All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30238463. in alzheimer's disease, the phosphorylation of tau is a critical event preceding the formation of neurofibrillary tangles. 2019-10-28 2023-08-13 mouse
Jeremy Koppel, Heidy Jimenez, Leslie Adrien, Eric H Chang, Anil K Malhotra, Peter Davie. Increased tau phosphorylation follows impeded dopamine clearance in a P301L and novel P301L/COMT-deleted (DM) tau mouse model. Journal of neurochemistry. vol 148. issue 1. 2019-10-28. PMID:30238463. in order to test this hypothesis, and in order to develop a mouse model of impaired dopamine metabolism and tauopathy, an extant p301l transgenic tau model of alzheimer's disease and a novel p301l/catechol-o-methyltransferase deleted model (dm mouse) were treated with the norepinephrine reuptake inhibitor reboxetine, and prefrontal dopamine concentrations and the phosphorylated state of tau was quantified. 2019-10-28 2023-08-13 mouse
Tadanori Hamano, Kouji Hayashi, Norimichi Shirafuji, Yasunari Nakamot. The Implications of Autophagy in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 14. 2019-10-28. PMID:30289076. the pathogenic mechanisms of alzheimer's disease (ad) involve the deposition of abnormally misfolded proteins, amyloid β protein (aβ) and tau protein. 2019-10-28 2023-08-13 Not clear
Hsu-Hsin Chen, Peter Liu, Paul Auger, Seung-Hye Lee, Oskar Adolfsson, Lorianne Rey-Bellet, Julien Lafrance-Vanasse, Brad A Friedman, Maria Pihlgren, Andreas Muhs, Andrea Pfeifer, James Ernst, Gai Ayalon, Kristin R Wildsmith, Thomas G Beach, Marcel P van der Bru. Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30425303. calpain-mediated tau fragmentation is altered in alzheimer's disease progression. 2019-10-28 2023-08-13 human
Hsu-Hsin Chen, Peter Liu, Paul Auger, Seung-Hye Lee, Oskar Adolfsson, Lorianne Rey-Bellet, Julien Lafrance-Vanasse, Brad A Friedman, Maria Pihlgren, Andreas Muhs, Andrea Pfeifer, James Ernst, Gai Ayalon, Kristin R Wildsmith, Thomas G Beach, Marcel P van der Bru. Calpain-mediated tau fragmentation is altered in Alzheimer's disease progression. Scientific reports. vol 8. issue 1. 2019-10-28. PMID:30425303. the aggregation of intracellular tau protein is a major hallmark of alzheimer's disease (ad). 2019-10-28 2023-08-13 human
Erika N Cline, Arighno Das, Maíra Assunção Bicca, Saad N Mohammad, Luis F Schachner, Josette M Kamel, Nadia DiNunno, Anthea Weng, Jacob D Paschall, Riana Lo Bu, Faraz M Khan, Madeline G Rollins, Ashley N Ives, Gajendra Shekhawat, Nilson Nunes-Tavares, Fernando G de Mello, Philip D Compton, Neil L Kelleher, William L Klei. A novel crosslinking protocol stabilizes amyloid β oligomers capable of inducing Alzheimer's-associated pathologies. Journal of neurochemistry. vol 148. issue 6. 2019-10-28. PMID:30565253. amyloid β oligomers (aβos) accumulate early in alzheimer's disease (ad) and experimentally cause memory dysfunction and the major pathologies associated with ad, for example, tau abnormalities, synapse loss, oxidative damage, and cognitive dysfunction. 2019-10-28 2023-08-13 mouse
Jun Wang, Wang-Sheng Jin, Xian-Le Bu, Fan Zeng, Zhi-Lin Huang, Wei-Wei Li, Lin-Lin Shen, Zhen-Qian Zhuang, Yuqiang Fang, Bin-Lu Sun, Jie Zhu, Xiu-Qing Yao, Gui-Hua Zeng, Zhi-Fang Dong, Jin-Tai Yu, Zhian Hu, Weihong Song, Hua-Dong Zhou, Jian-Xin Jiang, Yu-Hui Liu, Yan-Jiang Wan. Physiological clearance of tau in the periphery and its therapeutic potential for tauopathies. Acta neuropathologica. vol 136. issue 4. 2019-10-25. PMID:30074071. accumulation of pathological tau is the hallmark of alzheimer's disease and other tauopathies and is closely correlated with cognitive decline. 2019-10-25 2023-08-13 Not clear
Jun Sung Park, Junehawk Lee, Eun Sun Jung, Myeong-Heui Kim, Il Bin Kim, Hyeonju Son, Sangwoo Kim, Sanghyeon Kim, Young Mok Park, Inhee Mook-Jung, Seok Jong Yu, Jeong Ho Le. Brain somatic mutations observed in Alzheimer's disease associated with aging and dysregulation of tau phosphorylation. Nature communications. vol 10. issue 1. 2019-10-25. PMID:31300647. brain somatic mutations observed in alzheimer's disease associated with aging and dysregulation of tau phosphorylation. 2019-10-25 2023-08-13 Not clear
Jennifer N Rauch, John J Chen, Alexander W Sorum, Gregory M Miller, Tal Sharf, Stephanie K See, Linda C Hsieh-Wilson, Martin Kampmann, Kenneth S Kosi. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Scientific reports. vol 8. issue 1. 2019-10-22. PMID:29686391. the misfolding and accumulation of tau protein into intracellular aggregates known as neurofibrillary tangles is a pathological hallmark of neurodegenerative diseases such as alzheimer's disease. 2019-10-22 2023-08-13 mouse
