All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Leslie A Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T Calahatian, Devon S Placides, Mallory D Watler, Jerry B Hunt, April L Darling, Jeremy D Baker, Laura J Blair, Mackenzie D Martin, Sarah N Fontaine, Chad A Dickey, April L Lussier, Edwin J Weeber, Maj-Linda B Selenica, Kevin R Nash, Marcia N Gordon, Dave Morgan, Daniel C Le. Spermidine/spermine-N Alzheimer's research & therapy. vol 11. issue 1. 2020-07-15. PMID:31253191. spermidine/spermine-n tau stabilizes microtubules; however, in alzheimer's disease (ad) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. 2020-07-15 2023-08-13 Not clear
Ramsey Najm, Antara Rao, Yadong Huan. Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease. Cell stem cell. vol 26. issue 3. 2020-07-15. PMID:32142656. too much tau in interneurons impairs adult hippocampal neurogenesis in alzheimer's disease. 2020-07-15 2023-08-13 mouse
Alejandro R Roda, Laia Montoliu-Gaya, Sandra Villega. The Role of Apolipoprotein E Isoforms in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30775980. alzheimer's disease (ad), the most common type of dementia worldwide, is characterized by high levels of amyloid-β (aβ) peptide and hyperphosphorylated tau protein. 2020-07-14 2023-08-13 Not clear
Priya Devanarayan, Viswanath Devanarayan, Daniel A Llan. Identification of a Simple and Novel Cut-Point Based Cerebrospinal Fluid and MRI Signature for Predicting Alzheimer's Disease Progression that Reinforces the 2018 NIA-AA Research Framework. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30775985. the 2018 nia-aa research framework proposes a classification system with amyloid-β deposition, pathologic tau, and neurodegeneration (atn) for diagnosis and staging of alzheimer's disease (ad). 2020-07-14 2023-08-13 human
Andrew Umstead, Irving E Veg. Tau13 Antibody Preferentially Immunoprecipitates High Molecular Weight Tau Proteins. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-14. PMID:30814358. the accumulation of tau protein aggregates is a pathological hallmark in alzheimer's disease (ad) and other neurodegenerative diseases. 2020-07-14 2023-08-13 mouse
Harold G Selnick, J Fred Hess, Cuyue Tang, Kun Liu, Joel B Schachter, Jeanine E Ballard, Jacob Marcus, Daniel J Klein, Xiaohai Wang, Michelle Pearson, Mary J Savage, Ramesh Kaul, Tong-Shuang Li, David J Vocadlo, Yuanxi Zhou, Yongbao Zhu, Changwei Mu, Yaode Wang, Zhongyong Wei, Chang Bai, Joseph L Duffy, Ernest J McEacher. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. Journal of medicinal chemistry. vol 62. issue 22. 2020-07-14. PMID:31487175. inhibition of o-glcnacase (oga) has emerged as a promising therapeutic approach to treat tau pathology in neurodegenerative diseases such as alzheimer's disease and progressive supranuclear palsy. 2020-07-14 2023-08-13 Not clear
Ariana Myers, Paul McGonigl. Overview of Transgenic Mouse Models for Alzheimer's Disease. Current protocols in neuroscience. vol 89. issue 1. 2020-07-13. PMID:31532917. this review describes several transgenic mouse models of alzheimer's disease (ad), a devastating neurodegenerative disorder that causes progressive cognitive decline and is diagnosed postmortem by the presence of extracellular amyloid-β (aβ) plaques and intraneuronal tau neurofibrillary tangles in the cerebral cortex. 2020-07-13 2023-08-13 mouse
