| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terjahna Richards, Jeanette C Perron, Ketan Patel, John Wurpel, Sandra E Reznik, Francis Schann. Therapeutic Intervention of Neuroinflammatory Alzheimer Disease Model by Inhibition of Classical Complement Pathway with the Use of Anti-C1r Loaded Exosomes. Research square. 2023-10-27. PMID:37886595. |
alzheimer's disease (ad) is a complex neurodegenerative disease associated with memory decline, cognitive impairment, amyloid plaque formation and tau tangles. |
2023-10-27 |
2023-11-08 |
Not clear |
| Hisazumi Matsuki, Shintaro Mandai, Hiroki Shiwaku, Takaaki Koide, Naohiro Takahashi, Tomoki Yanagi, Shunsuke Inaba, Saaya Ida, Tamami Fujiki, Yutaro Mori, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Eisei Sohara, Hidehiko Takahashi, Shinichi Uchid. Chronic kidney disease causes blood-brain barrier breakdown via urea-activated matrix metalloproteinase-2 and insolubility of tau protein. Aging. vol 15. 2023-10-27. PMID:37889501. |
this study established a brain proteomic signature of ckd indicating bbb breakdown and insolubility of tau protein, which are pathologically linked to alzheimer's disease. |
2023-10-27 |
2023-11-08 |
mouse |
| Huimin Cai, Yana Pang, Xiaofeng Fu, Ziye Ren, Longfei Ji. Plasma biomarkers predict Alzheimer's disease before clinical onset in Chinese cohorts. Nature communications. vol 14. issue 1. 2023-10-26. PMID:37875471. |
plasma amyloid-β (aβ)42, phosphorylated tau (p-tau)181, and neurofilament light chain (nfl) are promising biomarkers of alzheimer's disease (ad). |
2023-10-26 |
2023-11-08 |
human |
| Tehniat Faraz Ahmed, Fauzia Imtiaz, Uzma Zaman, Affan Ahmed, Naila Shahba. Comparison Of Potential Plasma Biomarkers In Alzheimer's Disease And Neurodegenerative Dementias In Pakistani Population. JPMA. The Journal of the Pakistan Medical Association. vol 73. issue 10. 2023-10-26. PMID:37876071. |
this study aimed to compare the mean plasma levels of amyloid β42, phosphorylated tau and neurofilament light chain in patients diagnosed with alzheimer's clinical syndrome (acs), and other neurodegenerative dementias to find affordable and less-invasive means of diagnosing alzheimer's disease (ad) early in its course. |
2023-10-26 |
2023-11-08 |
human |
| Toshiya Oba, Daiki Homma, Sophia Jobien M Limlingan, Aoi Fukuchi, Akiko Asada, Taro Saito, Kanae And. A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity. Neurobiology of disease. 2023-10-26. PMID:37884211. |
abnormal activation of microtubule affinity-regulating kinase 4 (mark4) and its phosphorylation of the microtubule-associated protein tau are believed to play a role in the pathogenesis of alzheimer's disease, and mark4 inhibition can be a strategy to develop disease-modifying therapy. |
2023-10-26 |
2023-11-08 |
human |
| Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco, Giorgio Arrigoni, Francesca Munari, Michael Assfalg, Mariapina D'Onofrio, Stefano Capald. Site-Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP. Angewandte Chemie (International ed. in English). 2023-10-25. PMID:37878393. |
post-translational modifications of tau are emerging as key players in determining the onset and progression of different tauopathies such as alzheimer's disease, and are recognized to mediate the structural diversity of the disease-specific tau amyloids. |
2023-10-25 |
2023-11-08 |
Not clear |
| Pu Duan, Aurelio J Dregni, Nadia El Mammeri, Mei Hon. Structure of the nonhelical filament of the Alzheimer's disease tau core. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 44. 2023-10-25. PMID:37878719. |
