All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Tessa Timmers, Bart N M van Berckel, Adriaan A Lammertsma, Rik Ossenkoppel. Quantification of Tau Load in Alzheimer's Disease Clinical Trials Using Positron Emission Tomography. Methods in molecular biology (Clifton, N.J.). vol 1750. 2019-02-06. PMID:29512076. alzheimer's disease is a neurodegenerative condition that is neuropathologically characterized by the presence of amyloid-β plaques and neurofibrillary tangles consisting of tau. 2019-02-06 2023-08-13 Not clear
Elena Rodriguez-Vieitez, Agneta Nordber. Imaging Neuroinflammation: Quantification of Astrocytosis in a Multitracer PET Approach. Methods in molecular biology (Clifton, N.J.). vol 1750. 2019-02-06. PMID:29512077. alzheimer's disease (ad)-the most common neurodegenerative disorder-is characterized by a complex neuropathology involving the deposition of extracellular amyloid-β (aβ) plaques and intracellular neurofibrillary tangles (nft) of hyperphosphorylated tau proteins, accompanied by the activation of glial cells-astrocytes and microglia-and neuroinflammatory responses, leading to neurodegeneration and cognitive dysfunction. 2019-02-06 2023-08-13 Not clear
Kevin H Strang, Cara L Croft, Zachary A Sorrentino, Paramita Chakrabarty, Todd E Golde, Benoit I Giasso. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies. The Journal of biological chemistry. vol 293. issue 7. 2019-02-05. PMID:29259137. the accumulation of aberrantly aggregated mapt (microtubule-associated protein tau) defines a spectrum of tauopathies, including alzheimer's disease. 2019-02-05 2023-08-13 Not clear
Benjamin Falcon, Jessica Noad, Harvey McMahon, Felix Randow, Michel Goeder. Galectin-8-mediated selective autophagy protects against seeded tau aggregation. The Journal of biological chemistry. vol 293. issue 7. 2019-02-05. PMID:29282296. this process is thought to underlie the amplification and propagation of tau inclusions throughout the brain in neurodegenerative diseases, including alzheimer's disease. 2019-02-05 2023-08-13 Not clear
Prashanthi Vemuri, Michael Schöl. Linking Amyloid-β and Tau Deposition in Alzheimer Disease. JAMA neurology. vol 74. issue 7. 2019-02-04. PMID:28558092. linking amyloid-β and tau deposition in alzheimer disease. 2019-02-04 2023-08-13 Not clear
T N C Magalhães, M Weiler, C V L Teixeira, T Hayata, A S Moraes, V O Boldrini, L M Dos Santos, B M de Campos, T J R de Rezende, H P G Joaquim, L L Talib, O V Forlenza, F Cendes, Marcio L F Balthaza. Systemic Inflammation and Multimodal Biomarkers in Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29039020. there is increasing evidence suggesting that one of the most relevant pathophysiological features of alzheimer's disease (ad) is neuroinflammation, which plays an important role in the production and regulation of ad-related proteins (amyloid beta (aβ) and tau) and exacerbates ad pathology. 2019-02-04 2023-08-13 Not clear
b' Phillip F Giannopoulos, Domenico Pratic\\xc3\\xb. Overexpression of 5-Lipoxygenase Worsens the Phenotype of a Mouse Model of Tauopathy. Molecular neurobiology. vol 55. issue 7. 2019-02-04. PMID:29128902.' brain accumulation of increasing amount of phosphorylated microtubule associated tau protein is one the major hallmark lesions of alzheimer's disease (ad) and related tauopathies. 2019-02-04 2023-08-13 mouse
Laura Llorach-Pares, Alfons Nonell-Canals, Conxita Avila, Melchor Sanchez-Martine. Kororamides, Convolutamines, and Indole Derivatives as Possible Tau and Dual-Specificity Kinase Inhibitors for Alzheimer's Disease: A Computational Study. Marine drugs. vol 16. issue 10. 2019-02-04. PMID:30332805. kororamides, convolutamines, and indole derivatives as possible tau and dual-specificity kinase inhibitors for alzheimer's disease: a computational study. 2019-02-04 2023-08-13 Not clear
Shohreh Majd, Zohreh Majd, Simon Koblar, John Powe. Beta estradiol and norepinephrine treatment of differentiated SH-SY5Y cells enhances tau phosphorylation at (Ser Molecular and cellular neurosciences. vol 88. 2019-01-31. PMID:29427776. beta estradiol and norepinephrine treatment of differentiated sh-sy5y cells enhances tau phosphorylation at (ser hyperphosphorylation of tau is one of the main hallmarks for alzheimer's disease (ad) and many other tauopathies. 2019-01-31 2023-08-13 Not clear
Rachel E Bennett, Annie Bryant, Miwei Hu, Ashley B Robbins, Sarah C Hopp, Bradley T Hyma. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of neuroinflammation. vol 15. issue 1. 2019-01-29. PMID:30413160. activation of inflammation pathways in the brain occurs in alzheimer's disease and may contribute to the accumulation and spread of pathological proteins including tau. 2019-01-29 2023-08-13 mouse
