| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soha Ahmadi, Shaolong Zhu, Renu Sharma, Bing Wu, Ronald Soong, R Dutta Majumdar, Derek J Wilson, Andre J Simpson, Heinz-Bernhard Kraat. Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu ACS omega. vol 4. issue 3. 2020-09-29. PMID:31001602. |
aggregation of microtubule binding repeats of tau protein is promoted by cu understanding the factors that give rise to tau aggregation and reactive oxygen species (ros) is the key aspect in alzheimer's disease pathogenesis. |
2020-09-29 |
2023-08-13 |
Not clear |
| Cristina Lopez Lopez, Pierre N Tariot, Angelika Caputo, Jessica B Langbaum, Fonda Liu, Marie-Emmanuelle Riviere, Carolyn Langlois, Marie-Laure Rouzade-Dominguez, Martin Zalesak, Suzanne Hendrix, Ronald G Thomas, Vissia Viglietta, Rob Lenz, J Michael Ryan, Ana Graf, Eric M Reima. The Alzheimer's Prevention Initiative Generation Program: Study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.). vol 5. 2020-09-29. PMID:31211217. |
alzheimer's disease (ad) pathology, including the accumulation of amyloid beta (aβ) species and tau pathology, begins decades before the onset of cognitive impairment. |
2020-09-29 |
2023-08-13 |
Not clear |
| Elizabeth M Rhea, William A Bank. Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31213970. |
we also summarize how insulin can regulate levels of the pathological hallmarks of alzheimer's disease, including amyloid beta (aβ) and tau within each cell type. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shreyasi Chatterjee, Suren S Ambegaokar, George R Jackson, Amritpal Mudhe. Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31427921. |
insulin-mediated changes in tau hyperphosphorylation and autophagy in a almost 50 million people in the world are affected by dementia; the most prevalent form of which is alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Pallavi Duggal, Sidharth Meha. Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings. Journal of Alzheimer's disease reports. vol 3. issue 1. 2020-09-29. PMID:31435618. |
tau hyperphosphorylation mediates mt destabilization resulting in axonopathy and neurotransmitter deficit, and ultimately causing alzheimer's disease (ad), a dementing disorder affecting vast geriatric populations worldwide, characterized by the existence of extracellular amyloid plaques and intracellular neurofibrillary tangles in a hyperphosphorylated state. |
2020-09-29 |
2023-08-13 |
Not clear |
| Pascale Barbier, Orgeta Zejneli, Marlène Martinho, Alessia Lasorsa, Valérie Belle, Caroline Smet-Nocca, Philipp O Tsvetkov, François Devred, Isabelle Landrie. Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:31447664. |
a disruption of the mt network, which might be caused by tau loss of function, is observed in a group of related diseases called tauopathies, which includes alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Irving E Vega, Andrew Umstead, Nicholas M Kanaa. EFhd2 Affects Tau Liquid-Liquid Phase Separation. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31456657. |
the transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in alzheimer's disease and related dementias, is poorly understood. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ali Shoeibi, Nahid Olfati, Irene Litva. Frontrunner in Translation: Progressive Supranuclear Palsy. Frontiers in neurology. vol 10. 2020-09-29. PMID:31695675. |
abnormal tau deposition is not unique for psp and is the basic pathologic finding in some other neurodegenerative disorders such as alzheimer's disease (ad), age-related tauopathy, frontotemporal degeneration, corticobasal degeneration, and chronic traumatic encephalopathy. |
2020-09-29 |
2023-08-13 |
Not clear |
| Audrey Hector, Christina McAnulty, Maude-Éloïse Piché-Lemieux, Claire Alves-Pires, Valérie Buée-Scherrer, Luc Buée, Jonathan Brouillett. Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin-dependent protein kinase II. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-29. PMID:31908108. |
tau hyperphosphorylation is a major neuropathological hallmark of many neurodegenerative disorders such as alzheimer's disease. |
2020-09-29 |
2023-08-13 |
mouse |
| Melissa Birol, Ana M Mel. Untangling the Conformational Polymorphism of Disordered Proteins Associated With Neurodegeneration at the Single-Molecule Level. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31998071. |
moreover, several neurodegenerative disorders are associated with the pathological self-assembly of neuronal idps, including tau [alzheimer's disease (ad)], α-synuclein [parkinson's disease (pd)], and huntingtin exon 1 [huntington's disease (hd)]. |
