| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Abdullah R Chaudhary, Florian Berger, Christopher L Berger, Adam G Hendrick. Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams. Traffic (Copenhagen, Denmark). vol 19. issue 2. 2018-12-11. PMID:29077261. |
dysregulation of tau leads to a range of neurodegenerative diseases known as tauopathies including alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossma. Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease. Human brain mapping. vol 39. issue 2. 2018-12-11. PMID:29105977. |
tau pet imaging predicts cognition in atypical variants of alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
| Jeffrey S Phillips, Sandhitsu R Das, Corey T McMillan, David J Irwin, Emily E Roll, Fulvio Da Re, Ilya M Nasrallah, David A Wolk, Murray Grossma. Tau PET imaging predicts cognition in atypical variants of Alzheimer's disease. Human brain mapping. vol 39. issue 2. 2018-12-11. PMID:29105977. |
accumulation of paired helical filament tau contributes to neurodegeneration in alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Mehdi Jorfi, Carla D'Avanzo, Rudolph E Tanzi, Doo Yeon Kim, Daniel Irimi. Human Neurospheroid Arrays for In Vitro Studies of Alzheimer's Disease. Scientific reports. vol 8. issue 1. 2018-12-11. PMID:29402979. |
interestingly, we observed robust accumulation of amyloid-β and phosphorylated tau, key hallmarks of alzheimer's disease. |
2018-12-11 |
2023-08-13 |
human |
| Zhi-Hao Wang, Ke Gong, Xia Liu, Zhentao Zhang, Xiaoou Sun, Zheng Zachory Wei, Shan Ping Yu, Fredric P Manfredsson, Ivette M Sandoval, Peter F Johnson, Jianping Jia, Jian-Zhi Wang, Keqiang Y. C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature communications. vol 9. issue 1. 2018-12-11. PMID:29725016. |
delta-secretase cleaves both app and tau to mediate the formation of amyloid plaques and neurofibrillary tangle in alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
mouse |
| Justin R Welden, Jacob van Doorn, Peter T Nelson, Stefan Stam. The human MAPT locus generates circular RNAs. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 9 Pt B. 2018-12-11. PMID:29729314. |
the microtubule-associated protein tau, generated by the mapt gene is involved in dozens of neurodegenerative conditions ("tauopathies"), including alzheimer's disease (ad) and frontotemporal lobar degeneration/frontotemporal dementia (ftld/ftd). |
2018-12-11 |
2023-08-13 |
human |
| Sarah M Rothman, Keith Q Tanis, Pallavi Gandhi, Vladislav Malkov, Jacob Marcus, Michelle Pearson, Richard Stevens, Jason Gilliland, Christopher Ware, Veeravan Mahadomrongkul, Elaine O'Loughlin, Gonzalo Zeballos, Roger Smith, Bonnie J Howell, Joel Klappenbach, Matthew Kennedy, Christian Miresc. Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30189875. |
alzheimer's disease (ad) is a chronic neurodegenerative disease with pathological hallmarks including the formation of extracellular aggregates of amyloid-beta (aβ) known as plaques and intracellular tau tangles. |
2018-12-11 |
2023-08-13 |
mouse |
| Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
the role of microglia in processing and spreading of bioactive tau seeds in alzheimer's disease. |
2018-12-11 |
2023-08-13 |
Not clear |
| Sarah C Hopp, Yang Lin, Derek Oakley, Allyson D Roe, Sarah L DeVos, David Hanlon, Bradley T Hyma. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2018-12-11. PMID:30227881. |
misfolding of microtubule-associated protein tau (mapt) within neurons into neurofibrillary tangles is an important pathological feature of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Shengqi Xiang, Natalia Kulminskaya, Birgit Habenstein, Jacek Biernat, Katharina Tepper, Maria Paulat, Christian Griesinger, Stefan Becker, Adam Lange, Eckhard Mandelkow, Rasmus Linse. A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions. Journal of the American Chemical Society. vol 139. issue 7. 2018-11-27. PMID:28124562. |
fibrillar aggregates of aβ and tau in the brain are the major hallmarks of alzheimer's disease. |
2018-11-27 |
2023-08-13 |
Not clear |
| Magdalena J Kiprowska, Anna Stepanova, Dustin R Todaro, Alexander Galkin, Arthur Haas, Scott M Wilson, Maria E Figueiredo-Pereir. Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. vol 1863. issue 6. 2018-11-27. PMID:28372990. |
