| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hang-Rai Kim, Taeyeop Lee, Jung Kyoon Choi, Yong Jeon. Genetic variants beyond amyloid and tau associated with cognitive decline: A cohort study. Neurology. vol 95. issue 17. 2020-11-23. PMID:32938779. |
to identify single nucleotide polymorphisms (snps) associated with cognitive decline independent of β-amyloid (aβ) and tau pathology in alzheimer disease (ad). |
2020-11-23 |
2023-08-13 |
Not clear |
| Ju-Xian Song, Sandeep Malampati, Yu Zeng, Siva Sundara Kumar Durairajan, Chuan-Bin Yang, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Wen-Bin Shang, Sravan Gopalkrishnashetty Sreenivasmurthy, Zhou Zhu, King-Ho Cheung, Jia-Hong Lu, Chunzhi Tang, Nenggui Xu, Min L. A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models. Aging cell. vol 19. issue 2. 2020-11-20. PMID:31858697. |
a small molecule transcription factor eb activator ameliorates beta-amyloid precursor protein and tau pathology in alzheimer's disease models. |
2020-11-20 |
2023-08-13 |
mouse |
| Jorge A Trejo-Lopez, Zachary A Sorrentino, Cara J Riffe, Stefan Prokop, Dennis W Dickson, Anthony T Yachnis, Benoit I Giasso. Generation and Characterization of Novel Monoclonal Antibodies Targeting p62/sequestosome-1 Across Human Neurodegenerative Diseases. Journal of neuropathology and experimental neurology. vol 79. issue 4. 2020-11-20. PMID:32106300. |
both 5g3 and 2a5 revealed incidental astrocytic tau immunoreactivity in cases of alzheimer disease and lewy body disease with resolution superior to 7f2. |
2020-11-20 |
2023-08-13 |
human |
| Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V Riddick, Michelle S Itano, Ashutosh Tripathy, Sheryl S Moy, Virginia M Y Lee, John Q Trojanowski, David J Irwin, Todd J Cohe. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline. Nature communications. vol 11. issue 1. 2020-11-20. PMID:33139698. |
tauopathies including alzheimer's disease (ad) are marked by the accumulation of aberrantly modified tau proteins. |
2020-11-20 |
2023-08-13 |
mouse |
| Daniel Tward, Timothy Brown, Yusuke Kageyama, Jaymin Patel, Zhipeng Hou, Susumu Mori, Marilyn Albert, Juan Troncoso, Michael Mille. Diffeomorphic Registration With Intensity Transformation and Missing Data: Application to 3D Digital Pathology of Alzheimer's Disease. Frontiers in neuroscience. vol 14. 2020-11-19. PMID:32116503. |
by using a standard convolutional neural network to detect tau tangles in histology slices, this registration method enabled us to quantify the 3d density distribution of tauopathy throughout the medial temporal lobe of an alzheimer's disease postmortem specimen. |
2020-11-19 |
2023-08-13 |
Not clear |
| Daichi Sone, Yoko Shigemoto, Masayo Ogawa, Norihide Maikusa, Kyoji Okita, Harumasa Takano, Koichi Kato, Noriko Sato, Hiroshi Matsud. Association between neurite metrics and tau/inflammatory pathology in Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 12. issue 1. 2020-11-19. PMID:33204813. |
the molecular mechanism of neurodegeneration, including tau and neurite complexity, is an important topic in alzheimer's disease (ad) research. |
2020-11-19 |
2023-08-13 |
Not clear |
| Armine Hovakimyan, Tatevik Antonyan, Sepideh Kiani Shabestari, Olga Svystun, Gor Chailyan, Morgan A Coburn, William Carlen-Jones, Irina Petrushina, Jean Paul Chadarevian, Karen Zagorski, Nikolai Petrovsky, David H Cribbs, Michael G Agadjanyan, Anahit Ghochikyan, Hayk Davtya. A MultiTEP platform-based epitope vaccine targeting the phosphatase activating domain (PAD) of tau: therapeutic efficacy in PS19 mice. Scientific reports. vol 9. issue 1. 2020-11-18. PMID:31664089. |
pathological tau correlates well with cognitive impairments in alzheimer's disease (ad) patients and therefore represents a promising target for immunotherapy. |
2020-11-18 |
2023-08-13 |
mouse |
| Shuo Xiao, Lin-Lin Song, Jiang-Tao Li, He Wang, Na Yu, Zi-Qi Wang, Ying Zhang, Jin-Sheng He, Tao Hun. Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice. Journal of Alzheimer's disease : JAD. vol 73. issue 2. 2020-11-18. PMID:31839610. |
alzheimer's disease (ad) is the most common form of dementia, characterized by amyloid-β peptide (aβ) aggregates, phosphorylated tau protein (p-tau), and progressive neurodegeneration. |
2020-11-18 |
2023-08-13 |
mouse |
| Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. |
tau pathology in early alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. |
2020-11-18 |
2023-08-13 |
Not clear |
| Ece Kocagoncu, Andrew Quinn, Azadeh Firouzian, Elisa Cooper, Andrea Greve, Roger Gunn, Gary Green, Mark W Woolrich, Richard N Henson, Simon Lovestone, James B Row. Tau pathology in early Alzheimer's disease is linked to selective disruptions in neurophysiological network dynamics. Neurobiology of aging. vol 92. 2020-11-18. PMID:32280029. |
