| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cheril Tapia-Rojas, Nibaldo C Inestros. Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice. Journal of neurochemistry. vol 144. issue 4. 2019-03-08. PMID:29240990. |
alzheimer's disease (ad) is a neurodegenerative pathology characterized by aggregates of amyloid-β (aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. |
2019-03-08 |
2023-08-13 |
mouse |
| b' Maja Jazvin\\xc5\\xa1\\xc4\\x87ak Jembrek, Neda Slade, Patrick R Hof, Goran \\xc5\\xa0imi\\xc4\\x8. The interactions of p53 with tau and A\\xc3\\x9f as potential therapeutic targets for Alzheimer\'s disease. Progress in neurobiology. vol 168. 2019-03-08. PMID:29733887.' |
the interactions of p53 with tau and aß as potential therapeutic targets for alzheimer's disease. |
2019-03-08 |
2023-08-13 |
Not clear |
| Bingqing Shui, Dan Tao, Jing Cheng, Yong Mei, Nicole Jaffrezic-Renault, Zhenzhong Gu. A novel electrochemical aptamer-antibody sandwich assay for the detection of tau-381 in human serum. The Analyst. vol 143. issue 15. 2019-03-08. PMID:30004544. |
tau protein plays a crucial role in the pathogenesis of alzheimer's disease (ad). |
2019-03-08 |
2023-08-13 |
human |
| Peng Lv, Chun-Li Xia, Ning Wang, Zhen-Quan Liu, Zhi-Shu Huang, Shi-Liang Huan. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorganic & medicinal chemistry. vol 26. issue 16. 2019-03-07. PMID:30107970. |
amyloid-β (aβ) and tau protein are two crucial hallmarks in alzheimer's disease (ad). |
2019-03-07 |
2023-08-13 |
Not clear |
| Radhika Sharma, Karan Razdan, Yashika Bansal, Anurag Kuha. Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease. Expert opinion on therapeutic targets. vol 22. issue 10. 2019-03-07. PMID:30223691. |
alzheimer's disease (ad) is associated with cerebral cognitive deficits exhibiting two cardinal hallmarks: accruement of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. |
2019-03-07 |
2023-08-13 |
Not clear |
| Lucia Buccarello, Clara Alice Musi, Arianna Turati, Tiziana Borsell. The Stress c-Jun N-terminal Kinase Signaling Pathway Activation Correlates with Synaptic Pathology and Presents A Sex Bias in P301L Mouse Model of Tauopathy. Neuroscience. vol 393. 2019-03-07. PMID:30315879. |
pathological tau (p-tau) leads to dementia and neurodegeneration in tauopathies, including alzheimer's disease. |
2019-03-07 |
2023-08-13 |
mouse |
| Zhenhua Liu, Fumin Wang, Minglu Tang, Yongjun Zhao, Xiaoting Wan. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A(1) receptor. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30365112. |
amyloid β and tau are involved in sleep disorder in alzheimer's disease by orexin a and adenosine a(1) receptor. |
2019-03-05 |
2023-08-13 |
mouse |
| Yu Gao, Lin Tan, Jin-Tai Yu, Lan Ta. Tau in Alzheimer's Disease: Mechanisms and Therapeutic Strategies. Current Alzheimer research. vol 15. issue 3. 2019-03-04. PMID:28413986. |
tau in alzheimer's disease: mechanisms and therapeutic strategies. |
2019-03-04 |
2023-08-13 |
Not clear |
| A Bochicchio, L Schiavo, L Chiummiento, P Lupattelli, M Funicello, G Hanquet, S Choppin, F Colober. Convergent total synthesis of (±) myricanol, a cyclic natural diarylheptanoid. Organic & biomolecular chemistry. vol 16. issue 45. 2019-03-04. PMID:30411771. |
myricanol 1, a constituent of myrica species, has been reported to lower the levels of the microtubule-associated protein tau (mapt), whose accumulation plays an important role in some neurodegenerative diseases, such as alzheimer's disease (ad). |
2019-03-04 |
2023-08-13 |
Not clear |
| Aaron Y Lai, JoAnne McLauri. Rho-associated protein kinases as therapeutic targets for both vascular and parenchymal pathologies in Alzheimer's disease. Journal of neurochemistry. vol 144. issue 5. 2019-03-01. PMID:28722749. |
interestingly, they play an important role in several vascular and brain pathologies implicated in alzheimer's etiology, including hypertension, hypercholesterolemia, blood-brain barrier disruption, oxidative stress, deposition of vascular and parenchymal amyloid-beta peptides, tau hyperphosphorylation, and cognitive decline. |
2019-03-01 |
2023-08-13 |
Not clear |
| Malin Olsen, Ximena Aguilar, Dag Sehlin, Xiaotian T Fang, Gunnar Antoni, Anna Erlandsson, Stina Syväne. Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease. Molecular imaging and biology. vol 20. issue 4. 2019-02-28. PMID:29297157. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by amyloid-beta (aβ) deposition, hyperphosphorylation of tau, and neuroinflammation. |
