| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth M Rhea, William A Bank. Role of the Blood-Brain Barrier in Central Nervous System Insulin Resistance. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31213970. |
we also summarize how insulin can regulate levels of the pathological hallmarks of alzheimer's disease, including amyloid beta (aβ) and tau within each cell type. |
2020-09-29 |
2023-08-13 |
Not clear |
| Shreyasi Chatterjee, Suren S Ambegaokar, George R Jackson, Amritpal Mudhe. Insulin-Mediated Changes in Tau Hyperphosphorylation and Autophagy in a Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31427921. |
insulin-mediated changes in tau hyperphosphorylation and autophagy in a almost 50 million people in the world are affected by dementia; the most prevalent form of which is alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Pallavi Duggal, Sidharth Meha. Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings. Journal of Alzheimer's disease reports. vol 3. issue 1. 2020-09-29. PMID:31435618. |
tau hyperphosphorylation mediates mt destabilization resulting in axonopathy and neurotransmitter deficit, and ultimately causing alzheimer's disease (ad), a dementing disorder affecting vast geriatric populations worldwide, characterized by the existence of extracellular amyloid plaques and intracellular neurofibrillary tangles in a hyperphosphorylated state. |
2020-09-29 |
2023-08-13 |
Not clear |
| Pascale Barbier, Orgeta Zejneli, Marlène Martinho, Alessia Lasorsa, Valérie Belle, Caroline Smet-Nocca, Philipp O Tsvetkov, François Devred, Isabelle Landrie. Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:31447664. |
a disruption of the mt network, which might be caused by tau loss of function, is observed in a group of related diseases called tauopathies, which includes alzheimer's disease (ad). |
2020-09-29 |
2023-08-13 |
Not clear |
| Irving E Vega, Andrew Umstead, Nicholas M Kanaa. EFhd2 Affects Tau Liquid-Liquid Phase Separation. Frontiers in neuroscience. vol 13. 2020-09-29. PMID:31456657. |
the transition of tau proteins from its soluble physiological conformation to the pathological aggregate forms found in alzheimer's disease and related dementias, is poorly understood. |
2020-09-29 |
2023-08-13 |
Not clear |
| Ali Shoeibi, Nahid Olfati, Irene Litva. Frontrunner in Translation: Progressive Supranuclear Palsy. Frontiers in neurology. vol 10. 2020-09-29. PMID:31695675. |
abnormal tau deposition is not unique for psp and is the basic pathologic finding in some other neurodegenerative disorders such as alzheimer's disease (ad), age-related tauopathy, frontotemporal degeneration, corticobasal degeneration, and chronic traumatic encephalopathy. |
2020-09-29 |
2023-08-13 |
Not clear |
| Audrey Hector, Christina McAnulty, Maude-Éloïse Piché-Lemieux, Claire Alves-Pires, Valérie Buée-Scherrer, Luc Buée, Jonathan Brouillett. Tau hyperphosphorylation induced by the anesthetic agent ketamine/xylazine involved the calmodulin-dependent protein kinase II. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-29. PMID:31908108. |
tau hyperphosphorylation is a major neuropathological hallmark of many neurodegenerative disorders such as alzheimer's disease. |
2020-09-29 |
2023-08-13 |
mouse |
| Melissa Birol, Ana M Mel. Untangling the Conformational Polymorphism of Disordered Proteins Associated With Neurodegeneration at the Single-Molecule Level. Frontiers in molecular neuroscience. vol 12. 2020-09-29. PMID:31998071. |
moreover, several neurodegenerative disorders are associated with the pathological self-assembly of neuronal idps, including tau [alzheimer's disease (ad)], α-synuclein [parkinson's disease (pd)], and huntingtin exon 1 [huntington's disease (hd)]. |
2020-09-29 |
2023-08-13 |
human |
| Gurjit Kaur Bhatti, Arubala P Reddy, P Hemachandra Reddy, Jasvinder Singh Bhatt. Lifestyle Modifications and Nutritional Interventions in Aging-Associated Cognitive Decline and Alzheimer's Disease. Frontiers in aging neuroscience. vol 11. 2020-09-29. PMID:31998117. |
alzheimer's disease (ad) is a type of incurable neurodegenerative disease that is characterized by the accumulation of amyloid-β (aβ; plaques) and tau hyperphosphorylation as neurofibrillary tangles (nfts) in the brain followed by neuronal death, cognitive decline, and memory loss. |
2020-09-29 |
2023-08-13 |
Not clear |
| Nicole M Maphis, Shanya Jiang, Jessica Binder, Carrie Wright, Banu Gopalan, Bruce T Lamb, Kiran Bhaska. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Frontiers in molecular neuroscience. vol 10. 2020-09-28. PMID:28367114. |
increasing evidence suggests that hyperphosphorylation and aggregation of microtubule-associated protein tau (mapt or tau) correlates with the development of cognitive impairment in alzheimer's disease (ad) and related tauopathies. |
2020-09-28 |
2023-08-13 |
mouse |
