| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhibin Liang, Qing X L. Discovery of Selective, Substrate-Competitive, and Passive Membrane Permeable Glycogen Synthase Kinase-3β Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling of New C-Glycosylflavones. ACS chemical neuroscience. vol 9. issue 5. 2019-05-07. PMID:29381861. |
glycogen synthase kinase-3β (gsk-3β) is a key enzyme responsible for tau hyperphosphorylation and is a viable therapeutic target of alzheimer's disease (ad). |
2019-05-07 |
2023-08-13 |
Not clear |
| Federico d'Oleire Uquillas, Heidi I L Jacobs, Kelsey D Biddle, Michael Properzi, Bernard Hanseeuw, Aaron P Schultz, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Nancy J Donova. Regional tau pathology and loneliness in cognitively normal older adults. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30563962. |
this study examined whether greater loneliness was associated with tau pathology, the other defining feature of alzheimer's disease, in 117 cognitively normal older adults. |
2019-05-06 |
2023-08-13 |
Not clear |
| Federico d'Oleire Uquillas, Heidi I L Jacobs, Kelsey D Biddle, Michael Properzi, Bernard Hanseeuw, Aaron P Schultz, Dorene M Rentz, Keith A Johnson, Reisa A Sperling, Nancy J Donova. Regional tau pathology and loneliness in cognitively normal older adults. Translational psychiatry. vol 8. issue 1. 2019-05-06. PMID:30563962. |
we found that higher tau pathology in the right entorhinal cortex was associated with greater loneliness, controlling for age, sex, and apolipoprotein e ε4, the alzheimer's disease genetic risk marker. |
2019-05-06 |
2023-08-13 |
Not clear |
| Javier Oroz, Bliss J Chang, Piotr Wysoczanski, Chung-Tien Lee, Ángel Pérez-Lara, Pijush Chakraborty, Romina V Hofele, Jeremy D Baker, Laura J Blair, Jacek Biernat, Henning Urlaub, Eckhard Mandelkow, Chad A Dickey, Markus Zweckstette. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature communications. vol 9. issue 1. 2019-05-03. PMID:30382094. |
here, we report the solution structures of human full-length hsp90 in complex with the ppiase fkbp51, as well as the 280 kda hsp90/fkbp51 complex bound to the alzheimer's disease-related protein tau. |
2019-05-03 |
2023-08-13 |
human |
| Jacob I Ayers, Benoit I Giasson, David R Borchel. Prion-like Spreading in Tauopathies. Biological psychiatry. vol 83. issue 4. 2019-05-01. PMID:28506438. |
misfolded and aggregated forms of tau produce pathological structures in a number of neurodegenerative diseases, including alzheimer's disease (ad) and tauopathy dementias. |
2019-05-01 |
2023-08-13 |
mouse |
| Sudeepti Southekal, Michael D Devous, Ian Kennedy, Michael Navitsky, Ming Lu, Abhinay D Joshi, Michael J Pontecorvo, Mark A Mintu. Flortaucipir F 18 Quantitation Using Parametric Estimation of Reference Signal Intensity. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29191858. |
pet imaging of tau pathology in alzheimer disease may benefit from the use of white matter reference regions. |
2019-05-01 |
2023-08-13 |
Not clear |
| Michael D Devous, Abhinay D Joshi, Michael Navitsky, Sudeepti Southekal, Michael J Pontecorvo, Haiqing Shen, Ming Lu, William R Shankle, John P Seibyl, Ken Marek, Mark A Mintu. Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29284675. |
alzheimer disease (ad) is characterized by β-amyloid (aβ) plaques and tau neurofibrillary tangles. |
2019-05-01 |
2023-08-13 |
Not clear |
| Ruiqing Ni, Bin Ji, Maiko Ono, Naruhiko Sahara, Ming-Rong Zhang, Ichio Aoki, Agneta Nordberg, Tetsuya Suhara, Makoto Higuch. Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 59. issue 6. 2019-05-01. PMID:29419480. |
