| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Carla M Startin, Nicholas J Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K Wiseman, Kin Y Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, André Strydo. Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:30902060. |
plasma biomarkers for amyloid, tau, and cytokines in down syndrome and sporadic alzheimer's disease. |
2020-05-08 |
2023-08-13 |
Not clear |
| J S Miners, P G Kehoe, S Love, H Zetterberg, K Blenno. CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31521199. |
we aimed to assess the relationship between levels of a cerebrospinal fluid (csf) marker of pericyte damage, soluble platelet-derived growth factor receptor β (spdgfrβ) and csf markers of blood-brain barrier (bbb) integrity (csf albumin and csf/serum albumin ratio) and disease pathology (reduced csf aβ42 and elevated csf total and phosphorylated tau) in alzheimer's disease (ad). |
2020-05-08 |
2023-08-13 |
Not clear |
| Cecilia A Brunello, Maria Merezhko, Riikka-Liisa Uronen, Henri J Huttune. Mechanisms of secretion and spreading of pathological tau protein. Cellular and molecular life sciences : CMLS. vol 77. issue 9. 2020-05-08. PMID:31667556. |
accumulation of misfolded and aggregated forms of tau protein in the brain is a neuropathological hallmark of tauopathies, such as alzheimer's disease and frontotemporal lobar degeneration. |
2020-05-08 |
2023-08-13 |
Not clear |
| Jennifer N Rauch, Gabriel Luna, Elmer Guzman, Morgane Audouard, Collin Challis, Youssef E Sibih, Carolina Leshuk, Israel Hernandez, Susanne Wegmann, Bradley T Hyman, Viviana Gradinaru, Martin Kampmann, Kenneth S Kosi. LRP1 is a master regulator of tau uptake and spread. Nature. vol 580. issue 7803. 2020-05-08. PMID:32296178. |
the microtubule-associated protein tau has a central role in the pathogenesis of several forms of dementia known as tauopathies-including alzheimer's disease, frontotemporal dementia and chronic traumatic encephalopathy |
2020-05-08 |
2023-08-13 |
Not clear |
| Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. |
multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in alzheimer's disease. |
2020-05-07 |
2023-08-13 |
human |
| Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. |
individuals with alzheimer's disease (ad) dementia exhibit significant heterogeneity across clinical symptoms, atrophy patterns, and spatial distribution of tau deposition. |
2020-05-07 |
2023-08-13 |
human |
| Nanbo Sun, Elizabeth C Mormino, Jianzhong Chen, Mert R Sabuncu, B T Thomas Ye. Multi-modal latent factor exploration of atrophy, cognitive and tau heterogeneity in Alzheimer's disease. NeuroImage. vol 201. 2020-05-07. PMID:31344486. |
taken together, these results suggest that distinct atrophy-cognitive patterns exist in typical alzheimer's disease, and are associated with distinct patterns of tau depositions before clinical dementia emerges. |
2020-05-07 |
2023-08-13 |
human |
| Sepideh Shokouhi, Alexander C Conley, Suzanne L Baker, Kimberly Albert, Hakmook Kang, Harry E Gwirtsman, Paul A Newhous. The relationship between domain-specific subjective cognitive decline and Alzheimer's pathology in normal elderly adults. Neurobiology of aging. vol 81. 2020-05-06. PMID:31207466. |
we evaluated the associations of subjective (self-reported everyday cognition [ecog]) and objective cognitive measures with regional amyloid-β (aβ) and tau accumulation in 86 clinically normal elderly subjects from the alzheimer's disease neuroimaging initiative. |
2020-05-06 |
2023-08-13 |
human |
| Edmond Teng, Michael Ward, Paul T Manser, Sandra Sanabria-Bohorquez, Rebecca D Ray, Kristin R Wildsmith, Suzanne Baker, Geoffrey A Kerchner, Robby M Weime. Cross-sectional associations between [ Neurobiology of aging. vol 81. 2020-05-06. PMID:31280117. |
cross-sectional associations between [ the regional relationships between tau positron emission tomography (pet) imaging and cognitive impairment in alzheimer's disease (ad) remain uncertain. |
2020-05-06 |
2023-08-13 |
Not clear |
| Rik van der Kant, Lawrence S B Goldstein, Rik Ossenkoppel. Amyloid-β-independent regulators of tau pathology in Alzheimer disease. Nature reviews. Neuroscience. vol 21. issue 1. 2020-05-06. PMID:31780819. |
amyloid-β-independent regulators of tau pathology in alzheimer disease. |
2020-05-06 |
2023-08-13 |
mouse |
| Zhicheng Chen, David Mengel, Ashvini Keshavan, Robert A Rissman, Andrew Billinton, Michael Perkinton, Jennifer Percival-Alwyn, Aaron Schultz, Michael Properzi, Keith Johnson, Dennis J Selkoe, Reisa A Sperling, Purvish Patel, Henrik Zetterberg, Douglas Galasko, Jonathan M Schott, Dominic M Wals. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30419228. |
