| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobuyuki Okamura, Ryuichi Harada, Aiko Ishiki, Akio Kikuchi, Tadaho Nakamura, Yukitsuka Kud. The development and validation of tau PET tracers: current status and future directions. Clinical and translational imaging. vol 6. issue 4. 2020-09-29. PMID:30148121. |
to provide an overview on positron emission tomography (pet) imaging of tau pathology in alzheimer's disease (ad) and other neurodegenerative disorders. |
2020-09-29 |
2023-08-13 |
Not clear |
| Rubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Barnaly Rashi. A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer's Disease. Brain sciences. vol 8. issue 9. 2020-09-29. PMID:30149687. |
a closer look into the role of protein tau in the identification of promising therapeutic targets for alzheimer's disease. |
2020-09-29 |
2023-08-13 |
Not clear |
| Neha Atulkumar Singh, Vaishali Bhardwaj, Chandrika Ravi, Nithya Ramesh, Abul Kalam Azad Mandal, Zaved Ahmed Kha. EGCG Nanoparticles Attenuate Aluminum Chloride Induced Neurobehavioral Deficits, Beta Amyloid and Tau Pathology in a Rat Model of Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-29. PMID:30150930. |
egcg nanoparticles attenuate aluminum chloride induced neurobehavioral deficits, beta amyloid and tau pathology in a rat model of alzheimer's disease. |
2020-09-29 |
2023-08-13 |
rat |
| Hei-Nga Chan, Di Xu, See-Lok Ho, Man Shing Wong, Hung-Wing L. Ultra-sensitive detection of protein biomarkers for diagnosis of Alzheimer's disease. Chemical science. vol 8. issue 5. 2020-09-29. PMID:30155210. |
beta amyloid peptide, tau, and phosphorylated tau are well recognized as promising biomarkers for the diagnosis of alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Joana R Guedes, Taotao Lao, Ana L Cardoso, Joseph El Khour. Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies. Frontiers in neurology. vol 9. 2020-09-29. PMID:30158892. |
roles of microglial and monocyte chemokines and their receptors in regulating alzheimer's disease-associated amyloid-β and tau pathologies. |
2020-09-29 |
2023-08-13 |
mouse |
| Joana R Guedes, Taotao Lao, Ana L Cardoso, Joseph El Khour. Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies. Frontiers in neurology. vol 9. 2020-09-29. PMID:30158892. |
chemokines and their receptors have been shown to affect amyloid-β (aβ) and tau pathologies in mouse models of alzheimer's disease (ad) by regulating microglia and monocyte-associated neuroinflammation, microglial movement and monocyte recruitment into the brain. |
2020-09-29 |
2023-08-13 |
mouse |
| Ai-Hua Xu, Yang Yang, Yong-Xin Sun, Chao-Dong Zhan. Exogenous brain-derived neurotrophic factor attenuates cognitive impairment induced by okadaic acid in a rat model of Alzheimer's disease. Neural regeneration research. vol 13. issue 12. 2020-09-29. PMID:30323150. |
decreased expression of brain-derived neurotrophic factor (bdnf) plays an important role in the pathogenesis of alzheimer's disease, and a typical pathological change in alzheimer's disease is neurofibrillary tangles caused by hyperphosphorylation of tau. |
2020-09-29 |
2023-08-13 |
rat |
| Alejandra D Alonso, Leah S Cohen, Christopher Corbo, Viktoriya Morozova, Abdeslem ElIdrissi, Greg Phillips, Frida E Kleima. Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability. Frontiers in cellular neuroscience. vol 12. 2020-09-29. PMID:30356756. |
tau is an amazing protein that plays a key role in cognitive processes, however, deposits of abnormal forms of tau are associated with several neurodegenerative diseases, including alzheimer disease (ad), the most prevalent, and chronic traumatic encephalopathy (cte) and traumatic brain injury (tbi), the most recently associated to abnormal tau. |
2020-09-29 |
2023-08-13 |
mouse |
| Xingyu Zhang, Zhihui Fu, Lanxia Meng, Mingyang He, Zhentao Zhan. The Early Events That Initiate β-Amyloid Aggregation in Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-09-29. PMID:30542277. |
alzheimer's disease (ad) is characterized by the development of amyloid plaques and neurofibrillary tangles (nfts) consisting of aggregated β-amyloid (aβ) and tau, respectively. |
2020-09-29 |
2023-08-13 |
Not clear |
| Lili Zhong, Hong Liu, Weijia Zhang, Xu Liu, Bo Jiang, Hongxin Fei, Zhongren Su. Ellagic acid ameliorates learning and memory impairment in APP/PS1 transgenic mice via inhibition of β-amyloid production and tau hyperphosphorylation. Experimental and therapeutic medicine. vol 16. issue 6. 2020-09-29. PMID:30542451. |
