All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Stephen T Chen, Prabha Siddarth, David A Merrill, Jacqueline Martinez, Natacha D Emerson, Jie Liu, Koon-Pong Wong, Nagichettiar Satyamurthy, Christopher C Giza, Sung-Cheng Huang, Robert P Fitzsimmons, Julian Bailes, Bennet Omalu, Jorge R Barrio, Gary W Smal. FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy1. Journal of Alzheimer's disease : JAD. vol 65. issue 1. 2019-07-29. PMID:30040711. our group has shown that in vivo tau brain binding patterns from fddnp-pet scans in retired professional football players with suspected chronic traumatic encephalopathy differ from those of tau and amyloid aggregate binding observed in alzheimer's disease (ad) patients and cognitively-intact controls. 2019-07-29 2023-08-13 Not clear
Marc Vandermeeren, Marianne Borgers, Kristof Van Kolen, Clara Theunis, Bruno Vasconcelos, Astrid Bottelbergs, Cindy Wintmolders, Guy Daneels, Roland Willems, Koen Dockx, Lore Delbroek, André Marreiro, Luc Ver Donck, Cristiano Sousa, Rupesh Nanjunda, Eilyn Lacy, Tom Van De Casteele, Debby Van Dam, Peter Paul De Deyn, John A Kemp, Thomas J Malia, Marc H Mercke. Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo. Journal of Alzheimer's disease : JAD. vol 65. issue 1. 2019-07-29. PMID:30040731. the tau spreading hypothesis provides rationale for passive immunization with an anti-tau monoclonal antibody to block seeding by extracellular tau aggregates as a disease-modifying strategy for the treatment of alzheimer's disease (ad) and potentially other tauopathies. 2019-07-29 2023-08-13 human
Joanna Gerszon, Aleksandra Rodack. Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weight compounds in counteracting its aggregation and nuclear translocation. Ageing research reviews. vol 48. 2019-07-29. PMID:30254002. also the role of gapdh in neurodegenerative diseases is linked to it directly binding to specific amyloidogenic proteins and petides such as β-amyloid precursor protein, β-amyloid peptide and tau protein in alzheimer's disease, huntingtin in huntington's disease and α-synuclein in parkinson disease. 2019-07-29 2023-08-13 Not clear
Min Shi, Lu Tang, Jon B Toledo, Carmen Ginghina, Hua Wang, Patrick Aro, Poul H Jensen, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Murray Grossman, Leo McCluskey, Lauren B Elman, David A Wolk, Edward B Lee, Leslie M Shaw, John Q Trojanowski, Jing Zhan. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 8. 2019-07-26. PMID:29604263. the ability of alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers (amyloid β peptide 1-42, total tau, and phosphorylated tau) to discriminate ad from related disorders is limited. 2019-07-26 2023-08-13 Not clear
Jennifer L Whitwell, Jonathan Graff-Radford, Nirubol Tosakulwong, Stephen D Weigand, Mary M Machulda, Matthew L Senjem, Anthony J Spychalla, Prashanthi Vemuri, David T Jones, Daniel A Drubach, David S Knopman, Bradley F Boeve, Nilüfer Ertekin-Taner, Ronald C Petersen, Val J Lowe, Clifford R Jack, Keith A Joseph. Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 8. 2019-07-26. PMID:29605222. imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical alzheimer's disease. 2019-07-26 2023-08-13 Not clear
Michelle M Mielke, Clinton E Hagen, Jing Xu, Xiyun Chai, Prashanthi Vemuri, Val J Lowe, David C Airey, David S Knopman, Rosebud O Roberts, Mary M Machulda, Clifford R Jack, Ronald C Petersen, Jeffrey L Dag. Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 14. issue 8. 2019-07-26. PMID:29626426. we examined and compared plasma phospho-tau181 (ptau181) and total tau: (1) across the alzheimer's disease (ad) clinical spectrum; (2) in relation to brain amyloid β (aβ) positron emission tomography (pet), tau pet, and cortical thickness; and (3) as a screening tool for elevated brain aβ. 2019-07-26 2023-08-13 Not clear
Anupa Majumdar, Priyanka Dogra, Shiny Maity, Samrat Mukhopadhya. Liquid-Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules. The journal of physical chemistry letters. vol 10. issue 14. 2019-07-26. PMID:31260322. here we present a unique case to demonstrate that unusual conformational expansion events coupled with solvation and fluctuations drive phase separation of tau, an idp associated with alzheimer's disease. 2019-07-26 2023-08-13 Not clear
Ian Fyf. Alzheimer disease: Tau pathology in atomic detail. Nature reviews. Neurology. vol 13. issue 9. 2019-07-25. PMID:28731038. alzheimer disease: tau pathology in atomic detail. 2019-07-25 2023-08-13 Not clear
