| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D'Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amador. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954296. |
clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of alzheimer's disease. |
2020-09-28 |
2023-08-13 |
mouse |
| Veronica Corsetti, Antonella Borreca, Valentina Latina, Giacomo Giacovazzo, Annabella Pignataro, Paraskevi Krashia, Francesca Natale, Sara Cocco, Marco Rinaudo, Francesca Malerba, Rita Florio, Roberta Ciarapica, Roberto Coccurello, Marcello D'Amelio, Martine Ammassari-Teule, Claudio Grassi, Pietro Calissano, Giuseppina Amador. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954296. |
we have explored whether passive immunization with the 12a12 monoclonal antibody (26-36aa of tau protein) could improve the alzheimer's disease phenotype of two well-established mouse models, tg2576 and 3xtg mice. |
2020-09-28 |
2023-08-13 |
mouse |
| Alireza Faridar, Aaron D Thome, Weihua Zhao, Jason R Thonhoff, David R Beers, Belen Pascual, Joseph C Masdeu, Stanley H Appe. Restoring regulatory T-cell dysfunction in Alzheimer's disease through Brain communications. vol 2. issue 2. 2020-09-28. PMID:32954348. |
while neuroprotective microglia are important for containment/clearance of amyloid plaques and maintaining neuronal survival, alzheimer inflammatory microglia may play a detrimental role by eliciting tau pathogenesis and accelerating neurotoxicity. |
2020-09-28 |
2023-08-13 |
Not clear |
| Yan-Hui Zhang, Xin-Zhu Yan, Shuang-Feng Xu, Zhong-Qiu Pang, Lin-Bo Li, Yang Yang, Yong-Gang Fan, Zhuo Wang, Xin Yu, Chuang Guo, Qiang A. α-Lipoic Acid Maintains Brain Glucose Metabolism Frontiers in aging neuroscience. vol 12. 2020-09-28. PMID:32973490. |
α-lipoic acid maintains brain glucose metabolism the microtubule-associated protein tau is closely correlated with hypometabolism in alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
mouse |
| Sajini D Hettiarachchi, Yiqun Zhou, Elif Seven, Madepalli K Lakshmana, Ajeet K Kaushik, Hitendra S Chand, Roger M Leblan. Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics. Journal of controlled release : official journal of the Controlled Release Society. vol 314. 2020-09-25. PMID:31647979. |
deposition of the amyloid β plaques has been identified as the most common ad pathology; however, the excessive accumulation of phosphorylated or total tau proteins, reactive oxygen species, and higher acetylcholinesterase activity are also strongly associated with alzheimer's dementia. |
2020-09-25 |
2023-08-13 |
Not clear |
| Diana K Franco-Bocanegra, Bethany George, Laurie C Lau, Clive Holmes, James A R Nicoll, Delphine Boch. Microglial motility in Alzheimer's disease and after Aβ42 immunotherapy: a human post-mortem study. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31703599. |
experimental evidence suggests impaired microglial motility in alzheimer's disease (ad) and therefore we have investigated whether the expression of proteins associated with motility is altered in ad and affected by the aβ immunotherapy using post-mortem brain tissue of 32 controls, 44 ad cases, and 16 ad cases from our unique group of patients immunised against aβ42 (iad).sections of brain were immunolabelled and quantified for (i) the motility-related microglial proteins iba1, cofilin 1 (cfl1), coronin-1a (coro1a) and p2ry12, and (ii) pan-aβ, aβ42 and phosphorylated tau (ptau). |
2020-09-25 |
2023-08-13 |
human |
| Kerstin Schlegel, Khader Awwad, Roland G Heym, David Holzinger, Annika Doell, Stefan Barghorn, Thomas R Jahn, Corinna Klein, Yulia Mordashova, Michael Schulz, Laura Gasparin. N368-Tau fragments generated by legumain are detected only in trace amount in the insoluble Tau aggregates isolated from AD brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31722749. |
intraneuronal insoluble inclusions made of tau protein are neuropathological hallmarks of alzheimer disease (ad). |
2020-09-25 |
2023-08-13 |
mouse |
| Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Le. Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31733655. |
alzheimer's disease tau is a prominent pathology in lrrk2 parkinson's disease. |
2020-09-25 |
2023-08-13 |
Not clear |
