All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnso. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435558. association between amyloid and tau accumulation in young adults with autosomal dominant alzheimer disease. 2019-09-24 2023-08-13 Not clear
Eric McDade, Randall J Batema. Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435570. tau positron emission tomography in autosomal dominant alzheimer disease: small windows, big picture. 2019-09-24 2023-08-13 Not clear
K Blennow, H Zetterber. Biomarkers for Alzheimer's disease: current status and prospects for the future. Journal of internal medicine. vol 284. issue 6. 2019-09-23. PMID:30051512. accumulating data from the clinical research support that the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers amyloid-β (aβ42), total tau (t-tau), and phosphorylated tau (p-tau) reflect key elements of ad pathophysiology. 2019-09-23 2023-08-13 Not clear
Andrew J Doi. Positive Feedback Loops in Alzheimer's Disease: The Alzheimer's Feedback Hypothesis. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282364. the dominant model for alzheimer's disease (ad) is the amyloid cascade hypothesis, in which the accumulation of excess amyloid-β (aβ) leads to inflammation, excess glutamate and intracellular calcium, oxidative stress, tau hyperphosphorylation and tangle formation, neuronal loss, and ultimately dementia. 2019-09-18 2023-08-13 Not clear
Michele Fiorini, Matilde Bongianni, Maria Donata Benedetti, Salvatore Monaco, Gianluigi Zanuss. Reappraisal of Aβ40 and Aβ42 Peptides Measurements in Cerebrospinal Fluid of Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282368. cerebrospinal fluid (csf) biomarkers are currently included in the diagnostic criteria for alzheimer's disease (ad), in particular, decreased concentrations of amyloid-β peptide 1-42 (aβ42) in the csf, coupled with increased levels of tau and phosphorylated tau proteins, are supportive of ad diagnosis. 2019-09-18 2023-08-13 Not clear
Heng Zhang, Xueyong Zhu, Gabriel Pascual, Jehangir S Wadia, Elissa Keogh, Jeroen J Hoozemans, Berdien Siregar, Hanna Inganäs, Esther J M Stoop, Jaap Goudsmit, Adrian Apetri, Wouter Koudstaal, Ian A Wilso. Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. Structure (London, England : 1993). vol 26. issue 12. 2019-09-18. PMID:30318466. aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of alzheimer disease (ad). 2019-09-18 2023-08-13 human
Liqun Jiang, Huijie Dong, Hua Cao, Xiaofei Ji, Siyu Luan, Jing Li. Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31056537. alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid peptide 1-42 and phosphorylation of tau protein in the brain. 2019-09-18 2023-08-13 Not clear
Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C Cullen, Hlin Kvartsberg, Ulf Andreasson, Henrik Zetterberg, Åsa Sandelius, Leslie M Shaw, Virginia M Y Lee, David J Irwin, Murray Grossman, Daniel Weintraub, Alice Chen-Plotkin, David A Wolk, Leo McCluskey, Lauren Elman, Jennifer McBride, Jon B Toledo, John Q Trojanowski, Kaj Blenno. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29700597. higher csf ng levels were positively associated with greater aβ neuritic plaque (consortium to establish a registry for alzheimer's disease (cerad) neuritic plaque score, p = 0.0002) and tau tangle pathology (braak neurofibrillary tangles staging, p = 0.0007) scores. 2019-09-17 2023-08-13 Not clear
John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29916037. the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. 2019-09-17 2023-08-13 human
Emil Ygland, Danielle van Westen, Elisabet Englund, Rosa Rademakers, Zbigniew K Wszolek, Karin Nilsson, Christer Nilsson, Maria Landqvist Waldö, Irina Alafuzoff, Oskar Hansson, Lars Gustafson, Andreas Puschman. Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29370822. the mapt c.1216c > t (p.arg406trp; r406w) mutation is a known cause of frontotemporal dementia with parkinsonism linked to chromosome 17 tau with alzheimer's disease-like clinical features. 2019-09-16 2023-08-13 Not clear
Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. anti-β-sheet conformation monoclonal antibody reduces tau and aβ oligomer pathology in an alzheimer's disease model. 2019-09-16 2023-08-13 Not clear
Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. oligomeric forms of amyloid-β (aβ) and tau are increasing being recognized as key toxins in the pathogenesis of alzheimer's disease (ad). 2019-09-16 2023-08-13 Not clear
Chun-Ling Dai, Wen Hu, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29386065. tau passive immunization blocks seeding and spread of alzheimer hyperphosphorylated tau-induced pathology in 3 × tg-ad mice. 2019-09-16 2023-08-13 mouse
Chun-Ling Dai, Wen Hu, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29386065. thus, clearance of tau seeds by immunization with tau antibodies could provide a potential therapeutic opportunity to block the spread of the pathology in alzheimer's disease (ad) and other tauopathies. 2019-09-16 2023-08-13 mouse
Wiesje M van der Flier, Ingmar Skoog, Julie A Schneider, Leonardo Pantoni, Vincent Mok, Christopher L H Chen, Philip Schelten. Vascular cognitive impairment. Nature reviews. Disease primers. vol 4. 2019-09-16. PMID:29446769. indeed, most patients with vascular dementia also have other types of pathology, the most common of which is alzheimer disease (specifically, the diffuse accumulation of amyloid-β plaques and neurofibrillary tangles composed of tau). 2019-09-16 2023-08-13 Not clear
O G Zatsepina, O I Kechko, V A Mitkevich, S A Kozin, M M Yurinskaya, M G Vinokurov, M V Serebryakova, A P Rezvykh, M B Evgen'ev, A A Makaro. Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation. Scientific reports. vol 8. issue 1. 2019-09-16. PMID:29476081. neuronal dysfunction and loss associated with the accumulation of amyloid-β (aβ) in the form of extracellular amyloid plaques and hyperphosphorylated tau in the form of intraneuronal neurofibrillary tangles represent key features of alzheimer's disease (ad). 2019-09-16 2023-08-13 human
Tanusree Sen, Pampa Saha, Nilkantha Se. Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β. Science signaling. vol 11. issue 522. 2019-09-16. PMID:29559585. acetylation of the microtubule-associated protein tau promotes its polymerization into neurofibrillary tangles that are implicated in the pathology of alzheimer's disease (ad). 2019-09-16 2023-08-13 Not clear
Sabah Khan, Nadira Y Yuldasheva, Trevor F C Batten, Alasdair R Pickles, Katherine A B Kellett, Sikha Sah. Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia? Neurochemistry international. vol 118. 2019-09-16. PMID:29649504. the phf1 tau is the main component of neurofibrillary tangle, which is the pathological hallmark of alzheimer's disease and vascular dementia. 2019-09-16 2023-08-13 mouse
Lan Cao, Yan Liang, Yunsheng Liu, Yuxia Xu, Wenbin Wan, Cuiqing Zh. Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Experimental cell research. vol 370. issue 1. 2019-09-16. PMID:29908160. tau pathology in alzheimer's disease (ad) includes hyperphosphorylation and truncation of tau. 2019-09-16 2023-08-13 Not clear
Luca Ferrari, Stefan G D Rüdige. Recombinant production and purification of the human protein Tau. Protein engineering, design & selection : PEDS. vol 31. issue 12. 2019-09-13. PMID:31265107. tau protein is a microtubule-stabilising protein whose aggregation is linked to alzheimer's disease and other forms of dementia. 2019-09-13 2023-08-13 human