Maud Gratuze, Aurélie Joly-Amado, Didier Vieau, Luc Buée, David Blu. Mutual Relationship between Tau and Central Insulin Signalling: Consequences for AD and Tauopathies? Neuroendocrinology. vol 107. issue 2. 2019-01-25. PMID:29439247. alzheimer disease (ad) is a progressive neurodegenerative disorder mainly characterized by cognitive deficits and neuropathological changes such as tau lesions and amyloid plaques, but also associated with non-cognitive symptomatology. 2019-01-25 2023-08-13 Not clear
Nalini Vijay Gorantla, Subashchandrabose Chinnathamb. Tau Protein Squired by Molecular Chaperones During Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 66. issue 3. 2019-01-25. PMID:30267382. tau protein squired by molecular chaperones during alzheimer's disease. 2019-01-25 2023-08-13 Not clear
Nalini Vijay Gorantla, Subashchandrabose Chinnathamb. Tau Protein Squired by Molecular Chaperones During Alzheimer's Disease. Journal of molecular neuroscience : MN. vol 66. issue 3. 2019-01-25. PMID:30267382. alzheimer's disease (ad) is a neurodegenerative disorder characterized by progressive neuronal loss, caused by misfolding and accumulation of tau and amyloid β-42. 2019-01-25 2023-08-13 Not clear
Alan Tucholka, Oriol Grau-Rivera, Carles Falcon, Lorena Rami, Raquel Sánchez-Valle, Albert Lladó, Juan Domingo Gispert, José Luis Molinuev. Structural Connectivity Alterations Along the Alzheimer's Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29376852. structural connectivity alterations along the alzheimer's disease continuum: reproducibility across two independent samples and correlation with cerebrospinal fluid amyloid-β and tau. 2019-01-24 2023-08-13 Not clear
Che-Chuan Yang, Ming-Jang Chiu, Ta-Fu Chen, Hui-Ling Chang, Bing-Hsien Liu, Shieh-Yueh Yan. Assay of Plasma Phosphorylated Tau Protein (Threonine 181) and Total Tau Protein in Early-Stage Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29376870. assay of plasma phosphorylated tau protein (threonine 181) and total tau protein in early-stage alzheimer's disease. 2019-01-24 2023-08-13 human
Hua Wang, Tessandra Stewart, Jon B Toledo, Carmen Ginghina, Lu Tang, Anzari Atik, Patrick Aro, Leslie M Shaw, John Q Trojanowski, Douglas R Galasko, Steven Edland, Poul H Jensen, Min Shi, Jing Zhan. A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer's Disease and Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 61. issue 4. 2019-01-24. PMID:29376878. to determine whether addition of cerebrospinal fluid (csf) total α-synuclein and its form phosphorylated at s129 (ps129) to the ad biomarker panel [amyloid-β1-42 (aβ42), tau, and phosphorylated tau (p-tau181)] improves its performance, we examined csf samples collected longitudinally up to 7 years as part of the alzheimer's disease neuroimaging initiative. 2019-01-24 2023-08-13 Not clear
S Duke Han, Caroline P Nguyen, Nikki H Stricker, Daniel A Natio. Detectable Neuropsychological Differences in Early Preclinical Alzheimer's Disease: A Meta-Analysis. Neuropsychology review. vol 27. issue 4. 2019-01-22. PMID:28497179. the development of methods for in vivo detection of cerebral beta amyloid retention and tau accumulation have been increasingly useful in characterizing preclinical alzheimer's disease (ad). 2019-01-22 2023-08-13 Not clear
Anne Gauthier-Kemper, María Suárez Alonso, Frederik Sündermann, Benedikt Niewidok, Maria-Pilar Fernandez, Lidia Bakota, Jürgen Josef Heinisch, Roland Brand. Annexins A2 and A6 interact with the extreme N terminus of tau and thereby contribute to tau's axonal localization. The Journal of biological chemistry. vol 293. issue 21. 2019-01-22. PMID:29636414. in tauopathies such as alzheimer's disease, tau redistributes from the axon to the somatodendritic compartment. 2019-01-22 2023-08-13 Not clear
Qian Wu, Yan Lin, Jiaping Gu, Einar M Sigurdsso. Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging. EBioMedicine. vol 35. 2019-01-22. PMID:30146345. our original findings, showing the effectiveness of active and passive tau immunizations in mouse models, have now been confirmed and extended by many groups, with several clinical trials underway in alzheimer's disease and progressive supranuclear palsy. 2019-01-22 2023-08-13 mouse
Hilda Ferrero, Ignacio M Larrayoz, Maite Solas, Alfredo Martínez, María J Ramírez, Francisco J Gil-Be. Reduced Adrenomedullin Parallels Microtubule Dismantlement in Frontotemporal Lobar Degeneration. Molecular neurobiology. vol 55. issue 12. 2019-01-18. PMID:29671277. previous works in our groups have shown that increased adm products are positively correlated to microtubule disruption and tau pathology in alzheimer's disease brains. 2019-01-18 2023-08-13 Not clear