β-amyloid (aβ) aggregation and tau hyperphosphorylation are considered to be the primary pathological hallmarks of alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
mouse |
| Irving E Vega, Alexandra Sutter, Luke Parks, Andrew Umstead, Magdalena I Ivanov. Tau's Three-Repeat Domain and EFhd2 Co-incubation Leads to Increased Thioflavin Signal. Frontiers in neuroscience. vol 12. 2020-09-29. PMID:30559642. |
aggregation of the protein tau is a pathological hallmark of alzheimer's disease (ad) and related disorders. |
2020-09-29 |
2023-08-13 |
Not clear |
| Makoto Ishikawa, Takeshi Yoshitomi, Douglas F Covey, Charles F Zorumski, Yukitoshi Izum. Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease. Neuropsychiatry. vol 8. issue 1. 2020-09-29. PMID:30774720. |
accumulation of amyloid-beta (abeta) and hyperphosphorylated tau is thought to contribute to apoptotic neuronal death in alzheimer's disease, and similar changes have been linked to apoptotic rgc death in glaucoma. |
2020-09-29 |
2023-08-13 |
Not clear |
| Soha Ahmadi, Shaolong Zhu, Renu Sharma, Bing Wu, Ronald Soong, R Dutta Majumdar, Derek J Wilson, Andre J Simpson, Heinz-Bernhard Kraat. Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu ACS omega. vol 4. issue 3. 2020-09-29. PMID:31001602. |
aggregation of microtubule binding repeats of tau protein is promoted by cu understanding the factors that give rise to tau aggregation and reactive oxygen species (ros) is the key aspect in alzheimer's disease pathogenesis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Cristina Lopez Lopez, Pierre N Tariot, Angelika Caputo, Jessica B Langbaum, Fonda Liu, Marie-Emmanuelle Riviere, Carolyn Langlois, Marie-Laure Rouzade-Dominguez, Martin Zalesak, Suzanne Hendrix, Ronald G Thomas, Vissia Viglietta, Rob Lenz, J Michael Ryan, Ana Graf, Eric M Reima. The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 5. 2020-09-29. PMID:31211217. |
alzheimer's disease (ad) pathology, including the accumulation of amyloid beta (aβ) species and tau pathology, begins decades before the onset of cognitive impairment. |
2020-09-29 |
2023-08-13 |
Not clear |
| Elizabeth M Rhea, William A Bank. Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31213970. |
we also summarize how insulin can regulate levels of the pathological hallmarks of alzheimer's disease, including amyloid beta (aβ) and tau within each cell type. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shreyasi Chatterjee, Suren S Ambegaokar, George R Jackson, Amritpal Mudhe. Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31427921. |
insulin-mediated changes in tau hyperphosphorylation and autophagy in a almost 50 million people in the world are affected by dementia; the most prevalent form of which is alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Pallavi Duggal, Sidharth Meha. Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings. Journal of Alzheimer's disease reports. vol 3. issue 1. 2020-09-29. PMID:31435618. |
tau hyperphosphorylation mediates mt destabilization resulting in axonopathy and neurotransmitter deficit, and ultimately causing alzheimer's disease (ad), a dementing disorder affecting vast geriatric populations worldwide, characterized by the existence of extracellular amyloid plaques and intracellular neurofibrillary tangles in a hyperphosphorylated state. |
2020-09-29 |
2023-08-13 |
Not clear |
| Pascale Barbier, Orgeta Zejneli, Marlène Martinho, Alessia Lasorsa, Valérie Belle, Caroline Smet-Nocca, Philipp O Tsvetkov, François Devred, Isabelle Landrie. Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:31447664. |
a disruption of the mt network, which might be caused by tau loss of function, is observed in a group of related diseases called tauopathies, which includes alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Irving E Vega, Andrew Umstead, Nicholas M Kanaa. EFhd2 Affects Tau Liquid-Liquid Phase Separation. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31456657. |
the transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in alzheimer's disease and related dementias, is poorly understood. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ali Shoeibi, Nahid Olfati, Irene Litva. Frontrunner in Translation: Progressive Supranuclear Palsy. Frontiers in neurology. vol 10. 2020-09-29. PMID:31695675. |
abnormal tau deposition is not unique for psp and is the basic pathologic finding in some other neurodegenerative disorders such as alzheimer's disease (ad), age-related tauopathy, frontotemporal degeneration, corticobasal degeneration, and chronic traumatic encephalopathy. |
2020-09-29 |
2023-08-13 |
Not clear |