| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingfei Chen, Zhimin Long, Yanzhen Li, Min Luo, Shifang Luo, Guiqiong H. Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model. International journal of molecular medicine. vol 44. issue 1. 2019-11-27. PMID:31115485. |
the abnormal activation of glycogen synthase kinase 3β (gsk3β) is one of the mechanisms involved in the pathogenesis of alzheimer's disease (ad), which results in amyloid β‑peptide (aβ) plaque overproduction, tau hyperphosphorylation and neuronal loss. |
2019-11-27 |
2023-08-13 |
mouse |
| Ruensern Tan, Aileen J Lam, Tracy Tan, Jisoo Han, Dan W Nowakowski, Michael Vershinin, Sergi Simó, Kassandra M Ori-McKenney, Richard J McKenne. Microtubules gate tau condensation to spatially regulate microtubule functions. Nature cell biology. vol 21. issue 9. 2019-11-26. PMID:31481790. |
tau aggregation into insoluble fibrils is a hallmark of alzheimer's disease and other types of dementia |
2019-11-26 |
2023-08-13 |
Not clear |
| Garrett S Gibbons, Virginia M Y Lee, John Q Trojanowsk. Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review. JAMA neurology. vol 76. issue 1. 2019-11-25. PMID:30193298. |
intracellular tau protein aggregates are a pathological hallmark of neurodegenerative tauopathies, including alzheimer disease (ad), progressive supranuclear palsy (psp), corticobasal degeneration (cbd), and pick disease. |
2019-11-25 |
2023-08-13 |
Not clear |
| Nancy Bartolotti, Ahmed Disouky, Arthur Kalinski, Anat Elmann, Orly Lazaro. Phytochemicals from Achillea fragrantissima are Modulators of AβPP Metabolism. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30400087. |
here, we examined the effect of two af-derived phytochemicals on learning and memory, amyloid-β protein precursor (aβpp) metabolism, and tau phosphorylation in the familial alzheimer's disease-linked appswe/ps1Δe9 mouse model. |
2019-11-25 |
2023-08-13 |
mouse |
| Lilian Calderón-Garcidueñas, Partha S Mukherjee, Katharina Waniek, Max Holzer, Chih-Kai Chao, Charles Thompson, Rubén Ruiz-Ramos, Ana Calderón-Garcidueñas, Maricela Franco-Lira, Rafael Reynoso-Robles, Angélica Gónzalez-Maciel, Ingolf Lachman. Non-Phosphorylated Tau in Cerebrospinal Fluid is a Marker of Alzheimer's Disease Continuum in Young Urbanites Exposed to Air Pollution. Journal of Alzheimer's disease : JAD. vol 66. issue 4. 2019-11-25. PMID:30412505. |
non-phosphorylated tau in cerebrospinal fluid is a marker of alzheimer's disease continuum in young urbanites exposed to air pollution. |
2019-11-25 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Ruben Smith, Tomas Ohlsson, Olof Strandberg, Niklas Mattsson, Philip S Insel, Sebastian Palmqvist, Oskar Hansso. Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease. Neurology. vol 92. issue 6. 2019-11-25. PMID:30626656. |
associations between tau, aβ, and cortical thickness with cognition in alzheimer disease. |
2019-11-25 |
2023-08-13 |
Not clear |
| Rik Ossenkoppele, Ruben Smith, Tomas Ohlsson, Olof Strandberg, Niklas Mattsson, Philip S Insel, Sebastian Palmqvist, Oskar Hansso. Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease. Neurology. vol 92. issue 6. 2019-11-25. PMID:30626656. |
to examine the cross-sectional associations between regional tau, β-amyloid (aβ), and cortical thickness and neuropsychological function across the preclinical and clinical spectrum of alzheimer disease (ad). |
2019-11-25 |
2023-08-13 |
Not clear |
| Alberto J Espay, Joaquin A Vizcarra, Luca Marsili, Anthony E Lang, David K Simon, Aristide Merola, Keith A Josephs, Alfonso Fasano, Francesca Morgante, Rodolfo Savica, J Timothy Greenamyre, Franca Cambi, Tritia R Yamasaki, Caroline M Tanner, Ziv Gan-Or, Irene Litvan, Ignacio F Mata, Cyrus P Zabetian, Patrik Brundin, Hubert H Fernandez, David G Standaert, Marcelo A Kauffman, Michael A Schwarzschild, S Pablo Sardi, Todd Sherer, George Perry, James B Leveren. Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. Neurology. vol 92. issue 7. 2019-11-22. PMID:30745444. |
the gold standard for a definitive diagnosis of parkinson disease (pd) is the pathologic finding of aggregated α-synuclein into lewy bodies and for alzheimer disease (ad) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. |
2019-11-22 |
2023-08-13 |
Not clear |
| S.C. Papasozomenos, T. Papasozomeno. Androgens Prevent the Heat Shock-Induced Hyperphosphorylation but not Dephosphorylation of t in Female Rats. Implications for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 1. issue 3. 2019-11-20. PMID:12214000. |
because tau is abnormally hyperphosphorylated in alzheimer's disease, the possibility of using combined estrogen/androgen replacement therapy in postmenopausal women as a preventive measure against alzheimer's disease should be investigated. |
2019-11-20 |
2023-08-12 |
rat |
| Manish K. Pant, Veeranna V, Niranjana D. Amin, Nivee Amin, Harish C. Pan. Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in Vitro. Journal of Alzheimer's disease : JAD. vol 1. issue 3. 2019-11-20. PMID:12214002. |
