| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Troy T Roh. Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target Realized. International journal of neurology and neurotherapy. vol 2. issue 1. 2020-09-30. PMID:25639474. |
caspase cleaved tau in alzheimer's disease: a therapeutic target realized. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yong-Bo Hu, Yang Zou, Yue Huang, Yong-Fang Zhang, Guinevere F Lourenco, Sheng-Di Chen, Glenda M Halliday, Gang Wang, Ru-Jing Re. ROCK1 Is Associated with Alzheimer's Disease-Specific Plaques, as well as Enhances Autophagosome Formation But not Autophagic Aβ Clearance. Frontiers in cellular neuroscience. vol 10. 2020-09-30. PMID:27853422. |
alzheimer's disease (ad) is the most prevalent form of late-life dementia in the population, characterized by amyloid plaque formation and increased tau deposition, which is modulated by rho-associated coiled-coil kinase 1 (rock1). |
2020-09-30 |
2023-08-13 |
mouse |
| Athanasios Metaxas, Stefan J Kemp. Neurofibrillary tangles in Alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. Neural regeneration research. vol 11. issue 10. 2020-09-30. PMID:27904486. |
neurofibrillary tangles in alzheimer's disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics. |
2020-09-30 |
2023-08-13 |
Not clear |
| De-Yu Xia, Xin Huang, Chong-Feng Bi, Lin-Ling Mao, Li-Jun Peng, Hai-Rong Qia. PGC-1α or FNDC5 Is Involved in Modulating the Effects of Aβ Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28377712. |
pgc-1α or fndc5 is involved in modulating the effects of aβ alzheimer's disease (ad) is generally defined as the aberrant production of β-amyloid protein (aβ) and hyperphosphorylated tau protein, which are deposited in β-amyloid plaques (aps) and neurofibrillary tangles (nfts), respectively. |
2020-09-30 |
2023-08-13 |
mouse |
| Manuel Menéndez Gonzále. Mechanical Dilution of Beta-amyloid Peptide and Phosphorylated Tau Protein in Alzheimer's Disease: Too Simple to be True? Cureus. vol 9. issue 2. 2020-09-30. PMID:28382239. |
mechanical dilution of beta-amyloid peptide and phosphorylated tau protein in alzheimer's disease: too simple to be true? |
2020-09-30 |
2023-08-13 |
Not clear |
| Manuel Menéndez Gonzále. Mechanical Dilution of Beta-amyloid Peptide and Phosphorylated Tau Protein in Alzheimer's Disease: Too Simple to be True? Cureus. vol 9. issue 2. 2020-09-30. PMID:28382239. |
the neuropathology of alzheimer's disease (ad) is characterized by the widespread accumulation of neuritic plaques and neurofibrillary tangles composed of deposits of beta-amyloid peptide (aβ) and abnormally phosphorylated tau protein (phospho-tau) respectively. |
2020-09-30 |
2023-08-13 |
Not clear |
| Oskar Hansson, Michel J Grothe, Tor Olof Strandberg, Tomas Ohlsson, Douglas Hägerström, Jonas Jögi, Ruben Smith, Michael Schöl. Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:28408865. |
tau pathology distribution in alzheimer's disease corresponds differentially to cognition-relevant functional brain networks. |
2020-09-30 |
2023-08-13 |
human |
| Oskar Hansson, Michel J Grothe, Tor Olof Strandberg, Tomas Ohlsson, Douglas Hägerström, Jonas Jögi, Ruben Smith, Michael Schöl. Tau Pathology Distribution in Alzheimer's disease Corresponds Differentially to Cognition-Relevant Functional Brain Networks. Frontiers in neuroscience. vol 11. 2020-09-30. PMID:28408865. |
neuropathological studies have shown that the typical neurofibrillary pathology of hyperphosphorylated tau protein in alzheimer's disease (ad) preferentially affects specific brain regions whereas others remain relatively spared. |
2020-09-30 |
2023-08-13 |
human |
| Marvin H Berman, James P Halper, Trent W Nichols, H Jarrett, Alan Lundy, Jason H Huan. Photobiomodulation with Near Infrared Light Helmet in a Pilot, Placebo Controlled Clinical Trial in Dementia Patients Testing Memory and Cognition. Journal of neurology and neuroscience. vol 8. issue 1. 2020-09-30. PMID:28593105. |
the current pathophysiology of alzheimer's disease is the accumulation of neurofibrillary tangles (nfts) of hyperphosphorylated tau protein and amyloid-beta (aβ) plaques. |
2020-09-30 |
2023-08-13 |
mouse |
| Tomomichi Iizuka, Kozo Morimoto, Yuka Sasaki, Masashi Kameyama, Atsuyuki Kurashima, Kazumasa Hayasaka, Hideo Ogata, Hajime Got. Preventive Effect of Rifampicin on Alzheimer Disease Needs at Least 450 mg Daily for 1 Year: An FDG-PET Follow-Up Study. Dementia and geriatric cognitive disorders extra. vol 7. issue 2. 2020-09-30. PMID:28690634. |
rifampicin was reported to inhibit amyloid-β oligomerization and tau hyperphosphorylation in mouse models and could serve as a promising available medicine for the prevention of alzheimer disease (ad). |
2020-09-30 |
2023-08-13 |
mouse |