| Shannon L Risacher, Eileen F Tallman, John D West, Karmen K Yoder, Gary D Hutchins, James W Fletcher, Sujuan Gao, David A Kareken, Martin R Farlow, Liana G Apostolova, Andrew J Sayki. Olfactory identification in subjective cognitive decline and mild cognitive impairment: Association with tau but not amyloid positron emission tomography. Alzheimer's & dementia (Amsterdam, Netherlands). vol 9. 2020-09-28. PMID:29159268. |
we investigated the association between olfactory identification and alzheimer's disease biomarkers, including amyloid, tau, and neurodegeneration. |
2020-09-28 |
2023-08-13 |
Not clear |
| Sho Kaide, Masahiro Ono, Hiroyuki Watanabe, Ayane Kitada, Masashi Yoshimura, Yoichi Shimizu, Masafumi Ihara, Hideo Saj. Structure-Activity Relationships of Radioiodinated Benzoimidazopyridine Derivatives for Detection of Tau Pathology. ACS medicinal chemistry letters. vol 9. issue 5. 2020-09-28. PMID:29795763. |
it is generally accepted that neurofibrillary tangles consisting of tau proteins are involved in the pathogenesis of alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Léa Rodriguez, Julius Baya Mdzomba, Sandrine Joly, Mélissa Boudreau-Laprise, Emmanuel Planel, Vincent Perne. Human Tau Expression Does Not Induce Mouse Retina Neurodegeneration, Suggesting Differential Toxicity of Tau in Brain vs. Retinal Neurons. Frontiers in molecular neuroscience. vol 11. 2020-09-28. PMID:30197586. |
the implication of the microtubule-associated protein (map) tau in the ocular manifestations of alzheimer's disease (ad) is elusive due to the lack of relevant animal model. |
2020-09-28 |
2023-08-13 |
mouse |
| Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Hui Wong, Yin-Hsuan Wang, YunLing Lai, Chia-Hua Chou, Chihuei Wang, Joon-Khim Loh, Ann-Shung Lieu, Jiin-Tsuey Cheng, Yu-Te Lin, Pei-Jung Lu, Ming-Ji Fann, Chi-Ying F Huang, Yi-Ren Hon. GSKIP-Mediated Anchoring Increases Phosphorylation of Tau by PKA but Not by GSK3beta via cAMP/PKA/GSKIP/GSK3/Tau Axis Signaling in Cerebrospinal Fluid and iPS Cells in Alzheimer Disease. Journal of clinical medicine. vol 8. issue 10. 2020-09-28. PMID:31640277. |
gskip-mediated anchoring increases phosphorylation of tau by pka but not by gsk3beta via camp/pka/gskip/gsk3/tau axis signaling in cerebrospinal fluid and ips cells in alzheimer disease. |
2020-09-28 |
2023-08-13 |
Not clear |
| Liseth K Lavado, Michelle H Zhang, Karan Patel, Sohim Khan, Urvish K Pate. Biometals as Potential Predictors of the Neurodegenerative Decline in Alzheimer's Disease. Cureus. vol 11. issue 9. 2020-09-28. PMID:31695992. |
most of the research on alzheimer's disease focuses on the correlation of its neuropathological changes in the neurofibrillary tangles caused by hyper-phosphorylated tau protein and β-amyloid plaques with respect to cognitive impairment. |
2020-09-28 |
2023-08-13 |
Not clear |
| Chia-Lin Tsai, Chih-Sung Liang, Jiunn-Tay Lee, Ming-Wei Su, Chun-Chieh Lin, Hsuan-Te Chu, Chia-Kuang Tsai, Guan-Yu Lin, Yu-Kai Lin, Fu-Chi Yan. Associations between Plasma Biomarkers and Cognition in Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment: A Cross-Sectional and Longitudinal Study. Journal of clinical medicine. vol 8. issue 11. 2020-09-28. PMID:31698867. |
brain degeneration in patients with alzheimer's disease (ad) results from the accumulation of pathological amyloid- (aβ) plaques and tau protein tangles, leading to altered plasma levels of biomarkers. |
2020-09-28 |
2023-08-13 |
Not clear |
| Per K Eide, Geir Ringsta. In Vivo Imaging of Molecular Clearance From Human Entorhinal Cortex: A Possible Method for Preclinical Testing of Dementia. Gerontology & geriatric medicine. vol 5. 2020-09-28. PMID:31819895. |
accumulation in the brain of metabolic waste products such as amyloid-β and hyperphosporylated tau (tau) is a hallmark of dementia (e.g., alzheimer's disease). |
2020-09-28 |
2023-08-13 |
human |
| Masanori Kurihara, Tatsuo Mano, Yuko Saito, Shigeo Murayama, Tatsushi Toda, Atsushi Iwat. Colocalization of BRCA1 with Tau Aggregates in Human Tauopathies. Brain sciences. vol 10. issue 1. 2020-09-28. PMID:31861888. |
in alzheimer's disease (ad), we previously reported mislocalization of the dna repair nuclear protein brca1, its coaggregation with tau, and the possible importance of the subsequent dna repair dysfunction. |
2020-09-28 |
2023-08-13 |
human |
| Daniel J Apicco, Cheng Zhang, Brandon Maziuk, Lulu Jiang, Heather I Ballance, Samantha Boudeau, Choong Ung, Hu Li, Benjamin Wolozi. Dysregulation of RNA Splicing in Tauopathies. Cell reports. vol 29. issue 13. 2020-09-28. PMID:31875547. |
pathological aggregation of rna binding proteins (rbps) is associated with dysregulation of rna splicing in ps19 p301s tau transgenic mice and in alzheimer's disease brain tissues. |
2020-09-28 |
2023-08-13 |
mouse |
| Abdullah Al Mamun, Md Sahab Uddin, Bijo Mathew, Ghulam Md Ashra. Toxic tau: structural origins of tau aggregation in Alzheimer's disease. Neural regeneration research. vol 15. issue 8. 2020-09-28. PMID:31997800. |
toxic tau: structural origins of tau aggregation in alzheimer's disease. |
2020-09-28 |
2023-08-13 |
Not clear |