Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnso. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435558. |
association between amyloid and tau accumulation in young adults with autosomal dominant alzheimer disease. |
2019-09-24 |
2023-08-13 |
Not clear |
Eric McDade, Randall J Batema. Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435570. |
tau positron emission tomography in autosomal dominant alzheimer disease: small windows, big picture. |
2019-09-24 |
2023-08-13 |
Not clear |
K Blennow, H Zetterber. Biomarkers for Alzheimer's disease: current status and prospects for the future. Journal of internal medicine. vol 284. issue 6. 2019-09-23. PMID:30051512. |
accumulating data from the clinical research support that the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers amyloid-β (aβ42), total tau (t-tau), and phosphorylated tau (p-tau) reflect key elements of ad pathophysiology. |
2019-09-23 |
2023-08-13 |
Not clear |
Andrew J Doi. Positive Feedback Loops in Alzheimer's Disease: The Alzheimer's Feedback Hypothesis. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282364. |
the dominant model for alzheimer's disease (ad) is the amyloid cascade hypothesis, in which the accumulation of excess amyloid-β (aβ) leads to inflammation, excess glutamate and intracellular calcium, oxidative stress, tau hyperphosphorylation and tangle formation, neuronal loss, and ultimately dementia. |
2019-09-18 |
2023-08-13 |
Not clear |
Michele Fiorini, Matilde Bongianni, Maria Donata Benedetti, Salvatore Monaco, Gianluigi Zanuss. Reappraisal of Aβ40 and Aβ42 Peptides Measurements in Cerebrospinal Fluid of Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282368. |
cerebrospinal fluid (csf) biomarkers are currently included in the diagnostic criteria for alzheimer's disease (ad), in particular, decreased concentrations of amyloid-β peptide 1-42 (aβ42) in the csf, coupled with increased levels of tau and phosphorylated tau proteins, are supportive of ad diagnosis. |
2019-09-18 |
2023-08-13 |
Not clear |
Heng Zhang, Xueyong Zhu, Gabriel Pascual, Jehangir S Wadia, Elissa Keogh, Jeroen J Hoozemans, Berdien Siregar, Hanna Inganäs, Esther J M Stoop, Jaap Goudsmit, Adrian Apetri, Wouter Koudstaal, Ian A Wilso. Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. Structure (London, England : 1993). vol 26. issue 12. 2019-09-18. PMID:30318466. |
aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of alzheimer disease (ad). |
2019-09-18 |
2023-08-13 |
human |
Liqun Jiang, Huijie Dong, Hua Cao, Xiaofei Ji, Siyu Luan, Jing Li. Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31056537. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid peptide 1-42 and phosphorylation of tau protein in the brain. |
2019-09-18 |
2023-08-13 |
Not clear |
Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C Cullen, Hlin Kvartsberg, Ulf Andreasson, Henrik Zetterberg, Åsa Sandelius, Leslie M Shaw, Virginia M Y Lee, David J Irwin, Murray Grossman, Daniel Weintraub, Alice Chen-Plotkin, David A Wolk, Leo McCluskey, Lauren Elman, Jennifer McBride, Jon B Toledo, John Q Trojanowski, Kaj Blenno. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29700597. |
higher csf ng levels were positively associated with greater aβ neuritic plaque (consortium to establish a registry for alzheimer's disease (cerad) neuritic plaque score, p = 0.0002) and tau tangle pathology (braak neurofibrillary tangles staging, p = 0.0007) scores. |
2019-09-17 |
2023-08-13 |
Not clear |
John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29916037. |
the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. |
2019-09-17 |
2023-08-13 |
human |
Emil Ygland, Danielle van Westen, Elisabet Englund, Rosa Rademakers, Zbigniew K Wszolek, Karin Nilsson, Christer Nilsson, Maria Landqvist Waldö, Irina Alafuzoff, Oskar Hansson, Lars Gustafson, Andreas Puschman. Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29370822. |
