| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anupa Majumdar, Priyanka Dogra, Shiny Maity, Samrat Mukhopadhya. Liquid-Liquid Phase Separation Is Driven by Large-Scale Conformational Unwinding and Fluctuations of Intrinsically Disordered Protein Molecules. The journal of physical chemistry letters. vol 10. issue 14. 2019-07-26. PMID:31260322. |
here we present a unique case to demonstrate that unusual conformational expansion events coupled with solvation and fluctuations drive phase separation of tau, an idp associated with alzheimer's disease. |
2019-07-26 |
2023-08-13 |
Not clear |
| Ian Fyf. Alzheimer disease: Tau pathology in atomic detail. Nature reviews. Neurology. vol 13. issue 9. 2019-07-25. PMID:28731038. |
alzheimer disease: tau pathology in atomic detail. |
2019-07-25 |
2023-08-13 |
Not clear |
| Ana V Rojas, Gia G Maisuradze, Harold A Scherag. Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N-Terminal Region of Aβ. The journal of physical chemistry. B. vol 122. issue 28. 2019-07-25. PMID:29940109. |
one of the hallmarks of alzheimer's disease is the formation of aggregates of the tau protein, a process that can be facilitated by the presence of fibrils formed by the amyloid β peptide (aβ). |
2019-07-25 |
2023-08-13 |
Not clear |
| Evan Lester, Roy Parke. The Tau of Nuclear-Cytoplasmic Transport. Neuron. vol 99. issue 5. 2019-07-25. PMID:30189205. |
aggregation of microtubule-associated protein tau is the hallmark of tauopathies, including alzheimer's disease. |
2019-07-25 |
2023-08-13 |
Not clear |
| Steve Pedrini, Veer B Gupta, Eugene Hone, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martin. A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort. Scientific reports. vol 7. issue 1. 2019-07-24. PMID:29070909. |
alzheimer's disease (ad) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. |
2019-07-24 |
2023-08-13 |
human |
| Kyung Min Chung, Nancy Hernández, Andrew A Sproul, Wai Haung Y. Alzheimer's disease and the autophagic-lysosomal system. Neuroscience letters. vol 697. 2019-07-24. PMID:29758300. |
in particular, alzheimer's disease (ad) is characterized by abnormal accumulation of protein aggregates, primarily extracellular plaques composed of the aβ peptide and intracellular tangles comprised of the tau protein, both of which may indicate a primary defect in protein clearance. |
2019-07-24 |
2023-08-13 |
Not clear |
| Pranav Vemula, Yu Jing, Hu Zhang, Jerry B Hunt, Leslie A Sandusky-Beltran, Daniel C Lee, Ping Li. Altered brain arginine metabolism in a mouse model of tauopathy. Amino acids. vol 51. issue 3. 2019-07-24. PMID:30604097. |
tauopathies consist of intracellular accumulation of hyperphosphorylated and aggregated microtubule protein tau, which remains a histopathological feature of alzheimer's disease (ad) and frontotemporal dementia. |
2019-07-24 |
2023-08-13 |
mouse |
| b' Susann Schweiger, Frank Matthes, Karen Posey, Eva Kickstein, Stephanie Weber, Moritz M Hettich, Sandra Pfurtscheller, Dan Ehninger, Rainer Schneider, Sybille Krau\\xc3\\x9. Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex. Scientific reports. vol 7. issue 1. 2019-07-23. PMID:29062069.' |
the formation of paired helical filaments (phf), which are composed of hyperphosphorylated tau protein dissociating from microtubules, is one of the pathological hallmarks of alzheimer's disease (ad) and other tauopathies. |
2019-07-23 |
2023-08-13 |
Not clear |
| Helmut Heinsen, Lea T Grinber. On the origin of tau seeding activity in Alzheimer's disease. Acta neuropathologica. vol 136. issue 5. 2019-07-23. PMID:30039213. |
on the origin of tau seeding activity in alzheimer's disease. |
2019-07-23 |
2023-08-13 |
Not clear |
| Siddhartha Mondragón-Rodríguez, Ning Gu, Caroline Fasano, Fernando Peña-Ortega, Sylvain William. Functional Connectivity between Hippocampus and Lateral Septum is Affected in Very Young Alzheimer's Transgenic Mouse Model. Neuroscience. vol 401. 2019-07-23. PMID:30599271. |
alzheimer's disease (ad) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits. |
2019-07-23 |
2023-08-13 |
mouse |
| Elentina K Argyrousi, Agnieszka Staniszewski, Russell E Nicholls, Ottavio Aranci. Preparation of Tau Oligomers After the Protein Extraction from Bacteria and Brain Cortices. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886529. |
oligomerization of soluble tau protein is attracting the attention of an increasingly larger number of scientists involved in research on alzheimer's disease and other tauopathies. |
