All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Minesh Kapadia, M Firoz Mian, Bernadeta Michalski, Amber B Azam, Donglai Ma, Patrick Salwierz, Adam Christopher, Elyse Rosa, Iva B Zovkic, Paul Forsythe, Margaret Fahnestock, Boris Saki. Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 63. issue 3. 2019-06-10. PMID:29710702. the triple-transgenic (3xtg-ad) mouse strain is a valuable model of alzheimer's disease (ad) because it develops both amyloid-β (aβ) and tau brain pathology. 2019-06-10 2023-08-13 mouse
Belinda M Brown, Stephanie R Rainey-Smith, Vincent Dore, Jeremiah J Peiffer, Samantha C Burnham, Simon M Laws, Kevin Taddei, David Ames, Colin L Masters, Christopher C Rowe, Ralph N Martins, Victor L Villemagn. Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29758940. numerous animal studies have reported exercise reduces the accumulation of alzheimer's disease pathology, including amyloid-β (aβ) and tau. 2019-06-10 2023-08-13 human
Oluwatomi E S Akingbade, Claire Gibson, Raj N Kalaria, Elizabeta B Mukaetova-Ladinsk. Platelets: Peripheral Biomarkers of Dementia? Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843245. current platelet protein biomarkers that have been investigated for their clinical utility in the diagnosis of dementia, in particular alzheimer's disease, include amyloid-β protein precursor (aβpp), the aβpp secretases (bace1 and adam10), α-synuclein, tau protein, serotonin, cholesterol, phospholipases, clusterin, igg, surface receptors, mao-b, and coated platelets. 2019-06-10 2023-08-13 Not clear
Pedro Piccardo, David M Ashe. Complex proteinopathies and neurodegeneration: insights from the study of transmissible spongiform encephalopathies. Arquivos de neuro-psiquiatria. vol 76. issue 10. 2019-06-10. PMID:30427511. protein misfolding diseases are usually associated with deposits of single "key" proteins that somehow drive the pathology; β-amyloid and hyperphosphorylated tau accumulate in alzheimer's disease, α-synuclein in parkinson's disease, or abnormal prion protein (prptse) in transmissible spongiform encephalopathies (tses or prion diseases). 2019-06-10 2023-08-13 human
Minee L Choi, Sonia Gandh. Crucial role of protein oligomerization in the pathogenesis of Alzheimer's and Parkinson's diseases. The FEBS journal. vol 285. issue 19. 2019-06-07. PMID:29924502. misfolding and aggregation of the proteins amyloid-β, tau and alpha-synuclein is the predominant pathology underlying the neurodegenerative disorders, alzheimer's and parkinson's disease. 2019-06-07 2023-08-13 human
Thuy-Vi V Nguyen, Megan Hayes, Jacob C Zbesko, Jennifer B Frye, Nicole R Congrove, Nadia P Belichenko, Brian S McKay, Frank M Longo, Kristian P Doyl. Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. Acta neuropathologica communications. vol 6. issue 1. 2019-06-06. PMID:30249297. alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia. 2019-06-06 2023-08-13 mouse
Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcron. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients. Acta neuropathologica communications. vol 6. issue 1. 2019-06-06. PMID:30270816. these patients often present comorbidity with alzheimer's disease (ad), including ad pathological hallmarks such as amyloid plaques mainly consisting of amyloid β-peptide and neurofibrillary tangles consisting of hyperphosphorylated tau protein. 2019-06-06 2023-08-13 human
Arash Salardin. Interpretation of Biomarker Data in Diagnosis of Primary Dementias. Seminars in neurology. vol 39. issue 2. 2019-06-06. PMID:30925613. the current "biological" conception of alzheimer's disease is based on consideration of three biomarkers: amyloid, tau, and "neurodegeneration." 2019-06-06 2023-08-13 Not clear
Mahmoud B Maina, Laura J Bailey, Sherin Wagih, Luca Biasetti, Saskia J Pollack, James P Quinn, Julian R Thorpe, Aidan J Doherty, Louise C Serpel. The involvement of tau in nucleolar transcription and the stress response. Acta neuropathologica communications. vol 6. issue 1. 2019-06-05. PMID:30064522. tau is known for its pathological role in neurodegenerative diseases, including alzheimer's disease (ad) and other tauopathies. 2019-06-05 2023-08-13 human
Brandon F Maziuk, Daniel J Apicco, Anna Lourdes Cruz, Lulu Jiang, Peter E A Ash, Edroaldo Lummertz da Rocha, Cheng Zhang, Wai Haung Yu, John Leszyk, Jose F Abisambra, Hu Li, Benjamin Wolozi. RNA binding proteins co-localize with small tau inclusions in tauopathy. Acta neuropathologica communications. vol 6. issue 1. 2019-06-05. PMID:30068389. the development of insoluble, intracellular neurofibrillary tangles composed of the microtubule-associated protein tau is a defining feature of tauopathies, including alzheimer's disease (ad). 2019-06-05 2023-08-13 mouse
