| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Geoffrey Pires, Sacha McElligott, Shiron Drusinsky, Glenda Halliday, Marie-Claude Potier, Thomas Wisniewski, Eleanor Drummon. Secernin-1 is a novel phosphorylated tau binding protein that accumulates in Alzheimer's disease and not in other tauopathies. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796108. |
secernin-1 is a novel phosphorylated tau binding protein that accumulates in alzheimer's disease and not in other tauopathies. |
2020-09-25 |
2023-08-13 |
human |
| Ebru Ercan-Herbst, Jens Ehrig, David C Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E Ehrnhoefe. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796124. |
a post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage alzheimer's disease brain. |
2020-09-25 |
2023-08-13 |
human |
| Ebru Ercan-Herbst, Jens Ehrig, David C Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E Ehrnhoefe. A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer's disease brain. Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31796124. |
hyperphosphorylation of tau is linked to its aggregation and the formation of neurofibrillary tangles (nfts), which are a hallmark of alzheimer's disease (ad). |
2020-09-25 |
2023-08-13 |
human |
| Miguel Quintas-Neves, Merilee A Teylan, Lilah Besser, João Soares-Fernandes, Charles N Mock, Walter A Kukull, John F Crary, Tiago Gil Oliveir. Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART). Acta neuropathologica communications. vol 7. issue 1. 2020-09-25. PMID:31818331. |
alzheimer disease (ad) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (aβ) plaques and tau neurofibrillary tangles (nfts). |
2020-09-25 |
2023-08-13 |
Not clear |
| Keiichi Kadoyama, Kenji Matsuura, Masaoki Takano, Koji Maekura, Yukari Inoue, Shogo Matsuyam. Changes in the expression of prefoldin subunit 5 depending on synaptic plasticity in the mouse hippocampus. Neuroscience letters. vol 712. 2020-09-23. PMID:31505240. |
in transgenic mice overexpressing human tau with n279 k mutation as a model of alzheimer's disease that showed impaired synaptic plasticity, the levels of pfdn5 mrna and protein in the hippocampus were significantly decreased in an age-dependent manner as compared with age-matched control. |
2020-09-23 |
2023-08-13 |
mouse |
| Claire E Shepherd, Andrew J Affleck, Anita Y Bahar, Francine Carew-Jones, Glenda M Hallida. Intracellular and secreted forms of clusterin are elevated early in Alzheimer's disease and associate with both Aβ and tau pathology. Neurobiology of aging. vol 89. 2020-09-23. PMID:31813628. |
intracellular and secreted forms of clusterin are elevated early in alzheimer's disease and associate with both aβ and tau pathology. |
2020-09-23 |
2023-08-13 |
human |
| Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jone. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825838. |
amyloid beta and tau cooperate to cause reversible behavioral and transcriptional deficits in a model of alzheimer's disease. |
2020-09-23 |
2023-08-13 |
mouse |
| Eleanor K Pickett, Abigail G Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P Fjeldstad, Will Calkin, Leo Murison, Rosemary J Jackson, Makis Tzioras, Anna Stevenson, Marie d'Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M Henstridge, Giles E Hardingham, Tara L Spires-Jone. Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease. Cell reports. vol 29. issue 11. 2020-09-23. PMID:31825838. |
a key knowledge gap blocking development of effective therapeutics for alzheimer's disease (ad) is the lack of understanding of how amyloid beta (aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes. |
2020-09-23 |
2023-08-13 |
mouse |
| Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama, Yasunari Nakamot. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of aging. vol 89. 2020-09-23. PMID:31982202. |
neurofibrillary tangles, one of the pathological hallmarks of alzheimer's disease, consist of highly phosphorylated tau proteins. |
2020-09-23 |
2023-08-13 |
mouse |
| Tadanori Hamano, Norimichi Shirafuji, Shu-Hui Yen, Hirotaka Yoshida, Nicholas M Kanaan, Kouji Hayashi, Masamichi Ikawa, Osamu Yamamura, Youshi Fujita, Masaru Kuriyama, Yasunari Nakamot. Rho-kinase ROCK inhibitors reduce oligomeric tau protein. Neurobiology of aging. vol 89. 2020-09-23. PMID:31982202. |
collectively, these results suggest that rock inhibitors represent a viable therapeutic route to reduce the pathogenic forms of tau protein in tauopathies, including alzheimer's disease. |
2020-09-23 |
2023-08-13 |
mouse |
| Lynn van Olst, Daan Verhaege, Marc Franssen, Alwin Kamermans, Bart Roucourt, Sofie Carmans, Ellen Ytebrouck, Susanne M A van der Pol, Dennis Wever, Marko Popovic, Roosmarijn E Vandenbroucke, Tomás Sobrino, Marijn Schouten, Helga E de Vrie. Microglial activation arises after aggregation of phosphorylated-tau in a neuron-specific P301S tauopathy mouse model. Neurobiology of aging. vol 89. 2020-09-23. PMID:32008854. |
alzheimer's disease, progressive supranuclear palsy and frontotemporal dementia are characterized by neuronal expression of aberrant tau protein, tau hyperphosphorylation (ptau), tau aggregation and neurofibrillary tangle formation sequentially culminating into neuronal cell death, a process termed tauopathy. |
