| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anders Rosén, Nicklas Oscarsson, Andreas Kvarnström, Mikael Gennser, Göran Sandström, Kaj Blennow, Helen Seeman-Lodding, Henrik Zetterber. Serum tau concentration after diving - an observational pilot study. Diving and hyperbaric medicine. vol 49. issue 2. 2019-06-17. PMID:31177514. |
increased concentrations of tau protein are associated with medical conditions involving the central nervous system, such as alzheimer's disease, traumatic brain injury and hypoxia. |
2019-06-17 |
2023-08-13 |
Not clear |
| Naoya Tochio, Takuya Murata, Naoko Utsunomiya-Tat. Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides. Biochemical and biophysical research communications. vol 508. issue 1. 2019-06-13. PMID:30471859. |
tau, a microtubule-associated protein, is a major component of neurofibrillary tangles in alzheimer's disease. |
2019-06-13 |
2023-08-13 |
human |
| Naoya Tochio, Takuya Murata, Naoko Utsunomiya-Tat. Effect of site-specific amino acid D-isomerization on β-sheet transition and fibril formation profiles of Tau microtubule-binding repeat peptides. Biochemical and biophysical research communications. vol 508. issue 1. 2019-06-13. PMID:30471859. |
site-specific amino acid d-isomerization in tau has been observed in the brains of patients with alzheimer's disease. |
2019-06-13 |
2023-08-13 |
human |
| Yanping Zhu, Xiaoyang Shan, Farzaneh Safarpour, Nancy Erro Go, Nancy Li, Alice Shan, Mina C Huang, Matthew Deen, Viktor Holicek, Roger Ashmus, Zarina Madden, Sharon Gorski, Michael A Silverman, David J Vocadl. Pharmacological Inhibition of O-GlcNAcase Enhances Autophagy in Brain through an mTOR-Independent Pathway. ACS chemical neuroscience. vol 9. issue 6. 2019-06-11. PMID:29460617. |
pharmacological inhibition of o-glcnacase (oga), the sole enzyme that removes o-glcnac, reproducibly slows neurodegeneration in various alzheimer's disease (ad) mouse models manifesting either tau or amyloid pathology. |
2019-06-11 |
2023-08-13 |
mouse |
| Serge Gauthier, Kok Pin Ng, Tharick A Pascoal, Hua Zhang, Pedro Rosa-Net. Targeting Alzheimer's Disease at the Right Time and the Right Place: Validation of a Personalized Approach to Diagnosis and Treatment. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29504543. |
cautious optimism is appropriate for a near future (five years) time frame for a number of drugs acting on the different pathophysiological components of alzheimer's disease (amyloid deposition, tau hyperphosphorylation, neuroinflammation, vascular changes, to name the most important known so far). |
2019-06-11 |
2023-08-13 |
Not clear |
| Rebecca M Nisbet, Jürgen Göt. Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29562514. |
amyloid-β and tau in alzheimer's disease: novel pathomechanisms and non-pharmacological treatment strategies. |
2019-06-11 |
2023-08-13 |
Not clear |
| Rebecca M Nisbet, Jürgen Göt. Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29562514. |
accumulation of the peptide amyloid-β (aβ) and the protein tau in alzheimer's disease (ad) brains is a gradual process that involves the post-translational modification and assembly of monomeric forms into larger structures that eventually form fibrillar inclusions. |
2019-06-11 |
2023-08-13 |
Not clear |
| Félix Hernández, María Llorens-Martín, Marta Bolós, Mar Pérez, Raquel Cuadros, Noemí Pallas-Bazarra, Juan C Zabala, Jesús Avil. New Beginnings in Alzheimer's Disease: The Most Prevalent Tauopathy. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29562521. |
alzheimer's disease (ad) is characterized by the presence of two aberrant structures: namely senile plaques, composed of amyloid-β peptide (aβ), and neurofibrillary tangles, composed of tau protein. |
2019-06-11 |
2023-08-13 |
Not clear |
| Franziska Kundel, Liu Hong, Benjamin Falcon, William A McEwan, Thomas C T Michaels, Georg Meisl, Noemi Esteras, Andrey Y Abramov, Tuomas J P Knowles, Michel Goedert, David Klenerma. Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading. ACS chemical neuroscience. vol 9. issue 6. 2019-06-11. PMID:29590529. |
we then simulated the spreading time for aggregates through the brain and found this to be in good agreement with both the observed time frame for spreading of pathological tau deposits in alzheimer's disease and in experimental models of tauopathies. |
2019-06-11 |
2023-08-13 |
human |
| Alejandra D Alonso, Leah S Cohe. Our Tau Tales from Normal to Pathological Behavior. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29614672. |
the microtubule associated protein tau in a hyperphosphorylated form was identified as the building block of the filamentous aggregates found in the neurons of alzheimer's disease (ad) patients. |
2019-06-11 |
