All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Nina Rosenqvist, Ayodeji A Asuni, Christian R Andersson, Søren Christensen, Justus A Daechsel, Jan Egebjerg, Jeppe Falsig, Lone Helboe, Pia Jul, Fredrik Kartberg, Lars Ø Pedersen, Einar M Sigurdsson, Florence Sotty, Karsten Skjødt, Jeffrey B Stavenhagen, Christiane Volbracht, Jan T Pederse. Highly specific and selective anti-pS396-tau antibody C10.2 targets seeding-competent tau. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-10-01. PMID:30386817. the abnormal hyperphosphorylation of the microtubule-associated protein tau plays a crucial role in neurodegeneration in alzheimer's disease (ad) and other tauopathies. 2020-10-01 2023-08-13 Not clear
Joana Margarida Silva, Sara Rodrigues, Belém Sampaio-Marques, Patrícia Gomes, Andreia Neves-Carvalho, Chrysoula Dioli, Carina Soares-Cunha, Brandon F Mazuik, Akihiko Takashima, Paula Ludovico, Benjamin Wolozin, Nuno Sousa, Ioannis Sotiropoulo. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell death and differentiation. vol 26. issue 8. 2020-10-01. PMID:30442948. imbalance of neuronal proteostasis associated with misfolding and aggregation of tau protein is a common neurodegenerative feature in alzheimer's disease (ad) and other tauopathies. 2020-10-01 2023-08-13 mouse
Petr Novak, Eva Kontsekova, Norbert Zilka, Michal Nova. Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30450030. neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is alzheimer's disease. 2020-10-01 2023-08-13 Not clear
Jorge A Sierra-Fonseca, Kristin L Gosselin. Tauopathy and neurodegeneration: A role for stress. Neurobiology of stress. vol 9. 2020-10-01. PMID:30450376. alzheimer's disease, specifically, is pathologically defined by the formation of amyloid plaques and tangles of hyperphosphorylated tau protein. 2020-10-01 2023-08-13 Not clear
Jorge A Sierra-Fonseca, Kristin L Gosselin. Tauopathy and neurodegeneration: A role for stress. Neurobiology of stress. vol 9. 2020-10-01. PMID:30450376. the present review focuses on the influence of stress on a key feature of alzheimer's disease pathology, emphasizing the relationship between tau phosphorylation and accumulation and its connection to hpa axis dysfunction. 2020-10-01 2023-08-13 Not clear
David J Irwin, Howard I Hurti. The Contribution of Tau, Amyloid-Beta and Alpha-Synuclein Pathology to Dementia in Lewy Body Disorders. Journal of Alzheimer's disease & Parkinsonism. vol 8. issue 4. 2020-10-01. PMID:30473927. in particular, amyloid plaque and tau tangle pathology characteristic of alzheimer's disease (ad) (~50% of all lbd patients have sufficient pathology at autopsy for a secondary neuropathologic diagnosis of ad), appear to contribute to cognitive impairment in lbd, and the combination is associated with a shorter interval between onset of motor symptoms and development of dementia and a shorter life span. 2020-10-01 2023-08-13 Not clear
Tomoyuki Nishizak. IL-33 suppresses GSK-3β activation through an ST2-independent MyD88/TRAF6/RIP/PI3K/Akt pathway. Heliyon. vol 4. issue 11. 2020-10-01. PMID:30533546. the present study was conducted to explore the effect of interleukin-33 (il-33) on glycogen synthase kinase-3β (gsk-3β) activation involving tau phosphorylation, a critical causative factor for alzheimer's disease (ad). 2020-10-01 2023-08-13 Not clear
Irfan A Qureshi, Giridhar Tirucherai, Michael K Ahlijanian, Gerry Kolaitis, Clifford Bechtold, Michael Grundma. A randomized, single ascending dose study of intravenous BIIB092 in healthy participants. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-10-01. PMID:30581980. extracellular tau is hypothesized to mediate the onset and progression of tauopathies, including alzheimer's disease, progressive supranuclear palsy, and a subset of frontotemporal lobar degenerations. 2020-10-01 2023-08-13 human
Li-Ge Zhao, Ying Tang, Jia-Ze Tan, Jing-Wen Wang, Guo-Jun Chen, Bing-Lin Zh. The effect of NR4A1 on APP metabolism and tau phosphorylation. Genes & diseases. vol 5. issue 4. 2020-10-01. PMID:30591936. alzheimer's disease (ad) is characterized by senile plaques (sp) composed of β-amyloid protein (aβ) and neurofibrillary tangles (nfts) composed of intracellular hyperphosphorylated tau. 2020-10-01 2023-08-13 mouse
Seyedeh Maryam Alavi Naini, Nadia Soussi-Yanicosta. Heparan Sulfate as a Therapeutic Target in Tauopathies: Insights From Zebrafish. Frontiers in cell and developmental biology. vol 6. 2020-10-01. PMID:30619849. in many tauopathies, including alzheimer's disease (ad), progressive supranuclear palsy (psp) and pick's disease, tau aggregates are found associated with highly sulfated polysaccharides known as heparan sulfates (hss). 2020-10-01 2023-08-13 zebrafish