learnings about the complexity of extracellular tau aid development of a blood-based screen for alzheimer's disease. |
2020-05-05 |
2023-08-13 |
Not clear |
| Zhicheng Chen, David Mengel, Ashvini Keshavan, Robert A Rissman, Andrew Billinton, Michael Perkinton, Jennifer Percival-Alwyn, Aaron Schultz, Michael Properzi, Keith Johnson, Dennis J Selkoe, Reisa A Sperling, Purvish Patel, Henrik Zetterberg, Douglas Galasko, Jonathan M Schott, Dominic M Wals. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30419228. |
the tau protein plays a central role in alzheimer's disease (ad), and there is huge interest in measuring tau in blood and cerebrospinal fluid (csf). |
2020-05-05 |
2023-08-13 |
Not clear |
| Xiao-Guang Li, Xiao-Yue Hong, Ya-Li Wang, Shu-Juan Zhang, Jun-Fei Zhang, Xia-Chun Li, Yan-Chao Liu, Dong-Shen Sun, Qiong Feng, Jin-Wang Ye, Yuan Gao, Dan Ke, Qun Wang, Hong-Lian Li, Keqiang Ye, Gong-Ping Liu, Jian-Zhi Wan. Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression. EMBO reports. vol 20. issue 6. 2020-05-05. PMID:31085626. |
intracellular tau accumulation forming neurofibrillary tangles is hallmark pathology of alzheimer's disease (ad), but how tau accumulation induces synapse impairment is elusive. |
2020-05-05 |
2023-08-13 |
human |
| Sarah L Griner, Paul Seidler, Jeannette Bowler, Kevin A Murray, Tianxiao Peter Yang, Shruti Sahay, Michael R Sawaya, Duilio Cascio, Jose A Rodriguez, Stephan Philipp, Justyna Sosna, Charles G Glabe, Tamir Gonen, David S Eisenber. Structure-based inhibitors of amyloid beta core suggest a common interface with tau. eLife. vol 8. 2020-05-05. PMID:31612856. |
alzheimer's disease (ad) pathology is characterized by plaques of amyloid beta (aβ) and neurofibrillary tangles of tau. |
2020-05-05 |
2023-08-13 |
Not clear |
| Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. |
grk5 influences the phosphorylation of tau via gsk3β and contributes to alzheimer's disease. |
2020-05-04 |
2023-08-13 |
mouse |
| Jianghao Zhao, Xiaohui Li, Xiongjin Chen, Yujie Cai, Yan Wang, Wenjing Sun, Hui Mai, Jingqi Yang, Weihao Fan, Pei Tang, Mingqian Ou, Yuan Zhang, Xuemei Huang, Bin Zhao, Lili Cu. GRK5 influences the phosphorylation of tau via GSK3β and contributes to Alzheimer's disease. Journal of cellular physiology. vol 234. issue 7. 2020-05-04. PMID:30511419. |
taken together, our findings suggest that grk5 deficiency contributes to the pathogenesis of alzheimer's disease by influencing the hyperphosphorylation of tau through the activation of gsk3β. |
2020-05-04 |
2023-08-13 |
mouse |
| Angelique Camilleri, Stephanie Ghio, Mario Caruana, Daniel Weckbecker, Felix Schmidt, Frits Kamp, Andrei Leonov, Sergey Ryazanov, Christian Griesinger, Armin Giese, Ruben J Cauchi, Neville Vassall. Tau-induced mitochondrial membrane perturbation is dependent upon cardiolipin. Biochimica et biophysica acta. Biomembranes. vol 1862. issue 2. 2020-05-04. PMID:31521630. |
misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which includes alzheimer's disease. |
2020-05-04 |
2023-08-13 |
human |
| Samar S Khalaf, Mohamed M Hafez, Eman T Mehanna, Noha M Mesbah, Dina M Abo-Elmatt. Combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined Alzheimer's disease and type 2 diabetes. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 6. 2020-04-30. PMID:30759264. |
combined vildagliptin and memantine treatment downregulates expression of amyloid precursor protein, and total and phosphorylated tau in a rat model of combined alzheimer's disease and type 2 diabetes. |
2020-04-30 |
2023-08-13 |
rat |
| Kelly R Jacobs, Chai K Lim, Kaj Blennow, Henrik Zetterberg, Pratishtha Chatterjee, Ralph N Martins, Bruce J Brew, Gilles J Guillemin, David B Lovejo. Correlation between plasma and CSF concentrations of kynurenine pathway metabolites in Alzheimer's disease and relationship to amyloid-β and tau. Neurobiology of aging. vol 80. 2020-04-30. PMID:31055163. |
correlation between plasma and csf concentrations of kynurenine pathway metabolites in alzheimer's disease and relationship to amyloid-β and tau. |
2020-04-30 |
2023-08-13 |
human |
| Susanne Wegmann, Rachel E Bennett, Louis Delorme, Ashley B Robbins, Miwei Hu, Danny McKenzie, Molly J Kirk, Julia Schiantarelli, Nahel Tunio, Ana C Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T Hyma. Experimental evidence for the age dependence of tau protein spread in the brain. Science advances. vol 5. issue 6. 2020-04-30. PMID:31249873. |
the incidence of alzheimer's disease (ad), which is characterized by progressive cognitive decline that correlates with the spread of tau protein aggregation in the cortical mantle, is strongly age-related. |
2020-04-30 |
2023-08-13 |
mouse |