All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. tau pathology in early alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. 2020-11-18 2023-08-13 Not clear
Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. understanding the role of tau protein aggregation in the pathogenesis of alzheimer's disease is critical for the development of new tau-based therapeutic strategies to slow or prevent dementia. 2020-11-18 2023-08-13 Not clear
Kadja L C Monteiro, Marcone G Dos S Alcântara, Thiago M de Aquino, Edeildo F da Silva-Júnio. Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents. Current pharmaceutical design. vol 26. issue 15. 2020-11-18. PMID:32286939. tau protein aggregation in alzheimer's disease: recent advances in the development of novel therapeutic agents. 2020-11-18 2023-08-13 Not clear
Koji Yoshida, Yukiko Hata, Shojiro Ichimata, Naoki Nishid. Tau and Amyloid-β Pathology in Japanese Forensic Autopsy Series Under 40 Years of Age: Prevalence and Association with APOE Genotype and Suicide Risk. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594218. aggregation of abnormal phosphorylated tau in brain stem areas may be a possible early pathological manifestation of alzheimer's disease (ad). 2020-11-17 2023-08-13 Not clear
Xiaoguang Liu, Michaeline L Hebron, Sanjana Mulki, Chen Wang, Elizabeth Lekah, Dalila Ferrante, Wangke Shi, Bahjat Kurd-Misto, Charbel Mouss. Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594232. ubiquitin specific protease 13 regulates tau accumulation and clearance in models of alzheimer's disease. 2020-11-17 2023-08-13 human
Brent Aulston, Qing Liu, Michael Mante, Jazmin Florio, Robert A Rissman, Shauna H Yua. Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594233. extracellular vesicles isolated from familial alzheimer's disease neuronal cultures induce aberrant tau phosphorylation in the wild-type mouse brain. 2020-11-17 2023-08-13 mouse
Iason Keramidis, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios M C Skoulaki. Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192295. functional interactions of tau phosphorylation sites that mediate toxicity and deficient learning in hyperphosphorylated tau protein is the main component of the neurofibrillary tangles, characterizing degenerating neurons in alzheimer's disease and other tauopathies. 2020-11-17 2023-08-13 human
Daniel C Shippy, Tyler K Ullan. Microglial Immunometabolism in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192310. alzheimer's disease (ad) is a neurodegenerative disorder characterized by amyloid-β (aβ) plaques and the formation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. 2020-11-17 2023-08-13 Not clear
Eun-Chong Lee, Jae Myeong Kang, Seongho Seo, Ha-Eun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Young Noh, Joon-Kyung Seon. Association of Subcortical Structural Shapes With Tau, Amyloid, and Cortical Atrophy in Early-Onset and Late-Onset Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192457. association of subcortical structural shapes with tau, amyloid, and cortical atrophy in early-onset and late-onset alzheimer's disease. 2020-11-17 2023-08-13 human
Eun-Chong Lee, Jae Myeong Kang, Seongho Seo, Ha-Eun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Young Noh, Joon-Kyung Seon. Association of Subcortical Structural Shapes With Tau, Amyloid, and Cortical Atrophy in Early-Onset and Late-Onset Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192457. the objectives of this study were to compare the topographical subcortical shape and to investigate the effects of tau or amyloid burden on atrophic patterns in early onset alzheimer's disease (eoad) and late-onset alzheimer's disease (load). 2020-11-17 2023-08-13 human
Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Masaaki Waragai, Takato Takenouchi, Eliezer Masliah, Makoto Hashimot. Connecting Alzheimer's Disease With Diabetes Mellitus Through Amyloidogenic Evolvability. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192467. recently, we proposed that alzheimer's disease (ad)-relevant amyloidogenic proteins (aps), such as amyloid-β (aβ) and tau, might be involved in evolvability against diverse stressors in the brain. 2020-11-17 2023-08-13 Not clear
