| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Petronela Weisová, Ondrej Cehlár, Rostislav Škrabana, Monika Žilková, Peter Filipčík, Branislav Kováčech, Michal Prčina, Ľubica Wojčiaková, Ľubica Fialová, Tomáš Smolek, Eva Kontseková, Norbert Žilka, Michal Nová. Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31391090. |
pathologically altered tau protein is a common denominator of neurodegenerative disorders including alzheimer's disease (ad) and other tauopathies. |
2020-07-30 |
2023-08-13 |
mouse |
| Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E Koch, Fanny Petit, Pauline Gipchtein, Stephen J Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, Emmanuel Brouillet, Luc Buée, Emmanuel E Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenai. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31481130. |
alzheimer's disease is characterized by cognitive alterations, cerebral atrophy and neuropathological lesions including neuronal loss, accumulation of misfolded and aggregated β-amyloid peptides (aβ) and tau proteins. |
2020-07-30 |
2023-08-13 |
mouse |
| Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E Koch, Fanny Petit, Pauline Gipchtein, Stephen J Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, Emmanuel Brouillet, Luc Buée, Emmanuel E Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenai. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31481130. |
induction of aβ and tau lesions has been demonstrated in transgenic mice after contamination with alzheimer's disease brain homogenates, with very limited functional consequences. |
2020-07-30 |
2023-08-13 |
mouse |
| Charlotte Gary, Suzanne Lam, Anne-Sophie Hérard, James E Koch, Fanny Petit, Pauline Gipchtein, Stephen J Sawiak, Raphaëlle Caillierez, Sabiha Eddarkaoui, Morvane Colin, Fabienne Aujard, Jean-Philippe Deslys, Emmanuel Brouillet, Luc Buée, Emmanuel E Comoy, Fabien Pifferi, Jean-Luc Picq, Marc Dhenai. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31481130. |
unlike rodents, primates naturally express aβ or tau under normal conditions and attempts to transmit alzheimer pathology to primates have been made for decades. |
2020-07-30 |
2023-08-13 |
mouse |
| E Feneberg, M Ott. [Gene-specific treatment approaches in Alzheimer's disease and other tauopathies]. Der Nervenarzt. vol 91. issue 4. 2020-07-30. PMID:32076757. |
the pathological hallmarks of alzheimer's disease are aggregation and accumulation of amyloid-β and tau proteins. |
2020-07-30 |
2023-08-13 |
Not clear |
| E Feneberg, M Ott. [Gene-specific treatment approaches in Alzheimer's disease and other tauopathies]. Der Nervenarzt. vol 91. issue 4. 2020-07-30. PMID:32076757. |
so far most interventional studies have focused on the removal of the toxic protein products, such as antibody-based immunotherapies targeted against amyloid-β and tau proteins; however, the development of gene therapies targeting gene products involved in the disease has opened up new therapeutic strategies to reduce the development of toxic protein aggregates by inhibiting the translation of pathological alzheimer genes using antisense oligonucleotides (aso). |
2020-07-30 |
2023-08-13 |
Not clear |
| Atsuko Kubo, Hiroaki Misonou, Makoto Matsuyama, Akane Nomori, Satoko Wada-Kakuda, Akihiko Takashima, Mitsuhiro Kawata, Shigeo Murayama, Yasuo Ihara, Tomohiro Miyasak. Distribution of endogenous normal tau in the mouse brain. The Journal of comparative neurology. vol 527. issue 5. 2020-07-28. PMID:30408165. |
in alzheimer's disease (ad), the distribution of tau undergoes a remarkable alteration, leading to the formation of tau inclusions in the somatodendritic compartment. |
2020-07-28 |
2023-08-13 |
mouse |
| Fred Yeboah, Tae-Eun Kim, Anke Bill, Ulf Dettme. Dynamic behaviors of α-synuclein and tau in the cellular context: New mechanistic insights and therapeutic opportunities in neurodegeneration. Neurobiology of disease. vol 132. 2020-07-27. PMID:31351173. |
dyshomeostasis and aggregation of both proteins are central in the pathogenesis of neurodegenerative diseases: parkinson's disease, dementia with lewy bodies, multi-system atrophy and other 'synucleinopathies' in the case of αs; alzheimer's disease, frontotemporal dementia, progressive supranuclear palsy and other 'tauopathies' in the case of tau. |
2020-07-27 |
2023-08-13 |
Not clear |
| Lin-Lin Shen, Wei-Wei Li, Ya-Li Xu, Shi-Hao Gao, Man-Yu Xu, Xian-Le Bu, Yu-Hui Liu, Jun Wang, Jie Zhu, Fan Zeng, Xiu-Qing Yao, Chang-Yue Gao, Zhi-Qiang Xu, Xin-Fu Zhou, Yan-Jiang Wan. Neurotrophin receptor p75 mediates amyloid β-induced tau pathology. Neurobiology of disease. vol 132. 2020-07-27. PMID:31394202. |
neurofibrillary tangles of hyperphosphorylated tau protein (p-tau) are a key pathological feature of alzheimer's disease (ad). |
2020-07-27 |
2023-08-13 |
Not clear |
| Hitomi Fujiwara, Shoji Watanabe, Minori Iwata, Shouyou Ueda, Mika Nobuhara, Satoko Wada-Kakuda, Hiroaki Misonou, Tomohiro Miyasak. Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies. Biochemical and biophysical research communications. vol 521. issue 3. 2020-07-27. PMID:31699369. |
