All Relations between Alzheimer Disease and microtubule-associated protein tau

Publication Sentence Publish Date Extraction Date Species
Masaaki Waragai, Masaru Moriya, Takeshi Noj. Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:28968236. although molecular positron emission tomography imaging of amyloid and tau proteins can facilitate the detection of preclinical alzheimer's disease (ad) pathology, it is not useful in clinical practice. 2018-07-23 2023-08-13 human
Jeyapriya Raja Sundaram, Charlene Priscilla Poore, Noor Hazim Bin Sulaimee, Tej Pareek, Wei Fun Cheong, Markus R Wenk, Harish C Pant, Sally A Frautschy, Chian-Ming Low, Sashi Kesavapan. Curcumin Ameliorates Neuroinflammation, Neurodegeneration, and Memory Deficits in p25 Transgenic Mouse Model that Bears Hallmarks of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:29036814. deregulation of cyclin-dependent kinase 5 (cdk5) activity by production of its hyperactivator p25 is involved in the formation of tau and amyloid pathology reminiscent of alzheimer's disease (ad). 2018-07-23 2023-08-13 mouse
Loïc Dayon, Jérôme Wojcik, Antonio Núñez Galindo, John Corthésy, Ornella Cominetti, Aikaterini Oikonomidi, Hugues Henry, Eugenia Migliavacca, Gene L Bowman, Julius Pop. Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults. Journal of Alzheimer's disease : JAD. vol 60. issue 4. 2018-07-23. PMID:29125490. cerebrospinal fluid (csf) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing alzheimer's disease (ad). 2018-07-23 2023-08-13 human
Anna Ochalek, Balázs Mihalik, Hasan X Avci, Abinaya Chandrasekaran, Annamária Téglási, István Bock, Maria Lo Giudice, Zsuzsanna Táncos, Kinga Molnár, Lajos László, Jørgen E Nielsen, Bjørn Holst, Kristine Freude, Poul Hyttel, Julianna Kobolák, András Dinnyé. Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation. Alzheimer's research & therapy. vol 9. issue 1. 2018-07-23. PMID:29191219. neurons derived from sporadic alzheimer's disease ipscs reveal elevated tau hyperphosphorylation, increased amyloid levels, and gsk3b activation. 2018-07-23 2023-08-13 human
Laetitia Lemoine, Per-Göran Gillberg, Marie Svedberg, Vladimir Stepanov, Zhisheng Jia, Jinghai Huang, Sangram Nag, He Tian, Bernardino Ghetti, Nobuyuki Okamura, Makoto Higuchi, Christer Halldin, Agneta Nordber. Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains. Alzheimer's research & therapy. vol 9. issue 1. 2018-07-23. PMID:29229003. comparative binding properties of the tau pet tracers thk5117, thk5351, pbb3, and t807 in postmortem alzheimer brains. 2018-07-23 2023-08-13 human
Qian-Qian Ouyang, Shannon Zhao, Si-Dong Li, Cai Son. Application of Chitosan, Chitooligosaccharide, and Their Derivatives in the Treatment of Alzheimer's Disease. Marine drugs. vol 15. issue 11. 2018-07-20. PMID:29112116. classic hypotheses of alzheimer's disease (ad) include cholinergic neuron death, acetylcholine (ach) deficiency, metal ion dynamic equilibrium disorder, and deposition of amyloid and tau. 2018-07-20 2023-08-13 Not clear
Chuan-Xi Mao, Xue Wen, Shan Jin, Yong Q Zhan. Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Disease models & mechanisms. vol 10. issue 10. 2018-07-18. PMID:28819043. increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in tau normally associates with and stabilizes microtubules (mts), but is hyperphosphorylated and aggregated into neurofibrillary tangles in alzheimer's disease and related neurodegenerative diseases, which are collectively known as tauopathies. 2018-07-18 2023-08-13 human
Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Poonam Goswami, Sharad Sharma, Sarika Sing. Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. Cellular signalling. vol 42. 2018-07-18. PMID:29126976. the alzheimer's related pathological marker like acetylcholinesterase (ache) activity, tau phosphorylation and amyloid aggregation were observed after stz administration. 2018-07-18 2023-08-13 rat
Jeremy A Elman, Matthew S Panizzon, Donald J Hagler, Lisa T Eyler, Eric L Granholm, Christine Fennema-Notestine, Michael J Lyons, Linda K McEvoy, Carol E Franz, Anders M Dale, William S Kreme. Task-evoked pupil dilation and BOLD variance as indicators of locus coeruleus dysfunction. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29096196. the lc is an early site of abnormal tau deposition, which may contribute to key aspects of alzheimer's disease (ad) pathophysiology. 2018-07-17 2023-08-13 Not clear