2019-07-22 |
2023-08-13 |
Not clear |
| Senthilvelrajan Kaniyappan, Ram Reddy Chandupatla, Eckhard Mandelko. Purification and Characterization of Low-n Tau Oligomers. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886530. |
one of the most studied tauopathies is alzheimer disease (ad) in which tau protein aggregates into filaments and coalesces into neurofibrillary tangles. |
2019-07-22 |
2023-08-13 |
Not clear |
| Alexander Sandberg, Sofie Nyströ. Purification and Fibrillation of Recombinant Human Amyloid-β, Prion Protein, and Tau Under Native Conditions. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886532. |
we here report protocols for production, purification, and fibrillation of three different proteins commonly found in cerebral amyloid; aβ and tau found in alzheimer's disease, chronic traumatic brain injury, corticobasal degeneration, and progressive supranuclear palsy and human prion protein found in creutzfeldt-jakob's disease. |
2019-07-22 |
2023-08-13 |
human |
| Dov B Shamir, Yan Deng, Einar M Sigurdsso. Live Imaging of Pathological Tau Protein and Tau Antibodies in a Neuron-Like Cellular Model. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886544. |
several tau antibody therapies are now in clinical trials and numerous other tau antibodies are in various stages of preclinical development to treat alzheimer's disease and related tauopathies. |
2019-07-22 |
2023-08-13 |
mouse |
| Senthilkumar Krishnaswamy, Qian Wu, Yan Lin, Wajitha J Rajamohamedsait, Hameetha B Rajamohamedsait, Einar M Sigurdsso. In Vivo Imaging of Tauopathy in Mice. Methods in molecular biology (Clifton, N.J.). vol 1779. 2019-07-22. PMID:29886554. |
alzheimer's disease is characterized by amyloid-β plaques and neurofibrillary tangles composed of tau aggregates. |
2019-07-22 |
2023-08-13 |
mouse |
| Seyyed Mojtaba Mousavi, Maryam Zarei, Seyyed Alireza Hashemi, Aziz Babapoor, Ali Mohammad Aman. A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-07-22. PMID:30942110. |
then in the next step, the detailed description is followed on their applications in the fields of anticancer activity, drug discovery, and an innovative type of rhodanine (rh) and thiohydantoin (th) derivatives were created and combined in order to recognize tau pathology in the brains of patients with alzheimer's disease (ad). |
2019-07-22 |
2023-08-13 |
Not clear |
| Niklas Mattsson, Ruben Smith, Olof Strandberg, Sebastian Palmqvist, Michael Schöll, Philip S Insel, Douglas Hägerström, Tomas Ohlsson, Henrik Zetterberg, Kaj Blennow, Jonas Jögi, Oskar Hansso. Comparing Neurology. vol 90. issue 5. 2019-07-19. PMID:29321235. |
comparing to compare pet imaging of tau pathology with csf measurements (total tau [t-tau] and phosphorylated tau [p-tau]) in terms of diagnostic performance for alzheimer disease (ad). |
2019-07-19 |
2023-08-13 |
Not clear |
| Cara M Altimus, Kirstie Keller, Patrick Brannelly, Erin Ross, Chang-Ting Lin, Ekemini A U Riley, LaTese Briggs, Jeremy Smith, Melissa Steven. Analysis of tauopathy research funding between 2006 and 2016 reveals critical gaps in research priorities. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 1. 2019-07-18. PMID:30314799. |
specifically, the field experienced a strong bias toward funding tau in the context of alzheimer's disease, while at the same time generally decreasing the overall proportion of funding for basic research, treatment development, and evaluation. |
2019-07-18 |
2023-08-13 |
Not clear |
| Åsa Sandelius, Erik Portelius, Åsa Källén, Henrik Zetterberg, Uros Rot, Bob Olsson, Jon B Toledo, Leslie M Shaw, Virginia M Y Lee, David J Irwin, Murray Grossman, Daniel Weintraub, Alice Chen-Plotkin, David A Wolk, Leo McCluskey, Lauren Elman, Vesna Kostanjevecki, Manu Vandijck, Jennifer McBride, John Q Trojanowski, Kaj Blenno. Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 1. 2019-07-18. PMID:30321501. |
elevated csf gap-43 is alzheimer's disease specific and associated with tau and amyloid pathology. |
2019-07-18 |
2023-08-13 |
Not clear |
| Maud Gratuze, Jacinthe Julien, Franck R Petry, Françoise Morin, Emmanuel Plane. Insulin deprivation induces PP2A inhibition and tau hyperphosphorylation in hTau mice, a model of Alzheimer's disease-like tau pathology. Scientific reports. vol 7. 2019-07-17. PMID:28402338. |
insulin deprivation induces pp2a inhibition and tau hyperphosphorylation in htau mice, a model of alzheimer's disease-like tau pathology. |
2019-07-17 |
2023-08-13 |
mouse |