structure of the nonhelical filament of the alzheimer's disease tau core. |
2023-10-25 |
2023-11-08 |
Not clear |
| Pu Duan, Aurelio J Dregni, Nadia El Mammeri, Mei Hon. Structure of the nonhelical filament of the Alzheimer's disease tau core. Proceedings of the National Academy of Sciences of the United States of America. vol 120. issue 44. 2023-10-25. PMID:37878719. |
the microtubule-associated protein tau aggregates into neurofibrillary tangles in alzheimer's disease (ad). |
2023-10-25 |
2023-11-08 |
Not clear |
| Vali Akbari, Seifollah Bahramikia, Ali R Jalalvand, Masomeh Mehrabi, Mohammad Ezati, Reza Khodarahm. The induction of tau aggregation is restricted by sulfamethoxazole and provides new information regarding the use of the drug. Journal of biomolecular structure & dynamics. 2023-10-25. PMID:37878050. |
the aggregation of tau protein in the form of paired helical filament (phf) leads to the breakdown of microtubule structure and the development of neurodegenerative disorders, such as alzheimer's disease. |
2023-10-25 |
2023-11-08 |
Not clear |
| Ashok Iyaswamy, Abhimanyu Thakur, Xin-Jie Guan, Senthilkumar Krishnamoorthi, Tsz Yan Fung, Kejia Lu, Isha Gaurav, Zhijun Yang, Cheng-Fu Su, Kwok-Fai Lau, Kui Zhang, Roy Chun-Laam Ng, Qizhou Lian, King-Ho Cheung, Keqiang Ye, Huanhuan Joyce Chen, Min L. Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease. Signal transduction and targeted therapy. vol 8. issue 1. 2023-10-24. PMID:37867176. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the brain. |
2023-10-24 |
2023-11-08 |
mouse |
| Rajshri Dafre, Praful Wasni. Current Diagnostic and Treatment Methods of Alzheimer's Disease: A Narrative Review. Cureus. vol 15. issue 9. 2023-10-24. PMID:37868425. |
tau pathology is further complicated by the amyloid buildup that arises from the cellular phase of alzheimer's disease (ad). alzheimer's is a degenerative, diverse, complicated, and incurable neurological disorder primarily affecting elderly individuals. |
2023-10-24 |
2023-11-08 |
Not clear |
| Dibyadeep Datta, Isabella Perone, Yury M Morozov, Jon Arellano, Alvaro Duque, Pasko Rakic, Christopher H van Dyck, Amy F T Arnste. Localization of PDE4D, HCN1 channels, and mGluR3 in rhesus macaque entorhinal cortex may confer vulnerability in Alzheimer's disease. Cerebral cortex (New York, N.Y. : 1991). 2023-10-24. PMID:37874022. |
alzheimer's disease cortical tau pathology initiates in the layer ii cell clusters of entorhinal cortex, but it is not known why these specific neurons are so vulnerable. |
2023-10-24 |
2023-11-08 |
monkey |
| A Feizpour, V Doré, J D Doecke, Z S Saad, G Triana-Baltzer, R Slemmon, P Maruff, N Krishnadas, P Bourgeat, K Huang, C Fowler, S R Rainey-Smith, A I Bush, L Ward, J Robertson, R N Martins, C L Masters, V L Villemagne, J Fripp, H C Kolb, C C Row. Two-Year Prognostic Utility of Plasma p217+tau across the Alzheimer's Continuum. The journal of prevention of Alzheimer's disease. vol 10. issue 4. 2023-10-24. PMID:37874105. |
plasma p217+tau has shown high concordance with cerebrospinal fluid (csf) and positron emission tomography (pet) measures of amyloid-β (aβ) and tau in alzheimer's disease (ad). |
2023-10-24 |
2023-11-08 |
Not clear |
| Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S Day, Adam M Brickman, Michael Fulham, Clifford R Jack, Christian la La Fougère, Gerald Reischl, Peter R Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M Cash, Igor Yakushev, Takeshi Ikeuchi, William E Klunk, John C Morris, Randall J Bateman, Tammie L S Benzinge. T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease. Human brain mapping. 2023-10-23. PMID:37867465. |