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. tau, amyloid, and cascading network failure across the alzheimer's disease spectrum. 2018-07-17 2023-08-13 human
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. in a large cohort (n = 218) spanning the alzheimer's disease spectrum from young, amyloid negative, cognitively normal subjects to alzheimer's disease dementia, we found several distinct spatial patterns of tau deposition, including 'braak-like' and 'non-braak-like', across functionally related brain regions. 2018-07-17 2023-08-13 human
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. as predicted by the cascading network failure model of alzheimer's disease, we found that amyloid is a partial mediator of the relationship between functional network failure and tau deposition in functionally connected brain regions. 2018-07-17 2023-08-13 human
David T Jones, Jonathan Graff-Radford, Val J Lowe, Heather J Wiste, Jeffrey L Gunter, Matthew L Senjem, Hugo Botha, Kejal Kantarci, Bradley F Boeve, David S Knopman, Ronald C Petersen, Clifford R Jac. Tau, amyloid, and cascading network failure across the Alzheimer's disease spectrum. Cortex; a journal devoted to the study of the nervous system and behavior. vol 97. 2018-07-17. PMID:29102243. this study implicates large-scale brain networks in the pathophysiology of tau deposition and offers support to models incorporating large-scale network physiology into disease models linking tau and amyloid, such as the cascading network failure model of alzheimer's disease. 2018-07-17 2023-08-13 human
Xiu-Yin Shen, Tao Luo, Sheng Li, Ou-Yang Ting, Feng He, Jie Xu, Hua-Qiao Wan. Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+‑calpain‑p25‑CDK5 pathway in HT22 cells. International journal of molecular medicine. vol 41. issue 2. 2018-07-17. PMID:29207020. alzheimer's disease (ad) is a common neurodegenerative disorder characterized by aberrant tau protein hyperphosphorylation, which eventually leads to the formation of neurofibrillary tangles. 2018-07-17 2023-08-13 Not clear
Yan-Hui Zhang, Da-Wei Wang, Shuang-Feng Xu, Shuai Zhang, Yong-Gang Fan, Ying-Ying Yang, Shi-Qi Guo, Shan Wang, Tian Guo, Zhan-You Wang, Chuang Gu. α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice. Redox biology. vol 14. 2018-07-16. PMID:29126071. alzheimer's disease (ad) is the most common neurodegenerative disease and is characterized by neurofibrillary tangles (nfts) composed of tau protein. 2018-07-16 2023-08-13 mouse
Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. PloS one. vol 13. issue 4. 2018-07-16. PMID:29608591. tauopathies including alzheimer's disease and progressive supranuclear palsy are a diverse group of progressive neurodegenerative disorders pathologically defined by inclusions containing aberrantly aggregated, post-translationally modified tau. 2018-07-16 2023-08-13 mouse
Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasso. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. PloS one. vol 13. issue 4. 2018-07-16. PMID:29608591. these antibodies are highly specific for tau and recognize pathological tau inclusions in human tauopathies including alzheimer's disease and progressive supranuclear palsy and in transgenic mouse models of tauopathies. 2018-07-16 2023-08-13 mouse
Colin M Huber, Connor Yee, Taylor May, Apoorva Dhanala, Cassie S Mitchel. Cognitive Decline in Preclinical Alzheimer's Disease: Amyloid-Beta versus Tauopathy. Journal of Alzheimer's disease : JAD. vol 61. issue 1. 2018-07-13. PMID:29154274.  we perform a large-scale meta-analysis of 51 peer-reviewed 3xtg-ad mouse publications to compare alzheimer's disease (ad) quantitative clinical outcome measures, including amyloid-β (aβ), total tau, and phosphorylated tau (ptau), with cognitive performance in morris water maze (mwm) and novel object recognition (nor). 2018-07-13 2023-08-13 mouse
Aviva M Tolkovsky, Jack Brelstaf. Sensory Neurons from Tau Transgenic Mice and Their Utility in Drug Screening. Methods in molecular biology (Clifton, N.J.). vol 1727. 2018-07-13. PMID:29222775. tau misfolding is a major cause of neurodegeneration, tauopathies being a growing group of diseases in which tau forms insoluble aggregates, best known in alzheimer disease as neurofibrillary tangles (nfts). 2018-07-13 2023-08-13 mouse
Xiaoli Wu, Jayasankar Kosaraju, Kin Yip Ta. SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 110. 2018-07-10. PMID:28359686. attenuating tau hyperphosphorylation is considered as an effective therapeutic approach for alzheimer's disease (ad). 2018-07-10 2023-08-13 mouse