| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rucha Pandit, Gerhard Leinenga, Jürgen Göt. Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics. vol 9. issue 13. 2020-09-14. PMID:31281511. |
intracellular deposits of pathological tau are the hallmark of a broad spectrum of neurodegenerative disorders collectively known as tauopathies, with alzheimer's disease, a secondary tauopathy, being further characterized by extracellular amyloid plaques. |
2020-09-14 |
2023-08-13 |
mouse |
| Jeanna M Wheeler, Pamela McMillan, Timothy J Strovas, Nicole F Liachko, Alexandre Amlie-Wolf, Rebecca L Kow, Ronald L Klein, Patricia Szot, Linda Robinson, Chris Guthrie, Aleen Saxton, Nicholas M Kanaan, Murray Raskind, Elaine Peskind, John Q Trojanowski, Virginia M Y Lee, Li-San Wang, C Dirk Keene, Thomas Bird, Gerard D Schellenberg, Brian Kraeme. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science translational medicine. vol 11. issue 523. 2020-09-14. PMID:31852801. |
brain lesions composed of pathological tau help to drive neurodegeneration in alzheimer's disease (ad) and related tauopathies. |
2020-09-14 |
2023-08-13 |
Not clear |
| Constantin George Lyketso. Treatment Development for Alzheimer's Disease: How Are We Doing? Advances in experimental medicine and biology. vol 1195. 2020-09-11. PMID:32468453. |
the most common cause of dementia is believed to be alzheimer's, a brain disease associated with deposition of beta-amyloid protein and hyperphosphorylation of intraneuronal tau protein leading to synaptic degradation, neuronal loss, brain circuit disruption, a range of symptoms, and eventually, if the person lives long enough, death. |
2020-09-11 |
2023-08-13 |
Not clear |
| Shiping Li, Junxiang Yin, Megan Nielsen, Thomas G Beach, Li Guo, Jiong Sh. Sirtuin 3 Mediates Tau Deacetylation. Journal of Alzheimer's disease : JAD. vol 69. issue 2. 2020-09-10. PMID:30958373. |
emerging evidence shows tau acetylation has been observed in alzheimer's disease (ad) brain at early braak stages and is involved in regulating tau early accumulation. |
2020-09-10 |
2023-08-13 |
Not clear |
| Tobias Skillbäck, Johannes Kornhuber, Kaj Blennow, Henrik Zetterberg, Piotr Lewczu. Erlangen Score Predicts Cognitive and Neuroimaging Progression in Mild Cognitive Impairment Stage of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 69. issue 2. 2020-09-10. PMID:31104027. |
to alleviate the interpretation of the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers, amyloid β1-42 (aβ42), total tau (t-tau), and phosphorylated tau (p-tau), the erlangen score (es) interpretation algorithm has been proposed. |
2020-09-10 |
2023-08-13 |
Not clear |
| Ruma Raha-Chowdhury, James W Henderson, Animesh Alexander Raha, Romina Vuono, Anastasia Bickerton, Elizabeth Jones, Robert Fincham, Kieren Allinson, Anthony Holland, Shahid H Zama. Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer's Disease and in Down Syndrome Dementia. Journal of Alzheimer's disease : JAD. vol 69. issue 1. 2020-09-09. PMID:30909239. |
choroid plexus acts as gatekeeper for trem2, abnormal accumulation of apoe, and fibrillary tau in alzheimer's disease and in down syndrome dementia. |
2020-09-09 |
2023-08-13 |
Not clear |
| Lena L Law, Kate E Sprecher, Ryan J Dougherty, Dorothy F Edwards, Rebecca L Koscik, Catherine L Gallagher, Cynthia M Carlsson, Henrik Zetterberg, Kaj Blennow, Sanjay Asthana, Mark A Sager, Bruce P Hermann, Sterling C Johnson, Dane B Cook, Barbara B Bendlin, Ozioma C Okonkw. Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort. Journal of Alzheimer's disease : JAD. vol 69. issue 1. 2020-09-09. PMID:30958346. |
previous studies indicate that cardiorespiratory fitness (crf) and sleep are each favorably associated with alzheimer's disease (ad) pathophysiology, including reduced amyloid-β (aβ) and tau pathology. |
2020-09-09 |
2023-08-13 |
Not clear |
| Mamen Regalado-Reyes, Diana Furcila, Félix Hernández, Jesús Ávila, Javier DeFelipe, Gonzalo León-Espinos. Phospho-Tau Changes in the Human CA1 During Alzheimer's Disease Progression. Journal of Alzheimer's disease : JAD. vol 69. issue 1. 2020-09-09. PMID:30958368. |
despite extensive studies regarding tau phosphorylation progression in both human alzheimer's disease cases and animal models, the molecular and structural changes responsible for neurofibrillary tangle development are still not well understood. |
2020-09-09 |
2023-08-13 |
human |
| Alina Hategan, Eliezer Masliah, Avindra Nat. HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein. Journal of neurovirology. vol 25. issue 5. 2020-09-09. PMID:31016584. |
hiv and alzheimer's disease: complex interactions of hiv-tat with amyloid β peptide and tau protein. |
2020-09-09 |
2023-08-13 |
human |
| Alina Hategan, Eliezer Masliah, Avindra Nat. HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein. Journal of neurovirology. vol 25. issue 5. 2020-09-09. PMID:31016584. |
as the hiv-infected population is aging, it is becoming increasingly important to understand how hiv-tat may interact with proteins such as amyloid β and tau which accumulate in the aging brain and eventually result in alzheimer's disease. |