fibrillary tau aggregates in alzheimer disease and allied neurodegenerative disorders have been visualized in vivo by pet, whereas mechanistic links between pet-detectable tau deposits and neurotoxicity remain elusive. |
2019-05-01 |
2023-08-13 |
mouse |
| Shuko Taked. Progression of Alzheimer's disease, tau propagation, and its modifiable risk factors. Neuroscience research. vol 141. 2019-05-01. PMID:30120962. |
progression of alzheimer's disease, tau propagation, and its modifiable risk factors. |
2019-05-01 |
2023-08-13 |
Not clear |
| Won-Hee Nam, Young Pyo Cho. In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain. Prion. vol 13. issue 1. 2019-05-01. PMID:30422056. |
in vitro generation of tau aggregates conformationally distinct from parent tau seeds of alzheimer's brain. |
2019-05-01 |
2023-08-13 |
Not clear |
| Won-Hee Nam, Young Pyo Cho. In vitro generation of tau aggregates conformationally distinct from parent tau seeds of Alzheimer's brain. Prion. vol 13. issue 1. 2019-05-01. PMID:30422056. |
in this study, we induced the aggregation of tau repeat domain (rd) in cultured cells using detergent insoluble fractions of alzheimer's brain tissue as seeds. |
2019-05-01 |
2023-08-13 |
Not clear |
| Mariarosa Anna Beatrice Melone, Clemente Dato, Simona Paladino, Cinzia Coppola, Claudia Trebini, Maria Teresa Giordana, Lorena Perron. Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway. Pharmaceutical research. vol 35. issue 2. 2019-04-29. PMID:29404777. |
oxidative stress is a hallmark of alzheimer's disease (ad) and promotes tau phosphorylation. |
2019-04-29 |
2023-08-13 |
Not clear |
| Maxime Wc Rousseaux, Jean-Pierre Revelli, Gabriel E Vázquez-Vélez, Ji-Yoen Kim, Evelyn Craigen, Kristyn Gonzales, Jaclyn Beckinghausen, Huda Y Zoghb. Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau. eLife. vol 7. 2019-04-29. PMID:29863470. |
alzheimer's and parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-syn). |
2019-04-29 |
2023-08-13 |
mouse |
| Henrik Zetterberg, Jonathan M Schot. Biomarkers for Alzheimer's disease beyond amyloid and tau. Nature medicine. vol 25. issue 2. 2019-04-29. PMID:30728536. |
biomarkers for alzheimer's disease beyond amyloid and tau. |
2019-04-29 |
2023-08-13 |
Not clear |
| Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, W T Longstreth, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter, Joan S Reisch, Olivier Hanon, Chiara Cupidi, A G Andre Uitterlinden, Donald R Royall, Carole Dufouil, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George-Hyslop, Karen Ritchie, Magda Tsolaki, Debby W Tsuang, Bruno Dubois, David Craig, Chuang-Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L Albin, Laura Fratiglioni, Antonia Germanou, Liana G Apostolova, Lina Keller, Maria Koutroumani, Steven E Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice Whitehead, Craig S Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ángel Carracedo, Lars Lannfelt, David C Rubinsztein, Lisa L Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G Beach, Janet A Johnston, James T Becker, Peter Passmore, Eileen H Bigio, Jonathan M Schott, Thomas D Bird, Jason D Warren, Bradley F Boeve, Michelle K Lupton, James D Bowen, Petra Proitsi, Adam Boxer, John F Powell, James R Burke, John S K Kauwe, Jeffrey M Burns, Michelangelo Mancuso, Joseph D Buxbaum, Ubaldo Bonuccelli, Nigel J Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris S Carlson, Nicholas J Bass, Cynthia M Carlsson, John Hardy, Regina M Carney, Jose Bras, Minerva M Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth A Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R