neurotoxic mechanisms by which the usp14 inhibitor iu1 depletes ubiquitinated proteins and tau in rat cerebral cortical neurons: relevance to alzheimer's disease. |
2018-11-27 |
2023-08-13 |
mouse |
| Laetitia Lemoine, Laure Saint-Aubert, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordber. Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by Scientific reports. vol 7. 2018-11-26. PMID:28374768. |
cortical laminar tau deposits and activated astrocytes in alzheimer's disease visualised by hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of alzheimer disease (ad) pathology. |
2018-11-26 |
2023-08-13 |
Not clear |
| Benita Jebarupa, Monita Muralidharan, Arumugaperumal Arun, Amit Kumar Mandal, Gopa Mitr. Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease. Biophysical chemistry. vol 241. 2018-11-21. PMID:30081240. |
conformational heterogeneity of tau: implication on intrinsic disorder, acid stability and fibrillation in alzheimer's disease. |
2018-11-21 |
2023-08-13 |
Not clear |
| Benita Jebarupa, Monita Muralidharan, Arumugaperumal Arun, Amit Kumar Mandal, Gopa Mitr. Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease. Biophysical chemistry. vol 241. 2018-11-21. PMID:30081240. |
the self-assembly of intrinsically disordered protein tau into paired helical filament forms one of the hallmarks of alzheimer's disease. |
2018-11-21 |
2023-08-13 |
Not clear |
| Benita Jebarupa, Monita Muralidharan, Arumugaperumal Arun, Amit Kumar Mandal, Gopa Mitr. Conformational heterogeneity of tau: Implication on intrinsic disorder, acid stability and fibrillation in Alzheimer's disease. Biophysical chemistry. vol 241. 2018-11-21. PMID:30081240. |
disease-modifying therapies for alzheimer's disease targeting either to disrupt the essential fibril-forming interaction at third microtubule-binding repeat of tau or to perturb specific binding interaction of tau with endogenous polyanionic species might be of high benefit. |
2018-11-21 |
2023-08-13 |
Not clear |
| C E Shepherd, Y Yang, G M Hallida. Region- and Cell-specific Aneuploidy in Brain Aging and Neurodegeneration. Neuroscience. vol 374. 2018-11-20. PMID:29432756. |
the association between alzheimer's pathology and aneuploidy in regions with limited neurodegeneration is supported by a growing body of in vitro and in vivo data on aneuploidy and beta-amyloid and tau abnormalities. |
2018-11-20 |
2023-08-13 |
human |
| Lujia Zhou, Joseph McInnes, Keimpe Wierda, Matthew Holt, Abigail G Herrmann, Rosemary J Jackson, Yu-Chun Wang, Jef Swerts, Jelle Beyens, Katarzyna Miskiewicz, Sven Vilain, Ilse Dewachter, Diederik Moechars, Bart De Strooper, Tara L Spires-Jones, Joris De Wit, Patrik Verstreke. Tau association with synaptic vesicles causes presynaptic dysfunction. Nature communications. vol 8. 2018-11-19. PMID:28492240. |
tau is implicated in more than 20 neurodegenerative diseases, including alzheimer's disease. |
2018-11-19 |
2023-08-13 |
rat |
| Zhangyu Guo, Yanxing Chen, Yan-Fang Mao, Tingting Zheng, Yasi Jiang, Yaping Yan, Xinzhen Yin, Baorong Zhan. Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer's rat model. Scientific reports. vol 7. 2018-11-16. PMID:28382978. |
long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced alzheimer's rat model. |
2018-11-16 |
2023-08-13 |
human |
| V Guru KrishnaKumar, Ashim Paul, Ehud Gazit, Daniel Sega. Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids. Scientific reports. vol 8. issue 1. 2018-11-16. PMID:29311706. |
intra-cellular tau protein tangles and extra-cellular β-amyloid plaques are hallmarks of alzheimer's disease (ad), characterized by the conversion of natively unfolded monomeric protein/peptide into misfolded β-sheet rich aggregates. |
2018-11-16 |
2023-08-13 |
Not clear |
| Ryszard Pluta, Anna Bogucka-Kocka, Marzena Ułamek-Kozioł, Jacek Bogucki, Sławomir Januszewski, Janusz Kocki, Stanisław J Czuczwa. Ischemic tau protein gene induction as an additional key factor driving development of Alzheimer's phenotype changes in CA1 area of hippocampus in an ischemic model of Alzheimer's disease. Pharmacological reports : PR. vol 70. issue 5. 2018-11-16. PMID:30096486. |
ischemic tau protein gene induction as an additional key factor driving development of alzheimer's phenotype changes in ca1 area of hippocampus in an ischemic model of alzheimer's disease. |
2018-11-16 |
2023-08-13 |
Not clear |