2019-02-28 |
2023-08-13 |
mouse |
| Ke Li, Qing Wei, Fang-Fang Liu, Fan Hu, Ao-Ji Xie, Ling-Qiang Zhu, Dan Li. Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28456942. |
synaptic dysfunction in alzheimer's disease: aβ, tau, and epigenetic alterations. |
2019-02-26 |
2023-08-13 |
Not clear |
| Lin Wang, Bing-Jin Liu, Yun Cao, Wei-Qi Xu, Dong-Sheng Sun, Meng-Zhu Li, Fang-Xiao Shi, Man Li, Qing Tian, Jian-Zhi Wang, Xin-Wen Zho. Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer's Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28717968. |
deletion of type-2 cannabinoid receptor induces alzheimer's disease-like tau pathology and memory impairment through ampk/gsk3β pathway. |
2019-02-26 |
2023-08-13 |
Not clear |
| Lin Wang, Bing-Jin Liu, Yun Cao, Wei-Qi Xu, Dong-Sheng Sun, Meng-Zhu Li, Fang-Xiao Shi, Man Li, Qing Tian, Jian-Zhi Wang, Xin-Wen Zho. Deletion of Type-2 Cannabinoid Receptor Induces Alzheimer's Disease-Like Tau Pathology and Memory Impairment Through AMPK/GSK3β Pathway. Molecular neurobiology. vol 55. issue 6. 2019-02-26. PMID:28717968. |
although several studies have shown that type-2 cannabinoid receptor (cb2r) is involved in alzheimer's disease (ad) pathology, the effects of cb2r on ad-like tau abnormal phosphorylation and its underlying mechanism remain unclear. |
2019-02-26 |
2023-08-13 |
Not clear |
| Yann Decker, Andreas Müller, Eszter Németh, Walter J Schulz-Schaeffer, Marc Fatar, Michael D Menger, Yang Liu, Klaus Fassbende. Analysis of the vasculature by immunohistochemistry in paraffin-embedded brains. Brain structure & function. vol 223. issue 2. 2019-02-25. PMID:29260371. |
we subsequently showed that this method is fully compatible with the detection of glial cells and key markers of alzheimer's disease including amyloid beta and phosphorylated tau protein. |
2019-02-25 |
2023-08-13 |
mouse |
| Daniel Felsky, Tina Roostaei, Kwangsik Nho, Shannon L Risacher, Elizabeth M Bradshaw, Vlad Petyuk, Julie A Schneider, Andrew Saykin, David A Bennett, Philip L De Jage. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain. Nature communications. vol 10. issue 1. 2019-02-22. PMID:30679421. |
effect sizes for pam measures are substantial, comparable to that of apoe ε4, the strongest genetic risk factor for alzheimer's disease, and mediation models support an upstream role for microglial activation in alzheimer's disease via accumulation of tau. |
2019-02-22 |
2023-08-13 |
human |
| Jennifer L Whitwel. Alzheimer's disease neuroimaging. Current opinion in neurology. vol 31. issue 4. 2019-02-21. PMID:29762152. |
we now have the capability of measuring both tau and beta-amyloid (aβ) proteins in the brain, which together with more traditional neuroimaging modalities, has led the field to focus on using neuroimaging to better characterize disease mechanisms underlying alzheimer's disease. |
2019-02-21 |
2023-08-13 |
Not clear |
| Ercan Babür, Burak Tan, Sumeyra Delibaş, Marwa Yousef, Nurcan Dursun, Cem Süe. Depotentiation of Long-Term Potentiation Is Associated with Epitope-Specific Tau Hyper-/Hypophosphorylation in the Hippocampus of Adult Rats. Journal of molecular neuroscience : MN. vol 67. issue 2. 2019-02-19. PMID:30498986. |
therefore, we emphasize that tau may be crucial for physiological learning as well as alzheimer's disease pathology. |
2019-02-19 |
2023-08-13 |
rat |
| Yann Fichou, Yanxian Lin, Jennifer N Rauch, Michael Vigers, Zhikai Zeng, Madhur Srivastava, Timothy J Keller, Jack H Freed, Kenneth S Kosik, Songi Ha. Cofactors are essential constituents of stable and seeding-active tau fibrils. Proceedings of the National Academy of Sciences of the United States of America. vol 115. issue 52. 2019-02-19. PMID:30538196. |
accumulation of tau amyloid fibrils is involved in many neurodegenerative diseases, including alzheimer's disease (ad). |
2019-02-19 |
2023-08-13 |
mouse |
| Shohreh Majd, Simon Koblar, John Powe. Compound C enhances tau phosphorylation at Serine Neuroscience letters. vol 670. 2019-02-18. PMID:29398519. |
compound c enhances tau phosphorylation at serine aggregation of hyperphosphorylated tau (p-tau) in the form of neurofibrillary tangles (nft) is a main hallmark for alzheimer's disease (ad). |
2019-02-18 |
2023-08-13 |
Not clear |