Graff-Radford, Denis A Evans, Angela Hodges, Kelley M Faber, Martin Scherer, Kenneth B Fallon, Matthias Riemenschneider, David W Fardo, Reinhard Heun, Martin R Farlow, Heike Kölsch, Steven Ferris, Markus Leber, Tatiana M Foroud, Isabella Heuser, Douglas R Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H Geschwind, John R Gilbert, John Morris, Robert C Green, Kevin Mayo, John H Growdon, Thomas Feulner, Ronald L Hamilton, Lindy E Harrell, Dmitriy Drichel, Lawrence S Honig, Thomas D Cushion, Matthew J Huentelman, Paul Hollingworth, Christine M Hulette, Bradley T Hyman, Rachel Marshall, Gail P Jarvik, Alun Meggy, Erin Abner, Georgina E Menzies, Lee-Way Jin, Ganna Leonenko, Luis M Real, Gyungah R Jun, Clinton T Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jeffrey A Kaye, Ronald Kim, Frank Jessen, Neil W Kowall, Bruno Vellas, Joel H Kramer, Emma Vardy, Frank M LaFerla, Karl-Heinz Jöckel, James J Lah, Martin Dichgans, James B Leverenz, David Mann, Allan I Levey, Stuart Pickering-Brown, Andrew P Lieberman, Norman Klopp, Kathryn L Lunetta, H-Erich Wichmann, Constantine G Lyketsos, Kevin Morgan, Daniel C Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C Mash, Markus M Nöthen, Eliezer Masliah, Nigel M Hooper, Wayne C McCormick, Antonio Daniele, Susan M McCurry, Anthony Bayer, Andrew N McDavid, John Gallacher, Ann C McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L Miller, Steffi Riedel-Heller, Carol A Miller, Joshua W Miller, Ammar Al-Chalabi, John C Morris, Christopher E Shaw, Amanda J Myers, Jens Wiltfang, Sid O'Bryant, John M Olichney, Victoria Alvarez, Joseph E Parisi, Andrew B Singleton, Henry L Paulson, John Collinge, William R Perry, Simon Mead, Elaine Peskind, David H Cribbs, Martin Rossor, Aimee Pierce, Natalie S Ryan, Wayne W Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A David Smith, John M Ringman, Donald Warden, Erik D Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia Cecilia Bruni, Howard J Rosen, Maura Gallo, Roger N Rosenberg, Yoav Ben-Shlomo, Mark A Sager, Patrizia Mecocci, Andrew J Saykin, Pau Pastor, Michael L Cuccaro, Jeffery M Vance, Julie A Schneider, Lori S Schneider, Susan Slifer, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Mitchell Tang, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, Maria J Bullido, Oliver Peters, Paul K Crane, David Bennett, Paola Bosco, Eliecer Coto, Virginia Boccardi, Phil L De Jager, Alberto Lleo, Nick Warner, Oscar L Lopez, Martin Ingelsson, Panagiotis Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison M Goate, Pascual Sanchez-Juan, Patrick G Kehoe, Najaf Amin, Nilifur Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J Launer, Steven G Younkin, Jean-Francois Dartigues, Chris Corcoran, M Arfan Ikram, Dennis W Dickson, Gael Nicolas, Dominique Campion, JoAnn Tschanz, Helena Schmidt, Hakon Hakonarson, Jordi Clarimon, Ron Munger, Reinhold Schmidt, Lindsay A Farrer, Christine Van Broeckhoven, Michael C O'Donovan, Anita L DeStefano, Lesley Jones, Jonathan L Haines, Jean-Francois Deleuze, Michael J Owen, Vilmundur Gudnason, Richard Mayeux, Valentina Escott-Price, Bruce M Psaty, Alfredo Ramirez, Li-San Wang, Agustin Ruiz, Cornelia M van Duijn, Peter A Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D Schellenberg, Jean-Charles Lambert, Margaret A Pericak-Vanc. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics. vol 51. issue 3. 2019-04-24. PMID:30820047. |
genetic meta-analysis of diagnosed alzheimer's disease identifies new risk loci and implicates aβ, tau, immunity and lipid processing. |
2019-04-24 |
2023-08-13 |
human |
