All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian-Zhi Wan. A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau. Translational neurodegeneration. vol 12. issue 1. 2023-11-11. PMID:37950283. intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of alzheimer's disease (ad). 2023-11-11 2023-11-20 mouse
Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. tau was originally identified as a microtubule associated protein, and subsequently recognized to constitute the fibrillar assemblies found in alzheimer disease and related neurodegenerative tauopathies. 2023-11-11 2023-11-20 mouse
Jesús Andrade-Guerrero, Paola Rodríguez-Arellano, Nayeli Barron-Leon, Erika Orta-Salazar, Carlos Ledesma-Alonso, Sofía Díaz-Cintra, Luis O Soto-Roja. Advancing Alzheimer's Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients. Cells. vol 12. issue 21. 2023-11-10. PMID:37947609. alzheimer's disease (ad) is the main neurodegenerative disorder characterized by several pathophysiological features, including the misfolding of the tau protein and the amyloid beta (aβ) peptide, neuroinflammation, oxidative stress, synaptic dysfunction, metabolic alterations, and cognitive impairment. 2023-11-10 2023-11-20 Not clear
Suman Mishr. Emerging trends in cryo-EM-based structural studies of neuropathological amyloids. Journal of molecular biology. 2023-11-10. PMID:37949311. in 2017, the first cryo-em structure of tau filaments from an alzheimer's disease-affected brain established that in vitro assemblies might not necessarily reflect the native amyloid fold. 2023-11-10 2023-11-20 Not clear
Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. although previous studies reported increased csf soluble trem2 (strem2) in different clinical stages of alzheimer's disease, the exact association between alzheimer's disease hallmarks such as amyloid-beta and tau pathology remains unclear. 2023-11-09 2023-11-20 human
Fardin Nabizade. sTREM2 is associated with attenuated tau aggregate accumulation in the presence of amyloid-β pathology. Brain communications. vol 5. issue 6. 2023-11-09. PMID:37942087. in the present study, i aimed to investigate the association between trem2-related microglial responses and tau accumulation in the presence and absence of amyloid-beta pathology in order to give a better view of the role of microglial activation in alzheimer's disease development. 2023-11-09 2023-11-20 human
Jin Zhao, Xiaofang Wang, Yusheng He, Pingyi Xu, Laijun Lai, Younggie Chung, Xinghua Pa. The Role of T Cells in Alzheimer's Disease Pathogenesis. Critical reviews in immunology. vol 43. issue 6. 2023-11-09. PMID:37943150. alzheimer's disease (ad) is a progressive neurodegenerative disorder associated with memory decline and cognitive impairment, which is related to hallmark protein aggregates, amyloid-β (Аβ) plaques and neurofibrillary tangles; the latter are accumulated with hyperphosphorylated tau protein. 2023-11-09 2023-11-20 Not clear
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij Rb Singh, Rout George Kerr. Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 122. 2023-11-09. PMID:37944239. alzheimer's disease (ad) is characterized by neuroinflammation linked to amyloid β (aβ) aggregation and phosphorylated tau (τ) protein in neurofibrillary tangles (nfts). 2023-11-09 2023-11-20 Not clear
Xiao Guo, Chen Li, Jia Zhang, Maozhong Sun, Jun Xu, Chuanlai Xu, Hua Kuang, Liguang X. Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut-brain axis. Nature aging. 2023-11-09. PMID:37946041. alzheimer's disease (ad) is characterized by amyloid-β accumulation in the brain and hyperphosphorylated tau aggregation, as well as neuroinflammation. 2023-11-09 2023-11-20 mouse
Susu Kong, Xi Wen, Yueju Wang, Rong Tan, Huiling Li, Yifeng T. Development of a P-tau217 Electrochemiluminescent Immunosensor Reinforced with Au-Cu Nanoparticles for Alzheimer's Disease Precaution. ACS chemical neuroscience. 2023-11-08. PMID:37939215. to simply and rapidly detect the highly phosphorylated tau protein at threonine 217 (p-tau217) as a precautionary measure against alzheimer's disease and distinguish it from other neurodegenerative diseases, a novel immunosensor was prepared using luminol as the electrochemiluminescent (ecl) sensing probe reinforced by au-cu nanoparticles (au-cu nps). 2023-11-08 2023-11-20 human
Robert A Rissman, Oliver Langford, Rema Raman, Michael C Donohue, Sara Abdel-Latif, Matthew R Meyer, Traci Wente-Roth, Kristopher M Kirmess, Jennifer Ngolab, Charisse N Winston, Gustavo Jimenez-Maggiora, Michael S Rafii, Pallavi Sachdev, Tim West, Kevin E Yarasheski, Joel B Braunstein, Michael Irizarry, Keith A Johnson, Paul S Aisen, Reisa A Sperlin. Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-07. PMID:37932961. incorporating blood-based alzheimer's disease biomarkers such as tau and amyloid beta (aβ) into screening algorithms may improve screening efficiency. 2023-11-07 2023-11-08 Not clear