2023-08-13 |
human |
| Tomas Smolek, Santosh Jadhav, Veronika Brezovakova, Veronika Cubinkova, Bernadeta Valachova, Petr Novak, Norbert Zilk. First-in-Rat Study of Human Alzheimer's Disease Tau Propagation. Molecular neurobiology. vol 56. issue 1. 2019-06-11. PMID:29770957. |
first-in-rat study of human alzheimer's disease tau propagation. |
2019-06-11 |
2023-08-13 |
mouse |
| Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Progress and Potential Pitfalls. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29865056. |
tau immunotherapies for alzheimer's disease and related tauopathies: progress and potential pitfalls. |
2019-06-11 |
2023-08-13 |
Not clear |
| Walter Gulisano, Daniele Maugeri, Marian A Baltrons, Mauro Fà, Arianna Amato, Agostino Palmeri, Luciano D'Adamio, Claudio Grassi, D P Devanand, Lawrence S Honig, Daniela Puzzo, Ottavio Aranci. Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29865055. |
role of amyloid-β and tau proteins in alzheimer's disease: confuting the amyloid cascade. |
2019-06-11 |
2023-08-13 |
Not clear |
| Petr Novak, Ondrej Cehlar, Rostislav Skrabana, Michal Nova. Tau Conformation as a Target for Disease-Modifying Therapy: The Role of Truncation. Journal of Alzheimer's disease : JAD. vol 64. issue s1. 2019-06-11. PMID:29865059. |
tau protein plays a major role in the pathogenesis of alzheimer's disease. |
2019-06-11 |
2023-08-13 |
Not clear |
| Naruhiko Sahar. [Development of imaging-based diagnostic procedures for brain protein aging using a mouse model of tauopathy]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 1. 2019-06-11. PMID:29998952. |
neurodegenerative diseases including alzheimer's disease (ad), dementia with lewy bodies, and frontotemporal lobar degeneration are mostly diagnosed by neuropathological features with protein inclusions such as aβ, tau, α-synuclein, tdp-43, and fus. |
2019-06-11 |
2023-08-13 |
mouse |
| Leonardo Biscetti, Nicola Salvadori, Lucia Farotti, Samuela Cataldi, Paolo Eusebi, Silvia Paciotti, Lucilla Parnett. The added value of Aβ42/Aβ40 in the CSF signature for routine diagnostics of Alzheimer's disease. Clinica chimica acta; international journal of clinical chemistry. vol 494. 2019-06-11. PMID:30844364. |
the cerebrospinal fluid (csf) signature of alzheimer's disease (ad) includes abnormal levels of amyloid-β 1-42 (aβ42), total tau (t-tau) and phosphorylated tau (p-tau). |
2019-06-11 |
2023-08-13 |
Not clear |
| Minesh Kapadia, M Firoz Mian, Bernadeta Michalski, Amber B Azam, Donglai Ma, Patrick Salwierz, Adam Christopher, Elyse Rosa, Iva B Zovkic, Paul Forsythe, Margaret Fahnestock, Boris Saki. Sex-Dependent Differences in Spontaneous Autoimmunity in Adult 3xTg-AD Mice. Journal of Alzheimer's disease : JAD. vol 63. issue 3. 2019-06-10. PMID:29710702. |
the triple-transgenic (3xtg-ad) mouse strain is a valuable model of alzheimer's disease (ad) because it develops both amyloid-β (aβ) and tau brain pathology. |
2019-06-10 |
2023-08-13 |
mouse |
| Belinda M Brown, Stephanie R Rainey-Smith, Vincent Dore, Jeremiah J Peiffer, Samantha C Burnham, Simon M Laws, Kevin Taddei, David Ames, Colin L Masters, Christopher C Rowe, Ralph N Martins, Victor L Villemagn. Self-Reported Physical Activity is Associated with Tau Burden Measured by Positron Emission Tomography. Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29758940. |
numerous animal studies have reported exercise reduces the accumulation of alzheimer's disease pathology, including amyloid-β (aβ) and tau. |
2019-06-10 |
2023-08-13 |
human |
| Oluwatomi E S Akingbade, Claire Gibson, Raj N Kalaria, Elizabeta B Mukaetova-Ladinsk. Platelets: Peripheral Biomarkers of Dementia? Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843245. |
current platelet protein biomarkers that have been investigated for their clinical utility in the diagnosis of dementia, in particular alzheimer's disease, include amyloid-β protein precursor (aβpp), the aβpp secretases (bace1 and adam10), α-synuclein, tau protein, serotonin, cholesterol, phospholipases, clusterin, igg, surface receptors, mao-b, and coated platelets. |
2019-06-10 |
2023-08-13 |
Not clear |
| Pedro Piccardo, David M Ashe. Complex proteinopathies and neurodegeneration: insights from the study of transmissible spongiform encephalopathies. Arquivos de neuro-psiquiatria. vol 76. issue 10. 2019-06-10. PMID:30427511. |
protein misfolding diseases are usually associated with deposits of single "key" proteins that somehow drive the pathology; β-amyloid and hyperphosphorylated tau accumulate in alzheimer's disease, α-synuclein in parkinson's disease, or abnormal prion protein (prptse) in transmissible spongiform encephalopathies (tses or prion diseases). |
2019-06-10 |
2023-08-13 |
human |