2020-09-29 |
2023-08-13 |
human |
| Gurjit Kaur Bhatti, Arubala P Reddy, P Hemachandra Reddy, Jasvinder Singh Bhatt. Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:31998117. |
alzheimer's disease (ad) is a type of incurable neurodegenerative disease that is characterized by the accumulation of amyloid-β (aβ; plaques) and tau hyperphosphorylation as neurofibrillary tangles (nfts) in the brain followed by neuronal death, cognitive decline, and memory loss. |
2020-09-29 |
2023-08-13 |
Not clear |
| Nicole M Maphis, Shanya Jiang, Jessica Binder, Carrie Wright, Banu Gopalan, Bruce T Lamb, Kiran Bhaska. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Frontiers in molecular neuroscience. vol 10. 2020-09-28. PMID:28367114. |
increasing evidence suggests that hyperphosphorylation and aggregation of microtubule-associated protein tau (mapt or tau) correlates with the development of cognitive impairment in alzheimer's disease (ad) and related tauopathies. |
2020-09-28 |
2023-08-13 |
mouse |
| Shannon L Risacher, Eileen F Tallman, John D West, Karmen K Yoder, Gary D Hutchins, James W Fletcher, Sujuan Gao, David A Kareken, Martin R Farlow, Liana G Apostolova, Andrew J Sayki. Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography. Alzheimer's & dementia (Amsterdam, Netherlands). vol 9. 2020-09-28. PMID:29159268. |
we investigated the association between olfactory identification and alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sho Kaide, Masahiro Ono, Hiroyuki Watanabe, Ayane Kitada, Masashi Yoshimura, Yoichi Shimizu, Masafumi Ihara, Hideo Saj. Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology. ACS medicinal chemistry letters. vol 9. issue 5. 2020-09-28. PMID:29795763. |
it is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Léa Rodriguez, Julius Baya Mdzomba, Sandrine Joly, Mélissa Boudreau-Laprise, Emmanuel Planel, Vincent Perne. Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons. Frontiers in molecular neuroscience. vol 11. 2020-09-28. PMID:30197586. |
the implication of the microtubule-associated protein (map) tau in the ocular manifestations of alzheimer's disease (ad) is elusive due to the lack of relevant animal model. |
2020-09-28 |
2023-08-13 |
mouse |
| Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Hui Wong, Yin-Hsuan Wang, YunLing Lai, Chia-Hua Chou, Chihuei Wang, Joon-Khim Loh, Ann-Shung Lieu, Jiin-Tsuey Cheng, Yu-Te Lin, Pei-Jung Lu, Ming-Ji Fann, Chi-Ying F Huang, Yi-Ren Hon. GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease. Journal of clinical medicine. vol 8. issue 10. 2020-09-28. PMID:31640277. |
gskip-mediated anchoring increases phosphorylation of tau by pka but not by gsk3beta via camp/pka/gskip/gsk3/tau axis signaling in cerebrospinal fluid and ips cells in alzheimer disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Liseth K Lavado, Michelle H Zhang, Karan Patel, Sohim Khan, Urvish K Pate. Biometals as Potential Predictors of the Neurodegenerative Decline in Alzheimer's Disease. Cureus. vol 11. issue 9. 2020-09-28. PMID:31695992. |
most of the research on alzheimer's disease focuses on the correlation of its neuropathological changes in the neurofibrillary tangles caused by hyper-phosphorylated tau protein and β-amyloid plaques with respect to cognitive impairment. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chia-Lin Tsai, Chih-Sung Liang, Jiunn-Tay Lee, Ming-Wei Su, Chun-Chieh Lin, Hsuan-Te Chu, Chia-Kuang Tsai, Guan-Yu Lin, Yu-Kai Lin, Fu-Chi Yan. Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study. Journal of clinical medicine. vol 8. issue 11. 2020-09-28. PMID:31698867. |
brain degeneration in patients with alzheimer's disease (ad) results from the accumulation of pathological amyloid- (aβ) plaques and tau protein tangles, leading to altered plasma levels of biomarkers. |
2020-09-28 |
2023-08-13 |
Not clear |
| Per K Eide, Geir Ringsta. In Vivo Imaging of Molecular Clearance From Human Entorhinal Cortex: A Possible Method for Preclinical Testing of Dementia. Gerontology & geriatric medicine. vol 5. 2020-09-28. PMID:31819895. |
accumulation in the brain of metabolic waste products such as amyloid-β and hyperphosporylated tau (tau) is a hallmark of dementia (e.g., alzheimer's disease). |
2020-09-28 |
2023-08-13 |
human |
| Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwat. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31861888. |
in alzheimer's disease (ad), we previously reported mislocalization of the dna repair nuclear protein brca1, its coaggregation with tau, and the possible importance of the subsequent dna repair dysfunction. |
2020-09-28 |
2023-08-13 |
human |