All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors Hw Schere. Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. eLife. vol 8. 2020-03-26. PMID:30720432. tau filaments adopt different conformations in alzheimer's and pick's diseases. 2020-03-26 2023-08-13 human
Wenjuan Zhang, Benjamin Falcon, Alexey G Murzin, Juan Fan, R Anthony Crowther, Michel Goedert, Sjors Hw Schere. Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer's and Pick's diseases. eLife. vol 8. 2020-03-26. PMID:30720432. the heparin-induced tau filaments differ from those of alzheimer's or pick's disease, which have larger cores with different repeat compositions. 2020-03-26 2023-08-13 human
Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Gong Ju, Shengxi Wu, Keqiang Y. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 18. 2020-03-25. PMID:31004063. delta-secretase-cleaved tau antagonizes trkb neurotrophic signalings, mediating alzheimer's disease pathologies. 2020-03-25 2023-08-13 Not clear
Hamad Yadikar, Connor Johnson, Niko Pafundi, Edwin Mouhawasse, Lynn Nguyen, Isabel Torres, Milin Kurup, Zhihui Yang, Firas Kobeissy, Richard Yost, Kevin K Wan. Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges. International journal of molecular sciences. vol 20. issue 20. 2020-03-25. PMID:31640160. tau can be subjected to proteolysis upon calpain activation in alzheimer disease (ad), and traumatic brain injury (tbi). 2020-03-25 2023-08-13 mouse
Nicolas Sergeant, Valérie Vingtdeux, Sabiha Eddarkaoui, Marion Gay, Caroline Evrard, Nicolas Le Fur, Cyril Laurent, Raphaelle Caillierez, Hélène Obriot, Paul-Emmanuel Larchanché, Amaury Farce, Mathilde Coevoet, Pascal Carato, Mostafa Kouach, Amandine Descat, Patrick Dallemagne, Valérie Buée-Scherrer, David Blum, Malika Hamdane, Luc Buée, Patricia Melny. New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease. Neurobiology of disease. vol 129. 2020-03-24. PMID:30928644. the most promising hybrid molecule reduces both the amyloid pathology and the tau pathology as well as the memory impairments in a preclinical model of alzheimer's disease. 2020-03-24 2023-08-13 Not clear
Edgar Buhl, James P Higham, James J L Hodg. Alzheimer's disease-associated tau alters Drosophila circadian activity, sleep and clock neuron electrophysiology. Neurobiology of disease. vol 130. 2020-03-24. PMID:31207389. alzheimer's disease-associated tau alters drosophila circadian activity, sleep and clock neuron electrophysiology. 2020-03-24 2023-08-13 human
Clarissa Ferolla Mendonça, Magdalena Kuras, Fábio César Sousa Nogueira, Indira Plá, Tibor Hortobágyi, László Csiba, Miklós Palkovits, Éva Renner, Péter Döme, György Marko-Varga, Gilberto B Domont, Melinda Rezel. Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease. Neurobiology of disease. vol 130. 2020-03-24. PMID:31207390. proteomic signatures of brain regions affected by tau pathology in early and late stages of alzheimer's disease. 2020-03-24 2023-08-13 Not clear
Annika Behrendt, Maria Bichmann, Ebru Ercan-Herbst, Per Haberkant, David C Schöndorf, Michael Wolf, Salma A Fahim, Enrico Murolo, Dagmar E Ehrnhoefe. Asparagine endopeptidase cleaves tau at N167 after uptake into microglia. Neurobiology of disease. vol 130. 2020-03-24. PMID:31229689. tau cleavage by different proteolytic enzymes generates short, aggregation-prone fragments that have been implicated in the pathogenesis of alzheimer's disease (ad). 2020-03-24 2023-08-13 Not clear
Kyu-Ho Shim, Soo-Hwan Kim, Joon Hur, Dong-Hou Kim, Atanas Vladimirov Demirev, Seung-Yong Yoo. Small-molecule drug screening identifies drug Ro 31-8220 that reduces toxic phosphorylated tau in Drosophila melanogaster. Neurobiology of disease. vol 130. 2020-03-24. PMID:31233882. the intraneuronal aggregates of hyperphosphorylated and misfolded tau (neurofibrillary tangles, nfts) cause a stereotypical spatiotemporal alzheimer's disease (ad) progression that correlates with the severity of the associated cognitive decline. 2020-03-24 2023-08-13 human
Anupama Kizhakke P, Shilpa Olakkaran, Anet Antony, Siddanna Tilagul K, Gurushankara Hunasanahally . Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila model. Journal of chemical neuroanatomy. vol 95. 2020-03-23. PMID:29051039. convolvulus pluricaulis (shankhapushpi) ameliorates human microtubule-associated protein tau (hmapτ) induced neurotoxicity in alzheimer's disease drosophila model. 2020-03-23 2023-08-13 cat
Anupama Kizhakke P, Shilpa Olakkaran, Anet Antony, Siddanna Tilagul K, Gurushankara Hunasanahally . Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila model. Journal of chemical neuroanatomy. vol 95. 2020-03-23. PMID:29051039. we studied the neuroprotective effects of c. pluricaulis extract (aqueous) against human microtubule-associated protein tau (hmapτ) induced neurotoxicity in alzheimer's disease (ad) drosophila model. 2020-03-23 2023-08-13 cat
