All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Tae Ho Lee, Sungha Park, Mi-Hyeon You, Ji-Hong Lim, Sang-Hyun Min, Byeong Mo Ki. A potential therapeutic effect of saikosaponin C as a novel dual-target anti-Alzheimer agent. Journal of neurochemistry. vol 136. issue 6. 2019-11-20. PMID:26710244. tau and amyloid beta are two key features in alzheimer's disease. 2019-11-20 2023-08-13 human
Sachin Suresh Tiwari, Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi, Karl Peter Gies. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27524794. characteristic features of alzheimer's disease are memory loss, plaques resulting from abnormal processing of amyloid precursor protein (app), and presence of neurofibrillary tangles and dystrophic neurites containing hyperphosphorylated tau. 2019-11-20 2023-08-13 mouse
Sachin Suresh Tiwari, Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi, Karl Peter Gies. Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss. Brain : a journal of neurology. vol 139. issue Pt 10. 2019-11-20. PMID:27524794. our previous studies on p25 dysregulation put forward the hypothesis that cyfip2 expression is reduced in alzheimer's disease and that this contributes to memory impairment, abnormal app processing and tau hyperphosphorylation. 2019-11-20 2023-08-13 mouse
Meixia Guo, Dongliang Li, Huijun Shen, Baijie Jin, Yankai Ren, Manli Li, Ying Xin. Leptin-Sensitive JAK2 Activation in the Regulation of Tau Phosphorylation in PC12 Cells. Neuro-Signals. vol 24. issue 1. 2019-11-20. PMID:27603322. alzheimer's disease (ad) is characterized by two major hallmarks: the deposition and accumulation of β-amyloid (aβ) peptide and hyperphosphorylated tau in intracellular neurofibrillary tangles. 2019-11-20 2023-08-13 Not clear
Masahiro Ono, Hiroyuki Watanabe, Ayane Kitada, Kenji Matsumura, Masafumi Ihara, Hideo Saj. Highly Selective Tau-SPECT Imaging Probes for Detection of Neurofibrillary Tangles in Alzheimer's Disease. Scientific reports. vol 6. 2019-11-20. PMID:27687137. neurofibrillary tangles composed of aggregates of hyperphosphorylated tau proteins are one of the neuropathological hallmarks of alzheimer's disease (ad) in addition to the deposition of β-amyloid plaques. 2019-11-20 2023-08-13 mouse
Vishruti Makani, Bin Zhang, Heeoon Han, Yuemang Yao, Pierrik Lassalas, Kevin Lou, Ian Paterson, Virginia M Y Lee, John Q Trojanowski, Carlo Ballatore, Amos B Smith, Kurt R Brunde. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta neuropathologica communications. vol 4. issue 1. 2019-11-20. PMID:27687527. neurodegenerative disorders referred to as tauopathies, which includes alzheimer's disease (ad), are characterized by insoluble deposits of the tau protein within neuron cell bodies and dendritic processes in the brain. 2019-11-20 2023-08-13 mouse
Zhong-Hao Zhang, Chen Chen, Qiu-Yan Wu, Rui Zheng, Yao Chen, Qiong Liu, Jia-Zuan Ni, Guo-Li Son. Selenomethionine Ameliorates Neuropathology in the Olfactory Bulb of a Triple Transgenic Mouse Model of Alzheimer's Disease. International journal of molecular sciences. vol 17. issue 10. 2019-11-20. PMID:27689994. olfactory dysfunction is an early and common symptom in alzheimer's disease (ad) and is reported to be related to several pathologic changes, including the deposition of aβ and hyperphosphorylated tau protein as well as synaptic impairment. 2019-11-20 2023-08-13 mouse
Brittany N Dugger, Charisse M Whiteside, Chera L Maarouf, Douglas G Walker, Thomas G Beach, Lucia I Sue, Angelica Garcia, Travis Dunckley, Bessie Meechoovet, Eric M Reiman, Alex E Rohe. The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 54. issue 3. 2019-11-20. PMID:27716678. the presence of select tau species in human peripheral tissues and their relation to alzheimer's disease. 2019-11-20 2023-08-13 human
Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun, Shengdi Che. Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Translational neurodegeneration. vol 5. 2019-11-20. PMID:27933142. salidroside reduces tau hyperphosphorylation via up-regulating gsk-3β phosphorylation in a tau transgenic alzheimer's disease (ad) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. 2019-11-20 2023-08-13 Not clear
Gérard N Bischof, Frank Jessen, Klaus Fliessbach, Julian Dronse, Jochen Hammes, Bernd Neumaier, Oezguer Onur, Gereon R Fink, Juraj Kukolja, Alexander Drzezga, Thilo van Eimere. Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease. Annals of clinical and translational neurology. vol 3. issue 12. 2019-11-20. PMID:28097205. impact of tau and amyloid burden on glucose metabolism in alzheimer's disease. 2019-11-20 2023-08-13 Not clear
