| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nima N Naseri, Hong Wang, Jennifer Guo, Manu Sharma, Wenjie Lu. The complexity of tau in Alzheimer's disease. Neuroscience letters. vol 705. 2019-12-23. PMID:31028844. |
alzheimer's disease (ad) is characterized by two major pathological lesions in the brain, amyloid plaques and neurofibrillary tangles (nfts) composed mainly of amyloid-β (aβ) peptides and hyperphosphorylated tau, respectively. |
2019-12-23 |
2023-08-13 |
Not clear |
| Harrison Tudor Evans, Joseph Benetatos, Marloes van Roijen, Liviu-Gabriel Bodea, Jürgen Göt. Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling. The EMBO journal. vol 38. issue 13. 2019-12-23. PMID:31268600. |
tau is a scaffolding protein that serves multiple cellular functions that are perturbed in neurodegenerative diseases, including alzheimer's disease (ad) and frontotemporal dementia (ftd). |
2019-12-23 |
2023-08-13 |
mouse |
| Dario Tejera, Dilek Mercan, Juan M Sanchez-Caro, Mor Hanan, David Greenberg, Hermona Soreq, Eicke Latz, Douglas Golenbock, Michael T Henek. Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome. The EMBO journal. vol 38. issue 17. 2019-12-23. PMID:31359456. |
alzheimer's disease is the most prevalent type of dementia and is caused by the deposition of extracellular amyloid-beta and abnormal tau phosphorylation. |
2019-12-23 |
2023-08-13 |
mouse |
| Mickael Audrain, Benoit Souchet, Sandro Alves, Romain Fol, Arthur Viode, Alexis Haddjeri, Satoru Tada, Nicola S Orefice, Charlène Joséphine, Alexis-Pierre Bemelmans, Thierry Delzescaux, Nicole Déglon, Philippe Hantraye, Yvette Akwa, François Becher, Jean-Marie Billard, Brigitte Potier, Patrick Dutar, Nathalie Cartier, Jérôme Braudea. βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease. Cerebral cortex (New York, N.Y. : 1991). vol 28. issue 11. 2019-12-20. PMID:29048465. |
βapp processing drives gradual tau pathology in an age-dependent amyloid rat model of alzheimer's disease. |
2019-12-20 |
2023-08-13 |
human |
| Xia Liu, Toru Yamashita, Jingwei Shang, Xiaowen Shi, Ryuta Morihara, Yong Huang, Kota Sato, Mami Takemoto, Nozomi Hishikawa, Yasuyuki Ohta, Koji Ab. Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. vol 28. issue 10. 2019-12-18. PMID:31383622. |
twendee x ameliorates phosphorylated tau, α-synuclein and neurovascular dysfunction in alzheimer's disease transgenic mice with chronic cerebral hypoperfusion. |
2019-12-18 |
2023-08-13 |
mouse |
| Eva Dávila-Bouziguet, Georgina Targa-Fabra, Jesús Ávila, Eduardo Soriano, Marta Pascua. Differential accumulation of Tau phosphorylated at residues Thr231, Ser262 and Thr205 in hippocampal interneurons and its modulation by Tau mutations (VLW) and amyloid-β peptide. Neurobiology of disease. vol 125. 2019-12-16. PMID:30553886. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β peptide (aβ) and hyperphosphorylated tau protein (p-tau). |
2019-12-16 |
2023-08-13 |
mouse |
| Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blu. Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model. Neurobiology of disease. vol 125. 2019-12-16. PMID:30665005. |
accumulation of hyper-phosphorylated and aggregated tau proteins is a neuropathological hallmark of alzheimer's disease (ad) and tauopathies. |
2019-12-16 |
2023-08-13 |
mouse |
| Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease. Neurobiology of disease. vol 125. 2019-12-16. PMID:30738142. |
loss of biliverdin reductase-a favors tau hyper-phosphorylation in alzheimer's disease. |
2019-12-16 |
2023-08-13 |
mouse |
| Nidhi Sharma, Antonella Tramutola, Chiara Lanzillotta, Andrea Arena, Carla Blarzino, Tommaso Cassano, D Allan Butterfield, Fabio Di Domenico, Marzia Perluigi, Eugenio Baron. Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease. Neurobiology of disease. vol 125. 2019-12-16. PMID:30738142. |
hyper-active gsk-3β favors tau phosphorylation during the progression of alzheimer's disease (ad). |
2019-12-16 |