Ana V Rojas, Gia G Maisuradze, Harold A Scherag. Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N-Terminal Region of Aβ. The journal of physical chemistry. B. vol 122. issue 28. 2019-07-25. PMID:29940109. one of the hallmarks of alzheimer's disease is the formation of aggregates of the tau protein, a process that can be facilitated by the presence of fibrils formed by the amyloid β peptide (aβ). 2019-07-25 2023-08-13 Not clear
Evan Lester, Roy Parke. The Tau of Nuclear-Cytoplasmic Transport. Neuron. vol 99. issue 5. 2019-07-25. PMID:30189205. aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including alzheimer's disease. 2019-07-25 2023-08-13 Not clear
Steve Pedrini, Veer B Gupta, Eugene Hone, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martin. A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29070909. alzheimer's disease (ad) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. 2019-07-24 2023-08-13 human
Kyung Min Chung, Nancy Hernández, Andrew A Sproul, Wai Haung Y. Alzheimer's disease and the autophagic-lysosomal system. Neuroscience letters. vol 697. 2019-07-24. PMID:29758300. in particular, alzheimer's disease (ad) is characterized by abnormal accumulation of protein aggregates, primarily extracellular plaques composed of the aβ peptide and intracellular tangles comprised of the tau protein, both of which may indicate a primary defect in protein clearance. 2019-07-24 2023-08-13 Not clear
Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30604097. tauopathies consist of intracellular accumulation of hyperphosphorylated and aggregated microtubule protein tau, which remains a histopathological feature of alzheimer's disease (ad) and frontotemporal dementia. 2019-07-24 2023-08-13 mouse
b' Susann Schweiger, Frank Matthes, Karen Posey, Eva Kickstein, Stephanie Weber, Moritz M Hettich, Sandra Pfurtscheller, Dan Ehninger, Rainer Schneider, Sybille Krau\\xc3\\x9. Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific reports. vol 7. issue 1. 2019-07-23. PMID:29062069.' the formation of paired helical filaments (phf), which are composed of hyperphosphorylated tau protein dissociating from microtubules, is one of the pathological hallmarks of alzheimer's disease (ad) and other tauopathies. 2019-07-23 2023-08-13 Not clear
Helmut Heinsen, Lea T Grinber. On the origin of tau seeding activity in Alzheimer's disease. Acta neuropathologica. vol 136. issue 5. 2019-07-23. PMID:30039213. on the origin of tau seeding activity in alzheimer's disease. 2019-07-23 2023-08-13 Not clear
Siddhartha Mondragón-Rodríguez, Ning Gu, Caroline Fasano, Fernando Peña-Ortega, Sylvain William. Functional Connectivity between Hippocampus and Lateral Septum is Affected in Very Young Alzheimer's Transgenic Mouse Model. Neuroscience. vol 401. 2019-07-23. PMID:30599271. alzheimer's disease (ad) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits. 2019-07-23 2023-08-13 mouse
Elentina K Argyrousi, Agnieszka Staniszewski, Russell E Nicholls, Ottavio Aranci. Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886529. oligomerization of soluble tau protein is attracting the attention of an increasingly larger number of scientists involved in research on alzheimer's disease and other tauopathies. 2019-07-22 2023-08-13 Not clear
Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Eckhard Mandelko. Purification and Characterization of Low-n Tau Oligomers. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886530. one of the most studied tauopathies is alzheimer disease (ad) in which tau protein aggregates into filaments and coalesces into neurofibrillary tangles. 2019-07-22 2023-08-13 Not clear
Alexander Sandberg, Sofie Nyströ. Purification and Fibrillation of Recombinant Human Amyloid-β, Prion Protein, and Tau Under Native Conditions. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886532. we here report protocols for production, purification, and fibrillation of three different proteins commonly found in cerebral amyloid; aβ and tau found in alzheimer's disease, chronic traumatic brain injury, corticobasal degeneration, and progressive supranuclear palsy and human prion protein found in creutzfeldt-jakob's disease. 2019-07-22 2023-08-13 human
Dov B Shamir, Yan Deng, Einar M Sigurdsso. Live Imaging of Pathological Tau Protein and Tau Antibodies in a Neuron-Like Cellular Model. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886544. several tau antibody therapies are now in clinical trials and numerous other tau antibodies are in various stages of preclinical development to treat alzheimer's disease and related tauopathies. 2019-07-22 2023-08-13 mouse