Marta Marquié, Cinthya Agüero, Ana C Amaral, Alberto Villarejo-Galende, Prianca Ramanan, Michael Siao Tick Chong, Nil Sáez-Calveras, Rachel E Bennett, Eline E Verwer, Sally Ji Who Kim, Maeva Dhaynaut, Victor E Alvarez, Keith A Johnson, Ann C McKee, Matthew P Frosch, Teresa Gómez-Isl. [ Acta neuropathologica communications. vol 7. issue 1. 2020-07-13. PMID:31661038. recent studies have shown that positron emission tomography (pet) tracer av-1451 (flortaucipir) exhibits high binding affinity for paired helical filament (phf)-tau aggregates in alzheimer (ad) brains but relatively low affinity for tau lesions in other tauopathies like temporal lobal degeneration (ftld)-tau, progressive supranuclear palsy (psp) or corticobasal degeneration (cbd). 2020-07-13 2023-08-13 Not clear
Sang Su Kwak, Kevin J Washicosky, Emma Brand, Djuna von Maydell, Jenna Aronson, Susan Kim, Diane E Capen, Murat Cetinbas, Ruslan Sadreyev, Shen Ning, Enjana Bylykbashi, Weiming Xia, Steven L Wagner, Se Hoon Choi, Rudolph E Tanzi, Doo Yeon Ki. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-07-13. PMID:32170138. amyloid-β42/40 ratio drives tau pathology in 3d human neural cell culture models of alzheimer's disease. 2020-07-13 2023-08-13 human
Sang Su Kwak, Kevin J Washicosky, Emma Brand, Djuna von Maydell, Jenna Aronson, Susan Kim, Diane E Capen, Murat Cetinbas, Ruslan Sadreyev, Shen Ning, Enjana Bylykbashi, Weiming Xia, Steven L Wagner, Se Hoon Choi, Rudolph E Tanzi, Doo Yeon Ki. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-07-13. PMID:32170138. the relationship between amyloid-β (aβ) species and tau pathology in alzheimer's disease (ad) is not fully understood. 2020-07-13 2023-08-13 human
Lisa Vermunt, Sietske A M Sikkes, Ardo van den Hout, Ron Handels, Isabelle Bos, Wiesje M van der Flier, Silke Kern, Pierre-Jean Ousset, Paul Maruff, Ingmar Skoog, Frans R J Verhey, Yvonne Freund-Levi, Magda Tsolaki, Åsa K Wallin, Marcel Olde Rikkert, Hilkka Soininen, Luisa Spiru, Henrik Zetterberg, Kaj Blennow, Philip Scheltens, Graciela Muniz-Terrera, Pieter Jelle Visse. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 7. 2020-07-10. PMID:31164314. we estimated the age-specific duration of the preclinical, prodromal, and dementia stages of alzheimer's disease (ad) and the influence of sex, setting, apolipoprotein e (apoe) genotype, and cerebrospinal fluid tau on disease duration. 2020-07-10 2023-08-13 Not clear
Guru Krishnakumar Viswanathan, Dana Shwartz, Yelena Losev, Elad Arad, Chen Shemesh, Edward Pichinuk, Hamutal Engel, Avi Raveh, Raz Jelinek, Itzik Cooper, Fabien Gosselet, Ehud Gazit, Daniel Sega. Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer's disease-like symptoms in animal model. Cellular and molecular life sciences : CMLS. vol 77. issue 14. 2020-07-10. PMID:31562564. neurofibrillary tangles of the tau protein and plaques of the amyloid β peptide are hallmarks of alzheimer's disease (ad), which is characterized by the conversion of monomeric proteins/peptides into misfolded β-sheet rich fibrils. 2020-07-10 2023-08-13 Not clear
Sanjib Bhattacharyya, Kyongwan Kim, Winfried Teize. Remodeling Tau and Prion Proteins Using Nanochaperons. Advanced biosystems. vol 1. issue 10. 2020-07-10. PMID:32646192. it is found that tau protein is overexpressed in alzheimer's disease (ad) patient serum samples and the tau conformational change can also be affected in human serum samples of ad when treated with aunps ex vivo. 2020-07-10 2023-08-13 human