2023-08-13 |
mouse |
| Tiago Fleming Outeiro, Kirsten Harvey, Antonio Dominguez-Meijide, Ellen Gerhard. LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders? Biochemical Society transactions. vol 47. issue 3. 2019-12-13. PMID:31085616. |
hyperphosphorylated tau protein accumulates in neurofibrillary tangles in the brains of alzheimer's disease patients but is also seen in the brains of pd patients. |
2019-12-13 |
2023-08-13 |
Not clear |
| Sheng-Jun Fan, Fang-I Huang, Jing-Ping Liou, Chia-Ron Yan. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer's disease model. Cell death & disease. vol 9. issue 6. 2019-12-10. PMID:29844403. |
the novel histone de acetylase 6 inhibitor, mpt0g211, ameliorates tau phosphorylation and cognitive deficits in an alzheimer's disease model. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
tau pet in autosomal dominant alzheimer's disease: relationship with cognition, dementia and other biomarkers. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
the heritability of the age of dementia onset tied to the specific mutations found in autosomal dominant alzheimer's disease families provides an elegant model to study the spread of tau across the course of the disease as well as the cross-modal relationship between tau and other biomarkers. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
to better understand the pathobiology of alzheimer's disease we measured levels of tau pet binding in individuals with dominantly inherited alzheimer's disease using data from the dominantly inherited alzheimer network (dian). |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
for comparison, tau pet was acquired on 17 older adults with sporadic, late onset alzheimer disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
the brain areas demonstrating elevated tau pet binding overlapped with those seen in sporadic alzheimer's disease, but with a greater cortical involvement and greater levels of binding despite similar cognitive impairment. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
we demonstrate that tau pet binding is elevated in symptomatic individuals with dominantly inherited alzheimer's disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Brian A Gordon, Tyler M Blazey, Jon Christensen, Aylin Dincer, Shaney Flores, Sarah Keefe, Charles Chen, Yi Su, Eric M McDade, Guoqiao Wang, Yan Li, Jason Hassenstab, Andrew Aschenbrenner, Russ Hornbeck, Clifford R Jack, Beau M Ances, Sarah B Berman, Jared R Brosch, Douglas Galasko, Serge Gauthier, James J Lah, Mario Masellis, Christopher H van Dyck, Mark A Mintun, Gregory Klein, Smiljana Ristic, Nigel J Cairns, Daniel S Marcus, Chengjie Xiong, David M Holtzman, Marcus E Raichle, John C Morris, Randall J Bateman, Tammie L S Benzinge. Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30753379. |
tau pet uptake was tied to the onset of cognitive dysfunction, and there was a higher amount, and different regional pattern of binding compared to late onset, non-familial alzheimer's disease. |
2019-12-10 |
2023-08-13 |
Not clear |
| Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk L Na, Hee Jin Kim, Chul Hyoung Lyoo, Hana Cho, Sofia Finsterwalder, Marco Duering, Sang Won Seo, Michael Ewer. Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770704. |
functional connectivity associated with tau levels in ageing, alzheimer's, and small vessel disease. |
2019-12-10 |
2023-08-13 |
human |
| Nicolai Franzmeier, Anna Rubinski, Julia Neitzel, Yeshin Kim, Alexander Damm, Duk L Na, Hee Jin Kim, Chul Hyoung Lyoo, Hana Cho, Sofia Finsterwalder, Marco Duering, Sang Won Seo, Michael Ewer. Functional connectivity associated with tau levels in ageing, Alzheimer's, and small vessel disease. Brain : a journal of neurology. vol 142. issue 4. 2019-12-10. PMID:30770704. |
in alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout the cortex, ensuing cognitive decline and dementia. |
2019-12-10 |
2023-08-13 |
human |