Francesca Vitale, Luca Giliberto, Santiago Ruiz, Kristen Steslow, Philippe Marambaud, Cristina d'Abram. Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice. Acta neuropathologica communications. vol 6. issue 1. 2019-06-05. PMID:30134961. tau, the main component of the neurofibrillary tangles (nfts), is an attractive target for immunotherapy in alzheimer's disease (ad) and other tauopathies. 2019-06-05 2023-08-13 mouse
Joerg Neddens, Magdalena Temmel, Stefanie Flunkert, Bianca Kerschbaumer, Christina Hoeller, Tina Loeffler, Vera Niederkofler, Guenther Daum, Johannes Attems, Birgit Hutter-Paie. Phosphorylation of different tau sites during progression of Alzheimer's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29958544. phosphorylation of different tau sites during progression of alzheimer's disease. 2019-06-04 2023-08-13 human
Joerg Neddens, Magdalena Temmel, Stefanie Flunkert, Bianca Kerschbaumer, Christina Hoeller, Tina Loeffler, Vera Niederkofler, Guenther Daum, Johannes Attems, Birgit Hutter-Paie. Phosphorylation of different tau sites during progression of Alzheimer's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:29958544. alzheimer's disease is characterized by accumulation of amyloid plaques and tau aggregates in several cortical brain regions. 2019-06-04 2023-08-13 human
Mirta Borin, Claudia Saraceno, Marcella Catania, Erika Lorenzetto, Valeria Pontelli, Anna Paterlini, Silvia Fostinelli, Anna Avesani, Giuseppe Di Fede, Gianluigi Zanusso, Luisa Benussi, Giuliano Binetti, Simone Zorzan, Roberta Ghidoni, Mario Buffelli, Silvia Bologni. Rac1 activation links tau hyperphosphorylation and Aβ dysmetabolism in Alzheimer's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:30005699. rac1 activation links tau hyperphosphorylation and aβ dysmetabolism in alzheimer's disease. 2019-06-04 2023-08-13 mouse
Christina E Murray, Priya Gami-Patel, Eleni Gkanatsiou, Gunnar Brinkmalm, Erik Portelius, Oliver Wirths, Wendy Heywood, Kaj Blennow, Jorge Ghiso, Janice L Holton, Kevin Mills, Henrik Zetterberg, Tamas Revesz, Tammaryn Lashle. The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease. Acta neuropathologica communications. vol 6. issue 1. 2019-06-04. PMID:30029687. in the majority of affected brain regions the pathological hallmarks of alzheimer's disease (ad) are β-amyloid (aβ) deposits in the form of diffuse and neuritic plaques, tau pathology in the form of neurofibrillary tangles, neuropil threads and plaque-associated abnormal neurites in combination with an inflammatory response. 2019-06-04 2023-08-13 Not clear
Kevin Mullane, Michael William. Alzheimer's disease (AD) therapeutics - 1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality. Biochemical pharmacology. vol 158. 2019-06-03. PMID:30273553. deposits of amyloid plaques and neurofibrillary tangles of aggregated tau in the brain represent key hallmarks of the neurodegenerative disorder, alzheimer's disease (ad) and form the basis of the major hypotheses of ad causality. 2019-06-03 2023-08-13 Not clear
Simon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Sébastien Carrier, Sarah Lieger, Jose A Gonzalez, Vincent Deramecourt, Nicole Déglon, Claude-Alain Maurage, Matthew P Frosch, Bradley T Hyman, Morvane Colin, Luc Bué. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30497516. in some tauopathies such as alzheimer's disease (ad), tau protein aggregation follows stereotypical anatomical stages. 2019-06-03 2023-08-13 human
Jurre den Haan, Tjado H J Morrema, Frank D Verbraak, Johannes F de Boer, Philip Scheltens, Annemieke J Rozemuller, Arthur A B Bergen, Femke H Bouwman, Jeroen J Hoozeman. Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30593285. amyloid-beta and phosphorylated tau in post-mortem alzheimer's disease retinas. 2019-06-03 2023-08-13 human
Jurre den Haan, Tjado H J Morrema, Frank D Verbraak, Johannes F de Boer, Philip Scheltens, Annemieke J Rozemuller, Arthur A B Bergen, Femke H Bouwman, Jeroen J Hoozeman. Amyloid-beta and phosphorylated tau in post-mortem Alzheimer's disease retinas. Acta neuropathologica communications. vol 6. issue 1. 2019-06-03. PMID:30593285. in-vivo labeling of retinal amyloid-beta(aβ) and tau has potential as non-invasive biomarker for alzheimer's disease (ad). 2019-06-03 2023-08-13 human
Iván Méndez-López, Idoia Blanco-Luquin, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, Blanca Acha, Carmen Echavarri, Victoria Zelaya, Ivonne Jericó, Maite Mendioro. Hippocampal International journal of molecular sciences. vol 20. issue 4. 2019-05-31. PMID:30781626. here, we examined a-type and b-type lamin expression levels by rt-qpcr in alzheimer's disease (ad) patients and controls in the hippocampus, the core of tau pathology in the brain. 2019-05-31 2023-08-13 Not clear