phosphorylation activity in the alzheimer's disease and normal brain is modulated by microtubule-associated protein, tau in vitro. |
2019-11-20 |
2023-08-12 |
Not clear |
| Manish K. Pant, Veeranna V, Niranjana D. Amin, Nivee Amin, Harish C. Pan. Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in Vitro. Journal of Alzheimer's disease : JAD. vol 1. issue 3. 2019-11-20. PMID:12214002. |
processes leading to the hyperphosphorylation of tau and formation of neurofibrillary lesions in alzheimer's disease (ad) brains are not understood. |
2019-11-20 |
2023-08-12 |
Not clear |
| Manish K. Pant, Veeranna V, Niranjana D. Amin, Nivee Amin, Harish C. Pan. Phosphorylation Activity in the Alzheimer's Disease and Normal Brain is Modulated by Microtubule-Associated Protein, Tau in Vitro. Journal of Alzheimer's disease : JAD. vol 1. issue 3. 2019-11-20. PMID:12214002. |
these data suggest that the expression and differential phosphorylation of certain tau isoforms may be responsible for the robust increase in phosphorylation and may play an important role in alzheimer's pathology. |
2019-11-20 |
2023-08-12 |
Not clear |
| Gretchen Lorío, Jesús Avila, Javier Díaz-Nid. Modifications of tau protein during neuronal cell death. Journal of Alzheimer's disease : JAD. vol 3. issue 6. 2019-11-20. PMID:12214023. |
accumulation of hyperphosphorylated tau protein and progressive neuronal loss are among the major hallmarks of certain neurodegenerative disorders including alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| Fernando Moreno-Herrero, José M. Valpuesta, Mar Pérez, Jaime Colchero, Arturo M. Barö, Jesús Avila, Esteban Montejo De Garcin. Characterization by atomic force microscopy and cryoelectron microscopy of tau polymers assembled in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 3. issue 5. 2019-11-20. PMID:12214029. |
characterization by atomic force microscopy and cryoelectron microscopy of tau polymers assembled in alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| George C. Rube. CommentaryCommentary on: The Characterization by Atomic Force Microscopy and Cryoelectron Microscopy of Tau Polymers assembled in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 3. issue 5. 2019-11-20. PMID:12214030. |
commentarycommentary on: the characterization by atomic force microscopy and cryoelectron microscopy of tau polymers assembled in alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| Mikio Shoji, Mitsuyasu Kana. Cerebrospinal fluid Abeta40 and Abeta42: Natural course and clinical usefulness. Journal of Alzheimer's disease : JAD. vol 3. issue 3. 2019-11-20. PMID:12214052. |
combination assays of csf tau and abeta ratio provided further efficient diagnostic sensitivity (81%) reliability of the assay may prompt worldwide usage of these csf biomarkers for alzheimer's patients. |
2019-11-20 |
2023-08-12 |
Not clear |
| Jin-Jing Pei, Eva Braak, Heiko Braak, Inge Grundke-Iqbal, Khalid Iqbal, Bengt Winblad, Richard F. Cowbur. Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. Journal of Alzheimer's disease : JAD. vol 3. issue 1. 2019-11-20. PMID:12214071. |
the principal protein component of paired helical filaments (phfs) in alzheimer disease is abnormally hyperphosphorylated tau (phf-tau). |
2019-11-20 |
2023-08-12 |
Not clear |
| Juan Ramón Muñoz-Montaño, Filip Lim, Francisco J. Moreno, Jesús Avila, Javier Díaz-Nid. Glycogen Synthase Kinase-3 Modulates Neurite Outgrowth in Cultured Neurons: Possible Implications for Neurite Pathology in Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 1. issue 6. 2019-11-20. PMID:12214113. |
glycogen synthase kinase-3 (gsk-3) is thought to play an important role in the hyperphosphorylation of tau, and possibly other proteins, in alzheimer's disease (ad). |
2019-11-20 |
2023-08-12 |
Not clear |
| Garth F. Hal. PHF-Tau from Alzheimer Brain is Rapidly Dephosphorylated and Degraded When Injected into Neurons in situ. Journal of Alzheimer's disease : JAD. vol 1. issue 6. 2019-11-20. PMID:12214114. |
accumulation of abnormally modified tau protein (phf-tau) is the principal intracellular lesion in a variety of neurodegenerative diseases, including alzheimer's disease (ad), but the cellular mechanisms underlying this accumulation are unknown. |
2019-11-20 |
2023-08-12 |
Not clear |
| Gianfranco Natale, Francesca Biagioni, Giorgio Vivacqua, Loredana D'Este, Lorenzo Fumagalli, Francesco Forna. The neurobiology of dysautonomia in Parkinson's disease. Archives italiennes de biologie. vol 151. issue 4. 2019-11-20. PMID:24873928. |
inparticular, different proteinaceous aggregates accumulate to trigger a variety of clinical manifestations: prionprotein (prpsc) in prion diseases, β-amyloid (aβ) in alzheimer's disease (ad), α-synuclein in parkinson's disease(pd), huntingtin in huntington's disease (hd), superoxide dismutase and tdp-43 in amyotrophic lateral sclerosis(als), tau in tauopathies. |
2019-11-20 |
2023-08-13 |
Not clear |