| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Isabelle Bos, Stephanie J B Vos, Suzanne E Schindler, Jason Hassenstab, Chengjie Xiong, Elizabeth Grant, Frans Verhey, John C Morris, Pieter Jelle Visser, Anne M Faga. Vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 9. 2020-08-07. PMID:31378575. |
vascular risk factors are associated with longitudinal changes in cerebrospinal fluid tau markers and cognition in preclinical alzheimer's disease. |
2020-08-07 |
2023-08-13 |
Not clear |
| Lok-Kin Yeung, Christiane Hale, Briana S Last, Howard Andrews, Richard P Sloan, Lawrence S Honig, Scott A Small, Adam M Brickma. Cerebrospinal fluid amyloid levels are associated with delayed memory retention in cognitively normal biomarker-negative older adults. Neurobiology of aging. vol 84. 2020-08-06. PMID:31520793. |
alzheimer's disease is defined by abnormal levels of amyloid and tau biomarkers. |
2020-08-06 |
2023-08-13 |
Not clear |
| Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H Cribbs, Michael G Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikya. Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31847886. |
alzheimer disease (ad) is characterized by the accumulation of beta-amyloid (aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline. |
2020-08-06 |
2023-08-13 |
mouse |
| Jing Li, Weian Chen, Yanhong Yi, Qiuling Ton. miR-219-5p inhibits tau phosphorylation by targeting TTBK1 and GSK-3β in Alzheimer's disease. Journal of cellular biochemistry. vol 120. issue 6. 2020-08-05. PMID:30556160. |
mir-219-5p inhibits tau phosphorylation by targeting ttbk1 and gsk-3β in alzheimer's disease. |
2020-08-05 |
2023-08-13 |
mouse |
| Maud Gratuze, Nicolas Josset, Franck R Petry, Mathieu Pflieger, Laura Eyoum Jong, Geoffrey Truchetti, Isabelle Poitras, Jacinthe Julien, François Bezeau, Françoise Morin, Pershia Samadi, Francesca Cicchetti, Frédéric Bretzner, Emmanuel Plane. The toxin MPTP generates similar cognitive and locomotor deficits in hTau and tau knock-out mice. Brain research. vol 1711. 2020-08-04. PMID:30641037. |
studies have also documented the presence of other proteins within lewy bodies, particularly tau, a microtubule-associated protein implicated in a wide range of neurodegenerative diseases, including alzheimer's disease (ad). |
2020-08-04 |
2023-08-13 |
mouse |
| Maxime Sartori, Tiago Mendes, Shruti Desai, Alessia Lasorsa, Adrien Herledan, Nicolas Malmanche, Petra Mäkinen, Mikael Marttinen, Idir Malki, Julien Chapuis, Amandine Flaig, Anaïs-Camille Vreulx, Marion Ciancia, Philippe Amouyel, Florence Leroux, Benoit Déprez, François-Xavier Cantrelle, Damien Maréchal, Laurent Pradier, Mikko Hiltunen, Isabelle Landrieu, Devrim Kilinc, Yann Herault, Jocelyn Laporte, Jean-Charles Lamber. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31065832. |
bin1 recovers tauopathy-induced long-term memory deficits in mice and interacts with tau through thr the bridging integrator 1 gene (bin1) is a major genetic risk factor for alzheimer's disease (ad). |
2020-08-04 |
2023-08-13 |
mouse |
| Minkyung Lee, Hae-June Lee, Ye Ji Jeong, Se Jong Oh, Kyung Jun Kang, Sang Jin Han, Kyung Rok Nam, Yong Jin Lee, Kyo Chul Lee, Young Hoon Ryu, In Young Hyun, Jae Yong Cho. Age dependency of mGluR5 availability in 5xFAD mice measured by PET. Neurobiology of aging. vol 84. 2020-08-04. PMID:31570178. |
the major pathologies of alzheimer's disease (ad) are amyloid plaques and hyperphosphorylated tau. |
2020-08-04 |
2023-08-13 |
mouse |
| P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. |
neurofibrillary tau protein pathology is closely associated with the progression and phenotype of cognitive decline in alzheimer's disease and other tauopathies, and a high-priority target for disease-modifying therapies. |
2020-08-03 |
2023-08-13 |
mouse |
| P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. |
the vaccine was highly immunogenic in humans, inducing production of igg antibodies against the tau peptide in 29/30 treated elderly patients with mild-to-moderate alzheimer's. |
2020-08-03 |
2023-08-13 |
mouse |
| P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. |
these antibodies were able to recognise insoluble tau proteins in alzheimer patients' brains. |
2020-08-03 |
2023-08-13 |