neurofibrillary tangles, a pathological hallmark of alzheimer's disease (ad), are somatodendritic filamentous inclusions composed of hyperphosphorylated tau. |
2020-07-27 |
2023-08-13 |
mouse |
| Fernanda Dos Santos Petry, Bárbara Paranhos Coelho, Mariana Maier Gaelzer, Fernando Kreutz, Fátima Theresinha Costa Rodrigues Guma, Christianne Gazzana Salbego, Vera Maria Treis Trindad. Genistein protects against amyloid-beta-induced toxicity in SH-SY5Y cells by regulation of Akt and Tau phosphorylation. Phytotherapy research : PTR. vol 34. issue 4. 2020-07-27. PMID:31795012. |
alzheimer's disease is a neurodegenerative disorder characterized by extracellular deposition of amyloid-β (aβ) peptide and hyperphosphorylation of tau protein, which ultimately leads to the formation of intracellular neurofibrillary tangles and cell death. |
2020-07-27 |
2023-08-13 |
Not clear |
| Heiko Braak, Kelly Del Tredic. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. Journal of neuropathology and experimental neurology. vol 79. issue 2. 2020-07-27. PMID:31913466. |
the pathological process underlying alzheimer disease (ad) unfolds predominantly in the cerebral cortex with the gradual appearance and regional progression of abnormal tau. |
2020-07-27 |
2023-08-13 |
Not clear |
| S C Burnham, P M Coloma, Q-X Li, S Collins, G Savage, S Laws, J Doecke, P Maruff, R N Martins, D Ames, C C Rowe, C L Masters, V L Villemagn. Application of the NIA-AA Research Framework: Towards a Biological Definition of Alzheimer's Disease Using Cerebrospinal Fluid Biomarkers in the AIBL Study. The journal of prevention of Alzheimer's disease. vol 6. issue 4. 2020-07-24. PMID:31686097. |
the national institute on aging and alzheimer's association (nia-aa) have proposed a new research framework: towards a biological definition of alzheimer's disease, which uses a three-biomarker construct: aß-amyloid, tau and neurodegeneration at(n), to generate a biomarker based definition of alzheimer's disease. |
2020-07-24 |
2023-08-13 |
Not clear |
| D Michelson, M Grundman, K Magnuson, R Fisher, J M Levenson, P Aisen, K Marek, M Gray, F Heft. Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 6. issue 4. 2020-07-24. PMID:31686093. |
exploratory measurements included measurement of change in β-amyloid plaque and tau burden utilizing positron emission tomography imaging as well as measures of alzheimer's disease symptoms. |
2020-07-24 |
2023-08-13 |
mouse |
| D Michelson, M Grundman, K Magnuson, R Fisher, J M Levenson, P Aisen, K Marek, M Gray, F Heft. Randomized, Placebo Controlled Trial of NPT088, A Phage-Derived, Amyloid-Targeted Treatment for Alzheimer's Disease. The journal of prevention of Alzheimer's disease. vol 6. issue 4. 2020-07-24. PMID:31686093. |
no effect of npt088 on brain plaques, tau aggregates or alzheimer's disease symptoms was observed. |
2020-07-24 |
2023-08-13 |
mouse |
| Sjors H W Schere. Amyloid structure determination in RELION-3.1. Acta crystallographica. Section D, Structural biology. vol 76. issue Pt 2. 2020-07-24. PMID:32038040. |
their use is illustrated using a publicly available data set on tau filaments from the brain of an individual with alzheimer's disease. |
2020-07-24 |
2023-08-13 |
Not clear |
| Kelsey E McLimans, Bridget E Clark, Alexandra Plagman, Colleen Pappas, Brandon Klinedinst, Vellareddy Anatharam, Anumantha Kanthasamy, Auriel A Willett. Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease? Antioxidants & redox signaling. vol 31. issue 8. 2020-07-23. PMID:31088292. |
is cerebrospinal fluid superoxide dismutase 1 a biomarker of tau but not amyloid-induced neurodegeneration in alzheimer's disease? |
2020-07-23 |
2023-08-13 |
Not clear |
| Merle C Hoenig, Gérard N Bischof, Özgür A Onur, Juraj Kukolja, Frank Jessen, Klaus Fliessbach, Bernd Neumaier, Gereon R Fink, Elke Kalbe, Alexander Drzezga, Thilo van Eimere. Level of education mitigates the impact of tau pathology on neuronal function. European journal of nuclear medicine and molecular imaging. vol 46. issue 9. 2020-07-23. PMID:31183635. |
using pet imaging in a group of patients with alzheimer's disease (ad), we investigated whether level of education, a proxy for resilience, mitigates the harmful impact of tau pathology on neuronal function. |
2020-07-23 |
2023-08-13 |
Not clear |
| Nicolas R Barthélemy, Haiyan Liu, William Lu, Paul T Kotzbauer, Randall J Bateman, Brendan P Luce. Sleep Deprivation Affects Tau Phosphorylation in Human Cerebrospinal Fluid. Annals of neurology. vol 87. issue 5. 2020-07-23. PMID:32057125. |
tau hyperphosphorylation is an early step in tau-mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in alzheimer disease. |
2020-07-23 |
2023-08-13 |
human |
| Maximilian Strunz, Juliet T Jarrell, David S Cohen, Eric R Rosin, Charles R Vanderburg, Xudong Huan. Modulation of SPARC/Hevin Proteins in Alzheimer's Disease Brain Injury. Journal of Alzheimer's disease : JAD. vol 68. issue 2. 2020-07-22. PMID:30883351. |
alzheimer's disease (ad) is an age-related progressive form of dementia that features neuronal loss, intracellular tau, and extracellular amyloid-β (aβ) protein deposition. |
2020-07-22 |
2023-08-13 |
Not clear |