Tingting Xiao, Weiwei Zhang, Bin Jiao, Chu-Zheng Pan, Xixi Liu, Lu She. The role of exosomes in the pathogenesis of Alzheimer' disease. Translational neurodegeneration. vol 6. 2019-11-20. PMID:28184302. accumulating evidence has demonstrated that exosomes are associated with amyloid precursor (app) and tau proteins and play a controversial role in alzheimer's disease process. 2019-11-20 2023-08-13 Not clear
Urmi Sengupta, Erik Portelius, Oskar Hansson, Kathleen Farmer, Diana Castillo-Carranza, Randall Woltjer, Henrik Zetterberg, Douglas Galasko, Kaj Blennow, Rakez Kaye. Tau oligomers in cerebrospinal fluid in Alzheimer's disease. Annals of clinical and translational neurology. vol 4. issue 4. 2019-11-20. PMID:28382304. tau oligomers in cerebrospinal fluid in alzheimer's disease. 2019-11-20 2023-08-13 Not clear
Urmi Sengupta, Erik Portelius, Oskar Hansson, Kathleen Farmer, Diana Castillo-Carranza, Randall Woltjer, Henrik Zetterberg, Douglas Galasko, Kaj Blennow, Rakez Kaye. Tau oligomers in cerebrospinal fluid in Alzheimer's disease. Annals of clinical and translational neurology. vol 4. issue 4. 2019-11-20. PMID:28382304. with an increasing incidence of alzheimer's disease (ad) and neurodegenerative tauopathies, there is an urgent need to develop reliable biomarkers for the diagnosis and monitoring of the disease, such as the recently discovered toxic tau oligomers. 2019-11-20 2023-08-13 Not clear
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Paha. Correction: A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer's Disease. PloS one. vol 12. issue 6. 2019-11-20. PMID:28654697. correction: a physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of alzheimer's disease. 2019-11-20 2023-08-13 Not clear
Alessia Galasso, Charles S Cameron, Bruno G Frenguelli, Kevin G Moffa. An AMPK-dependent regulatory pathway in tau-mediated toxicity. Biology open. vol 6. issue 10. 2019-11-20. PMID:28808138. alongside its metabolic functions, it is also known to be activated in alzheimer's brains, phosphorylate tau, and be a critical autophagy activator. 2019-11-20 2023-08-13 Not clear
Fulvio Florenzano, Corsetti Veronica, Gabriele Ciasca, Maria Teresa Ciotti, Anna Pittaluga, Gunedalina Olivero, Marco Feligioni, Filomena Iannuzzi, Valentina Latina, Michele Francesco Maria Sciacca, Alessandro Sinopoli, Danilo Milardi, Giuseppe Pappalardo, De Spirito Marco, Massimiliano Papi, Anna Atlante, Antonella Bobba, Antonella Borreca, Pietro Calissano, Giuseppina Amador. Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies. Oncotarget. vol 8. issue 39. 2019-11-20. PMID:29029390. extracellular truncated tau causes early presynaptic dysfunction associated with alzheimer's disease and other tauopathies. 2019-11-20 2023-08-13 Not clear
Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. the influence of two functional genetic variants of grk5 on tau phosphorylation and their association with alzheimer's disease risk. 2019-11-20 2023-08-13 mouse
Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. we confirmed that grk5 translocates from the cellular membrane to the cytosol in the hippocampus of alzheimer's disease mice and that grk5 deficiency promotes tau hyperphosphorylation, a hallmark of alzheimer's disease pathology. 2019-11-20 2023-08-13 mouse
Yuan Zhang, Jianghao Zhao, Mingkang Yin, Yujie Cai, Shengyuan Liu, Yan Wang, Xingliang Zhang, Hao Cao, Ting Chen, Pengru Huang, Hui Mai, Zhou Liu, Hua Tao, Bin Zhao, Lili Cu. The influence of two functional genetic variants of GRK5 on tau phosphorylation and their association with Alzheimer's disease risk. Oncotarget. vol 8. issue 42. 2019-11-20. PMID:29069820. our findings suggest that the grk5-gln41leu mutant may resist tau hyperphosphorylation by promoting grk5 membrane stability and, in effect, may contribute to lower alzheimer's disease risk. 2019-11-20 2023-08-13 mouse
Andrea C Klaver, Mary P Coffey, David A Bennett, David A Loeffle. Specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and Alzheimer's disease subjects: an exploratory study. Translational neurodegeneration. vol 6. 2019-11-20. PMID:29204273. specific serum antibody binding to phosphorylated and non-phosphorylated tau in non-cognitively impaired, mildly cognitively impaired, and alzheimer's disease subjects: an exploratory study. 2019-11-20 2023-08-13 mouse