t1 and flair signal intensities are related to tau pathology in dominantly inherited alzheimer disease. |
2023-10-23 |
2023-11-08 |
human |
| Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S Day, Adam M Brickman, Michael Fulham, Clifford R Jack, Christian la La Fougère, Gerald Reischl, Peter R Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M Cash, Igor Yakushev, Takeshi Ikeuchi, William E Klunk, John C Morris, Randall J Bateman, Tammie L S Benzinge. T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease. Human brain mapping. 2023-10-23. PMID:37867465. |
we used 1104 longitudinal mr, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the dominantly inherited alzheimer network observational study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of t1-weighted and fluid attenuated inversion recovery (flair) mr scans. |
2023-10-23 |
2023-11-08 |
human |
| Sujin Kim, Da Gyeong Hyun, Yunkwon Nam, Soo Jung Shin, Dongjoon Im, Hyeon Soo Kim, Seol Hwa Leem, Hyun Ha Park, Byeong-Hyeon Kim, Yong Ho Park, Eunbi Cho, William A Goddard, Dong Hyun Kim, Hugh I Kim, Minho Moo. Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 168. 2023-10-22. PMID:37865990. |
alzheimer's disease (ad) is characterized by the aggregation of disordered proteins, such as amyloid beta (aβ) and tau, leading to neurotoxicity and disease progression. |
2023-10-22 |
2023-11-08 |
Not clear |
| Xingyu Zhang, Li Tang, Jiaolong Yang, Lanxia Meng, Jiehui Chen, Lingyan Zhou, Jiangyu Wang, Min Xiong, Zhentao Zhan. Soluble TREM2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in Alzheimer's disease. Nature communications. vol 14. issue 1. 2023-10-21. PMID:37865646. |
soluble trem2 ameliorates tau phosphorylation and cognitive deficits through activating transgelin-2 in alzheimer's disease. |
2023-10-21 |
2023-11-08 |
mouse |
| Ester Piovesana, Claudia Magrin, Matteo Ciccaldo, Martina Sola, Manolo Bellotto, Maurizio Molinari, Stéphanie Papin, Paolo Paganett. Tau accumulation in degradative organelles is associated to lysosomal stress. Scientific reports. vol 13. issue 1. 2023-10-21. PMID:37865674. |
here, we show in human primary fibroblasts that tau seeds isolated from the brain of alzheimer's disease induce tau accumulation in acidic degradative organelles and lysosomal stress. |
2023-10-21 |
2023-11-08 |
human |
| Ester Piovesana, Claudia Magrin, Matteo Ciccaldo, Martina Sola, Manolo Bellotto, Maurizio Molinari, Stéphanie Papin, Paolo Paganett. Tau accumulation in degradative organelles is associated to lysosomal stress. Scientific reports. vol 13. issue 1. 2023-10-21. PMID:37865674. |
considering the presence of tau lesions in parkinson's disease as well as in multiple neurodegenerative disorders including alzheimer's disease, our data call for further studies on strategies to alleviate alp dysfunction as new therapeutic opportunity for neurodegenerative diseases and lsd. |
2023-10-21 |
2023-11-08 |
human |
| Carolyn Tallon, Benjamin J Bell, Medhinee M Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G Thomas, Kristen R Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R Joe, Rana Rais, Norman J Haughey, Dimitrios Kapogiannis, Barbara S Slushe. Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in murine Alzheimer's disease. Research square. 2023-10-20. PMID:37502930. |
cognitive decline in alzheimer's disease (ad) is associated with prion-like tau propagation between neurons along synaptically connected networks, in part via extracellular vesicles (ev). |
2023-10-20 |
2023-11-08 |
Not clear |