Derya Metin-Armağan, Duygu Gezen-Ak, Erdinç Dursun, İrem Lütfiye Atasoy, Arzu Karabay, Selma Yılmazer, Melek Öztür. Okadaic acid-induced tau hyperphosphorylation and the downregulation of Pin1 expression in primary cortical neurons. Journal of chemical neuroanatomy. vol 92. 2019-10-22. PMID:29860071. hyperphosphorylation of tau leading to neurofibrillary tangles (nft) is one of the key pathological hallmarks in neurodegenerative disorders such as alzheimer disease (ad). 2019-10-22 2023-08-13 rat
Joshua M Tublin, Jeremy M Adelstein, Federica Del Monte, Colin K Combs, Loren E Wol. Getting to the Heart of Alzheimer Disease. Circulation research. vol 124. issue 1. 2019-10-22. PMID:30605407. in a somewhat narrow diagnostic lens, alzheimer disease (ad) has been considered a brain-specific disease characterized by the presence of aβ (β-amyloid) plaques and tau neural fibrillary tangles and neural inflammation; these pathologies lead to neuronal death and consequently clinical symptoms, such as memory loss, confusion, and impaired cognitive function. 2019-10-22 2023-08-13 Not clear
Nicolas Musi, Joseph M Valentine, Kathryn R Sickora, Eric Baeuerle, Cody S Thompson, Qiang Shen, Miranda E Or. Tau protein aggregation is associated with cellular senescence in the brain. Aging cell. vol 17. issue 6. 2019-10-21. PMID:30126037. tau protein accumulation is the most common pathology among degenerative brain diseases, including alzheimer's disease (ad), progressive supranuclear palsy (psp), traumatic brain injury (tbi), and over twenty others. 2019-10-21 2023-08-13 mouse
Diana L Castillo-Carranza, Marcos J Guerrero-Muñoz, Urmi Sengupta, Julia E Gerson, Rakez Kaye. α-Synuclein Oligomers Induce a Unique Toxic Tau Strain. Biological psychiatry. vol 84. issue 7. 2019-10-18. PMID:29478699. the coexistence of α-synuclein and tau aggregates in several neurodegenerative disorders, including parkinson's disease and alzheimer's disease, raises the possibility that a seeding mechanism is involved in disease progression. 2019-10-18 2023-08-13 Not clear
Hyunjung Baek, Chan-Ju Lee, Da Bin Choi, Nam-Sik Kim, Yong-Suk Kim, Young Jun Ye, Youn-Sub Kim, Jin Su Kim, Insop Shim, Hyunsu Ba. Bee venom phospholipase A2 ameliorates Alzheimer's disease pathology in Aβ vaccination treatment without inducing neuro-inflammation in a 3xTg-AD mouse model. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30478329. alzheimer's disease (ad) is the most common form of dementia and is characterized by an imbalance between the production and clearance of amyloid-beta (aβ) and tau proteins. 2019-10-18 2023-08-13 mouse
Rashmi Das, Subashchandrabose Chinnathamb. Microglial priming of antigen presentation and adaptive stimulation in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 76. issue 19. 2019-10-17. PMID:31093687. the prominent pathological consequences of alzheimer's disease (ad) are the misfolding and mis-sorting of two cellular proteins, amyloid-β and microtubule-associated protein tau. 2019-10-17 2023-08-13 Not clear
Melissa Wee, Fariba Chegini, John H T Power, Shohreh Maj. Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29895248. tau positive neurons show marked mitochondrial loss and nuclear degradation in alzheimer's disease. 2019-10-16 2023-08-13 Not clear
Melissa Wee, Fariba Chegini, John H T Power, Shohreh Maj. Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29895248. alzheimer's disease (ad) pathology consists of intraneuronal neurofibrillary tangles, made of hyperphosphorylated tau and extracellular accumulation of beta amyloid (aβ) in aβ plaques. 2019-10-16 2023-08-13 Not clear
Charlotte Macron, Lydie Lane, Antonio Núñez Galindo, Loïc Dayo. Deep Dive on the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification. Journal of proteome research. vol 17. issue 12. 2019-10-16. PMID:30124047. the principal alzheimer's disease biomarkers (e.g., tau protein, amyloid-β, apolipoprotein e, and neurogranin) were detected. 2019-10-16 2023-08-13 human
Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. animal studies demonstrate that hyperactive neurons facilitate early accumulation and spread of tau and amyloid-β proteins in the pathological cascade of alzheimer's disease (ad). 2019-10-16 2023-08-13 human
Carol J Huseby, Ralf Bundschuh, Jeff Kure. The role of annealing and fragmentation in human tau aggregation dynamics. The Journal of biological chemistry. vol 294. issue 13. 2019-10-16. PMID:30745358. alzheimer's disease pathogenesis is associated with the conversion of monomeric tau protein into filamentous aggregates. 2019-10-16 2023-08-13 human