| Michael X Henderson, Medha Sengupta, John Q Trojanowski, Virginia M Y Le. Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31733655. |
we further use an antibody which selectively binds alzheimer's disease (ad)-type tau and use quantitative analysis of tau pathology to demonstrate that ad tau is the prominent type of tau present in lrrk2 mutation carriers. |
2020-09-25 |
2023-08-13 |
Not clear |
| Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, Glenda Halliday, Marie-Claude Potier, Thomas Wisniewski, Eleanor Drummon. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796108. |
secernin-1 is a novel phosphorylated tau binding protein that accumulates in alzheimer's disease and not in other tauopathies. |
2020-09-25 |
2023-08-13 |
human |
| Ebru Ercan-Herbst, Jens Ehrig, David C Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E Ehrnhoefe. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796124. |
a post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage alzheimer's disease brain. |
2020-09-25 |
2023-08-13 |
human |
| Ebru Ercan-Herbst, Jens Ehrig, David C Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E Ehrnhoefe. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796124. |
hyperphosphorylation of tau is linked to its aggregation and the formation of neurofibrillary tangles (nfts), which are a hallmark of alzheimer's disease (ad). |
2020-09-25 |
2023-08-13 |
human |
| Miguel Quintas-Neves, Merilee A Teylan, Lilah Besser, João Soares-Fernandes, Charles N Mock, Walter A Kukull, John F Crary, Tiago Gil Oliveir. Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART). Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31818331. |
alzheimer disease (ad) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (aβ) plaques and tau neurofibrillary tangles (nfts). |
2020-09-25 |
2023-08-13 |
Not clear |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-08-13 |
mouse |
| Claire E Shepherd, Andrew J Affleck, Anita Y Bahar, Francine Carew-Jones, Glenda M Hallida. Intracellular and secreted forms of clusterin are elevated early in Alzheimer's disease and associate with both Aβ and tau pathology. Neurobiology of aging. vol 89. 2020-09-23. PMID:31813628. |
intracellular and secreted forms of clusterin are elevated early in alzheimer's disease and associate with both aβ and tau pathology. |
2020-09-23 |
2023-08-13 |
human |
| Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jone. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825838. |
amyloid beta and tau cooperate to cause reversible behavioral and transcriptional deficits in a model of alzheimer's disease. |
2020-09-23 |
2023-08-13 |
mouse |
| Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jone. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825838. |
a key knowledge gap blocking development of effective therapeutics for alzheimer's disease (ad) is the lack of understanding of how amyloid beta (aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes. |
2020-09-23 |
2023-08-13 |
mouse |
| Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama, Yasunari Nakamot. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of aging. vol 89. 2020-09-23. PMID:31982202. |
neurofibrillary tangles, one of the pathological hallmarks of alzheimer's disease, consist of highly phosphorylated tau proteins. |
2020-09-23 |
2023-08-13 |
mouse |
| Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama, Yasunari Nakamot. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of aging. vol 89. 2020-09-23. PMID:31982202. |
collectively, these results suggest that rock inhibitors represent a viable therapeutic route to reduce the pathogenic forms of tau protein in tauopathies, including alzheimer's disease. |
2020-09-23 |
2023-08-13 |
mouse |
| Lynn van Olst, Daan Verhaege, Marc Franssen, Alwin Kamermans, Bart Roucourt, Sofie Carmans, Ellen Ytebrouck, Susanne M A van der Pol, Dennis Wever, Marko Popovic, Roosmarijn E Vandenbroucke, Tomás Sobrino, Marijn Schouten, Helga E de Vrie. Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. Neurobiology of aging. vol 89. 2020-09-23. PMID:32008854. |
alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (ptau), tau aggregation and neurofibrillary tangle formation sequentially culminating into neuronal cell death, a process termed tauopathy. |
2020-09-23 |
2023-08-13 |
mouse |