| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Morgane Perrotte, Mohamed Haddad, Aurélie Le Page, Eric H Frost, Tamàs Fulöp, Charles Ramassam. Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease. Neurobiology of aging. vol 86. 2020-09-07. PMID:31883770. |
accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (evs) and be associated with the onset and the progression of alzheimer's disease (ad). |
2020-09-07 |
2023-08-13 |
human |
| Yam Nath Paudel, Efthalia Angelopoulou, Nigel C Jones, Terence J O'Brien, Patrick Kwan, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaik. Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 10. 2020-09-04. PMID:31532186. |
tau related pathways as a connecting link between epilepsy and alzheimer's disease. |
2020-09-04 |
2023-08-13 |
human |
| Megan M Bernath, Sudeepa Bhattacharyya, Kwangsik Nho, Dinesh Kumar Barupal, Oliver Fiehn, Rebecca Baillie, Shannon L Risacher, Matthias Arnold, Tanner Jacobson, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, P Murali Doraiswamy, Rima Kaddurah-Daouk, Andrew J Sayki. Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers. Neurology. vol 94. issue 20. 2020-09-03. PMID:32358220. |
to investigate the association of triglyceride (tg) principal component scores with alzheimer disease (ad) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (a/t/n/v) biomarkers for ad. |
2020-09-03 |
2023-08-13 |
Not clear |
| Derek Kellar, Suzanne Craf. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches. The Lancet. Neurology. vol 19. issue 9. 2020-09-01. PMID:32730766. |
insulin also has a role in proteostasis, influencing clearance of the amyloid β peptide and phosphorylation of tau, which are hallmarks of alzheimer's disease. |
2020-09-01 |
2023-08-13 |
human |
| Hector Rosas-Hernandez, Elvis Cuevas, James B Raymick, Bonnie L Robinson, Syed F Ali, Joseph Hanig, Sumit Sarka. Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer's Disease. Current Alzheimer research. vol 16. issue 5. 2020-08-31. PMID:30907317. |
alzheimer's disease (ad) is the most common type of dementia characterized by amyloid plaques containing amyloid beta (aβ) peptides and neurofibrillary tangles containing tau protein. |
2020-08-31 |
2023-08-13 |
mouse |
| Yong-Chan Kim, Byung-Hoon Jeon. In Silico Evaluation of Acetylation Mimics in the 27 Lysine Residues of Human Tau Protein. Current Alzheimer research. vol 16. issue 5. 2020-08-31. PMID:30907318. |
various neurodegenerative diseases, including alzheimer's disease (ad), are related to abnormal hyperphosphorylated microtubule-associated protein tau accumulation in brain lesions. |
2020-08-31 |
2023-08-13 |
human |
| Elian Dupré, Clément Danis, Alexis Arrial, Xavier Hanoulle, Mégane Homa, François-Xavier Cantrelle, Hamida Merzougui, Morvane Colin, Jean-Christophe Rain, Luc Buée, Isabelle Landrie. Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies. ACS chemical neuroscience. vol 10. issue 9. 2020-08-31. PMID:31380615. |
tau is a neuronal protein linked to pathologies called tauopathies, including alzheimer's disease. |
2020-08-31 |
2023-08-13 |
mouse |
| Elian Dupré, Clément Danis, Alexis Arrial, Xavier Hanoulle, Mégane Homa, François-Xavier Cantrelle, Hamida Merzougui, Morvane Colin, Jean-Christophe Rain, Luc Buée, Isabelle Landrie. Single Domain Antibody Fragments as New Tools for the Detection of Neuronal Tau Protein in Cells and in Mice Studies. ACS chemical neuroscience. vol 10. issue 9. 2020-08-31. PMID:31380615. |
in alzheimer's disease, tau aggregates into filaments, leading to the observation of intraneuronal fibrillary tangles. |
2020-08-31 |
2023-08-13 |
mouse |
| Tiffany Wu, Borislav Dejanovic, Vineela D Gandham, Alvin Gogineni, Rose Edmonds, Stephen Schauer, Karpagam Srinivasan, Melanie A Huntley, Yuanyuan Wang, Tzu-Ming Wang, Maj Hedehus, Kai H Barck, Maya Stark, Hai Ngu, Oded Foreman, William J Meilandt, Justin Elstrott, Michael C Chang, David V Hansen, Richard A D Carano, Morgan Sheng, Jesse E Hanso. Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. Cell reports. vol 28. issue 8. 2020-08-31. PMID:31433986. |
although alzheimer's disease (ad) is characterized by β-amyloid plaques and tau tangles, previous work examining complement has largely focused on amyloidosis models. |
2020-08-31 |
2023-08-13 |
mouse |
| Ladislav Volice. Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review. The Chinese journal of physiology. vol 63. issue 3. 2020-08-31. PMID:32594062. |
the review summarizes pathological features of alzheimer brain, aβ plaques, neurofibrillary tangles composed of hyperphosphorylated tau, and brain atrophy. |
2020-08-31 |
2023-08-13 |
Not clear |
| Anna Zettergren, Kina Höglund, Silke Kern, Valgeir Thorvaldsson, Msc Johan Skoog, Oskar Hansson, Niels Andreasen, Nenad Bogdanovic, Kaj Blennow, Ingmar Skoog, Henrik Zetterber. Association of IL1RAP-related genetic variation with cerebrospinal fluid concentration of Alzheimer-associated tau protein. Scientific reports. vol 9. issue 1. 2020-08-28. PMID:30792413. |
