| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Diana L Castillo-Carranza, Marcos J Guerrero-Muñoz, Urmi Sengupta, Julia E Gerson, Rakez Kaye. α-Synuclein Oligomers Induce a Unique Toxic Tau Strain. Biological psychiatry. vol 84. issue 7. 2019-10-18. PMID:29478699. |
the coexistence of α-synuclein and tau aggregates in several neurodegenerative disorders, including parkinson's disease and alzheimer's disease, raises the possibility that a seeding mechanism is involved in disease progression. |
2019-10-18 |
2023-08-13 |
Not clear |
| Hyunjung Baek, Chan-Ju Lee, Da Bin Choi, Nam-Sik Kim, Yong-Suk Kim, Young Jun Ye, Youn-Sub Kim, Jin Su Kim, Insop Shim, Hyunsu Ba. Bee venom phospholipase A2 ameliorates Alzheimer's disease pathology in Aβ vaccination treatment without inducing neuro-inflammation in a 3xTg-AD mouse model. Scientific reports. vol 8. issue 1. 2019-10-18. PMID:30478329. |
alzheimer's disease (ad) is the most common form of dementia and is characterized by an imbalance between the production and clearance of amyloid-beta (aβ) and tau proteins. |
2019-10-18 |
2023-08-13 |
mouse |
| Rashmi Das, Subashchandrabose Chinnathamb. Microglial priming of antigen presentation and adaptive stimulation in Alzheimer's disease. Cellular and molecular life sciences : CMLS. vol 76. issue 19. 2019-10-17. PMID:31093687. |
the prominent pathological consequences of alzheimer's disease (ad) are the misfolding and mis-sorting of two cellular proteins, amyloid-β and microtubule-associated protein tau. |
2019-10-17 |
2023-08-13 |
Not clear |
| Melissa Wee, Fariba Chegini, John H T Power, Shohreh Maj. Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29895248. |
tau positive neurons show marked mitochondrial loss and nuclear degradation in alzheimer's disease. |
2019-10-16 |
2023-08-13 |
Not clear |
| Melissa Wee, Fariba Chegini, John H T Power, Shohreh Maj. Tau Positive Neurons Show Marked Mitochondrial Loss and Nuclear Degradation in Alzheimer's Disease. Current Alzheimer research. vol 15. issue 10. 2019-10-16. PMID:29895248. |
alzheimer's disease (ad) pathology consists of intraneuronal neurofibrillary tangles, made of hyperphosphorylated tau and extracellular accumulation of beta amyloid (aβ) in aβ plaques. |
2019-10-16 |
2023-08-13 |
Not clear |
| Charlotte Macron, Lydie Lane, Antonio Núñez Galindo, Loïc Dayo. Deep Dive on the Proteome of Human Cerebrospinal Fluid: A Valuable Data Resource for Biomarker Discovery and Missing Protein Identification. Journal of proteome research. vol 17. issue 12. 2019-10-16. PMID:30124047. |
the principal alzheimer's disease biomarkers (e.g., tau protein, amyloid-β, apolipoprotein e, and neurogranin) were detected. |
2019-10-16 |
2023-08-13 |
human |
| Willem Huijbers, Aaron P Schultz, Kathryn V Papp, Molly R LaPoint, Bernard Hanseeuw, Jasmeer P Chhatwal, Trey Hedden, Keith A Johnson, Reisa A Sperlin. Tau Accumulation in Clinically Normal Older Adults Is Associated with Hippocampal Hyperactivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 39. issue 3. 2019-10-16. PMID:30482786. |
animal studies demonstrate that hyperactive neurons facilitate early accumulation and spread of tau and amyloid-β proteins in the pathological cascade of alzheimer's disease (ad). |
2019-10-16 |
2023-08-13 |
human |
| Carol J Huseby, Ralf Bundschuh, Jeff Kure. The role of annealing and fragmentation in human tau aggregation dynamics. The Journal of biological chemistry. vol 294. issue 13. 2019-10-16. PMID:30745358. |
alzheimer's disease pathogenesis is associated with the conversion of monomeric tau protein into filamentous aggregates. |
2019-10-16 |
2023-08-13 |
human |
| Olufemi D Akilo, Pradeep Kumar, Yahya E Choonara, Priyamvada Pradeep, Lisa C du Toit, Viness Pilla. Hypothesis: apo-lactoferrin-Galantamine Proteo-alkaloid Conjugate for Alzheimer's disease Intervention. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-15. PMID:29377514. |
alzheimer's disease (ad) is known to be caused by the accumulation of deformed beta amyloid and hyperphosphorylated tau proteins resulting into formation and aggregation of senile plaques and neurofibrillary tangles in the brain. |
2019-10-15 |
2023-08-13 |
Not clear |
| Jessica E Chukwu, Jan T Pedersen, Lars Ø Pedersen, Christiane Volbracht, Einar M Sigurdsson, Xiang-Peng Kon. Tau Antibody Structure Reveals a Molecular Switch Defining a Pathological Conformation of the Tau Protein. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:29670132. |
tau antibodies have shown therapeutic potential for alzheimer's disease and several are in clinical trials. |
2019-10-15 |
2023-08-13 |
Not clear |
| Ramon Velazquez, Eric Ferreira, An Tran, Emily C Turner, Ramona Belfiore, Caterina Branca, Salvatore Odd. Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits. Aging cell. vol 17. issue 4. 2019-10-14. PMID:29749079. |