| Brian W Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C Bis, Vincent Damotte, Adam C Naj, Anne Boland, Maria Vronskaya, Sven J van der Lee, Alexandre Amlie-Wolf, Céline Bellenguez, Aura Frizatti, Vincent Chouraki, Eden R Martin, Kristel Sleegers, Nandini Badarinarayan, Johanna Jakobsdottir, Kara L Hamilton-Nelson, Sonia Moreno-Grau, Robert Olaso, Rachel Raybould, Yuning Chen, Amanda B Kuzma, Mikko Hiltunen, Taniesha Morgan, Shahzad Ahmad, Badri N Vardarajan, Jacques Epelbaum, Per Hoffmann, Merce Boada, Gary W Beecham, Jean-Guillaume Garnier, Denise Harold, Annette L Fitzpatrick, Otto Valladares, Marie-Laure Moutet, Amy Gerrish, Albert V Smith, Liming Qu, Delphine Bacq, Nicola Denning, Xueqiu Jian, Yi Zhao, Maria Del Zompo, Nick C Fox, Seung-Hoan Choi, Ignacio Mateo, Joseph T Hughes, Hieab H Adams, John Malamon, Florentino Sanchez-Garcia, Yogen Patel, Jennifer A Brody, Beth A Dombroski, Maria Candida Deniz Naranjo, Makrina Daniilidou, Gudny Eiriksdottir, Shubhabrata Mukherjee, David Wallon, James Uphill, Thor Aspelund, Laura B Cantwell, Fabienne Garzia, Daniela Galimberti, Edith Hofer, Mariusz Butkiewicz, Bertrand Fin, Elio Scarpini, Chloe Sarnowski, Will S Bush, Stéphane Meslage, Johannes Kornhuber, Charles C White, Yuenjoo Song, Robert C Barber, Sebastiaan Engelborghs, Sabrina Sordon, Dina Voijnovic, Perrie M Adams, Rik Vandenberghe, Manuel Mayhaus, L Adrienne Cupples, Marilyn S Albert, Peter P De Deyn, Wei Gu, Jayanadra J Himali, Duane Beekly, Alessio Squassina, Annette M Hartmann, Adelina Orellana, Deborah Blacker, Eloy Rodriguez-Rodriguez, Simon Lovestone, Melissa E Garcia, Rachelle S Doody, Carmen Munoz-Fernadez, Rebecca Sussams, Honghuang Lin, Thomas J Fairchild, Yolanda A Benito, Clive Holmes, Hata Karamujić-Čomić, Matthew P Frosch, Hakan Thonberg, Wolfgang Maier, Gennady Roshchupkin, Bernardino Ghetti, Vilmantas Giedraitis, Amit Kawalia, Shuo Li, Ryan M Huebinger, Lena Kilander, Susanne Moebus, Isabel Hernández, M Ilyas Kamboh, RoseMarie Brundin, James Turton, Qiong Yang, Mindy J Katz, Letizia Concari, Jenny Lord, Alexa S Beiser, C Dirk Keene, Seppo Helisalmi, Iwona Kloszewska, Walter A Kukull, Anne Maria Koivisto, Aoibhinn Lynch, Lluís Tarraga, Eric B Larson, Annakaisa Haapasalo, Brian Lawlor, Thomas H Mosley, Richard B Lipton, Vincenzo Solfrizzi, Michael Gill, W T Longstreth, Thomas J Montine, Vincenza Frisardi, Monica Diez-Fairen, Fernando Rivadeneira, Ronald C Petersen, Vincent Deramecourt, Ignacio Alvarez, Francesca Salani, Antonio Ciaramella, Eric Boerwinkle, Eric M Reiman, Nathalie Fievet, Jerome I Rotter, Joan S Reisch, Olivier Hanon, Chiara Cupidi, A G Andre Uitterlinden, Donald R Royall, Carole Dufouil, Raffaele Giovanni Maletta, Itziar de Rojas, Mary Sano, Alexis Brice, Roberta Cecchetti, Peter St George-Hyslop, Karen Ritchie, Magda Tsolaki, Debby W Tsuang, Bruno Dubois, David Craig, Chuang-Kuo Wu, Hilkka Soininen, Despoina Avramidou, Roger L Albin, Laura Fratiglioni, Antonia Germanou, Liana G Apostolova, Lina Keller, Maria Koutroumani, Steven E Arnold, Francesco Panza, Olymbia Gkatzima, Sanjay Asthana, Didier Hannequin, Patrice Whitehead, Craig S Atwood, Paolo Caffarra, Harald Hampel, Inés Quintela, Ángel Carracedo, Lars Lannfelt, David C Rubinsztein, Lisa L Barnes, Florence Pasquier, Lutz Frölich, Sandra Barral, Bernadette McGuinness, Thomas G Beach, Janet A Johnston, James T Becker, Peter Passmore, Eileen H Bigio, Jonathan M Schott, Thomas D Bird, Jason D Warren, Bradley F Boeve, Michelle K Lupton, James D Bowen, Petra Proitsi, Adam Boxer, John F Powell, James R Burke, John S K Kauwe, Jeffrey M Burns, Michelangelo Mancuso, Joseph D Buxbaum, Ubaldo