| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah K Kaufman, Kelly Del Tredici, Talitha L Thomas, Heiko Braak, Marc I Diamon. Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29752551. |
tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in alzheimer's disease and part. |
2019-09-27 |
2023-08-13 |
human |
| Sarah K Kaufman, Kelly Del Tredici, Talitha L Thomas, Heiko Braak, Marc I Diamon. Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer's disease and PART. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29752551. |
alzheimer's disease (ad) is characterized by accumulation of tau neurofibrillary tangles (nfts) and, according to the prion model, transcellular propagation of pathological "seeds" may underlie its progression. |
2019-09-27 |
2023-08-13 |
human |
| Maitrayee Sardar Sinha, Anna Ansell-Schultz, Livia Civitelli, Camilla Hildesjö, Max Larsson, Lars Lannfelt, Martin Ingelsson, Martin Hallbec. Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers. Acta neuropathologica. vol 136. issue 1. 2019-09-27. PMID:29934873. |
the gradual deterioration of cognitive functions in alzheimer's disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. |
2019-09-27 |
2023-08-13 |
Not clear |
| Nicholas J Ashton, Mark Ide, Michael Schöll, Kaj Blennow, Simon Lovestone, Abdul Hye, Henrik Zetterber. No association of salivary total tau concentration with Alzheimer's disease. Neurobiology of aging. vol 70. 2019-09-27. PMID:30007161. |
no association of salivary total tau concentration with alzheimer's disease. |
2019-09-27 |
2023-08-13 |
human |
| Dong Liu, Hanbing Lu, Elliot Stein, Zhujuan Zhou, Yihong Yang, Mark P Mattso. Brain regional synchronous activity predicts tauopathy in 3×TgAD mice. Neurobiology of aging. vol 70. 2019-09-27. PMID:30015035. |
alzheimer's disease (ad) is characterized by progressive cognitive impairment and by extensive neuronal loss associated with extracellular amyloid β-peptide (aβ) plaques and intraneuronal tau pathology in temporal and parietal lobes. |
2019-09-27 |
2023-08-13 |
mouse |
| Juan Antonio García-León, Alfredo Cabrera-Socorro, Kristel Eggermont, Ann Swijsen, Joke Terryn, Raheem Fazal, FatemehArefeh Nami, Laura Ordovás, Ana Quiles, Frederic Lluis, Lutgarde Serneels, Keimpe Wierda, Annerieke Sierksma, Mohamed Kreir, Francisco Pestana, Philip Van Damme, Bart De Strooper, Lieven Thorrez, Andreas Ebneth, Catherine M Verfailli. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 10. 2019-09-27. PMID:30036493. |
tauopathies are neurodegenerative diseases characterized by tau protein-related pathology, including frontotemporal dementia and alzheimer's disease among others. |
2019-09-27 |
2023-08-13 |
human |
| Antonella Tramutola, Giulia Abate, Chiara Lanzillotta, Francesca Triani, Eugenio Barone, Federica Iavarone, Federica Vincenzoni, Massimo Castagnola, Mariagrazia Marziano, Maurizio Memo, Emirena Garrafa, D Allan Butterfield, Marzia Perluigi, Fabio Di Domenico, Daniela Ubert. Protein nitration profile of CD3 Free radical biology & medicine. vol 129. 2019-09-27. PMID:30321702. |
protein nitration profile of cd3 alzheimer's disease (ad) is a progressive form of dementia characterized by increased production of amyloid-β plaques and hyperphosphorylated tau protein, mitochondrial dysfunction, elevated oxidative stress, reduced protein clearance, among other. |
2019-09-27 |
2023-08-13 |
Not clear |
| Klaus Fließbach, Cornelia McCormick, Barbara Kaulen, Anja Schneide. [Anti-tau therapies-what can be expected?] Der Nervenarzt. vol 90. issue 9. 2019-09-25. PMID:31332452. |
alzheimer's disease is histopathologically characterized by aggregation of two proteins, namely amyloid-beta peptide and tau protein. |
2019-09-25 |
2023-08-13 |
Not clear |
| Yakeel T Quiroz, Reisa A Sperling, Daniel J Norton, Ana Baena, Joseph F Arboleda-Velasquez, Danielle Cosio, Aaron Schultz, Molly Lapoint, Edmarie Guzman-Velez, John B Miller, Leo A Kim, Kewei Chen, Pierre N Tariot, Francisco Lopera, Eric M Reiman, Keith A Johnso. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435558. |
association between amyloid and tau accumulation in young adults with autosomal dominant alzheimer disease. |
2019-09-24 |
2023-08-13 |
Not clear |
| Eric McDade, Randall J Batema. Tau Positron Emission Tomography in Autosomal Dominant Alzheimer Disease: Small Windows, Big Picture. JAMA neurology. vol 75. issue 5. 2019-09-24. PMID:29435570. |
tau positron emission tomography in autosomal dominant alzheimer disease: small windows, big picture. |
2019-09-24 |
2023-08-13 |
Not clear |
| K Blennow, H Zetterber. Biomarkers for Alzheimer's disease: current status and prospects for the future. Journal of internal medicine. vol 284. issue 6. 2019-09-23. PMID:30051512. |