Yohan Kim, Guanghao Liu, Chad J Leugers, Joseph D Mueller, Meghan B Francis, Marco M Hefti, Julie A Schneider, Gloria Le. Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains. Journal of cell science. vol 132. issue 14. 2020-07-09. PMID:31201283. tau interacts with shp2 in neuronal systems and in alzheimer's disease brains. 2020-07-09 2023-08-13 mouse
Qingyuan Fan, Wanxia He, Manoshi Gayen, Marc Robert Benoit, Xiaoyang Luo, Xiangyou Hu, Riqiang Ya. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 5. 2020-07-09. PMID:31822518. activated cx3cl1/smad2 signals prevent neuronal loss and alzheimer's tau pathology-mediated cognitive dysfunction. 2020-07-09 2023-08-13 mouse
Qingyuan Fan, Wanxia He, Manoshi Gayen, Marc Robert Benoit, Xiaoyang Luo, Xiangyou Hu, Riqiang Ya. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 5. 2020-07-09. PMID:31822518. when tg-cx3cl1 mice were crossed with alzheimer's ps19 mice, which overexpress a tau p301s mutation and exhibit age-dependent neurofibrillary tangles and neurodegeneration, overexpressed cx3cl1 in both male and female mice was sufficient to rescue the neurodegeneration, increase survival time, and improve cognitive function. 2020-07-09 2023-08-13 mouse
Miguel Tábuas-Pereira, João Durães, Joana Lopes, Francisco Sales, Conceição Bento, Diana Duro, Beatriz Santiago, Maria Rosário Almeida, Maria João Leitão, Inês Baldeiras, Isabel Santan. Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease. Epilepsy & behavior : E&B. vol 98. issue Pt A. 2020-07-08. PMID:31382178. increased csf tau is associated with a higher risk of seizures in patients with alzheimer's disease. 2020-07-08 2023-08-13 Not clear
Miguel Tábuas-Pereira, João Durães, Joana Lopes, Francisco Sales, Conceição Bento, Diana Duro, Beatriz Santiago, Maria Rosário Almeida, Maria João Leitão, Inês Baldeiras, Isabel Santan. Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease. Epilepsy & behavior : E&B. vol 98. issue Pt A. 2020-07-08. PMID:31382178. neurofibrillary tangles and tau protein, the neuropathological hallmarks of alzheimer's disease (ad), have been identified in patients with epilepsy. 2020-07-08 2023-08-13 Not clear
Giacomo Siano, Maria Claudia Caiazza, Martina Varisco, Mariantonietta Calvello, Valentina Quercioli, Antonino Cattaneo, Cristina Di Primi. Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes. Journal of visualized experiments : JoVE. issue 154. 2020-07-07. PMID:31904014. we have recently demonstrated that nuclear tau is involved in the expression of the vglut1 gene, suggesting a molecular mechanism that could explain the pathological increase of glutamate release in the early stages of alzheimer's disease. 2020-07-07 2023-08-13 Not clear
Kaj Blennow, Chun Chen, Claudia Cicognola, Kristin R Wildsmith, Paul T Manser, Sandra M Sanabria Bohorquez, Zhentao Zhang, Boer Xie, Junmin Peng, Oskar Hansson, Hlin Kvartsberg, Erik Portelius, Henrik Zetterberg, Tammaryn Lashley, Gunnar Brinkmalm, Geoffrey A Kerchner, Robby M Weimer, Keqiang Ye, Kina Höglun. Cerebrospinal fluid tau fragment correlates with tau PET: a candidate biomarker for tangle pathology. Brain : a journal of neurology. vol 143. issue 2. 2020-07-06. PMID:31834365. to date, there is no validated fluid biomarker for tau pathology in alzheimer's disease, with contradictory results from studies evaluating the correlation between phosphorylated tau in csf with tau pet imaging. 2020-07-06 2023-08-13 Not clear