| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicola Spotorno, Julio Acosta-Cabronero, Erik Stomrud, Björn Lampinen, Olof T Strandberg, Danielle van Westen, Oskar Hansso. Relationship between cortical iron and tau aggregation in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32330946. |
together, these results provide in vivo evidence of an association between iron deposition and both tau aggregation and neurodegeneration, which help advance our understanding of the role of iron dysregulation in the alzheimer's disease aetiology. |
2020-12-14 |
2023-08-13 |
human |
| Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. Microglial activation and tau burden predict cognitive decline in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32380523. |
microglial activation and tau burden predict cognitive decline in alzheimer's disease. |
2020-12-14 |
2023-08-13 |
human |
| Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. Microglial activation and tau burden predict cognitive decline in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32380523. |
tau pathology, neuroinflammation, and neurodegeneration are key aspects of alzheimer's disease. |
2020-12-14 |
2023-08-13 |
human |
| Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. Microglial activation and tau burden predict cognitive decline in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32380523. |
here, we studied how baseline assessments of in vivo tau pathology (measured by 18f-av-1451 pet), neuroinflammation (measured by 11c-pk11195 pet) and brain atrophy (derived from structural mri) predicted longitudinal cognitive changes in patients with alzheimer's disease pathology. |
2020-12-14 |
2023-08-13 |
human |
| Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. Microglial activation and tau burden predict cognitive decline in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32380523. |
we conclude that temporo-parietal tau pathology and anterior temporal neuroinflammation predict cognitive decline in patients with symptomatic alzheimer's disease pathology. |
2020-12-14 |
2023-08-13 |
human |
| Maura Malpetti, Rogier A Kievit, Luca Passamonti, P Simon Jones, Kamen A Tsvetanov, Timothy Rittman, Elijah Mak, Nicolas Nicastro, W Richard Bevan-Jones, Li Su, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, John T O'Brien, James B Row. Microglial activation and tau burden predict cognitive decline in Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32380523. |
our findings also support the strategy for targeting tau and neuroinflammation in disease-modifying therapy against alzheimer's disease. |
2020-12-14 |
2023-08-13 |
human |
| John D Arena, Douglas H Smith, Edward B Lee, Garrett S Gibbons, David J Irwin, John L Robinson, Virginia M-Y Lee, John Q Trojanowski, William Stewart, Victoria E Johnso. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32390044. |
tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and alzheimer's disease. |
2020-12-14 |
2023-08-13 |
Not clear |
| John D Arena, Douglas H Smith, Edward B Lee, Garrett S Gibbons, David J Irwin, John L Robinson, Virginia M-Y Lee, John Q Trojanowski, William Stewart, Victoria E Johnso. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32390044. |
using immunohistochemistry, we performed tau phenotyping of cte neuropathologies and compared this to a range of tau pathologies, including alzheimer's disease, primary age-related tauopathy, ageing-related tau astrogliopathy and multiple subtypes of frontotemporal lobar degeneration with tau inclusions. |
2020-12-14 |
2023-08-13 |
Not clear |
| John D Arena, Douglas H Smith, Edward B Lee, Garrett S Gibbons, David J Irwin, John L Robinson, Virginia M-Y Lee, John Q Trojanowski, William Stewart, Victoria E Johnso. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32390044. |
in contrast, neurofibrillary tangles of cte contain both 3r and 4r tau, with post-translational modifications and conformations consistent with alzheimer's disease and primary age-related tauopathy. |
2020-12-14 |
2023-08-13 |
Not clear |
| John D Arena, Douglas H Smith, Edward B Lee, Garrett S Gibbons, David J Irwin, John L Robinson, Virginia M-Y Lee, John Q Trojanowski, William Stewart, Victoria E Johnso. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a journal of neurology. vol 143. issue 5. 2020-12-14. PMID:32390044. |
