| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen L P Lippi, Meghann L Smith, Jane M Flin. A Novel hAPP/htau Mouse Model of Alzheimer's Disease: Inclusion of APP With Tau Exacerbates Behavioral Deficits and Zinc Administration Heightens Tangle Pathology. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30524268. |
the brains of those with alzheimer's disease have amyloid and tau pathology; thus, mice modeling ad should have both markers. |
2020-09-30 |
2023-08-13 |
mouse |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
tau and mtor: the hotspots for multifarious diseases in alzheimer's development. |
2020-09-30 |
2023-08-13 |
Not clear |
| Zeba Mueed, Pallavi Tandon, Sanjeev Kumar Maurya, Ravi Deval, Mohammad A Kamal, Nitesh Kumar Podda. Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30686983. |
the hyperphosphorylation of tau protein and the overexpression of mtor are considered to be the driving force behind aβ plaques and neurofibrillay tangles (nft's), hallmarks of alzheimer's disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Kenjiro Ono, Mayumi Tsuj. Pharmacological Potential of Cilostazol for Alzheimer's Disease. Frontiers in pharmacology. vol 10. 2020-09-30. PMID:31191308. |
alzheimer's disease (ad), a slow progressive form of dementia, is clinically characterized by cognitive dysfunction and memory impairment and neuropathologically characterized by the accumulation of extracellular plaques containing amyloid β-protein (aβ) and neurofibrillary tangles containing tau in the brain, with neuronal degeneration and high level of oxidative stress. |
2020-09-30 |
2023-08-13 |
Not clear |
| Rawan Tarawne. Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer Disease: Protocol for a Cross-Sectional Study. JMIR research protocols. vol 8. issue 7. 2020-09-30. PMID:31271547. |
synaptic loss is the best surrogate for cognitive decline in alzheimer disease (ad) and is more closely associated with cognitive function than amyloid or tau pathologies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Bhaskar C Das, Somsankar Dasgupta, Swapan K Ra. Potential therapeutic roles of retinoids for prevention of neuroinflammation and neurodegeneration in Alzheimer's disease. Neural regeneration research. vol 14. issue 11. 2020-09-30. PMID:31290437. |
impaired retinoic acid signaling results in neuroinflammation, oxidative stress, mitochondrial malfunction, and neurodegeneration leading to progressive alzheimer's disease, which is pathologically characterized by extra-neuronal accumulation of amyloid plaques (aggregated amyloid-beta) and intra-neurofibrillary tangles (hyperphosphorylated tau protein) in the temporal lobe of the brain. |
2020-09-30 |
2023-08-13 |
mouse |
| Camille Pernègre, Antoine Duquette, Nicole Lecler. Tau Secretion: Good and Bad for Neurons. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293374. |
in alzheimer's disease (ad), neurofibrillary tangles (nfts), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex. |
2020-09-30 |
2023-08-13 |
Not clear |
| Xu-Qiao Chen, William C Moble. Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31293377. |
alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric aβ and tau species. |
2020-09-30 |
2023-08-13 |
human |
| Kwang Hun Li. Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases. Frontiers in molecular neuroscience. vol 12. 2020-09-30. PMID:31338019. |
there is an increasing body of evidence that suggests other aggregation-prone proteins including tau and α-synuclein associated with alzheimer's and parkinson's diseases, respectively, also behave like a prion that has conformational strains with self-propagation (seeding) property. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yuan Zhang, Yanfang Zhao, Lei Zhang, Wanpeng Yu, Yu Wang, Wenguang Chan. Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31417361. |
the pathological features of alzheimer's disease (ad) include senile plaques induced by amyloid-β (aβ) protein deposits, neurofibrillary tangles formed by aggregates of hyperphosphorylated tau proteins and neuronal cell loss in specific position within the brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Alfonso Grimaldi, Natalia Pediconi, Francesca Oieni, Rocco Pizzarelli, Maria Rosito, Maria Giubettini, Tiziana Santini, Cristina Limatola, Giancarlo Ruocco, Davide Ragozzino, Silvia Di Angelantoni. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31551688. |
alzheimer's disease (ad), a primary cause of dementia in the aging population, is characterized by extracellular amyloid-beta peptides aggregation, intracellular deposits of hyperphosphorylated tau, neurodegeneration and glial activation in the brain. |
2020-09-30 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Fumiaki Tanak. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in neurology. vol 10. 2020-09-30. PMID:31551922. |
tau pathology in chronic traumatic encephalopathy and alzheimer's disease: similarities and differences. |
2020-09-30 |
2023-08-13 |
Not clear |
| Atsuko Katsumoto, Hideyuki Takeuchi, Fumiaki Tanak. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in neurology. vol 10. 2020-09-30. PMID:31551922. |
traumatic brain injury (tbi) has been associated with the development of alzheimer's disease (ad) because these conditions share common pathological hallmarks: amyloid-β and hyperphosphorylated tau accumulation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Viktoriya Morozova, Leah S Cohen, Ali El-Hadi Makki, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Alejandra D Alons. Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31555098. |
in neurodegenerative diseases, like alzheimer's disease (ad), pathological tau spreads from neuron to neuron enhancing neurodegeneration. |
2020-09-30 |
2023-08-13 |
human |
| Nataliya I Trushina, Lidia Bakota, Armen Y Mulkidjanian, Roland Brand. The Evolution of Tau Phosphorylation and Interactions. Frontiers in aging neuroscience. vol 11. 2020-09-30. PMID:31619983. |
in alzheimer's disease (ad) and other tauopathies, tau exhibits pathologically increased phosphorylation (hyperphosphorylation) at selected sites and aggregates into neurofibrillary tangles (nfts). |
2020-09-30 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Md Tanvir Kabi. Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest. Frontiers in cell and developmental biology. vol 7. 2020-09-30. PMID:31620438. |
alzheimer's disease (ad) is a progressive, irreversible brain disorder characterized by pathological aggregation of the amyloid-β peptide (aβ) and tau protein; both of these are toxic to neurons. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Vinod G Landge, Pramod Gudigenahally Nagaraju, Poornima Priyadarshini Cg, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer's Disease. ACS omega. vol 4. issue 16. 2020-09-30. PMID:31646215. |
molecular cobalt(ii) complexes for tau polymerization in alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Nalini Vijay Gorantla, Vinod G Landge, Pramod Gudigenahally Nagaraju, Poornima Priyadarshini Cg, Ekambaram Balaraman, Subashchandrabose Chinnathamb. Molecular Cobalt(II) Complexes for Tau Polymerization in Alzheimer's Disease. ACS omega. vol 4. issue 16. 2020-09-30. PMID:31646215. |
tau is an axonal protein known to form abnormal aggregates and is the biomarker of alzheimer's disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Stefania Zappettini, Emilie Faivre, Antoine Ghestem, Sébastien Carrier, Luc Buée, David Blum, Monique Esclapez, Christophe Bernar. Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31680863. |
here, we tested the long-term consequences of early life exposure to caffeine in thy-tau22 transgenic mice, a model of alzheimer's disease-like tau pathology. |
2020-09-30 |
2023-08-13 |
mouse |
| Shuko Taked. Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31920473. |
a unique clinical course of alzheimer's disease (ad), beginning with memory deficit as the earliest symptom, is well-correlated with a progressive pattern of intracellular aggregates of tau (neurofibrillary tangles), which spread from the medial temporal lobe to other brain areas in a stereotypical manner. |
2020-09-30 |
2023-08-13 |
Not clear |