a possible involvement of the gene il1rap (interleukin-1 receptor-associated protein) in the pathogenesis of alzheimer's disease (ad) has been suggested in gwass of cerebrospinal fluid (csf) tau levels and longitudinal change in brain amyloid burden. |
2020-08-28 |
2023-08-13 |
Not clear |
| Abhishek Ankur Balmik, Rashmi Das, Abha Dangi, Nalini Vijay Gorantla, Udaya Kiran Marelli, Subashchandrabose Chinnathamb. Melatonin interacts with repeat domain of Tau to mediate disaggregation of paired helical filaments. Biochimica et biophysica acta. General subjects. vol 1864. issue 3. 2020-08-28. PMID:31715192. |
in alzheimer's disease, tau self-assembles to form intracellular protein aggregates which are toxic to cells. |
2020-08-28 |
2023-08-13 |
Not clear |
| Long-Long Cao, Pei-Pei Guan, Yun-Yue Liang, Xue-Shi Huang, Pu Wan. Cyclooxygenase-2 is Essential for Mediating the Effects of Calcium Ions on Stimulating Phosphorylation of Tau at the Sites of Ser 396 and Ser 404. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30883354. |
alzheimer's disease (ad) is reported to be associated with the accumulation of calcium ions (ca2+), which is responsible for the phosphorylation of tau. |
2020-08-27 |
2023-08-13 |
mouse |
| Chloé Manca, Lucie Hopes, Anna Kearney-Schwartz, Véronique Roch, Gilles Karcher, Cédric Baumann, Pierre-Yves Marie, Catherine Malaplate-Armand, Thérèse Rivasseau Jonveaux, Antoine Verge. Assessment of 18F-Florbetaben Amyloid PET Imaging in Patients with Suspected Alzheimer's Disease and Isolated Increase in Cerebrospinal Fluid Tau Proteins. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30883358. |
assessment of 18f-florbetaben amyloid pet imaging in patients with suspected alzheimer's disease and isolated increase in cerebrospinal fluid tau proteins. |
2020-08-27 |
2023-08-13 |
Not clear |
| Desheng Wan. Tumor Necrosis Factor-Alpha Alters Electrophysiological Properties of Rabbit Hippocampal Neurons. Journal of Alzheimer's disease : JAD. vol 68. issue 3. 2020-08-27. PMID:30909246. |
previous studies have shown tumor necrosis factor-alpha (tnf-α) may impact neurodegeneration in alzheimer's disease (ad) by regulating amyloid-β and tau pathogenesis. |
2020-08-27 |
2023-08-13 |
rabbit |
| Bin He, Wei Chen, Jingsong Zeng, Wusong Tong, Ping Zhen. MicroRNA-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the JNK signaling pathway by targeting VAV1 in Alzheimer's disease. Journal of cellular physiology. vol 235. issue 1. 2020-08-25. PMID:31385301. |
microrna-326 decreases tau phosphorylation and neuron apoptosis through inhibition of the jnk signaling pathway by targeting vav1 in alzheimer's disease. |
2020-08-25 |
2023-08-13 |
mouse |
| Jing Wang, Yabing Chen, Changliang Zhang, Zou Xiang, Jie Ding, Xiaodong Ha. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of hazardous materials. vol 373. 2020-08-24. PMID:30947040. |
mc-lr exposure at this concentration induced dysfunction of learning and memory, accompanied with apoptosis of neuronal cells (with 10% reduction of the neurons in the ca1 region and 15% in the ca2 region), reduction of spine density, accumulation of β-amyloid plaques 1-42 (aβ1-42), and enhanced phosphorylation of tau (p-tau) in the brain, which is characteristic of alzheimer's disease (ad). |
2020-08-24 |
2023-08-13 |
mouse |
| Tamta Arakhamia, Christina E Lee, Yari Carlomagno, Duc M Duong, Sean R Kundinger, Kevin Wang, Dewight Williams, Michael DeTure, Dennis W Dickson, Casey N Cook, Nicholas T Seyfried, Leonard Petrucelli, Anthony W P Fitzpatric. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell. vol 180. issue 4. 2020-08-24. PMID:32032505. |
by comparing the structures and ptms of tau filaments from cbd and alzheimer's disease, it is found that ubiquitination of tau can mediate inter-protofilament interfaces. |
2020-08-24 |
2023-08-13 |
human |
| Yutong Zhang, Ke Li, Chuanqiang Pu, Haodan Dang, Jiajin Liu, Qiang Sh. A novel application of tau PET in the diagnosis of sporadic inclusion body myositis: A case report. Medicine. vol 99. issue 31. 2020-08-24. PMID:32756195. |
thk5317, an f-labelled positron emission tomography (pet) marker, targets tau protein deposits, which are expressed in the brain of patients with alzheimer's disease (ad). |
2020-08-24 |
2023-08-13 |
Not clear |
| Taxiarchis Katsinelos, Benjamin J Tuck, Aamir S Mukadam, William A McEwa. The Role of Antibodies and Their Receptors in Protection Against Ordered Protein Assembly in Neurodegeneration. Frontiers in immunology. vol 10. 2020-08-21. PMID:31214163. |
the cytoplasmic microtubule associated protein tau and alpha-synuclein (αs) are found in an assembled state in alzheimer's disease and parkinson's disease, respectively. |
2020-08-21 |
2023-08-13 |
Not clear |