflammation are neuropathological hallmarks of alzheimer's disease (ad). |
2021-01-04 |
2023-08-13 |
mouse |
| Haibo Zhang, Aihua Lin, Ping Gong, Yanqing Chen, Richard D Ye, Feng Qian, Yan Zhang, Yang Y. The Chemokine-like Receptor 1 Deficiency Improves Cognitive Deficits of AD Mice and Attenuates Tau Hyperphosphorylation via Regulating Tau Seeding. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 36. 2021-01-01. PMID:32801154. |
pathologic features of alzheimer's disease (ad) include accumulation of amyloid β (aβ) and hyperphosphorylated tau protein. |
2021-01-01 |
2023-08-13 |
mouse |
| Niklas Reich, Christian Hölsche. Acylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease. Frontiers in neuroscience. vol 14. 2021-01-01. PMID:33381011. |
much thought has been given to the impact of amyloid beta, tau and alpha-synuclein in the development of alzheimer's disease (ad) and parkinson's disease (pd), yet the clinical failures of the recent decades indicate that there are further pathological mechanisms at work. |
2021-01-01 |
2023-08-13 |
Not clear |
| Nozomi Tagai, Ayako Tanaka, Akira Sato, Fumiaki Uchiumi, Sei-Ichi Tanum. Low Levels of Brain-Derived Neurotrophic Factor Trigger Self-aggregated Amyloid β-Induced Neuronal Cell Death in an Alzheimer's Cell Model. Biological & pharmaceutical bulletin. vol 43. issue 7. 2020-12-31. PMID:32612070. |
alzheimer's disease (ad) is pathologically characterized by accumulation of amyloid β (aβ) and hyperphosphorylated tau, and thereby induction of neuronal cell death. |
2020-12-31 |
2023-08-13 |
human |
| Zhourui Wu, Zhi-Hao Wang, Xia Liu, Zhentao Zhang, Xiaohuan Gu, Shan Ping Yu, C Dirk Keene, Liming Cheng, Keqiang Y. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. Progress in neurobiology. vol 185. 2020-12-30. PMID:31778772. |
traumatic brain injury triggers app and tau cleavage by delta-secretase, mediating alzheimer's disease pathology. |
2020-12-30 |
2023-08-13 |
mouse |
| Zhourui Wu, Zhi-Hao Wang, Xia Liu, Zhentao Zhang, Xiaohuan Gu, Shan Ping Yu, C Dirk Keene, Liming Cheng, Keqiang Y. Traumatic brain injury triggers APP and Tau cleavage by delta-secretase, mediating Alzheimer's disease pathology. Progress in neurobiology. vol 185. 2020-12-30. PMID:31778772. |
traumatic brain injury (tbi) is associated in some studies with clinical dementia, and neuropathological features, including amyloid plaque deposition and tau neurofibrillary degeneration commonly identified in alzheimer's disease (ad). |
2020-12-30 |
2023-08-13 |
mouse |
| Irene Sintini, Jonathan Graff-Radford, Matthew L Senjem, Christopher G Schwarz, Mary M Machulda, Peter R Martin, David T Jones, Bradley F Boeve, David S Knopman, Kejal Kantarci, Ronald C Petersen, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32572464. |
the topography of longitudinal tau accumulation and atrophy differed across phenotypes, with key regions of tau accumulation in the frontal and temporal lobes for all phenotypes and key regions of atrophy in the occipitotemporal regions for posterior cortical atrophy, left temporal lobe for logopenic progressive aphasia and medial and lateral temporal lobe for typical alzheimer's disease. |
2020-12-30 |
2023-08-13 |
human |
| Irene Sintini, Jonathan Graff-Radford, Matthew L Senjem, Christopher G Schwarz, Mary M Machulda, Peter R Martin, David T Jones, Bradley F Boeve, David S Knopman, Kejal Kantarci, Ronald C Petersen, Clifford R Jack, Val J Lowe, Keith A Josephs, Jennifer L Whitwel. Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32572464. |
baseline tau tracer retention showed the highest fidelity to clinical phenotype, supporting the important causal role of tau as a driver of clinical dysfunction in alzheimer's disease. |
2020-12-30 |
2023-08-13 |
human |
| Katheryn A Q Cousins, David J Irwin, David A Wolk, Edward B Lee, Leslie M J Shaw, John Q Trojanowski, Fulvio Da Re, Garrett S Gibbons, Murray Grossman, Jeffrey S Phillip. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32666090. |
under the atn framework, csf analytes provide evidence of the presence or absence of alzheimer's disease pathological hallmarks: amyloid plaques (a), phosphorylated tau (t), and accompanying neurodegeneration (n). |
2020-12-30 |
2023-08-13 |
Not clear |
| Katheryn A Q Cousins, David J Irwin, David A Wolk, Edward B Lee, Leslie M J Shaw, John Q Trojanowski, Fulvio Da Re, Garrett S Gibbons, Murray Grossman, Jeffrey S Phillip. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32666090. |
we assess the diagnostic accuracy of csf markers for amyloid, tau, and neurodegeneration in an autopsy cohort of 118 alzheimer's disease patients (98 amnestic; 20 non-amnestic) and 64 frontotemporal lobar degeneration patients (five amnestic; 59 non-amnestic). |
2020-12-30 |
2023-08-13 |
Not clear |
| Katheryn A Q Cousins, David J Irwin, David A Wolk, Edward B Lee, Leslie M J Shaw, John Q Trojanowski, Fulvio Da Re, Garrett S Gibbons, Murray Grossman, Jeffrey S Phillip. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32666090. |
however, csf concentrations of phosphorylated tau, total tau, and the ratio of phosphorylated tau to amyloid-β1-42 were significantly lower in non-amnestic compared to amnestic alzheimer's disease patients. |
2020-12-30 |
2023-08-13 |
Not clear |
| Katheryn A Q Cousins, David J Irwin, David A Wolk, Edward B Lee, Leslie M J Shaw, John Q Trojanowski, Fulvio Da Re, Garrett S Gibbons, Murray Grossman, Jeffrey S Phillip. ATN status in amnestic and non-amnestic Alzheimer's disease and frontotemporal lobar degeneration. Brain : a journal of neurology. vol 143. issue 7. 2020-12-30. PMID:32666090. |
in contrast, t and n status biomarkers differed between amnestic and non-amnestic alzheimer's disease; standard cut-offs for phosphorylated tau and total tau may thus result in misclassifications for non-amnestic alzheimer's disease patients. |
2020-12-30 |
2023-08-13 |
Not clear |