accumulating data from the clinical research support that the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers amyloid-β (aβ42), total tau (t-tau), and phosphorylated tau (p-tau) reflect key elements of ad pathophysiology. |
2019-09-23 |
2023-08-13 |
Not clear |
| Andrew J Doi. Positive Feedback Loops in Alzheimer's Disease: The Alzheimer's Feedback Hypothesis. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282364. |
the dominant model for alzheimer's disease (ad) is the amyloid cascade hypothesis, in which the accumulation of excess amyloid-β (aβ) leads to inflammation, excess glutamate and intracellular calcium, oxidative stress, tau hyperphosphorylation and tangle formation, neuronal loss, and ultimately dementia. |
2019-09-18 |
2023-08-13 |
Not clear |
| Michele Fiorini, Matilde Bongianni, Maria Donata Benedetti, Salvatore Monaco, Gianluigi Zanuss. Reappraisal of Aβ40 and Aβ42 Peptides Measurements in Cerebrospinal Fluid of Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-18. PMID:30282368. |
cerebrospinal fluid (csf) biomarkers are currently included in the diagnostic criteria for alzheimer's disease (ad), in particular, decreased concentrations of amyloid-β peptide 1-42 (aβ42) in the csf, coupled with increased levels of tau and phosphorylated tau proteins, are supportive of ad diagnosis. |
2019-09-18 |
2023-08-13 |
Not clear |
| Heng Zhang, Xueyong Zhu, Gabriel Pascual, Jehangir S Wadia, Elissa Keogh, Jeroen J Hoozemans, Berdien Siregar, Hanna Inganäs, Esther J M Stoop, Jaap Goudsmit, Adrian Apetri, Wouter Koudstaal, Ian A Wilso. Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody. Structure (London, England : 1993). vol 26. issue 12. 2019-09-18. PMID:30318466. |
aggregation of the hyperphosphorylated protein tau into neurofibrillary tangles and neuropil threads is a hallmark of alzheimer disease (ad). |
2019-09-18 |
2023-08-13 |
human |
| Liqun Jiang, Huijie Dong, Hua Cao, Xiaofei Ji, Siyu Luan, Jing Li. Exosomes in Pathogenesis, Diagnosis, and Treatment of Alzheimer's Disease. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-18. PMID:31056537. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid peptide 1-42 and phosphorylation of tau protein in the brain. |
2019-09-18 |
2023-08-13 |
Not clear |
| Erik Portelius, Bob Olsson, Kina Höglund, Nicholas C Cullen, Hlin Kvartsberg, Ulf Andreasson, Henrik Zetterberg, Åsa Sandelius, Leslie M Shaw, Virginia M Y Lee, David J Irwin, Murray Grossman, Daniel Weintraub, Alice Chen-Plotkin, David A Wolk, Leo McCluskey, Lauren Elman, Jennifer McBride, Jon B Toledo, John Q Trojanowski, Kaj Blenno. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29700597. |
higher csf ng levels were positively associated with greater aβ neuritic plaque (consortium to establish a registry for alzheimer's disease (cerad) neuritic plaque score, p = 0.0002) and tau tangle pathology (braak neurofibrillary tangles staging, p = 0.0007) scores. |
2019-09-17 |
2023-08-13 |
Not clear |
| John L Robinson, Maria M Corrada, Gabor G Kovacs, Myrna Dominique, Carrie Caswell, Sharon X Xie, Virginia M-Y Lee, Claudia H Kawas, John Q Trojanowsk. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta neuropathologica. vol 136. issue 3. 2019-09-17. PMID:29916037. |
the diagnosis of alzheimer's disease (ad) in the oldest-old is complicated by the increasing prevalence of age-related neurofibrillary tangles, plaques and non-ad pathologies such as cerebrovascular disease (cvd), hippocampal sclerosis (hs), aging-related tau astrogliopathy (artag), as well as tdp-43 and lewy pathology. |
2019-09-17 |
2023-08-13 |
human |
| Emil Ygland, Danielle van Westen, Elisabet Englund, Rosa Rademakers, Zbigniew K Wszolek, Karin Nilsson, Christer Nilsson, Maria Landqvist Waldö, Irina Alafuzoff, Oskar Hansson, Lars Gustafson, Andreas Puschman. Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29370822. |
the mapt c.1216c > t (p.arg406trp; r406w) mutation is a known cause of frontotemporal dementia with parkinsonism linked to chromosome 17 tau with alzheimer's disease-like clinical features. |
2019-09-16 |
2023-08-13 |
Not clear |
| Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. |
anti-β-sheet conformation monoclonal antibody reduces tau and aβ oligomer pathology in an alzheimer's disease model. |
2019-09-16 |
2023-08-13 |
Not clear |
| Fernando Goñi, Mitchell Martá-Ariza, Krystal Herline, Daniel Peyser, Allal Boutajangout, Pankaj Mehta, Eleanor Drummond, Frances Prelli, Thomas Wisniewsk. Anti-β-sheet conformation monoclonal antibody reduces tau and Aβ oligomer pathology in an Alzheimer's disease model. Alzheimer's research & therapy. vol 10. issue 1. 2019-09-16. PMID:29378642. |
oligomeric forms of amyloid-β (aβ) and tau are increasing being recognized as key toxins in the pathogenesis of alzheimer's disease (ad). |
2019-09-16 |
2023-08-13 |
Not clear |