| Lih-Fen Lue, Andre Guerra, Douglas G Walke. Amyloid Beta and Tau as Alzheimer's Disease Blood Biomarkers: Promise From New Technologies. Neurology and therapy. vol 6. issue Suppl 1. 2020-09-30. PMID:28733956. |
amyloid beta and tau as alzheimer's disease blood biomarkers: promise from new technologies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lih-Fen Lue, Andre Guerra, Douglas G Walke. Amyloid Beta and Tau as Alzheimer's Disease Blood Biomarkers: Promise From New Technologies. Neurology and therapy. vol 6. issue Suppl 1. 2020-09-30. PMID:28733956. |
the utility of the levels of amyloid beta (aβ) peptide and tau in blood for diagnosis, drug development, and assessment of clinical trials for alzheimer's disease (ad) has not been established. |
2020-09-30 |
2023-08-13 |
Not clear |
| Juhyun Song, Young-Kook Ki. Identification of the Role of miR-142-5p in Alzheimer's Disease by Comparative Bioinformatics and Cellular Analysis. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:28769761. |
alzheimer's disease (ad) is the most common neurodegenerative disease characterized by the formation of amyloid beta (aβ) or tau protein aggregates, the hallmark of cognitive decline. |
2020-09-30 |
2023-08-13 |
mouse |
| Palaniswamy Rani, Sreeram Krishnan, Chellappa Rani Cathrin. Study on Analysis of Peripheral Biomarkers for Alzheimer's Disease Diagnosis. Frontiers in neurology. vol 8. 2020-09-30. PMID:28769864. |
many factors are involved in alzheimer's disease (ad) pathology including tau phosphorylation, amyloid β protein (aβ) accumulation, lipid dysregulation, oxidative stress, and inflammation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Juanjuan Zhao, Dongxu Yue, Ya Zhou, Li Jia, Hairong Wang, Mengmeng Guo, Hualin Xu, Chao Chen, Jidong Zhang, Lin X. The Role of MicroRNAs in Aβ Deposition and Tau Phosphorylation in Alzheimer's Disease. Frontiers in neurology. vol 8. 2020-09-30. PMID:28769871. |
the role of micrornas in aβ deposition and tau phosphorylation in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Filippo S Giorgi, Larisa Ryskalin, Riccardo Ruffoli, Francesca Biagioni, Fiona Limanaqi, Michela Ferrucci, Carla L Busceti, Ubaldo Bonuccelli, Francesco Forna. The Neuroanatomy of the Reticular Nucleus Locus Coeruleus in Alzheimer's Disease. Frontiers in neuroanatomy. vol 11. 2020-09-30. PMID:28974926. |
alzheimer's disease (ad) features the accumulation of β-amyloid and tau aggregates, which deposit as extracellular plaques and intracellular neurofibrillary tangles (nfts), respectively. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Blaine S Greenwald, Philippe Marambaud, Ezra Cinamon, Peter Davie. Haloperidol inactivates AMPK and reduces tau phosphorylation in a tau mouse model of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 2. issue 2. 2020-09-30. PMID:29067299. |
haloperidol inactivates ampk and reduces tau phosphorylation in a tau mouse model of alzheimer's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Jonathan M Levenson, Sally Schroeter, Jenna C Carroll, Valerie Cullen, Eva Asp, Ming Proschitsky, Charlotte H-Y Chung, Sharon Gilead, Muhammad Nadeem, Hemraj B Dodiya, Shadiyat Shoaga, Elliott J Mufson, Haim Tsubery, Rajaraman Krishnan, Jason Wright, Beka Solomon, Richard Fisher, Kimberley S Ganno. NPT088 reduces both amyloid-β and tau pathologies in transgenic mice. Alzheimer's & dementia (New York, N. Y.). vol 2. issue 3. 2020-09-30. PMID:29067301. |
alzheimer's disease (ad) is characterized by appearance of both extracellular senile plaques and intracellular neurofibrillary tangles, comprised of aggregates of misfolded amyloid-β (aβ) and hyper-phosphorylated tau, respectively. |
2020-09-30 |
2023-08-13 |
mouse |
| Ming-Hui Lee, Yao-Hsiang Shih, Sing-Ru Lin, Jean-Yun Chang, Yu-Hao Lin, Chun-I Sze, Yu-Min Kuo, Nan-Shan Chan. Zfra restores memory deficits in Alzheimer's disease triple-transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF-κB activation. Alzheimer's & dementia (New York, N. Y.). vol 3. issue 2. 2020-09-30. PMID:29067327. |
zfra restores memory deficits in alzheimer's disease triple-transgenic mice by blocking aggregation of trappc6aΔ, sh3glb2, tau, and amyloid β, and inflammatory nf-κb activation. |
2020-09-30 |
2023-08-13 |
mouse |
| Luis Fernando Arredondo, Saray Aranda-Romo, Ildefonso Rodríguez-Leyva, Erika Chi-Ahumada, Sami K Saikaly, Diana P Portales-Pérez, Roberto González-Amaro, Mariana Salgado-Bustamante, Lourdes Enriquez-Macias, William Eng, Robert A Norman, Maria E Jimenez-Capdevill. Tau Protein in Oral Mucosa and Cognitive State: A Cross-sectional Study. Frontiers in neurology. vol 8. 2020-09-30. PMID:29081764. |
among them, the presence of aggregates of phosphorylated tau protein (p-tau) is the hallmark of alzheimer's disease (ad) and other major neurodegenerative disorders such as corticobasal degeneration and frontotemporal dementia among others. |
2020-09-30 |
2023-08-13 |
human |