misfolded and hyperphosphorylated tau accumulates in several neurodegenerative disorders including alzheimer's disease, frontotemporal dementia with parkinsonism, corticobasal degeneration, progressive supranuclear palsy, down syndrome, and pick's disease. |
2019-10-14 |
2023-08-13 |
mouse |
| Marija Iljina, Alexander J Dear, Gonzalo A Garcia, Suman De, Laura Tosatto, Patrick Flagmeier, Daniel R Whiten, Thomas C T Michaels, Daan Frenkel, Christopher M Dobson, Tuomas P J Knowles, David Klenerma. Quantifying Co-Oligomer Formation by α-Synuclein. ACS nano. vol 12. issue 11. 2019-10-14. PMID:30371053. |
in addition, αs can form co-aggregates with its mutational variants and with other proteins such as amyloid-β (aβ) and tau, which are implicated in alzheimer's disease. |
2019-10-14 |
2023-08-13 |
Not clear |
| Radu Constantinescu, Lars Rosengren, Barbro Eriksson, Kaj Blennow, Markus Axelsso. Cerebrospinal fluid neurofilament light and tau protein as mortality biomarkers in parkinsonism. Acta neurologica Scandinavica. vol 140. issue 2. 2019-10-14. PMID:31070772. |
the cerebrospinal fluid (csf) neurodegeneration biomarkers such as neurofilament light chain (nf-l), total tau (t-tau), and the tau pathology marker phosphorylated tau (p-tau) are related to mortality in other neurological disorders (eg, amyotrophic lateral sclerosis, alzheimer's disease), but have not been investigated in this respect in parkinsonian disorders. |
2019-10-14 |
2023-08-13 |
Not clear |
| Yuetiva Deming, Logan Dumitrescu, Lisa L Barnes, Madhav Thambisetty, Brian Kunkle, Katherine A Gifford, William S Bush, Lori B Chibnik, Shubhabrata Mukherjee, Philip L De Jager, Walter Kukull, Matt Huentelman, Paul K Crane, Susan M Resnick, C Dirk Keene, Thomas J Montine, Gerard D Schellenberg, Jonathan L Haines, Henrik Zetterberg, Kaj Blennow, Eric B Larson, Sterling C Johnson, Marilyn Albert, Abhay Moghekar, Jorge L Del Aguila, Maria Victoria Fernandez, John Budde, Jason Hassenstab, Anne M Fagan, Matthias Riemenschneider, Ronald C Petersen, Lennart Minthon, Michael J Chao, Vivianna M Van Deerlin, Virginia M-Y Lee, Leslie M Shaw, John Q Trojanowski, Elaine R Peskind, Gail Li, Lea K Davis, Julia M Sealock, Nancy J Cox, Alison M Goate, David A Bennett, Julie A Schneider, Angela L Jefferson, Carlos Cruchaga, Timothy J Hohma. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta neuropathologica. vol 136. issue 6. 2019-10-09. PMID:29967939. |
cerebrospinal fluid (csf) levels of amyloid-β 42 (aβ42) and tau have been evaluated as endophenotypes in alzheimer's disease (ad) genetic studies. |
2019-10-09 |
2023-08-13 |
Not clear |
| Tomas Ondrejcak, Igor Klyubin, Grant T Corbett, Graham Fraser, Wei Hong, Alexandra J Mably, Matthew Gardener, Jayne Hammersley, Michael S Perkinton, Andrew Billinton, Dominic M Walsh, Michael J Rowa. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 38. issue 50. 2019-10-09. PMID:30355631. |
cellular prion protein mediates the disruption of hippocampal synaptic plasticity by soluble tau intracellular neurofibrillary tangles (nfts) composed of tau protein are a neuropathological hallmark of several neurodegenerative diseases, the most common of which is alzheimer's disease (ad). |
2019-10-09 |
2023-08-13 |
rat |
| Kurt A Jellinge. Different patterns of hippocampal tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30088091. |
different patterns of hippocampal tau pathology in alzheimer's disease and part. |
2019-10-08 |
2023-08-13 |
Not clear |
| Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. |
epitope determines efficacy of therapeutic anti-tau antibodies in a functional assay with human alzheimer tau. |
2019-10-08 |
2023-08-13 |
human |
| Jean-Philippe Courade, Rachel Angers, Georges Mairet-Coello, Nathalie Pacico, Kerry Tyson, Daniel Lightwood, Rebecca Munro, David McMillan, Robert Griffin, Terry Baker, Dale Starkie, Ruodan Nan, Marta Westwood, Marie-Laetitia Mushikiwabo, Sophie Jung, Geofrey Odede, Berni Sweeney, Andrew Popplewell, Gillian Burgess, Patrick Downey, Martin Citro. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30238240. |
in alzheimer's disease (ad) and other tauopathies, the cytosolic protein tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. |
2019-10-08 |
2023-08-13 |
human |
| Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. |
tau filaments from multiple cases of sporadic and inherited alzheimer's disease adopt a common fold. |
2019-10-08 |
2023-08-13 |
Not clear |
| Benjamin Falcon, Wenjuan Zhang, Manuel Schweighauser, Alexey G Murzin, Ruben Vidal, Holly J Garringer, Bernardino Ghetti, Sjors H W Scheres, Michel Goeder. Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta neuropathologica. vol 136. issue 5. 2019-10-08. PMID:30276465. |
the ordered assembly of tau protein into abnormal filaments is a defining characteristic of alzheimer's disease (ad) and other neurodegenerative disorders. |
2019-10-08 |
2023-08-13 |
Not clear |