Anna Steward, Davina Biel, Anna Dewenter, Sebastian Roemer, Fabian Wagner, Amir Dehsarvi, Saima Rathore, Diana Otero Svaldi, Ixavier Higgins, Matthias Brendel, Martin Dichgans, Sergey Shcherbinin, Michael Ewers, Nicolai Franzmeie. ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels. JAMA neurology. 2023-11-06. PMID:37930695. for the alzheimer disease (ad) therapies to effectively attenuate clinical progression, it may be critical to intervene before the onset of amyloid-associated tau spreading, which drives neurodegeneration and cognitive decline. 2023-11-06 2023-11-08 Not clear
Neha Sawant, Sudhir Kshirsagar, P Hemachandra Reddy, Arubala P Redd. Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-06. PMID:37931714. protective effects of ssri, citalopram in mutant app and mutant tau expressed dorsal raphe neurons in alzheimer's disease. 2023-11-06 2023-11-08 Not clear
Yoon A Kim, Marian Mellen, Caghan Kizil, Ismael Santa-Mari. Mechanisms linking cerebrovascular dysfunction and tauopathy: adding a layer of epiregulatory complexity. British journal of pharmacology. 2023-11-05. PMID:37926507. intracellular accumulation of hyperphosphorylated misfolded tau proteins is found in many neurodegenerative tauopathies, including alzheimer's disease (ad). 2023-11-05 2023-11-08 Not clear
Zhengshi Yang, Karthik Sreenivasan, Erin N Toledano Strom, Amanda M Leisgang Osse, Lorenzo Gabriel Pasia, Celica Glenn Cosme, Maya Rae N Mugosa, Emma Léa Chevalier, Aaron Ritter, Justin B Miller, Dietmar Cordes, Jeffrey L Cummings, Jefferson W Kinne. Clinical and biological relevance of glial fibrillary acidic protein in Alzheimer's disease. Alzheimer's research & therapy. vol 15. issue 1. 2023-11-04. PMID:37924152. there is a tremendous need for identifying reliable blood-based biomarkers for alzheimer's disease (ad) that are tied to the biological atn (amyloid, tau and neurodegeneration) framework as well as clinical assessment and progression. 2023-11-04 2023-11-08 Not clear
Xuhua Li, Yujie Chen, Zhiwei Yang, Shengli Zhang, Guanghong Wei, Lei Zhan. Structural insights into the co-aggregation of Aβ and tau amyloid core peptides: Revealing potential pathological heterooligomers by simulations. International journal of biological macromolecules. 2023-11-04. PMID:37924907. the self-aggregation of amyloid-β (aβ) and tau proteins are closely implicated in alzheimer's disease (ad). 2023-11-04 2023-11-08 Not clear
Zhenfeng Song, Kuang-Wei Wang, Hsiao-Tien Chien Hagar, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, Min-Hao Ku. Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine. Molecular neurobiology. 2023-11-03. PMID:37919601. abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for alzheimer's disease and additional neurodegenerative tauopathies. 2023-11-03 2023-11-08 Not clear
Thasma Loganath Babu Vasanth Kanth, Archi Raha, R M Vijay Murali, Natesan Yuvatha, Kasinathan Kumaran, Rangasamy Kirubakaran, K N ArulJoth. Repurposing of clinically proven bioactive compounds for targeted treatment of Alzheimer's disease using molecular docking approach. In silico pharmacology. vol 11. issue 1. 2023-11-03. PMID:37920821. tau protein is found to be playing a major role in alzheimer's disease, and the majority of drugs that are currently on the market are not only prohibitively expensive but also come packaged with side effects that the body cannot tolerate. 2023-11-03 2023-11-08 Not clear
Xujiao Chen, Mengjing Wang, Jianying Niu, Jun Ma, Jing Qian, Li Ni, Ping Cheng, Huaizhou You, Jing Che. Plasma Aβ Clinical kidney journal. vol 16. issue 11. 2023-11-02. PMID:37915896. although the cerebrospinal fluid amyloid beta (aβ) and tau (τ) have proven to be valid biomarkers for the diagnosis of alzheimer's disease (ad) in the general population, the roles of plasma aβ and τ for the diagnosis of cognitive impairment in hd patients remain unknown. 2023-11-02 2023-11-08 Not clear
Doha M Beltagy, Nagat F Nawar, Tarek M Mohamed, Ehab Tousson, Mai M El-Kee. The Synergistic Effect of Nanocurcumin and Donepezil on Alzheimer's via PI3K/AKT/GSK-3β Pathway Modulating. Prostaglandins & other lipid mediators. 2023-11-02. PMID:37918555. alzheimer's disease (ad) hallmarks include amyloid-βeta (aβ) and tau proteins aggregates, neurite degeneration, microglial activation with cognitive impairment. 2023-11-02 2023-11-08 rat