mouse |
| P Novak, N Zilka, M Zilkova, B Kovacech, R Skrabana, M Ondrus, L Fialova, E Kontsekova, M Otto, M Nova. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development. The journal of prevention of Alzheimer's disease. vol 6. issue 1. 2020-08-03. PMID:30569088. |
aadvac1 is currently being investigated in a phase 2 study in alzheimer's disease, and a phase 1 study in non-fluent primary progressive aphasia, a neurodegenerative disorder with a high tau pathology component. |
2020-08-03 |
2023-08-13 |
mouse |
| G Amadoro, V Latina, V Corsetti, P Calissan. N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approach. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31676377. |
n-terminal tau truncation in the pathogenesis of alzheimer's disease (ad): developing a novel diagnostic and therapeutic approach. |
2020-08-03 |
2023-08-13 |
human |
| G Amadoro, V Latina, V Corsetti, P Calissan. N-terminal tau truncation in the pathogenesis of Alzheimer's disease (AD): Developing a novel diagnostic and therapeutic approach. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31676377. |
tau truncation occurs at early stages during the development of human alzheimer's disease (ad) and other tauopathy dementias. |
2020-08-03 |
2023-08-13 |
human |
| Maria Anele Romeo, Maria Saveria Gilardini Montani, Aurelia Gaeta, Gabriella D'Orazi, Alberto Faggioni, Mara Ciron. HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1866. issue 3. 2020-08-03. PMID:31866416. |
hhv-6a infection dysregulates autophagy/upr interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to alzheimer's disease. |
2020-08-03 |
2023-08-13 |
Not clear |
| Shorena Janelidze, Erik Stomrud, Ruben Smith, Sebastian Palmqvist, Niklas Mattsson, David C Airey, Nicholas K Proctor, Xiyun Chai, Sergey Shcherbinin, John R Sims, Gallen Triana-Baltzer, Clara Theunis, Randy Slemmon, Marc Mercken, Hartmuth Kolb, Jeffrey L Dage, Oskar Hansso. Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-07-31. PMID:32246036. |
cerebrospinal fluid (csf) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of alzheimer's disease (ad), reflecting abnormal tau metabolism in the brain. |
2020-07-31 |
2023-08-13 |
Not clear |
| J Cummings, K Blennow, K Johnson, M Keeley, R J Bateman, J L Molinuevo, J Touchon, P Aisen, B Vella. Anti-Tau Trials for Alzheimer's Disease: A Report from the EU/US/CTAD Task Force. The journal of prevention of Alzheimer's disease. vol 6. issue 3. 2020-07-30. PMID:31062825. |
efforts to develop effective disease-modifying treatments for alzheimer's disease (ad) have mostly targeted the amyloid β (aβ) protein; however, there has recently been increased interest in other targets including phosphorylated tau and other forms of tau. |
2020-07-30 |
2023-08-13 |
Not clear |
| Emre Fertan, Aimée A Wong, Nicole A Vienneau, Richard E Brow. Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb-Williams maze. Behavioural brain research. vol 370. 2020-07-30. PMID:31121220. |
the 3xtg-ad mouse model of alzheimer's disease (ad) has both amyloid beta plaque and tau tangle pathology. |
2020-07-30 |
2023-08-13 |
mouse |
| Caitlin S Latimer, Bridget T Burke, Nicole F Liachko, Heather N Currey, Mitchell D Kilgore, Laura E Gibbons, Jonathan Henriksen, Martin Darvas, Kimiko Domoto-Reilly, Suman Jayadev, Tom J Grabowski, Paul K Crane, Eric B Larson, Brian C Kraemer, Thomas D Bird, C Dirk Keen. Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31174609. |
alzheimer's disease neuropathologic change (adnc) is defined by progressive accumulation of β-amyloid plaques and hyperphosphorylated tau (ptau) neurofibrillary tangles across diverse regions of brain. |
2020-07-30 |
2023-08-13 |
human |
| Bradley R Groveman, Simote T Foliaki, Christina D Orru, Gianluigi Zanusso, James A Carroll, Brent Race, Cathryn L Haig. Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31196223. |
organoids can model aspects of neurodegeneration in alzheimer's disease and down's syndrome, reproducing tau hyperphosphorylation and amyloid plaque pathology. |
2020-07-30 |
2023-08-13 |
human |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as alzheimer's disease (ad), progressive supranuclear palsy and chronic traumatic encephalopathy. |
2020-07-30 |
2023-08-13 |
Not clear |