our observations establish that the astroglial and neurofibrillary tau pathologies of cte are phenotypically distinct from each other and recapitulate the tau immunophenotypes encountered in ageing and alzheimer's disease. |
2020-12-14 |
2023-08-13 |
Not clear |
| Marc Aurel Busche, Bradley T Hyma. Synergy between amyloid-β and tau in Alzheimer's disease. Nature neuroscience. vol 23. issue 10. 2020-12-14. PMID:32778792. |
synergy between amyloid-β and tau in alzheimer's disease. |
2020-12-14 |
2023-08-13 |
human |
| David Mengel, Shorena Janelidze, Robert J Glynn, Wen Liu, Oskar Hansson, Dominic M Wals. Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease. Annals of neurology. vol 88. issue 5. 2020-12-14. PMID:32829532. |
plasma nt1 tau is a specific and early marker of alzheimer's disease. |
2020-12-14 |
2023-08-13 |
Not clear |
| Allie N Greene, Lois G Parks, Matia B Solomon, Lisa M Privette Vinnedg. Loss of DEK Expression Induces Alzheimer's Disease Phenotypes in Differentiated SH-SY5Y Cells. Frontiers in molecular neuroscience. vol 13. 2020-12-12. PMID:33304240. |
alzheimer's disease (ad) is the most common cause of dementia and is characterized by the buildup of β-amyloid plaques and neurofibrillary tau tangles. |
2020-12-12 |
2023-08-13 |
Not clear |
| Paul J Derry, Muralidhar L Hegde, George R Jackson, Rakez Kayed, James M Tour, Ah-Lim Tsai, Thomas A Ken. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective. Progress in neurobiology. vol 184. 2020-12-10. PMID:31604111. |
revisiting the intersection of amyloid, pathologically modified tau and iron in alzheimer's disease from a ferroptosis perspective. |
2020-12-10 |
2023-08-13 |
Not clear |
| Armin Vosoughi, Saeed Sadigh-Eteghad, Mohammad Ghorbani, Sedaghat Shahmorad, Mehdi Farhoudi, Mohammad A Rafi, Yadollah Omid. Mathematical Models to Shed Light on Amyloid-Beta and Tau Protein Dependent Pathologies in Alzheimer's Disease. Neuroscience. vol 424. 2020-12-10. PMID:31682825. |
mathematical models to shed light on amyloid-beta and tau protein dependent pathologies in alzheimer's disease. |
2020-12-10 |
2023-08-13 |
Not clear |
| Masaki Taka. [Dementia of the Oldest-Old]. Brain and nerve = Shinkei kenkyu no shinpo. vol 72. issue 12. 2020-12-10. PMID:33293469. |
the neuropathologic changes of dementia in the oldest-old individuals are associated with alzheimer's disease, lewy body disease, cerebrovascular disease, primary age-related tauopathy (part), limbic-predominant age-related tdp-43 encephalopathy (late), and aging-related tau astrogliopathy (artag). |
2020-12-10 |
2023-08-13 |
Not clear |
| Alex Crowe, Mark J Henderson, Johnathon Anderson, Steven A Titus, Alexey Zakharov, Anton Simeonov, Arjan Buist, Charlotte Delay, Diederik Moechars, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunde. Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays. The Journal of biological chemistry. vol 295. issue 12. 2020-12-08. PMID:32034092. |
the hallmark pathological features of alzheimer's disease (ad) brains are senile plaques, comprising β-amyloid (aβ) peptides, and neuronal inclusions formed from tau protein. |
2020-12-08 |
2023-08-13 |
rat |
| Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara, Subashchandrabose Chinnathamb. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32704015. |
the intracellular tau aggregates are known to be associated with alzheimer's disease. |
2020-12-08 |
2023-08-13 |
drosophila_melanogaster |
| Tushar Dubey, Nalini Vijay Gorantla, Kagepura Thammaiah Chandrashekara, Subashchandrabose Chinnathamb. Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells. Scientific reports. vol 10. issue 1. 2020-12-08. PMID:32704015. |
the inhibition of tau aggregation is an important strategy for screening of therapeutic molecules in alzheimer's disease. |
2020-12-08 |
2023-08-13 |
drosophila_melanogaster |
| Xingzhi Guo, Yanying Liu, David Morgan, Li-Ru Zha. Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS1 Mice. Aging and disease. vol 11. issue 6. 2020-12-08. PMID:33269098. |
alzheimer's disease (ad), characterized by the accumulation of β-amyloid (aβ) plaques and tau neurofibrillary tangles in the brain, neuroinflammation and neurodegeneration, is the most common form of neurodegenerative disease among the elderly. |
2020-12-08 |
2023-08-13 |
mouse |