understanding the role of tau protein aggregation in the pathogenesis of alzheimer's disease is critical for the development of new tau-based therapeutic strategies to slow or prevent dementia. |
2020-11-18 |
2023-08-13 |
Not clear |
| Kadja L C Monteiro, Marcone G Dos S Alcântara, Thiago M de Aquino, Edeildo F da Silva-Júnio. Tau Protein Aggregation in Alzheimer's Disease: Recent Advances in the Development of Novel Therapeutic Agents. Current pharmaceutical design. vol 26. issue 15. 2020-11-18. PMID:32286939. |
tau protein aggregation in alzheimer's disease: recent advances in the development of novel therapeutic agents. |
2020-11-18 |
2023-08-13 |
Not clear |
| Koji Yoshida, Yukiko Hata, Shojiro Ichimata, Naoki Nishid. Tau and Amyloid-β Pathology in Japanese Forensic Autopsy Series Under 40 Years of Age: Prevalence and Association with APOE Genotype and Suicide Risk. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594218. |
aggregation of abnormal phosphorylated tau in brain stem areas may be a possible early pathological manifestation of alzheimer's disease (ad). |
2020-11-17 |
2023-08-13 |
Not clear |
| Xiaoguang Liu, Michaeline L Hebron, Sanjana Mulki, Chen Wang, Elizabeth Lekah, Dalila Ferrante, Wangke Shi, Bahjat Kurd-Misto, Charbel Mouss. Ubiquitin Specific Protease 13 Regulates Tau Accumulation and Clearance in Models of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594232. |
ubiquitin specific protease 13 regulates tau accumulation and clearance in models of alzheimer's disease. |
2020-11-17 |
2023-08-13 |
human |
| Brent Aulston, Qing Liu, Michael Mante, Jazmin Florio, Robert A Rissman, Shauna H Yua. Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. Journal of Alzheimer's disease : JAD. vol 72. issue 2. 2020-11-17. PMID:31594233. |
extracellular vesicles isolated from familial alzheimer's disease neuronal cultures induce aberrant tau phosphorylation in the wild-type mouse brain. |
2020-11-17 |
2023-08-13 |
mouse |
| Iason Keramidis, Ergina Vourkou, Katerina Papanikolopoulou, Efthimios M C Skoulaki. Functional Interactions of Tau Phosphorylation Sites That Mediate Toxicity and Deficient Learning in Frontiers in molecular neuroscience. vol 13. 2020-11-17. PMID:33192295. |
functional interactions of tau phosphorylation sites that mediate toxicity and deficient learning in hyperphosphorylated tau protein is the main component of the neurofibrillary tangles, characterizing degenerating neurons in alzheimer's disease and other tauopathies. |
2020-11-17 |
2023-08-13 |
human |
| Daniel C Shippy, Tyler K Ullan. Microglial Immunometabolism in Alzheimer's Disease. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192310. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by amyloid-β (aβ) plaques and the formation of neurofibrillary tangles (nfts) composed of hyperphosphorylated tau. |
2020-11-17 |
2023-08-13 |
Not clear |
| Eun-Chong Lee, Jae Myeong Kang, Seongho Seo, Ha-Eun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Young Noh, Joon-Kyung Seon. Association of Subcortical Structural Shapes With Tau, Amyloid, and Cortical Atrophy in Early-Onset and Late-Onset Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192457. |
association of subcortical structural shapes with tau, amyloid, and cortical atrophy in early-onset and late-onset alzheimer's disease. |
2020-11-17 |
2023-08-13 |
human |
| Eun-Chong Lee, Jae Myeong Kang, Seongho Seo, Ha-Eun Seo, Sang-Yoon Lee, Kee Hyung Park, Duk L Na, Young Noh, Joon-Kyung Seon. Association of Subcortical Structural Shapes With Tau, Amyloid, and Cortical Atrophy in Early-Onset and Late-Onset Alzheimer's Disease. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192457. |
the objectives of this study were to compare the topographical subcortical shape and to investigate the effects of tau or amyloid burden on atrophic patterns in early onset alzheimer's disease (eoad) and late-onset alzheimer's disease (load). |
2020-11-17 |
2023-08-13 |
human |
| Gilbert Ho, Yoshiki Takamatsu, Ryoko Wada, Shuei Sugama, Masaaki Waragai, Takato Takenouchi, Eliezer Masliah, Makoto Hashimot. Connecting Alzheimer's Disease With Diabetes Mellitus Through Amyloidogenic Evolvability. Frontiers in aging neuroscience. vol 12. 2020-11-17. PMID:33192467. |
recently, we proposed that alzheimer's disease (ad)-relevant amyloidogenic proteins (aps), such as amyloid-β (aβ) and tau, might be involved in evolvability against diverse stressors in the brain. |
2020-11-17 |
2023-08-13 |
Not clear |
| A Iyaswamy, S K Krishnamoorthi, Y W Liu, J X Song, A K Kammala, S G Sreenivasmurthy, S Malampati, B C K Tong, K Selvarasu, K H Cheung, J H Lu, J Q Tan, C Y Huang, S S K Durairajan, M L. Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. Frontiers in pharmacology. vol 11. 2020-11-17. PMID:33192524. |
yuan-hu zhi tong prescription mitigates tau pathology and alleviates memory deficiency in the preclinical models of alzheimer's disease. |
2020-11-17 |
2023-08-13 |
Not clear |