All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Robert A Stern, Charles H Adler, Kewei Chen, Michael Navitsky, Ji Luo, David W Dodick, Michael L Alosco, Yorghos Tripodis, Dhruman D Goradia, Brett Martin, Diego Mastroeni, Nathan G Fritts, Johnny Jarnagin, Michael D Devous, Mark A Mintun, Michael J Pontecorvo, Martha E Shenton, Eric M Reima. Tau Positron-Emission Tomography in Former National Football League Players. The New England journal of medicine. vol 380. issue 18. 2019-05-28. PMID:30969506. the neuropathological diagnosis is based on a specific pattern of tau deposition with minimal amyloid-beta deposition that differs from other disorders, including alzheimer's disease. 2019-05-28 2023-08-13 Not clear
Rosa Crespo, Wouter Koudstaal, Adrian Apetr. In Vitro Assay for Studying the Aggregation of Tau Protein and Drug Screening. Journal of visualized experiments : JoVE. issue 141. 2019-05-23. PMID:30531722. aggregation of tau protein and formation of paired helical filaments is a hallmark of alzheimer's disease and other tauopathies. 2019-05-23 2023-08-13 Not clear
Zhuohao He, Jing L Guo, Jennifer D McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A Coulter, Ted Abel, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Le. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine. vol 24. issue 1. 2019-05-22. PMID:29200205. amyloid-β plaques enhance alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. 2019-05-22 2023-08-13 mouse
Zhuohao He, Jing L Guo, Jennifer D McBride, Sneha Narasimhan, Hyesung Kim, Lakshmi Changolkar, Bin Zhang, Ronald J Gathagan, Cuiyong Yue, Christopher Dengler, Anna Stieber, Magdalena Nitla, Douglas A Coulter, Ted Abel, Kurt R Brunden, John Q Trojanowski, Virginia M-Y Le. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature medicine. vol 24. issue 1. 2019-05-22. PMID:29200205. alzheimer's disease (ad) is characterized by extracellular amyloid-β (aβ) plaques and intracellular tau inclusions. 2019-05-22 2023-08-13 mouse
Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier Vieau, Luc Buée, David Blu. [Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]. Medecine sciences : M/S. vol 34. issue 11. 2019-05-22. PMID:30526837. [brain insulin signaling and tau: impact for alzheimer's disease and tauopathies]. 2019-05-22 2023-08-13 Not clear
Aurélie Joly-Amado, Maud Gratuze, Hamza Benderradji, Didier Vieau, Luc Buée, David Blu. [Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]. Medecine sciences : M/S. vol 34. issue 11. 2019-05-22. PMID:30526837. alzheimer's disease (ad) is a neurodegenerative disease primarily characterized by cognitive deficits and neuropathological lesions such as tau aggregates and amyloid plaques, but also associated with metabolic and neuroendocrine abnormalities, such as impairment of cerebral insulin. 2019-05-22 2023-08-13 Not clear
Dawid Panek, Anna Więckowska, Jakub Jończyk, Justyna Godyń, Marek Bajda, Tomasz Wichur, Anna Pasieka, Damijan Knez, Anja Pišlar, Jan Korabecny, Ondrej Soukup, Vendula Sepsova, Raimon Sabaté, Janko Kos, Stanislav Gobec, Barbara Malawsk. Design, Synthesis, and Biological Evaluation of 1-Benzylamino-2-hydroxyalkyl Derivatives as New Potential Disease-Modifying Multifunctional Anti-Alzheimer's Agents. ACS chemical neuroscience. vol 9. issue 5. 2019-05-21. PMID:29345897. herein, we present the discovery of a unique series of 1-benzylamino-2-hydroxyalkyl derivatives combining inhibitory activity against butyrylcholinesterase, β-secretase, β-amyloid, and tau protein aggregation, all related to mechanisms which underpin alzheimer's disease. 2019-05-21 2023-08-13 Not clear
Kedar Batkulwar, Rashmi Godbole, Reema Banarjee, Omar Kassaar, Robert J Williams, Mahesh J Kulkarn. Advanced Glycation End Products Modulate Amyloidogenic APP Processing and Tau Phosphorylation: A Mechanistic Link between Glycation and the Development of Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 5. 2019-05-21. PMID:29384651. advanced glycation end products modulate amyloidogenic app processing and tau phosphorylation: a mechanistic link between glycation and the development of alzheimer's disease. 2019-05-21 2023-08-13 Not clear
Hongjun Fu, Andrea Possenti, Rosie Freer, Yoshikazu Nakano, Nancy C Hernandez Villegas, Maoping Tang, Paula V M Cauhy, Benjamin A Lassus, Shuo Chen, Stephanie L Fowler, Helen Y Figueroa, Edward D Huey, Gail V W Johnson, Michele Vendruscolo, Karen E Duf. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559469. here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to inhibitory neurons, not only in the entorhinal cortex, a brain region affected in early alzheimer's disease, but also in areas affected later by the disease. 2019-05-21 2023-08-13 Not clear
Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V Kamath, George A Carlson, Israel Nelken, Bradley T Hyma. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559471. tau impairs neural circuits, dominating amyloid-β effects, in alzheimer models in vivo. 2019-05-21 2023-08-13 Not clear
Marc Aurel Busche, Susanne Wegmann, Simon Dujardin, Caitlin Commins, Julia Schiantarelli, Naomi Klickstein, Tarun V Kamath, George A Carlson, Israel Nelken, Bradley T Hyma. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559471. the coexistence of amyloid-β (aβ) plaques and tau neurofibrillary tangles in the neocortex is linked to neural system failure and cognitive decline in alzheimer's disease. 2019-05-21 2023-08-13 Not clear
Hans-Ulrich Klein, Cristin McCabe, Elizabeta Gjoneska, Sarah E Sullivan, Belinda J Kaskow, Anna Tang, Robert V Smith, Jishu Xu, Andreas R Pfenning, Bradley E Bernstein, Alexander Meissner, Julie A Schneider, Sara Mostafavi, Li-Huei Tsai, Tracy L Young-Pearse, David A Bennett, Philip L De Jage. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559478. epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and alzheimer's human brains. 2019-05-21 2023-08-13 mouse
Hans-Ulrich Klein, Cristin McCabe, Elizabeta Gjoneska, Sarah E Sullivan, Belinda J Kaskow, Anna Tang, Robert V Smith, Jishu Xu, Andreas R Pfenning, Bradley E Bernstein, Alexander Meissner, Julie A Schneider, Sara Mostafavi, Li-Huei Tsai, Tracy L Young-Pearse, David A Bennett, Philip L De Jage. Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains. Nature neuroscience. vol 22. issue 1. 2019-05-21. PMID:30559478. accumulation of tau and amyloid-β are two pathologic hallmarks of alzheimer's disease. 2019-05-21 2023-08-13 mouse
Evandro F Fang, Yujun Hou, Konstantinos Palikaras, Bryan A Adriaanse, Jesse S Kerr, Beimeng Yang, Sofie Lautrup, Md Mahdi Hasan-Olive, Domenica Caponio, Xiuli Dan, Paula Rocktäschel, Deborah L Croteau, Mansour Akbari, Nigel H Greig, Tormod Fladby, Hilde Nilsen, M Zameel Cader, Mark P Mattson, Nektarios Tavernarakis, Vilhelm A Boh. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease. Nature neuroscience. vol 22. issue 3. 2019-05-21. PMID:30742114. mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of alzheimer's disease. 2019-05-21 2023-08-13 human
Jesús Avil. Our Working Point of View of Tau Protein. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29036830. in this issue of the journal of alzheimer's disease commemorating its 20th year of publication, i will provide a short review of some of the features of my relationship with tau. 2019-05-20 2023-08-13 Not clear
Claude M Wischik, Björn O Schelter, Damon J Wischik, John M D Storey, Charles R Harringto. Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29226873. modeling prion-like processing of tau protein in alzheimer's disease for pharmaceutical development. 2019-05-20 2023-08-13 Not clear
Claude M Wischik, Björn O Schelter, Damon J Wischik, John M D Storey, Charles R Harringto. Modeling Prion-Like Processing of Tau Protein in Alzheimer's Disease for Pharmaceutical Development. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29226873. following our discovery of a fragment from the repeat domain of tau protein as a structural constituent of the phf-core in alzheimer's disease (ad), we developed an assay that captured several key features of the aggregation process. 2019-05-20 2023-08-13 Not clear
Jaume Folch, Oriol Busquets, Miren Ettcheto, Elena Sánchez-López, Ruben Dario Castro-Torres, Ester Verdaguer, Maria Luisa Garcia, Jordi Olloquequi, Gemma Casadesús, Carlos Beas-Zarate, Carme Pelegri, Jordi Vilaplana, Carme Auladell, Antoni Camin. Memantine for the Treatment of Dementia: A Review on its Current and Future Applications. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29254093. alzheimer's disease (ad) is a neurodegenerative disorder characterized by the presence in the brain of extracellular amyloid-β protein (aβ) and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. 2019-05-20 2023-08-13 Not clear
Kaj Blennow, Henrik Zetterber. The Past and the Future of Alzheimer's Disease Fluid Biomarkers. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29562534. following the development of the first methods to measure the core alzheimer's disease (ad) cerebrospinal fluid (csf) biomarkers total-tau (t-tau), phosphorylated tau (p-tau) and the 42 amino acid form of amyloid-β (aβ42), there has been an enormous expansion of this scientific research area. 2019-05-20 2023-08-13 Not clear
Ying Yang, Jian-Zhi Wan. Nature of Tau-Associated Neurodegeneration and the Molecular Mechanisms. Journal of Alzheimer's disease : JAD. vol 62. issue 3. 2019-05-20. PMID:29562535. alzheimer's disease (ad) is the most common neurodegenerative disorder, and tau accumulation forming neurofibrillary tangles is a hallmark pathology in the ad brains, suggesting that tau must play a critical role in ad neurodegeneration. 2019-05-20 2023-08-13 Not clear