| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pierre De Rossi, Virginie Buggia-Prevot, Robert J Andrew, Sofia V Krause, Elizabeth Woo, Peter T Nelson, Peter Pytel, Gopal Thinakara. BIN1 localization is distinct from Tau tangles in Alzheimer's disease. Matters. vol 2017. 2020-09-30. PMID:29479533. |
bin1 localization is distinct from tau tangles in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Min Chen, Zhi-Yun Du, Xi Zheng, Dong-Li Li, Ren-Ping Zhou, Kun Zhan. Use of curcumin in diagnosis, prevention, and treatment of Alzheimer's disease. Neural regeneration research. vol 13. issue 4. 2020-09-30. PMID:29722330. |
for diagnosis of alzheimer's disease, amyloid-β and highly phosphorylated tau protein are the major biomarkers. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bettina M Foidl, Christian Humpe. Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29725295. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder of the brain, characterized by extracellular aggregation of beta-amyloid (aβ) and hyperphosphorylation of tau causing intraneuronal neurofibrillary tangles (nfts). |
2020-09-30 |
2023-08-13 |
mouse |
| John R Veloria, Luxi Chen, Lin Li, Gail A M Breen, Jiyong Lee, Warren J Gou. Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells. MedChemComm. vol 9. issue 1. 2020-09-30. PMID:30108906. |
here we demonstrate that two separate amyloid-forming hexapeptides, one from the microtubule associated protein tau involved in formation of paired helical filaments of alzheimer's disease, and the other an amyloid forming sequence from apolipoprotein a |
2020-09-30 |
2023-08-13 |
human |
| Mahmoud B Maina, Laura J Bailey, Aidan J Doherty, Louise C Serpel. The Involvement of Aβ42 and Tau in Nucleolar and Protein Synthesis Machinery Dysfunction. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30123109. |
alzheimer's disease (ad) is the most common form of dementia and is distinguished from other dementias by observation of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles, comprised of fibrils of aβ and tau protein, respectively. |
2020-09-30 |
2023-08-13 |
human |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (ache) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. |
2020-09-30 |
2023-08-13 |
rat |
| Rodrigo S Chaves, Amajad I Kazi, Carolliny M Silva, Michael F Almeida, Raquel S Lima, Daniel C Carrettiero, Marilene Demasi, Merari F R Ferrar. Presence of insoluble Tau following rotenone exposure ameliorates basic pathways associated with neurodegeneration. IBRO reports. vol 1. 2020-09-30. PMID:30135926. |
in alzheimer's disease (ad) protein aggregates are composed of hyperphosphorylated tau and amyloid beta peptide (aβ). |
2020-09-30 |
2023-08-13 |
rat |
| Shohreh Majd, John H T Power, Simon A Koblar, Hugh J M Grantha. The impact of tau hyperphosphorylation at Ser IBRO reports. vol 2. 2020-09-30. PMID:30135928. |
the impact of tau hyperphosphorylation at ser an increase in phosphorylated tau (p-tau) is associated with alzheimer's disease (ad), and brain hypoxia. |
2020-09-30 |
2023-08-13 |
human |
| David M Smit. Could a Common Mechanism of Protein Degradation Impairment Underlie Many Neurodegenerative Diseases? Journal of experimental neuroscience. vol 12. 2020-09-30. PMID:30147359. |
prominent species that accumulate early and play fundamental roles in disease pathogenesis are amyloid β (aβ) and tau in alzheimer disease, α-synuclein (α-syn) in parkinson disease, and polyq-expanded huntingtin (htt) in huntington disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Onder Albayram, Peter Angeli, Elizabeth Bernstein, Sean Baxley, Ziang Gao, Kun Ping Lu, Xiao Zhen Zho. Targeting Prion-like Cis Phosphorylated Tau Pathology in Neurodegenerative Diseases. Journal of Alzheimer's disease & Parkinsonism. vol 8. issue 3. 2020-09-30. PMID:30197831. |
tau is a microtubule-associated protein heavily implicated in neurodegenerative diseases collectively known as tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Kwun Chung Yu, Ping Kwan, Stanley K K Cheung, Amy Ho, Larry Bau. Effects of Resveratrol and Morin on Insoluble Tau in Tau Transgenic Mice. Translational neuroscience. vol 9. 2020-09-30. PMID:30479844. |
tauopathies are neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd), in which tau protein aggregates within neurons. |
2020-09-30 |
2023-08-13 |
mouse |
| Md Rashidur Rahman, Afsana Tajmim, Mohammad Ali, Mostakim Shari. Overview and Current Status of Alzheimer's Disease in Bangladesh. Journal of Alzheimer's disease reports. vol 1. issue 1. 2020-09-30. PMID:30480227. |
alzheimer's disease (ad) is a complex neurological disorder with economic, social, and medical burdens which is acknowledged as leading cause of dementia marked by the accumulation and aggregation of amyloid-β peptide and phosphorylated tau (p-tau) protein and concomitant dementia, neuron loss and brain atrophy. |
2020-09-30 |
2023-08-13 |
Not clear |
| Stephen L P Lippi, Meghann L Smith, Jane M Flin. A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30524268. |
a novel happ/htau mouse model of alzheimer's disease: inclusion of app with tau exacerbates behavioral deficits and zinc administration heightens tangle pathology. |
2020-09-30 |
2023-08-13 |
mouse |
| Stephen L P Lippi, Meghann L Smith, Jane M Flin. A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30524268. |
the brains of those with alzheimer's disease have amyloid and tau pathology; thus, mice modeling ad should have both markers. |
2020-09-30 |
2023-08-13 |
mouse |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
tau and mtor: the hotspots for multifarious diseases in alzheimer's development. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
the hyperphosphorylation of tau protein and the overexpression of mtor are considered to be the driving force behind aβ plaques and neurofibrillay tangles (nft's), hallmarks of alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Kenjiro Ono, Mayumi Tsuj. Pharmacological Potential of Cilostazol for Alzheimer's Disease. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31191308. |
alzheimer's disease (ad), a slow progressive form of dementia, is clinically characterized by cognitive dysfunction and memory impairment and neuropathologically characterized by the accumulation of extracellular plaques containing amyloid β-protein (aβ) and neurofibrillary tangles containing tau in the brain, with neuronal degeneration and high level of oxidative stress. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rawan Tarawne. Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer Disease: Protocol for a Cross-Sectional Study. JMIR research protocols. vol 8. issue 7. 2020-09-30. PMID:31271547. |
synaptic loss is the best surrogate for cognitive decline in alzheimer disease (ad) and is more closely associated with cognitive function than amyloid or tau pathologies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bhaskar C Das, Somsankar Dasgupta, Swapan K Ra. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural regeneration research. vol 14. issue 11. 2020-09-30. PMID:31290437. |
impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive alzheimer's disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques (aggregated amyloid-beta) and intra-neurofibrillary tangles (hyperphosphorylated tau protein) in the temporal lobe of the brain. |
2020-09-30 |
2023-08-13 |
mouse |
| Camille Pernègre, Antoine Duquette, Nicole Lecler. Tau Secretion: Good and Bad for Neurons. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293374. |
in alzheimer's disease (ad), neurofibrillary tangles (nfts), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex. |
2020-09-30 |
2023-08-13 |
Not clear |