2020-09-23 |
2023-08-13 |
mouse |
| Moira Marizzoni, Clarissa Ferrari, Claudio Babiloni, Diego Albani, Frederik Barkhof, Libera Cavaliere, Mira Didic, Gianluigi Forloni, Federica Fusco, Samantha Galluzzi, Tilman Hensch, Jorge Jovicich, Camillo Marra, José Luis Molinuevo, Flavio Nobili, Lucilla Parnetti, Pierre Payoux, Jean-Philippe Ranjeva, Federica Ribaldi, Elena Rolandi, Paolo Maria Rossini, Marco Salvatore, Andrea Soricelli, Magda Tsolaki, Pieter Jelle Visser, Jens Wiltfang, Jill C Richardson, Régis Bordet, Olivier Blin, Giovanni B Frison. CSF cutoffs for MCI due to AD depend on APOEε4 carrier status. Neurobiology of aging. vol 89. 2020-09-23. PMID:32029236. |
amyloid and tau pathological accumulation should be considered for alzheimer's disease (ad) definition and before subjects' enrollment in disease-modifying trials. |
2020-09-23 |
2023-08-13 |
human |
| Milan Stoiljkovic, Craig Kelley, Bernardo Stutz, Tamas L Horvath, Mihály Hajó. Altered Cortical and Hippocampal Excitability in TgF344-AD Rats Modeling Alzheimer's Disease Pathology. Cerebral cortex (New York, N.Y. : 1991). vol 29. issue 6. 2020-09-22. PMID:29920597. |
current findings suggest that accumulation of amyloid-β (aβ) and hyperphosphorylated tau in the brain disrupt synaptic function in hippocampal-cortical neuronal networks leading to impairment in cognitive and affective functions in alzheimer's disease (ad). |
2020-09-22 |
2023-08-13 |
rat |
| Benoît Melchior, Gopi Kumar Mittapalli, Carolyn Lai, Karen Duong-Polk, Joshua Stewart, Bora Güner, Brian Hofilena, Amanda Tjitro, Scott D Anderson, David S Herman, Luis Dellamary, Christopher J Swearingen, K C Sunil, Yusuf Yazic. Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease. Aging cell. vol 18. issue 5. 2020-09-22. PMID:31267651. |
tau pathology reduction with sm07883, a novel, potent, and selective oral dyrk1a inhibitor: a potential therapeutic for alzheimer's disease. |
2020-09-22 |
2023-08-13 |
mouse |
| Benoît Melchior, Gopi Kumar Mittapalli, Carolyn Lai, Karen Duong-Polk, Joshua Stewart, Bora Güner, Brian Hofilena, Amanda Tjitro, Scott D Anderson, David S Herman, Luis Dellamary, Christopher J Swearingen, K C Sunil, Yusuf Yazic. Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease. Aging cell. vol 18. issue 5. 2020-09-22. PMID:31267651. |
overexpression is correlated with tau hyperphosphorylation and neurofibrillary tangle (nft) formation in alzheimer's disease (ad). |
2020-09-22 |
2023-08-13 |
mouse |
| Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D Johnson, Michael G Kharas, Rakez Kaye. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature communications. vol 11. issue 1. 2020-09-21. PMID:32855391. |
oligomeric assemblies of tau and the rna-binding proteins (rbps) musashi (msi) are reported in alzheimer's disease (ad). |
2020-09-21 |
2023-08-13 |
mouse |
| Mauro Montalbano, Salome McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D Johnson, Michael G Kharas, Rakez Kaye. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature communications. vol 11. issue 1. 2020-09-21. PMID:32855391. |
here, we investigated the expression and cellular localization of msi1 and msi2 in the brains tissues of alzheimer's disease (ad), amyotrophic lateral sclerosis (als) and frontotemporal dementia (ftd) as well as in the wild-type mice and tau knock-out and p301l tau mouse models. |
2020-09-21 |
2023-08-13 |
mouse |
| Nobuya Kitaguchi, Harutsugu Tatebe, Kazuyoshi Sakai, Kazunori Kawaguchi, Shinji Matsunaga, Tomoko Kitajima, Hiroshi Tomizawa, Masao Kato, Satoshi Sugiyama, Nobuo Suzuki, Masao Mizuno, Hajime Takechi, Shigeru Nakai, Yoshiyuki Hiki, Hiroko Kushimoto, Midori Hasegawa, Yukio Yuzawa, Takahiko Tokud. Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156161. |
influx of tau and amyloid-β proteins into the blood during hemodialysis as a therapeutic extracorporeal blood amyloid-β removal system for alzheimer's disease. |
2020-09-18 |
2023-08-13 |
human |
| Nobuya Kitaguchi, Harutsugu Tatebe, Kazuyoshi Sakai, Kazunori Kawaguchi, Shinji Matsunaga, Tomoko Kitajima, Hiroshi Tomizawa, Masao Kato, Satoshi Sugiyama, Nobuo Suzuki, Masao Mizuno, Hajime Takechi, Shigeru Nakai, Yoshiyuki Hiki, Hiroko Kushimoto, Midori Hasegawa, Yukio Yuzawa, Takahiko Tokud. Influx of Tau and Amyloid-β Proteins into the Blood During Hemodialysis as a Therapeutic Extracorporeal Blood Amyloid-β Removal System for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156161. |
the accumulation of amyloid-β protein (aβ) and tau in the brain is a major pathological change related to alzheimer's disease. |
2020-09-18 |
2023-08-13 |
human |
| Hong-Bin Cai, Zhen-Zhen Fan, Ting Tian, Chon-Chon Zhao, Zhao-Ming G. Epigenetic Control of CDK5 Promoter Regulates Diabetes-Associated Development of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31156174. |
cyclin-dependent kinase-5 (cdk5) is activated by p35 and then binds to both p35 and its truncated form p25 to promote hyperphosphorylation of tau protein, thereby facilitating the pathological progression of alzheimer's disease (ad). |
2020-09-18 |
2023-08-13 |
rat |