Nahid Ahmadian, Sajjad Hejazi, Javad Mahmoudi, Mahnaz Taleb. Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation. Basic and clinical neuroscience. vol 9. issue 5. 2020-10-01. PMID:30719245. tau pathology of alzheimer disease: possible role of sleep deprivation. 2020-10-01 2023-08-13 Not clear
Bridget Martinez, Philip V Peplo. Amelioration of Alzheimer's disease pathology and cognitive deficits by immunomodulatory agents in animal models of Alzheimer's disease. Neural regeneration research. vol 14. issue 7. 2020-10-01. PMID:30804241. the most common age-related neurodegenerative disease is alzheimer's disease (ad) characterized by aggregated amyloid-β (aβ) peptides in extracellular plaques and aggregated hyperphosphorylated tau protein in intraneuronal neurofibrillary tangles, together with loss of cholinergic neurons, synaptic alterations, and chronic inflammation within the brain. 2020-10-01 2023-08-13 Not clear
Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. the link between tau and insulin signaling: implications for alzheimer's disease and other tauopathies. 2020-10-01 2023-08-13 Not clear
Rafaella Araujo Gonçalves, Nadeeja Wijesekara, Paul E Fraser, Fernanda G De Felic. The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies. Frontiers in cellular neuroscience. vol 13. 2020-10-01. PMID:30804755. we further highlight the deleterious consequences of tau pathology-induced insulin resistance to the brain and/or peripheral tissues, suggesting that these are key events mediating cognitive decline in alzheimer's disease (ad) and other tauopathies. 2020-10-01 2023-08-13 Not clear
Christian Rungsted Andersson, Jeppe Falsig, Jeffrey B Stavenhagen, Søren Christensen, Fredrik Kartberg, Nina Rosenqvist, Bente Finsen, Jan Torleif Pederse. Antibody-mediated clearance of tau in primary mouse microglial cultures requires Fcγ-receptor binding and functional lysosomes. Scientific reports. vol 9. issue 1. 2020-10-01. PMID:30874605. neurodegenerative diseases such as alzheimer's disease are characterized by the progressive spreading and accumulation of hyper-phosphorylated tau protein in the brain. 2020-10-01 2023-08-13 mouse
Jin Miao, Ruirui Shi, Longfei Li, Feng Chen, Yan Zhou, Yunn Chyn Tung, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau Frontiers in aging neuroscience. vol 11. 2020-10-01. PMID:30890929. pathological tau from alzheimer's brain induces site-specific hyperphosphorylation and sds- and reducing agent-resistant aggregation of tau neurofibrillary tangles (nfts) made up of hyperphosphorylated tau are a histopathological hallmark of alzheimer's disease (ad) and related tauopathies. 2020-10-01 2023-08-13 mouse
Oh Dae Kwo. Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging. Dementia and neurocognitive disorders. vol 15. issue 3. 2020-10-01. PMID:30906344. apolipoprotein e ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationship with the early onset of late-onset alzheimer's disease. 2020-10-01 2023-08-13 Not clear
Andreas Nabers, Henning Hafermann, Jens Wiltfang, Klaus Gerwer. Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands). vol 11. 2020-10-01. PMID:30911600. aβ and tau structure-based biomarkers for a blood- and csf-based two-step recruitment strategy to identify patients with dementia due to alzheimer's disease. 2020-10-01 2023-08-13 Not clear
Maria Anele Romeo, Alberto Faggioni, Mara Ciron. Could autophagy dysregulation link neurotropic viruses to Alzheimer's disease? Neural regeneration research. vol 14. issue 9. 2020-10-01. PMID:31089040. indeed autophagosome accumulation, indicating an unbalance between autophagosome formation and autophagosome degradation, has been observed in neurons of alzheimer's disease patients and may play a role in the intracellular and extracellular accumulation of amyloid β and in the altered protein tau metabolism. 2020-10-01 2023-08-13 human
Eftychia Vasili, Antonio Dominguez-Meijide, Tiago Fleming Outeir. Spreading of α-Synuclein and Tau: A Systematic Comparison of the Mechanisms Involved. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31105524. alzheimer's disease (ad) and parkinson's disease (pd) are age-associated neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (asyn) and tau, respectively. 2020-10-01 2023-08-13 Not clear