Bonuccelli, Nigel J Cairns, Andrew McQuillin, Chuanhai Cao, Gill Livingston, Chris S Carlson, Nicholas J Bass, Cynthia M Carlsson, John Hardy, Regina M Carney, Jose Bras, Minerva M Carrasquillo, Rita Guerreiro, Mariet Allen, Helena C Chui, Elizabeth Fisher, Carlo Masullo, Elizabeth A Crocco, Charles DeCarli, Gina Bisceglio, Malcolm Dick, Li Ma, Ranjan Duara, Neill R Graff-Radford, Denis A Evans, Angela Hodges, Kelley M Faber, Martin Scherer, Kenneth B Fallon, Matthias Riemenschneider, David W Fardo, Reinhard Heun, Martin R Farlow, Heike Kölsch, Steven Ferris, Markus Leber, Tatiana M Foroud, Isabella Heuser, Douglas R Galasko, Ina Giegling, Marla Gearing, Michael Hüll, Daniel H Geschwind, John R Gilbert, John Morris, Robert C Green, Kevin Mayo, John H Growdon, Thomas Feulner, Ronald L Hamilton, Lindy E Harrell, Dmitriy Drichel, Lawrence S Honig, Thomas D Cushion, Matthew J Huentelman, Paul Hollingworth, Christine M Hulette, Bradley T Hyman, Rachel Marshall, Gail P Jarvik, Alun Meggy, Erin Abner, Georgina E Menzies, Lee-Way Jin, Ganna Leonenko, Luis M Real, Gyungah R Jun, Clinton T Baldwin, Detelina Grozeva, Anna Karydas, Giancarlo Russo, Jeffrey A Kaye, Ronald Kim, Frank Jessen, Neil W Kowall, Bruno Vellas, Joel H Kramer, Emma Vardy, Frank M LaFerla, Karl-Heinz Jöckel, James J Lah, Martin Dichgans, James B Leverenz, David Mann, Allan I Levey, Stuart Pickering-Brown, Andrew P Lieberman, Norman Klopp, Kathryn L Lunetta, H-Erich Wichmann, Constantine G Lyketsos, Kevin Morgan, Daniel C Marson, Kristelle Brown, Frank Martiniuk, Christopher Medway, Deborah C Mash, Markus M Nöthen, Eliezer Masliah, Nigel M Hooper, Wayne C McCormick, Antonio Daniele, Susan M McCurry, Anthony Bayer, Andrew N McDavid, John Gallacher, Ann C McKee, Hendrik van den Bussche, Marsel Mesulam, Carol Brayne, Bruce L Miller, Steffi Riedel-Heller, Carol A Miller, Joshua W Miller, Ammar Al-Chalabi, John C Morris, Christopher E Shaw, Amanda J Myers, Jens Wiltfang, Sid O'Bryant, John M Olichney, Victoria Alvarez, Joseph E Parisi, Andrew B Singleton, Henry L Paulson, John Collinge, William R Perry, Simon Mead, Elaine Peskind, David H Cribbs, Martin Rossor, Aimee Pierce, Natalie S Ryan, Wayne W Poon, Benedetta Nacmias, Huntington Potter, Sandro Sorbi, Joseph F Quinn, Eleonora Sacchinelli, Ashok Raj, Gianfranco Spalletta, Murray Raskind, Carlo Caltagirone, Paola Bossù, Maria Donata Orfei, Barry Reisberg, Robert Clarke, Christiane Reitz, A David Smith, John M Ringman, Donald Warden, Erik D Roberson, Gordon Wilcock, Ekaterina Rogaeva, Amalia Cecilia Bruni, Howard J Rosen, Maura Gallo, Roger N Rosenberg, Yoav Ben-Shlomo, Mark A Sager, Patrizia Mecocci, Andrew J Saykin, Pau Pastor, Michael L Cuccaro, Jeffery M Vance, Julie A Schneider, Lori S Schneider, Susan Slifer, William W Seeley, Amanda G Smith, Joshua A Sonnen, Salvatore Spina, Robert A Stern, Russell H Swerdlow, Mitchell Tang, Rudolph E Tanzi, John Q Trojanowski, Juan C Troncoso, Vivianna M Van Deerlin, Linda J Van Eldik, Harry V Vinters, Jean Paul Vonsattel, Sandra Weintraub, Kathleen A Welsh-Bohmer, Kirk C Wilhelmsen, Jennifer Williamson, Thomas S Wingo, Randall L Woltjer, Clinton B Wright, Chang-En Yu, Lei Yu, Yasaman Saba, Alberto Pilotto, Maria J Bullido, Oliver Peters, Paul K Crane, David Bennett, Paola Bosco, Eliecer Coto, Virginia Boccardi, Phil L De Jager, Alberto Lleo, Nick Warner, Oscar L Lopez, Martin Ingelsson, Panagiotis Deloukas, Carlos Cruchaga, Caroline Graff, Rhian Gwilliam, Myriam Fornage, Alison M Goate, Pascual Sanchez-Juan, Patrick G Kehoe, Najaf Amin, Nilifur Ertekin-Taner, Claudine Berr, Stéphanie Debette, Seth Love, Lenore J