A Iyaswamy, S K Krishnamoorthi, Y W Liu, J X Song, A K Kammala, S G Sreenivasmurthy, S Malampati, B C K Tong, K Selvarasu, K H Cheung, J H Lu, J Q Tan, C Y Huang, S S K Durairajan, M L. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. Frontiers in pharmacology. vol 11. 2020-11-17. PMID:33192524. yuan-hu zhi tong prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of alzheimer's disease. 2020-11-17 2023-08-13 Not clear
Roland Brandt, Nataliya I Trushina, Lidia Bakot. Much More Than a Cytoskeletal Protein: Physiological and Pathological Functions of the Non-microtubule Binding Region of Tau. Frontiers in neurology. vol 11. 2020-11-17. PMID:33193056. in tauopathies, such as alzheimer's disease, tau is distributed more in the somatodendritic compartment, where it aggregates into filamentous structures, the formation of which correlates with cognitive impairments in patients. 2020-11-17 2023-08-13 Not clear
Shanya Jiang, Kiran Bhaska. Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy. Frontiers in molecular neuroscience. vol 13. 2020-11-14. PMID:33177989. tauopathies are a class of neurodegenerative diseases, including alzheimer's disease (ad), frontotemporal dementia (ftd), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and many others where microtubule-associated protein tau (mapt or tau) is hyperphosphorylated and aggregated to form insoluble paired helical filaments (phfs) and ultimately neurofibrillary tangles (nfts). 2020-11-14 2023-08-13 Not clear
Guy Griebel, Jeanne Stemmelin, Mati Lopez-Grancha, Denis Boulay, Gerald Boquet, Franck Slowinski, Philippe Pichat, Sandra Beeské, Shinji Tanaka, Akiko Mori, Masatake Fujimura, Junichi Eguch. The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents. Scientific reports. vol 9. issue 1. 2020-11-13. PMID:31792284. glycogen synthase kinase 3 (gsk3) has been identified as a promising target for the treatment of alzheimer's disease (ad), where abnormal activation of this enzyme has been associated with hyperphosphorylation of tau proteins. 2020-11-13 2023-08-13 mouse
Kenjiro Ono, Mayumi Tsuj. Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 3. 2020-11-13. PMID:32023927. worldwide, alzheimer's disease (ad) is the most common age-related neurodegenerative disease and is characterized by unique pathological hallmarks in the brain, including plaques composed of amyloid β-protein (aβ) and neurofibrillary tangles of tau protein. 2020-11-13 2023-08-13 mouse
Xiaohai Wang, Wenping Li, Jacob Marcus, Michelle Pearson, Lixin Song, Karen Smith, Giuseppe Terracina, Julie Lee, Kwok-Lam Karen Hong, Sherry X Lu, Lynn Hyde, Shu-Cheng Chen, David Kinsley, Jerry P Melchor, Daniel J Rubins, Xiangjun Meng, Eric Hostetler, Cyrille Sur, Lili Zhang, Joel B Schachter, J Fred Hess, Harold G Selnick, David J Vocadlo, Ernest J McEachern, Jason M Uslaner, Joseph L Duffy, Sean M Smit. MK-8719, a Novel and Selective The Journal of pharmacology and experimental therapeutics. vol 374. issue 2. 2020-11-12. PMID:32493725. mk-8719, a novel and selective deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of alzheimer disease and other tauopathies. 2020-11-12 2023-08-13 human
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Shengjun Hong, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2020-11-11. PMID:33173883. cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in alzheimer's disease. 2020-11-11 2023-08-13 Not clear
Pieter Jelle Visser, Lianne M Reus, Johan Gobom, Iris Jansen, Ellen Dicks, Magda Tsolaki, Frans R J Verhey, Julius Popp, Pablo Martinez-Lage, Rik Vandenberghe, Alberto Lleó, José Luís Molinuevo, Sebastiaan Engelborghs, Yvonne Freund-Levi, Lutz Froelich, Kristel Sleegers, Valerija Dobricic, Shengjun Hong, Simon Lovestone, Johannes Streffer, Stephanie J B Vos, Isabelle Bos, August B Smit, Kaj Blennow, Philip Scheltens, Charlotte E Teunissen, Lars Bertram, Henrik Zetterberg, Betty M Tijm. Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease. medRxiv : the preprint server for health sciences. 2020-11-11. PMID:33173883. alzheimer's disease (ad) is characterised by abnormal amyloid beta and tau processing. 2020-11-11 2023-08-13 Not clear
Serge Nataf, Marine Guillen, Laurent Pay. Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1. Frontiers in immunology. vol 10. 2020-11-10. PMID:31824497. in contrast, peptides deriving from microtubule-associated protein tau, presenilin 2 and serine/threonine-protein kinase tbk1 were exclusively reported to bind mhc molecules encoded by the hla-drb1 1501 allele, a recently-identified susceptibility gene for late onset alzheimer's disease. 2020-11-10 2023-08-13 human