Amir Zeb, Chanin Park, Shailima Rampogu, Minky Son, GiHwan Lee, Keun Woo Le. Structure-Based Drug Designing Recommends HDAC6 Inhibitors To Attenuate Microtubule-Associated Tau-Pathogenesis. ACS chemical neuroscience. vol 10. issue 3. 2020-03-23. PMID:30407786. in tau-pathogenesis, hdac6 tightly regulates microtubule-associated tau physiology, and its inhibition suppresses alzheimer's phenotype. 2020-03-23 2023-08-13 Not clear
Rebecca L Best, Nichole E LaPointe, Jiahao Liang, Kevin Ruan, Madeleine F Shade, Leslie Wilson, Stuart C Feinstei. Tau isoform-specific stabilization of intermediate states during microtubule assembly and disassembly. The Journal of biological chemistry. vol 294. issue 33. 2020-03-23. PMID:31266806. accordingly, aberrant tau action is tightly associated with alzheimer's disease and is genetically linked to several additional neurodegenerative diseases known as tauopathies. 2020-03-23 2023-08-13 Not clear
Aurelio J Dregni, Venkata S Mandala, Haifan Wu, Matthew R Elkins, Harrison K Wang, Ivan Hung, William F DeGrado, Mei Hon. In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 33. 2020-03-23. PMID:31358628. misfolding of the microtubule-binding protein tau into filamentous aggregates is characteristic of many neurodegenerative diseases such as alzheimer's disease and progressive supranuclear palsy. 2020-03-23 2023-08-13 Not clear
Enrica Cavedo, Simone Lista, Marion Houot, Andrea Vergallo, Michel J Grothe, Stefan Teipel, Henrik Zetterberg, Kaj Blennow, Marie-Odile Habert, Marie C Potier, Bruno Dubois, Harald Hampel, Alzheimer Precision Medicine Initiativ. Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease. Neurology. vol 94. issue 1. 2020-03-23. PMID:31801830. plasma tau correlates with basal forebrain atrophy rates in people at risk for alzheimer disease. 2020-03-23 2023-08-13 Not clear
Enrica Cavedo, Simone Lista, Marion Houot, Andrea Vergallo, Michel J Grothe, Stefan Teipel, Henrik Zetterberg, Kaj Blennow, Marie-Odile Habert, Marie C Potier, Bruno Dubois, Harald Hampel, Alzheimer Precision Medicine Initiativ. Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease. Neurology. vol 94. issue 1. 2020-03-23. PMID:31801830. to investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (nfl) chain proteins are associated with annual percent change (apc) of the basal forebrain cholinergic system (bfcs) in cognitively intact older adults at risk for alzheimer disease (ad). 2020-03-23 2023-08-13 Not clear
Rik Ossenkoppele, Leonardo Iaccarino, Daniel R Schonhaut, Jesse A Brown, Renaud La Joie, James P O'Neil, Mustafa Janabi, Suzanne L Baker, Joel H Kramer, Maria-Luisa Gorno-Tempini, Bruce L Miller, Howard J Rosen, William W Seeley, William J Jagust, Gil D Rabinovic. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. NeuroImage. Clinical. vol 23. 2020-03-20. PMID:31077982. tau covariance patterns in alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. 2020-03-20 2023-08-13 Not clear
Martha S Foiani, Claudia Cicognola, Natalia Ermann, Ione O C Woollacott, Carolin Heller, Amanda J Heslegrave, Ashvini Keshavan, Ross W Paterson, Keqiang Ye, Johannes Kornhuber, Nick C Fox, Jonathan M Schott, Jason D Warren, Piotr Lewczuk, Henrik Zetterberg, Kaj Blennow, Kina Höglund, Jonathan D Rohre. Searching for novel cerebrospinal fluid biomarkers of tau pathology in frontotemporal dementia: an elusive quest. Journal of neurology, neurosurgery, and psychiatry. vol 90. issue 7. 2020-03-17. PMID:30981993. frontotemporal dementia (ftd) is a pathologically heterogeneous neurodegenerative disorder associated usually with tau or tdp-43 pathology, although some phenotypes such as logopenic variant primary progressive aphasia are more commonly associated with alzheimer's disease pathology. 2020-03-17 2023-08-13 Not clear
Seulgi Shin, Dohee Kim, Ji Yeon Song, Hyeanjeong Jeong, Seung Jae Hyeon, Neil W Kowall, Hoon Ryu, Ae Nim Pae, Sungsu Lim, Yun Kyung Ki. Visualization of soluble tau oligomers in TauP301L-BiFC transgenic mice demonstrates the progression of tauopathy. Progress in neurobiology. 2020-03-17. PMID:32105751. accumulation of abnormal tau aggregates in the brain is a pathological hallmark of multiple neurodegenerative disorders including alzheimer's disease. 2020-03-17 2023-08-13 mouse
Yuan Li, Zhijun Yao, Yue Yu, Ying Zou, Yu Fu, Bin H. Brain network alterations in individuals with and without mild cognitive impairment: parallel independent component analysis of AV1451 and AV45 positron emission tomography. BMC psychiatry. vol 19. issue 1. 2020-03-16. PMID:31159754. amyloid β (aβ) and tau proteins are considered as critical factors that affect alzheimer's disease (ad) and mild cognitive impairment (mci). 2020-03-16 2023-08-13 Not clear