2020-09-09 |
2023-08-13 |
human |
| Alina Hategan, Eliezer Masliah, Avindra Nat. HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein. Journal of neurovirology. vol 25. issue 5. 2020-09-09. PMID:31016584. |
hiv-tat may also induce tau phosphorylation through a cascade of cellular processes that lead to the formation of neurofibrillary tangles, another hallmark of alzheimer's disease. |
2020-09-09 |
2023-08-13 |
human |
| Sneha Narasimhan, Lakshmi Changolkar, Dawn M Riddle, Alexandra Kats, Anna Stieber, Sarah A Weitzman, Bin Zhang, Zhiyong Li, Erik D Roberson, John Q Trojanowski, Virginia M Y Le. Human tau pathology transmits glial tau aggregates in the absence of neuronal tau. The Journal of experimental medicine. vol 217. issue 2. 2020-09-09. PMID:31826239. |
in alzheimer's disease (ad), tau aggregates in neurons, while in corticobasal degeneration (cbd) and progressive supranuclear palsy (psp), tau also aggregates in astrocytes and oligodendrocytes. |
2020-09-09 |
2023-08-13 |
mouse |
| Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Marlene Jimenez-Del-Ri. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications. PloS one. vol 15. issue 5. 2020-09-09. PMID:32437347. |
cholinergic-like neurons carrying psen1 e280a mutation from familial alzheimer's disease reveal intraneuronal sappβ fragments accumulation, hyperphosphorylation of tau, oxidative stress, apoptosis and ca2+ dysregulation: therapeutic implications. |
2020-09-09 |
2023-08-13 |
Not clear |
| Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Francisco Lopera, Marlene Jimenez-Del-Ri. Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer's disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca2+ dysregulation: Therapeutic implications. PloS one. vol 15. issue 5. 2020-09-09. PMID:32437347. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive memory loss and cognitive disturbance as a consequence of the loss of cholinergic neurons in the brain, neuritic plaques and hyperphosphorylation of tau protein. |
2020-09-09 |
2023-08-13 |
Not clear |
| Zhen Wei, Yacoubou Abdoul Razak Mahaman, Feiqi Zhu, Mengjuan Wu, Yiyuan Xia, Kuan Zeng, Ying Yang, Rong Liu, Jian-Zhi Wang, Xiji Shu, Xiaochuan Wan. GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats. Aging. vol 11. issue 18. 2020-09-08. PMID:31548435. |
post-traumatic stress disorder (ptsd) manifests in neurocognitive deficits in association with increased tau deposition, which mainly consist of phosphorylated tau in alzheimer disease (ad) brain. |
2020-09-08 |
2023-08-13 |
rat |
| Yi-Chen Hsieh, Caiwei Guo, Hari K Yalamanchili, Measho Abreha, Rami Al-Ouran, Yarong Li, Eric B Dammer, James J Lah, Allan I Levey, David A Bennett, Philip L De Jager, Nicholas T Seyfried, Zhandong Liu, Joshua M Shulma. Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer's Disease. Cell reports. vol 29. issue 2. 2020-09-08. PMID:31597093. |
in alzheimer's disease (ad), spliceosomal proteins with critical roles in rna processing aberrantly aggregate and mislocalize to tau neurofibrillary tangles. |
2020-09-08 |
2023-08-13 |
human |
| Grace E Weber, Katherine A Koenig, Maria Khrestian, Yvonne Shao, Elizabeth D Tuason, Marie Gramm, Dennis Lal, James B Leverenz, Lynn M Bekri. An Altered Relationship between Soluble TREM2 and Inflammatory Markers in Young Adults with Down Syndrome: A Preliminary Report. Journal of immunology (Baltimore, Md. : 1950). vol 204. issue 5. 2020-09-08. PMID:31959733. |
individuals with down syndrome (ds) develop alzheimer's disease (ad)-related neuropathology, characterized by amyloid plaques with amyloid β (aβ) and neurofibrillary tangles with tau accumulation. |
2020-09-08 |
2023-08-13 |
Not clear |
| Morgane Perrotte, Mohamed Haddad, Aurélie Le Page, Eric H Frost, Tamàs Fulöp, Charles Ramassam. Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease. Neurobiology of aging. vol 86. 2020-09-07. PMID:31883770. |
accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (evs) and be associated with the onset and the progression of alzheimer's disease (ad). |
2020-09-07 |
2023-08-13 |
human |
| Yam Nath Paudel, Efthalia Angelopoulou, Nigel C Jones, Terence J O'Brien, Patrick Kwan, Christina Piperi, Iekhsan Othman, Mohd Farooq Shaik. Tau Related Pathways as a Connecting Link between Epilepsy and Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 10. 2020-09-04. PMID:31532186. |
tau related pathways as a connecting link between epilepsy and alzheimer's disease. |
2020-09-04 |
2023-08-13 |
human |
| Megan M Bernath, Sudeepa Bhattacharyya, Kwangsik Nho, Dinesh Kumar Barupal, Oliver Fiehn, Rebecca Baillie, Shannon L Risacher, Matthias Arnold, Tanner Jacobson, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, P Murali Doraiswamy, Rima Kaddurah-Daouk, Andrew J Sayki. Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers. Neurology. vol 94. issue 20. 2020-09-03. PMID:32358220. |
to investigate the association of triglyceride (tg) principal component scores with alzheimer disease (ad) and the amyloid, tau, neurodegeneration, and cerebrovascular disease (a/t/n/v) biomarkers for ad. |
2020-09-03 |
2023-08-13 |
Not clear |