the mapt c.1216c > t (p.arg406trp; r406w) mutation is a known cause of frontotemporal dementia with parkinsonism linked to chromosome 17 tau with alzheimer's disease-like clinical features. |
2019-09-16 |
2023-08-13 |
Not clear |
Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. |
anti-β-sheet conformation monoclonal antibody reduces tau and aβ oligomer pathology in an alzheimer's disease model. |
2019-09-16 |
2023-08-13 |
Not clear |
Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. |
oligomeric forms of amyloid-β (aβ) and tau are increasing being recognized as key toxins in the pathogenesis of alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
Not clear |
Chun-Ling Dai, Wen Hu, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29386065. |
tau passive immunization blocks seeding and spread of alzheimer hyperphosphorylated tau-induced pathology in 3 × tg-ad mice. |
2019-09-16 |
2023-08-13 |
mouse |
Chun-Ling Dai, Wen Hu, Yunn Chyn Tung, Fei Liu, Cheng-Xin Gong, Khalid Iqba. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29386065. |
thus, clearance of tau seeds by immunization with tau antibodies could provide a potential therapeutic opportunity to block the spread of the pathology in alzheimer's disease (ad) and other tauopathies. |
2019-09-16 |
2023-08-13 |
mouse |
Wiesje M van der Flier, Ingmar Skoog, Julie A Schneider, Leonardo Pantoni, Vincent Mok, Christopher L H Chen, Philip Schelten. Vascular cognitive impairment. Nature reviews. Disease primers. vol 4. 2019-09-16. PMID:29446769. |
indeed, most patients with vascular dementia also have other types of pathology, the most common of which is alzheimer disease (specifically, the diffuse accumulation of amyloid-β plaques and neurofibrillary tangles composed of tau). |
2019-09-16 |
2023-08-13 |
Not clear |
O G Zatsepina, O I Kechko, V A Mitkevich, S A Kozin, M M Yurinskaya, M G Vinokurov, M V Serebryakova, A P Rezvykh, M B Evgen'ev, A A Makaro. Amyloid-β with isomerized Asp7 cytotoxicity is coupled to protein phosphorylation. Scientific reports. vol 8. issue 1. 2019-09-16. PMID:29476081. |
neuronal dysfunction and loss associated with the accumulation of amyloid-β (aβ) in the form of extracellular amyloid plaques and hyperphosphorylated tau in the form of intraneuronal neurofibrillary tangles represent key features of alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
human |
Tanusree Sen, Pampa Saha, Nilkantha Se. Nitrosylation of GAPDH augments pathological tau acetylation upon exposure to amyloid-β. Science signaling. vol 11. issue 522. 2019-09-16. PMID:29559585. |
acetylation of the microtubule-associated protein tau promotes its polymerization into neurofibrillary tangles that are implicated in the pathology of alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
Not clear |
Sabah Khan, Nadira Y Yuldasheva, Trevor F C Batten, Alasdair R Pickles, Katherine A B Kellett, Sikha Sah. Tau pathology and neurochemical changes associated with memory dysfunction in an optimised murine model of global cerebral ischaemia - A potential model for vascular dementia? Neurochemistry international. vol 118. 2019-09-16. PMID:29649504. |
the phf1 tau is the main component of neurofibrillary tangle, which is the pathological hallmark of alzheimer's disease and vascular dementia. |
2019-09-16 |
2023-08-13 |
mouse |
Lan Cao, Yan Liang, Yunsheng Liu, Yuxia Xu, Wenbin Wan, Cuiqing Zh. Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Experimental cell research. vol 370. issue 1. 2019-09-16. PMID:29908160. |
tau pathology in alzheimer's disease (ad) includes hyperphosphorylation and truncation of tau. |
2019-09-16 |
2023-08-13 |
Not clear |
Luca Ferrari, Stefan G D Rüdige. Recombinant production and purification of the human protein Tau. Protein engineering, design & selection : PEDS. vol 31. issue 12. 2019-09-13. PMID:31265107. |
tau protein is a microtubule-stabilising protein whose aggregation is linked to alzheimer's disease and other forms of dementia. |
2019-09-13 |
2023-08-13 |
human |