Launer, Steven G Younkin, Jean-Francois Dartigues, Chris Corcoran, M Arfan Ikram, Dennis W Dickson, Gael Nicolas, Dominique Campion, JoAnn Tschanz, Helena Schmidt, Hakon Hakonarson, Jordi Clarimon, Ron Munger, Reinhold Schmidt, Lindsay A Farrer, Christine Van Broeckhoven, Michael C O'Donovan, Anita L DeStefano, Lesley Jones, Jonathan L Haines, Jean-Francois Deleuze, Michael J Owen, Vilmundur Gudnason, Richard Mayeux, Valentina Escott-Price, Bruce M Psaty, Alfredo Ramirez, Li-San Wang, Agustin Ruiz, Cornelia M van Duijn, Peter A Holmans, Sudha Seshadri, Julie Williams, Phillippe Amouyel, Gerard D Schellenberg, Jean-Charles Lambert, Margaret A Pericak-Vanc. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature genetics. vol 51. issue 3. 2019-04-24. PMID:30820047. |
pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (app) metabolism, showing that genetic variants affecting app and aβ processing are associated not only with early-onset autosomal dominant alzheimer's disease but also with load. |
2019-04-24 |
2023-08-13 |
human |
| Lei Zhang, Laigao Chen, Jason K Dutra, Elizabeth M Beck, Sangram Nag, Akihiro Takano, Nahid Amini, Ryosuke Arakawa, Michael A Brodney, Leanne M Buzon, Shawn D Doran, Lorraine F Lanyon, Timothy J McCarthy, Kelly R Bales, Charles E Nolan, Brian T O'Neill, Klaas Schildknegt, Christer Halldin, Anabella Villalobo. Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain. Journal of medicinal chemistry. vol 61. issue 8. 2019-04-23. PMID:29356535. |
alzheimer's disease (ad) is characterized by accumulation of β-amyloid (aβ) plaques and neurofibrillary tau tangles in the brain. |
2019-04-23 |
2023-08-13 |
Not clear |
| Shieh-Yueh Yang, Ming-Jang Chiu, Ta-Fu Chen, Chin-Hsien Lin, Jiann-Shing Jeng, Sung-Chun Tang, Yen-Fu Lee, Che-Chuan Yang, Bing-Hsien Liu, Hsin-Hsien Chen, Chau-Chung W. Analytical performance of reagent for assaying tau protein in human plasma and feasibility study screening neurodegenerative diseases. Scientific reports. vol 7. issue 1. 2019-04-17. PMID:28839167. |
the ultra-sensitive imr assay was applied to detect the plasma tau protein levels of subjects with prevalent neurodegenerative diseases, such as alzheimer's disease (ad), mild cognitive impairment (mci) due to ad, parkinson's disease (pd), frontotemporal dementia (ftd) and vascular dementia (vd). |
2019-04-17 |
2023-08-13 |
human |
| Stephan Müller, Oliver Preische, Jens C Göpfert, Viviana A Carcamo Yañez, Thomas O Joos, Henning Boecker, Emrah Düzel, Peter Falkai, Josef Priller, Katharina Buerger, Cihan Catak, Daniel Janowitz, Michael T Heneka, Frederic Brosseron, Peter Nestor, Oliver Peters, Felix Menne, Carola G Schipke, Anja Schneider, Annika Spottke, Klaus Fließbach, Ingo Kilimann, Stefan Teipel, Michael Wagner, Jens Wiltfang, Frank Jessen, Christoph Lask. Tau plasma levels in subjective cognitive decline: Results from the DELCODE study. Scientific reports. vol 7. issue 1. 2019-04-16. PMID:28842559. |
previous studies have demonstrated increased tau plasma levels in patients with alzheimer's disease (ad) and mild cognitive impairment (mci) due to ad. |
2019-04-16 |
2023-08-13 |
Not clear |
| Jennifer L Whitwell, J Eric Ahlskog, Nirubol Tosakulwong, Matthew L Senjem, Anthony J Spychalla, Ronald C Petersen, Clifford R Jack, Val J Lowe, Keith A Joseph. Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy. Parkinsonism & related disorders. vol 48. 2019-04-16. PMID:29254665. |
little is known about alzheimer's disease molecular proteins, beta-amyloid and paired helical filament (phf) tau, in progressive supranuclear palsy (psp). |
2019-04-16 |
2023-08-13 |
Not clear |